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Volumn 10, Issue 11, 2013, Pages 4082-4098

Overcoming nonviral gene delivery barriers: Perspective and future

Author keywords

gene delivery; gene therapy; lipoplexes; nonviral vectors; polyplexes

Indexed keywords

AMINE; CATIONIC LIPID; CATIONIC POLYMER; CHOLESTEROL; DOUBLE STRANDED RNA; GENE THERAPY AGENT; HYDROCARBON; LIPID; LIPOPLEX; NITROGEN; NUCLEIC ACID; PLASMID DNA; POLYLACTIDE; POLYMER; PROTEIN KINASE C; QUATERNARY AMINE; QUATERNARY AMMONIUM DERIVATIVE; SINGLE STRANDED RNA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 84887324806     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400467x     Document Type: Review
Times cited : (360)

References (138)
  • 1
    • 0015492624 scopus 로고
    • Gene therapy for human genetic disease?
    • Friedmann, T.; Roblin, R. Gene therapy for human genetic disease? Science 1972, 175 (4025) 949-55
    • (1972) Science , vol.175 , Issue.4025 , pp. 949-955
    • Friedmann, T.1    Roblin, R.2
  • 2
    • 79953774326 scopus 로고    scopus 로고
    • Non-viral nucleic acid delivery: Key challenges and future directions
    • Elsabahy, M.; Nazarali, A.; Foldvari, M. Non-viral nucleic acid delivery: key challenges and future directions Curr. Drug Delivery 2011, 8 (3) 235-44
    • (2011) Curr. Drug Delivery , vol.8 , Issue.3 , pp. 235-244
    • Elsabahy, M.1    Nazarali, A.2    Foldvari, M.3
  • 3
    • 84863485635 scopus 로고    scopus 로고
    • In vivo gene delivery by nonviral vectors: Overcoming hurdles?
    • Zhang, Y.; Satterlee, A.; Huang, L. In vivo gene delivery by nonviral vectors: overcoming hurdles? Mol. Ther. 2012, 20 (7) 1298-304
    • (2012) Mol. Ther. , vol.20 , Issue.7 , pp. 1298-1304
    • Zhang, Y.1    Satterlee, A.2    Huang, L.3
  • 6
    • 64549134676 scopus 로고    scopus 로고
    • Nonviral vectors for gene delivery
    • Mintzer, M. A.; Simanek, E. E. Nonviral vectors for gene delivery Chemical reviews 2009, 109 (2) 259-302
    • (2009) Chemical Reviews , vol.109 , Issue.2 , pp. 259-302
    • Mintzer, M.A.1    Simanek, E.E.2
  • 9
    • 14044250982 scopus 로고    scopus 로고
    • Formation and intracellular trafficking of lipoplexes and polyplexes
    • Elouahabi, A.; Ruysschaert, J. M. Formation and intracellular trafficking of lipoplexes and polyplexes Mol. Ther. 2005, 11 (3) 336-47
    • (2005) Mol. Ther. , vol.11 , Issue.3 , pp. 336-347
    • Elouahabi, A.1    Ruysschaert, J.M.2
  • 11
    • 0031447208 scopus 로고    scopus 로고
    • DNA condensation by multivalent cations
    • Bloomfield, V. A. DNA condensation by multivalent cations Biopolymers 1997, 44 (3) 269-82
    • (1997) Biopolymers , vol.44 , Issue.3 , pp. 269-282
    • Bloomfield, V.A.1
  • 12
    • 33746438424 scopus 로고    scopus 로고
    • Toxicity of cationic lipids and cationic polymers in gene delivery
    • Lv, H.; Zhang, S.; Wang, B.; Cui, S.; Yan, J. Toxicity of cationic lipids and cationic polymers in gene delivery J. Controlled Release 2006, 114 (1) 100-9
    • (2006) J. Controlled Release , vol.114 , Issue.1 , pp. 100-109
    • Lv, H.1    Zhang, S.2    Wang, B.3    Cui, S.4    Yan, J.5
  • 13
    • 0039006004 scopus 로고    scopus 로고
    • Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity
    • Guenin, E.; Herve, A. C.; Floch, V. V.; Loisel, S.; Yaouanc, J. J.; Clement, J. C.; Ferec, C.; des Abbayes, H. Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity Angew. Chem. 2000, 39 (3) 629-631
    • (2000) Angew. Chem. , vol.39 , Issue.3 , pp. 629-631
    • Guenin, E.1    Herve, A.C.2    Floch, V.V.3    Loisel, S.4    Yaouanc, J.J.5    Clement, J.C.6    Ferec, C.7    Des Abbayes, H.8
  • 15
    • 0031443122 scopus 로고    scopus 로고
    • Cationic lipid-mediated gene delivery to murine lung: Correlation of lipid hydration with in vivo transfection activity
    • Bennett, M. J.; Aberle, A. M.; Balasubramaniam, R. P.; Malone, J. G.; Malone, R. W.; Nantz, M. H. Cationic lipid-mediated gene delivery to murine lung: correlation of lipid hydration with in vivo transfection activity J. Med. Chem. 1997, 40 (25) 4069-78
    • (1997) J. Med. Chem. , vol.40 , Issue.25 , pp. 4069-4078
    • Bennett, M.J.1    Aberle, A.M.2    Balasubramaniam, R.P.3    Malone, J.G.4    Malone, R.W.5    Nantz, M.H.6
  • 17
    • 0035935745 scopus 로고    scopus 로고
    • Design, synthesis, and transfection biology of novel cationic glycolipids for use in liposomal gene delivery
    • Banerjee, R.; Mahidhar, Y. V.; Chaudhuri, A.; Gopal, V.; Rao, N. M. Design, synthesis, and transfection biology of novel cationic glycolipids for use in liposomal gene delivery J. Med. Chem. 2001, 44 (24) 4176-85
    • (2001) J. Med. Chem. , vol.44 , Issue.24 , pp. 4176-4185
    • Banerjee, R.1    Mahidhar, Y.V.2    Chaudhuri, A.3    Gopal, V.4    Rao, N.M.5
  • 18
    • 0001425605 scopus 로고    scopus 로고
    • Nature of linkage between the cationic headgroup and cholesteryl skeleton controls gene transfection efficiency
    • Ghosh, Y. K.; Visweswariah, S. S.; Bhattacharya, S. Nature of linkage between the cationic headgroup and cholesteryl skeleton controls gene transfection efficiency FEBS Lett. 2000, 473 (3) 341-344
    • (2000) FEBS Lett. , vol.473 , Issue.3 , pp. 341-344
    • Ghosh, Y.K.1    Visweswariah, S.S.2    Bhattacharya, S.3
  • 21
    • 0037805617 scopus 로고    scopus 로고
    • Cationic liposomes for gene delivery: From biophysics to biological applications
    • Pedroso de Lima, M. C.; Neves, S.; Filipe, A.; Duzgunes, N.; Simoes, S. Cationic liposomes for gene delivery: from biophysics to biological applications Curr. Med. Chem. 2003, 10 (14) 1221-31
    • (2003) Curr. Med. Chem. , vol.10 , Issue.14 , pp. 1221-1231
    • Pedroso De Lima, M.C.1    Neves, S.2    Filipe, A.3    Duzgunes, N.4    Simoes, S.5
  • 22
    • 0029949266 scopus 로고    scopus 로고
    • Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection
    • Xu, Y.; Szoka, F. C., Jr. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection Biochemistry 1996, 35 (18) 5616-23
    • (1996) Biochemistry , vol.35 , Issue.18 , pp. 5616-5623
    • Xu, Y.1    Szoka Jr., F.C.2
  • 23
    • 0037029804 scopus 로고    scopus 로고
    • Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene delivery
    • Hasegawa, S.; Hirashima, N.; Nakanishi, M. Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene delivery Bioorg. Med. Chem. Lett. 2002, 12 (9) 1299-302
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , Issue.9 , pp. 1299-1302
    • Hasegawa, S.1    Hirashima, N.2    Nakanishi, M.3
  • 24
    • 68149089776 scopus 로고    scopus 로고
    • Advances in gene delivery through molecular design of cationic lipids
    • Bhattacharya, S.; Bajaj, A. Advances in gene delivery through molecular design of cationic lipids Chem. Commun. (Cambridge) 2009, 31, 4632-56
    • (2009) Chem. Commun. (Cambridge) , vol.31 , pp. 4632-4656
    • Bhattacharya, S.1    Bajaj, A.2
  • 25
    • 77951263153 scopus 로고    scopus 로고
    • Transfection efficiency of cationic lipids with different hydrophobic domains in gene delivery
    • Zhi, D.; Zhang, S.; Wang, B.; Zhao, Y.; Yang, B.; Yu, S. Transfection efficiency of cationic lipids with different hydrophobic domains in gene delivery Bioconjugate Chem. 2010, 21 (4) 563-77
    • (2010) Bioconjugate Chem. , vol.21 , Issue.4 , pp. 563-577
    • Zhi, D.1    Zhang, S.2    Wang, B.3    Zhao, Y.4    Yang, B.5    Yu, S.6
  • 26
    • 0038482013 scopus 로고    scopus 로고
    • Structure-activity relationship in cationic lipid mediated gene transfection
    • Niculescu-Duvaz, D.; Heyes, J.; Springer, C. J. Structure-activity relationship in cationic lipid mediated gene transfection Curr. Med. Chem. 2003, 10 (14) 1233-61
    • (2003) Curr. Med. Chem. , vol.10 , Issue.14 , pp. 1233-1261
    • Niculescu-Duvaz, D.1    Heyes, J.2    Springer, C.J.3
  • 27
    • 40449110701 scopus 로고    scopus 로고
    • Structure-function relationship research of glycerol backbone-based cationic lipids for gene delivery
    • Liu, D.; Qiao, W.; Li, Z.; Chen, Y.; Cui, X.; Li, K.; Yu, L.; Yan, K.; Zhu, L.; Guo, Y.; Cheng, L. Structure-function relationship research of glycerol backbone-based cationic lipids for gene delivery Chem. Biol. Drug Des. 2008, 71 (4) 336-44
    • (2008) Chem. Biol. Drug Des. , vol.71 , Issue.4 , pp. 336-344
    • Liu, D.1    Qiao, W.2    Li, Z.3    Chen, Y.4    Cui, X.5    Li, K.6    Yu, L.7    Yan, K.8    Zhu, L.9    Guo, Y.10    Cheng, L.11
  • 28
    • 30444443146 scopus 로고    scopus 로고
    • In vivo studies of dialkynoyl analogues of DOTAP demonstrate improved gene transfer efficiency of cationic liposomes in mouse lung
    • Fletcher, S.; Ahmad, A.; Perouzel, E.; Heron, A.; Miller, A. D.; Jorgensen, M. R. In vivo studies of dialkynoyl analogues of DOTAP demonstrate improved gene transfer efficiency of cationic liposomes in mouse lung J. Med. Chem. 2006, 49 (1) 349-57
    • (2006) J. Med. Chem. , vol.49 , Issue.1 , pp. 349-357
    • Fletcher, S.1    Ahmad, A.2    Perouzel, E.3    Heron, A.4    Miller, A.D.5    Jorgensen, M.R.6
  • 29
    • 0033154811 scopus 로고    scopus 로고
    • Gene transfer by guanidinium-cholesterol: Dioleoylphosphatidyl- ethanolamine liposome-DNA complexes in aerosol
    • Densmore, C. L.; Giddings, T. H.; Waldrep, J. C.; Kinsey, B. M.; Knight, V. Gene transfer by guanidinium-cholesterol: dioleoylphosphatidyl-ethanolamine liposome-DNA complexes in aerosol J. Gene Med. 1999, 1 (4) 251-64
    • (1999) J. Gene Med. , vol.1 , Issue.4 , pp. 251-264
    • Densmore, C.L.1    Giddings, T.H.2    Waldrep, J.C.3    Kinsey, B.M.4    Knight, V.5
  • 30
    • 0038585173 scopus 로고    scopus 로고
    • Photoenhancement of transfection efficiency using novel cationic lipids having a photocleavable spacer
    • Nagasaki, T.; Taniguchi, A.; Tamagaki, S. Photoenhancement of transfection efficiency using novel cationic lipids having a photocleavable spacer Bioconjugate Chem. 2003, 14 (3) 513-6
    • (2003) Bioconjugate Chem. , vol.14 , Issue.3 , pp. 513-516
    • Nagasaki, T.1    Taniguchi, A.2    Tamagaki, S.3
  • 31
    • 0038518258 scopus 로고    scopus 로고
    • Chemical approaches to triggerable lipid vesicles for drug and gene delivery
    • Guo, X.; Szoka, F. C., Jr. Chemical approaches to triggerable lipid vesicles for drug and gene delivery Acc. Chem. Res. 2003, 36 (5) 335-41
    • (2003) Acc. Chem. Res. , vol.36 , Issue.5 , pp. 335-341
    • Guo, X.1    Szoka Jr., F.C.2
  • 32
    • 27144505740 scopus 로고    scopus 로고
    • Mesomorphic complexes of DNA with the mixtures of a cationic surfactant and a neutral lipid
    • Hsu, W. L.; Chen, H. L.; Liou, W.; Lin, H. K.; Liu, W. L. Mesomorphic complexes of DNA with the mixtures of a cationic surfactant and a neutral lipid Langmuir 2005, 21 (21) 9426-31
    • (2005) Langmuir , vol.21 , Issue.21 , pp. 9426-9431
    • Hsu, W.L.1    Chen, H.L.2    Liou, W.3    Lin, H.K.4    Liu, W.L.5
  • 34
    • 0026667564 scopus 로고
    • Inhibition of protein kinase C by cationic amphiphiles
    • Bottega, R.; Epand, R. M. Inhibition of protein kinase C by cationic amphiphiles Biochemistry 1992, 31 (37) 9025-30
    • (1992) Biochemistry , vol.31 , Issue.37 , pp. 9025-9030
    • Bottega, R.1    Epand, R.M.2
  • 35
    • 0028801156 scopus 로고
    • A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery
    • Solodin, I.; Brown, C. S.; Bruno, M. S.; Chow, C. Y.; Jang, E. H.; Debs, R. J.; Heath, T. D. A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery Biochemistry 1995, 34 (41) 13537-44
    • (1995) Biochemistry , vol.34 , Issue.41 , pp. 13537-13544
    • Solodin, I.1    Brown, C.S.2    Bruno, M.S.3    Chow, C.Y.4    Jang, E.H.5    Debs, R.J.6    Heath, T.D.7
  • 38
    • 12844262409 scopus 로고    scopus 로고
    • Pyridinium cationic lipids in gene delivery: An in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener
    • Ilies, M. A.; Johnson, B. H.; Makori, F.; Miller, A.; Seitz, W. A.; Thompson, E. B.; Balaban, A. T. Pyridinium cationic lipids in gene delivery: an in vitro and in vivo comparison of transfection efficiency versus a tetraalkylammonium congener Arch. Biochem. Biophys. 2005, 435 (1) 217-26
    • (2005) Arch. Biochem. Biophys. , vol.435 , Issue.1 , pp. 217-226
    • Ilies, M.A.1    Johnson, B.H.2    Makori, F.3    Miller, A.4    Seitz, W.A.5    Thompson, E.B.6    Balaban, A.T.7
  • 39
    • 33745662122 scopus 로고    scopus 로고
    • Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery
    • Ilies, M. A.; Seitz, W. A.; Johnson, B. H.; Ezell, E. L.; Miller, A. L.; Thompson, E. B.; Balaban, A. T. Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery J. Med. Chem. 2006, 49 (13) 3872-87
    • (2006) J. Med. Chem. , vol.49 , Issue.13 , pp. 3872-3887
    • Ilies, M.A.1    Seitz, W.A.2    Johnson, B.H.3    Ezell, E.L.4    Miller, A.L.5    Thompson, E.B.6    Balaban, A.T.7
  • 41
    • 0025356901 scopus 로고
    • Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles
    • Leventis, R.; Silvius, J. R. Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles Biochim. Biophys. Acta, Biomembr. 1990, 1023 (1) 124-132
    • (1990) Biochim. Biophys. Acta, Biomembr. , vol.1023 , Issue.1 , pp. 124-132
    • Leventis, R.1    Silvius, J.R.2
  • 42
    • 0026497428 scopus 로고
    • Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity
    • Farhood, H.; Bottega, R.; Epand, R. M.; Huang, L. Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity Biochim. Biophys. Acta, Biomembr. 1992, 1111 (2) 239-246
    • (1992) Biochim. Biophys. Acta, Biomembr. , vol.1111 , Issue.2 , pp. 239-246
    • Farhood, H.1    Bottega, R.2    Epand, R.M.3    Huang, L.4
  • 43
    • 0035139627 scopus 로고    scopus 로고
    • New cationic liposomes for gene transfer into mammalian cells with high efficiency and low toxicity
    • Choi, J. S.; Lee, E. J.; Jang, H. S.; Park, J. S. New cationic liposomes for gene transfer into mammalian cells with high efficiency and low toxicity Bioconjugate Chem. 2001, 12 (1) 108-13
    • (2001) Bioconjugate Chem. , vol.12 , Issue.1 , pp. 108-113
    • Choi, J.S.1    Lee, E.J.2    Jang, H.S.3    Park, J.S.4
  • 44
    • 0034736033 scopus 로고    scopus 로고
    • Cation substitution in cationic phosphonolipids: A new concept to improve transfection activity and decrease cellular toxicity
    • Floch, V.; Loisel, S.; Guenin, E.; Herve, A. C.; Clement, J. C.; Yaouanc, J. J.; des Abbayes, H.; Ferec, C. Cation substitution in cationic phosphonolipids: a new concept to improve transfection activity and decrease cellular toxicity J. Med. Chem. 2000, 43 (24) 4617-28
    • (2000) J. Med. Chem. , vol.43 , Issue.24 , pp. 4617-4628
    • Floch, V.1    Loisel, S.2    Guenin, E.3    Herve, A.C.4    Clement, J.C.5    Yaouanc, J.J.6    Des Abbayes, H.7    Ferec, C.8
  • 45
    • 0024464635 scopus 로고
    • Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells
    • Pinnaduwage, P.; Schmitt, L.; Huang, L. Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells Biochim. Biophys. Acta 1989, 985 (1) 33-7
    • (1989) Biochim. Biophys. Acta , vol.985 , Issue.1 , pp. 33-37
    • Pinnaduwage, P.1    Schmitt, L.2    Huang, L.3
  • 46
    • 0032828009 scopus 로고    scopus 로고
    • Synthesis of a single-tailed cationic lipid and investigation of its transfection
    • Tang, F.; Hughes, J. A. Synthesis of a single-tailed cationic lipid and investigation of its transfection J. Controlled Release 1999, 62 (3) 345-58
    • (1999) J. Controlled Release , vol.62 , Issue.3 , pp. 345-358
    • Tang, F.1    Hughes, J.A.2
  • 47
    • 78751546014 scopus 로고    scopus 로고
    • Functionalized Nonionic Dextran Backbones by Atom Transfer Radical Polymerization for Efficient Gene Delivery
    • Wang, Z. H.; Li, W. B.; Ma, J.; Tang, G. P.; Yang, W. T.; Xu, F. J. Functionalized Nonionic Dextran Backbones by Atom Transfer Radical Polymerization for Efficient Gene Delivery Macromolecules 2010, 44 (2) 230-239
    • (2010) Macromolecules , vol.44 , Issue.2 , pp. 230-239
    • Wang, Z.H.1    Li, W.B.2    Ma, J.3    Tang, G.P.4    Yang, W.T.5    Xu, F.J.6
  • 48
    • 77957195112 scopus 로고    scopus 로고
    • Functionalization of Chitosan via Atom Transfer Radical Polymerization for Gene Delivery
    • Ping, Y.; Liu, C.-D.; Tang, G.-P.; Li, J.-S.; Li, J.; Yang, W.-T.; Xu, F.-J. Functionalization of Chitosan via Atom Transfer Radical Polymerization for Gene Delivery Adv. Funct. Mater. 2010, 20 (18) 3106-3116
    • (2010) Adv. Funct. Mater. , vol.20 , Issue.18 , pp. 3106-3116
    • Ping, Y.1    Liu, C.-D.2    Tang, G.-P.3    Li, J.-S.4    Li, J.5    Yang, W.-T.6    Xu, F.-J.7
  • 49
    • 84863229405 scopus 로고    scopus 로고
    • Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection
    • Zhu, C.; Zheng, M.; Meng, F.; Mickler, F. M.; Ruthardt, N.; Zhu, X.; Zhong, Z. Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection Biomacromolecules 2012, 13 (3) 769-78
    • (2012) Biomacromolecules , vol.13 , Issue.3 , pp. 769-778
    • Zhu, C.1    Zheng, M.2    Meng, F.3    Mickler, F.M.4    Ruthardt, N.5    Zhu, X.6    Zhong, Z.7
  • 50
    • 84875315407 scopus 로고    scopus 로고
    • Poly(2-deoxy-2-methacrylamido glucopyranose)-b-Poly(methacrylate amine)s: Optimization of Diblock Glycopolycations for Nucleic Acid Delivery
    • Li, H.; Cortez, M. A.; Phillips, H. R.; Wu, Y.; Reineke, T. M. Poly(2-deoxy-2-methacrylamido glucopyranose)-b-Poly(methacrylate amine)s: Optimization of Diblock Glycopolycations for Nucleic Acid Delivery ACS Macro Lett. 2013, 2 (3) 230-235
    • (2013) ACS Macro Lett. , vol.2 , Issue.3 , pp. 230-235
    • Li, H.1    Cortez, M.A.2    Phillips, H.R.3    Wu, Y.4    Reineke, T.M.5
  • 51
    • 84877044193 scopus 로고    scopus 로고
    • Linear polycations by ring-opening polymerization as non-viral gene delivery vectors
    • Zhang, Q. F.; Yi, W. J.; Wang, B.; Zhang, J.; Ren, L.; Chen, Q. M.; Guo, L.; Yu, X. Q. Linear polycations by ring-opening polymerization as non-viral gene delivery vectors Biomaterials 2013, 34 (21) 5391-401
    • (2013) Biomaterials , vol.34 , Issue.21 , pp. 5391-5401
    • Zhang, Q.F.1    Yi, W.J.2    Wang, B.3    Zhang, J.4    Ren, L.5    Chen, Q.M.6    Guo, L.7    Yu, X.Q.8
  • 52
    • 84874621531 scopus 로고    scopus 로고
    • Synthesis of cationic polylactides with tunable charge densities as nanocarriers for effective gene delivery
    • Jones, C. H.; Chen, C. K.; Jiang, M.; Fang, L.; Cheng, C.; Pfeifer, B. A. Synthesis of cationic polylactides with tunable charge densities as nanocarriers for effective gene delivery Mol. Pharmaceutics 2013, 10 (3) 1138-45
    • (2013) Mol. Pharmaceutics , vol.10 , Issue.3 , pp. 1138-1145
    • Jones, C.H.1    Chen, C.K.2    Jiang, M.3    Fang, L.4    Cheng, C.5    Pfeifer, B.A.6
  • 54
    • 84874606242 scopus 로고    scopus 로고
    • Well-Defined Degradable Brush Polymer-Drug Conjugates for Sustained Delivery of Paclitaxel
    • Yu, Y.; Chen, C. K.; Law, W. C.; Mok, J.; Zou, J.; Prasad, P. N.; Cheng, C. Well-Defined Degradable Brush Polymer-Drug Conjugates for Sustained Delivery of Paclitaxel Mol. Pharmaceutics 2013, 10 (3) 867-74
    • (2013) Mol. Pharmaceutics , vol.10 , Issue.3 , pp. 867-874
    • Yu, Y.1    Chen, C.K.2    Law, W.C.3    Mok, J.4    Zou, J.5    Prasad, P.N.6    Cheng, C.7
  • 55
    • 0034623567 scopus 로고    scopus 로고
    • Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA
    • Lynn, D. M.; Langer, R. Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA J. Am. Chem. Soc. 2000, 122, 10761-10768
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 10761-10768
    • Lynn, D.M.1    Langer, R.2
  • 56
    • 84934435915 scopus 로고    scopus 로고
    • Poly(beta-amino esters): Procedures for synthesis and gene delivery
    • Green, J. J.; Zugates, G. T.; Langer, R.; Anderson, D. G. Poly(beta-amino esters): procedures for synthesis and gene delivery Methods Mol. Biol. 2009, 480, 53-63
    • (2009) Methods Mol. Biol. , vol.480 , pp. 53-63
    • Green, J.J.1    Zugates, G.T.2    Langer, R.3    Anderson, D.G.4
  • 57
    • 84861316754 scopus 로고    scopus 로고
    • Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo
    • Sunshine, J. C.; Sunshine, S. B.; Bhutto, I.; Handa, J. T.; Green, J. J. Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells in vitro and in vivo PLoS One 2012, 7 (5) e37543
    • (2012) PLoS One , vol.7 , Issue.5 , pp. 37543
    • Sunshine, J.C.1    Sunshine, S.B.2    Bhutto, I.3    Handa, J.T.4    Green, J.J.5
  • 58
    • 84868584913 scopus 로고    scopus 로고
    • Uptake and Transfection with Polymeric Nanoparticles Are Dependent on Polymer End-Group Structure, but Largely Independent of Nanoparticle Physical and Chemical Properties
    • Sunshine, J. C.; Peng, D. Y.; Green, J. J. Uptake and Transfection with Polymeric Nanoparticles Are Dependent on Polymer End-Group Structure, but Largely Independent of Nanoparticle Physical and Chemical Properties Mol. Pharmaceutics 2012, 9 (11) 3375-83
    • (2012) Mol. Pharmaceutics , vol.9 , Issue.11 , pp. 3375-3383
    • Sunshine, J.C.1    Peng, D.Y.2    Green, J.J.3
  • 60
    • 0031048568 scopus 로고    scopus 로고
    • Peptide-Mediated Gene Delivery: Influence of Peptide Structure on Gene Expression
    • Wadhwa, M. S.; Collard, W. T.; Adami, R. C.; McKenzie, D. L.; Rice, K. G. Peptide-Mediated Gene Delivery: Influence of Peptide Structure on Gene Expression Bioconjugate Chem. 1997, 8 (1) 81-88
    • (1997) Bioconjugate Chem. , vol.8 , Issue.1 , pp. 81-88
    • Wadhwa, M.S.1    Collard, W.T.2    Adami, R.C.3    McKenzie, D.L.4    Rice, K.G.5
  • 61
    • 0033585470 scopus 로고    scopus 로고
    • Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes
    • Plank, C.; Tang, M. X.; Wolfe, A. R.; Szoka, F. C., Jr. Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes Hum. Gene Ther. 1999, 10 (2) 319-32
    • (1999) Hum. Gene Ther. , vol.10 , Issue.2 , pp. 319-332
    • Plank, C.1    Tang, M.X.2    Wolfe, A.R.3    Szoka Jr., F.C.4
  • 62
    • 0034607160 scopus 로고    scopus 로고
    • Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery
    • Schaffer, D. V.; Fidelman, N. A.; Dan, N.; Lauffenburger, D. A. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery Biotechnol. Bioeng. 2000, 67 (5) 598-606
    • (2000) Biotechnol. Bioeng. , vol.67 , Issue.5 , pp. 598-606
    • Schaffer, D.V.1    Fidelman, N.A.2    Dan, N.3    Lauffenburger, D.A.4
  • 63
    • 49749087562 scopus 로고    scopus 로고
    • Modified pectin-based carrier for gene delivery: Cellular barriers in gene delivery course
    • Katav, T.; Liu, L.; Traitel, T.; Goldbart, R.; Wolfson, M.; Kost, J. Modified pectin-based carrier for gene delivery: cellular barriers in gene delivery course J. Controlled Release 2008, 130 (2) 183-91
    • (2008) J. Controlled Release , vol.130 , Issue.2 , pp. 183-191
    • Katav, T.1    Liu, L.2    Traitel, T.3    Goldbart, R.4    Wolfson, M.5    Kost, J.6
  • 64
    • 43049154835 scopus 로고    scopus 로고
    • Pentablock copolymers of poly(ethylene glycol), poly((2-dimethyl amino)ethyl methacrylate) and poly(2-hydroxyethyl methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene delivery
    • Xu, F. J.; Li, H.; Li, J.; Zhang, Z.; Kang, E. T.; Neoh, K. G. Pentablock copolymers of poly(ethylene glycol), poly((2-dimethyl amino)ethyl methacrylate) and poly(2-hydroxyethyl methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene delivery Biomaterials 2008, 29 (20) 3023-33
    • (2008) Biomaterials , vol.29 , Issue.20 , pp. 3023-3033
    • Xu, F.J.1    Li, H.2    Li, J.3    Zhang, Z.4    Kang, E.T.5    Neoh, K.G.6
  • 66
    • 0032892476 scopus 로고    scopus 로고
    • Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle
    • Godbey, W. T.; Wu, K. K.; Mikos, A. G. Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle J. Biomed. Mater. Res. 1999, 45 (3) 268-75
    • (1999) J. Biomed. Mater. Res. , vol.45 , Issue.3 , pp. 268-275
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 67
    • 80054115169 scopus 로고    scopus 로고
    • HPMA-oligolysine copolymers for gene delivery: Optimization of peptide length and polymer molecular weight
    • Johnson, R. N.; Chu, D. S.; Shi, J.; Schellinger, J. G.; Carlson, P. M.; Pun, S. H. HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight J. Controlled Release 2011, 155 (2) 303-11
    • (2011) J. Controlled Release , vol.155 , Issue.2 , pp. 303-311
    • Johnson, R.N.1    Chu, D.S.2    Shi, J.3    Schellinger, J.G.4    Carlson, P.M.5    Pun, S.H.6
  • 68
    • 84863392986 scopus 로고    scopus 로고
    • Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity
    • Eltoukhy, A. A.; Siegwart, D. J.; Alabi, C. A.; Rajan, J. S.; Langer, R.; Anderson, D. G. Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity Biomaterials 2012, 33 (13) 3594-603
    • (2012) Biomaterials , vol.33 , Issue.13 , pp. 3594-3603
    • Eltoukhy, A.A.1    Siegwart, D.J.2    Alabi, C.A.3    Rajan, J.S.4    Langer, R.5    Anderson, D.G.6
  • 69
    • 78549274320 scopus 로고    scopus 로고
    • Amphiphilic and biodegradable methoxy polyethylene glycol-block- (polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier
    • Guo, S.; Huang, Y.; Wei, T.; Zhang, W.; Wang, W.; Lin, D.; Zhang, X.; Kumar, A.; Du, Q.; Xing, J.; Deng, L.; Liang, Z.; Wang, P. C.; Dong, A.; Liang, X. J. Amphiphilic and biodegradable methoxy polyethylene glycol-block- (polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier Biomaterials 2011, 32 (3) 879-89
    • (2011) Biomaterials , vol.32 , Issue.3 , pp. 879-889
    • Guo, S.1    Huang, Y.2    Wei, T.3    Zhang, W.4    Wang, W.5    Lin, D.6    Zhang, X.7    Kumar, A.8    Du, Q.9    Xing, J.10    Deng, L.11    Liang, Z.12    Wang, P.C.13    Dong, A.14    Liang, X.J.15
  • 70
    • 77954694217 scopus 로고    scopus 로고
    • Cationic polymer optimization for efficient gene delivery
    • Sun, X.; Zhang, N. Cationic polymer optimization for efficient gene delivery Mini-Rev. Med. Chem. 2010, 10 (2) 108-25
    • (2010) Mini-Rev. Med. Chem. , vol.10 , Issue.2 , pp. 108-125
    • Sun, X.1    Zhang, N.2
  • 71
    • 84861122836 scopus 로고    scopus 로고
    • Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors
    • Bacalocostantis, I.; Mane, V. P.; Kang, M. S.; Goodley, A. S.; Muro, S.; Kofinas, P. Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors Biomacromolecules 2012, 13 (5) 1331-9
    • (2012) Biomacromolecules , vol.13 , Issue.5 , pp. 1331-1339
    • Bacalocostantis, I.1    Mane, V.P.2    Kang, M.S.3    Goodley, A.S.4    Muro, S.5    Kofinas, P.6
  • 72
    • 80054071515 scopus 로고    scopus 로고
    • A strategy to improve serum-tolerant transfection activity of polycation vectors by surface hydroxylation
    • Luo, X. H.; Huang, F. W.; Qin, S. Y.; Wang, H. F.; Feng, J.; Zhang, X. Z.; Zhuo, R. X. A strategy to improve serum-tolerant transfection activity of polycation vectors by surface hydroxylation Biomaterials 2011, 32 (36) 9925-39
    • (2011) Biomaterials , vol.32 , Issue.36 , pp. 9925-9939
    • Luo, X.H.1    Huang, F.W.2    Qin, S.Y.3    Wang, H.F.4    Feng, J.5    Zhang, X.Z.6    Zhuo, R.X.7
  • 73
    • 84868152447 scopus 로고    scopus 로고
    • Extraordinarily enhanced gene transfection and cellular uptake by aromatic hydrophobicization to PEI25K
    • Jia, H.-z.; Luo, X.-h.; Cheng, H.; Yang, J.; Li, C.; Liu, C.-W.; Feng, J.; Zhang, X.-z.; Zhuo, R.-x. Extraordinarily enhanced gene transfection and cellular uptake by aromatic hydrophobicization to PEI25K J. Mater. Chem. 2012, 22 (45) 24092-24101
    • (2012) J. Mater. Chem. , vol.22 , Issue.45 , pp. 24092-24101
    • Jia, H.-Z.1    Luo, X.-H.2    Cheng, H.3    Yang, J.4    Li, C.5    Liu, C.-W.6    Feng, J.7    Zhang, X.-Z.8    Zhuo, R.-X.9
  • 75
    • 13844269030 scopus 로고    scopus 로고
    • Polyethylenimine with acid-labile linkages as a biodegradable gene carrier
    • Kim, Y. H.; Park, J. H.; Lee, M.; Park, T. G.; Kim, S. W. Polyethylenimine with acid-labile linkages as a biodegradable gene carrier J. Controlled Release 2005, 103 (1) 209-19
    • (2005) J. Controlled Release , vol.103 , Issue.1 , pp. 209-219
    • Kim, Y.H.1    Park, J.H.2    Lee, M.3    Park, T.G.4    Kim, S.W.5
  • 76
    • 14044252938 scopus 로고    scopus 로고
    • Toward synthetic viruses: Endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
    • Walker, G. F.; Fella, C.; Pelisek, J.; Fahrmeir, J.; Boeckle, S.; Ogris, M.; Wagner, E. Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo Mol. Ther. 2005, 11 (3) 418-25
    • (2005) Mol. Ther. , vol.11 , Issue.3 , pp. 418-425
    • Walker, G.F.1    Fella, C.2    Pelisek, J.3    Fahrmeir, J.4    Boeckle, S.5    Ogris, M.6    Wagner, E.7
  • 77
    • 76749105116 scopus 로고    scopus 로고
    • Acid-transforming polypeptide micelles for targeted nonviral gene delivery
    • Shim, M. S.; Kwon, Y. J. Acid-transforming polypeptide micelles for targeted nonviral gene delivery Biomaterials 2010, 31 (12) 3404-13
    • (2010) Biomaterials , vol.31 , Issue.12 , pp. 3404-3413
    • Shim, M.S.1    Kwon, Y.J.2
  • 78
    • 48149091967 scopus 로고    scopus 로고
    • Charge-conversion ternary polyplex with endosome disruption moiety: A technique for efficient and safe gene delivery
    • Lee, Y.; Miyata, K.; Oba, M.; Ishii, T.; Fukushima, S.; Han, M.; Koyama, H.; Nishiyama, N.; Kataoka, K. Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery Angew. Chem. 2008, 47 (28) 5163-6
    • (2008) Angew. Chem. , vol.47 , Issue.28 , pp. 5163-5166
    • Lee, Y.1    Miyata, K.2    Oba, M.3    Ishii, T.4    Fukushima, S.5    Han, M.6    Koyama, H.7    Nishiyama, N.8    Kataoka, K.9
  • 79
    • 50249125911 scopus 로고    scopus 로고
    • Acetal linked oligoethylenimines for use as pH-sensitive gene carriers
    • Knorr, V.; Russ, V.; Allmendinger, L.; Ogris, M.; Wagner, E. Acetal linked oligoethylenimines for use as pH-sensitive gene carriers Bioconjugate Chem. 2008, 19 (8) 1625-34
    • (2008) Bioconjugate Chem. , vol.19 , Issue.8 , pp. 1625-1634
    • Knorr, V.1    Russ, V.2    Allmendinger, L.3    Ogris, M.4    Wagner, E.5
  • 80
    • 79955774513 scopus 로고    scopus 로고
    • A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA
    • Hwang do, W.; Son, S.; Jang, J.; Youn, H.; Lee, S.; Lee, D.; Lee, Y. S.; Jeong, J. M.; Kim, W. J.; Lee, D. S. A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA Biomaterials 2011, 32 (21) 4968-75
    • (2011) Biomaterials , vol.32 , Issue.21 , pp. 4968-4975
    • Hwang Do, W.1    Son, S.2    Jang, J.3    Youn, H.4    Lee, S.5    Lee, D.6    Lee, Y.S.7    Jeong, J.M.8    Kim, W.J.9    Lee, D.S.10
  • 82
    • 84862791234 scopus 로고    scopus 로고
    • Biodegradable copolymers with identical cationic segments and their performance in siRNA delivery
    • Qi, R.; Liu, S.; Chen, J.; Xiao, H.; Yan, L.; Huang, Y.; Jing, X. Biodegradable copolymers with identical cationic segments and their performance in siRNA delivery J. Controlled Release 2012, 159 (2) 251-60
    • (2012) J. Controlled Release , vol.159 , Issue.2 , pp. 251-260
    • Qi, R.1    Liu, S.2    Chen, J.3    Xiao, H.4    Yan, L.5    Huang, Y.6    Jing, X.7
  • 83
    • 78651246499 scopus 로고    scopus 로고
    • Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA
    • Kano, A.; Moriyama, K.; Yamano, T.; Nakamura, I.; Shimada, N.; Maruyama, A. Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA J. Controlled Release 2011, 149 (1) 2-7
    • (2011) J. Controlled Release , vol.149 , Issue.1 , pp. 2-7
    • Kano, A.1    Moriyama, K.2    Yamano, T.3    Nakamura, I.4    Shimada, N.5    Maruyama, A.6
  • 84
    • 82555192621 scopus 로고    scopus 로고
    • Functional Degradable Polymers via Radical Ring-Opening Polymerization and Click Chemistry
    • Maji, S.; Zheng, M.; Agarwal, S. Functional Degradable Polymers via Radical Ring-Opening Polymerization and Click Chemistry Macromol Chem Physic 2011, 212 (23) 2573-2582
    • (2011) Macromol Chem Physic , vol.212 , Issue.23 , pp. 2573-2582
    • Maji, S.1    Zheng, M.2    Agarwal, S.3
  • 85
    • 80053583366 scopus 로고    scopus 로고
    • Enhanced cell uptake via non-covalent decollation of a single-walled carbon nanotube-DNA hybrid with polyethylene glycol-grafted poly(l-lysine) labeled with an Alexa-dye and its efficient uptake in a cancer cell
    • Fujigaya, T.; Yamamoto, Y.; Kano, A.; Maruyama, A.; Nakashima, N. Enhanced cell uptake via non-covalent decollation of a single-walled carbon nanotube-DNA hybrid with polyethylene glycol-grafted poly(l-lysine) labeled with an Alexa-dye and its efficient uptake in a cancer cell Nanoscale 2011, 3 (10) 4352-8
    • (2011) Nanoscale , vol.3 , Issue.10 , pp. 4352-4358
    • Fujigaya, T.1    Yamamoto, Y.2    Kano, A.3    Maruyama, A.4    Nakashima, N.5
  • 86
    • 84858642577 scopus 로고    scopus 로고
    • Rational design of smart supramolecular assemblies for gene delivery: Chemical challenges in the creation of artificial viruses
    • Miyata, K.; Nishiyama, N.; Kataoka, K. Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses Chem. Soc. Rev. 2012, 41 (7) 2562-74
    • (2012) Chem. Soc. Rev. , vol.41 , Issue.7 , pp. 2562-2574
    • Miyata, K.1    Nishiyama, N.2    Kataoka, K.3
  • 87
    • 84872407943 scopus 로고    scopus 로고
    • Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery
    • Yin, L.; Song, Z.; Kim, K. H.; Zheng, N.; Tang, H.; Lu, H.; Gabrielson, N.; Cheng, J. Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery Biomaterials 2013, 34 (9) 2340-2349
    • (2013) Biomaterials , vol.34 , Issue.9 , pp. 2340-2349
    • Yin, L.1    Song, Z.2    Kim, K.H.3    Zheng, N.4    Tang, H.5    Lu, H.6    Gabrielson, N.7    Cheng, J.8
  • 88
    • 79958782444 scopus 로고    scopus 로고
    • Structure-activity examination of poly(glycoamidoguanidine)s: Glycopolycations containing guanidine units for nucleic acid delivery
    • Taori, V. P.; Lu, H.; Reineke, T. M. Structure-activity examination of poly(glycoamidoguanidine)s: glycopolycations containing guanidine units for nucleic acid delivery Biomacromolecules 2011, 12 (6) 2055-63
    • (2011) Biomacromolecules , vol.12 , Issue.6 , pp. 2055-2063
    • Taori, V.P.1    Lu, H.2    Reineke, T.M.3
  • 89
    • 44449087885 scopus 로고    scopus 로고
    • Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma
    • Ladd, J.; Zhang, Z.; Chen, S.; Hower, J. C.; Jiang, S. Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma Biomacromolecules 2008, 9 (5) 1357-61
    • (2008) Biomacromolecules , vol.9 , Issue.5 , pp. 1357-1361
    • Ladd, J.1    Zhang, Z.2    Chen, S.3    Hower, J.C.4    Jiang, S.5
  • 91
    • 0035955205 scopus 로고    scopus 로고
    • A novel biodegradable gene carrier based on polyphosphoester
    • Wang, J.; Mao, H. Q.; Leong, K. W. A novel biodegradable gene carrier based on polyphosphoester J. Am. Chem. Soc. 2001, 123 (38) 9480-1
    • (2001) J. Am. Chem. Soc. , vol.123 , Issue.38 , pp. 9480-9481
    • Wang, J.1    Mao, H.Q.2    Leong, K.W.3
  • 92
    • 34548156169 scopus 로고    scopus 로고
    • Synthesis of functionalized biodegradable polyesters
    • Williams, C. K. Synthesis of functionalized biodegradable polyesters Chem. Soc. Rev. 2007, 36 (10) 1573-80
    • (2007) Chem. Soc. Rev. , vol.36 , Issue.10 , pp. 1573-1580
    • Williams, C.K.1
  • 93
    • 84863923771 scopus 로고    scopus 로고
    • Bioreducible polymers for gene silencing and delivery
    • Son, S.; Namgung, R.; Kim, J.; Singha, K.; Kim, W. J. Bioreducible polymers for gene silencing and delivery Acc. Chem. Res. 2012, 45 (7) 1100-12
    • (2012) Acc. Chem. Res. , vol.45 , Issue.7 , pp. 1100-1112
    • Son, S.1    Namgung, R.2    Kim, J.3    Singha, K.4    Kim, W.J.5
  • 94
    • 84858749727 scopus 로고    scopus 로고
    • Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery
    • Shi, J.; Johnson, R. N.; Schellinger, J. G.; Carlson, P. M.; Pun, S. H. Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery Int. J. Pharm. 2012, 427 (1) 113-22
    • (2012) Int. J. Pharm. , vol.427 , Issue.1 , pp. 113-122
    • Shi, J.1    Johnson, R.N.2    Schellinger, J.G.3    Carlson, P.M.4    Pun, S.H.5
  • 96
    • 84872122976 scopus 로고    scopus 로고
    • How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances
    • Rehman, Z.; Zuhorn, I. S.; Hoekstra, D. How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances J. Controlled Release 2013, 166 (1) 46-56
    • (2013) J. Controlled Release , vol.166 , Issue.1 , pp. 46-56
    • Rehman, Z.1    Zuhorn, I.S.2    Hoekstra, D.3
  • 97
    • 77950516882 scopus 로고    scopus 로고
    • Nanoparticles targeted with NGR motif deliver c-myc siRNA and doxorubicin for anticancer therapy
    • Chen, Y.; Wu, J. J.; Huang, L. Nanoparticles targeted with NGR motif deliver c-myc siRNA and doxorubicin for anticancer therapy Mol. Ther. 2010, 18 (4) 828-34
    • (2010) Mol. Ther. , vol.18 , Issue.4 , pp. 828-834
    • Chen, Y.1    Wu, J.J.2    Huang, L.3
  • 98
    • 79951944060 scopus 로고    scopus 로고
    • Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor
    • Manjappa, A. S.; Chaudhari, K. R.; Venkataraju, M. P.; Dantuluri, P.; Nanda, B.; Sidda, C.; Sawant, K. K.; Murthy, R. S. Antibody derivatization and conjugation strategies: application in preparation of stealth immunoliposome to target chemotherapeutics to tumor J. Controlled Release 2011, 150 (1) 2-22
    • (2011) J. Controlled Release , vol.150 , Issue.1 , pp. 2-22
    • Manjappa, A.S.1    Chaudhari, K.R.2    Venkataraju, M.P.3    Dantuluri, P.4    Nanda, B.5    Sidda, C.6    Sawant, K.K.7    Murthy, R.S.8
  • 99
    • 77949741829 scopus 로고    scopus 로고
    • Intracellular transduction using cell-penetrating peptides
    • Sawant, R.; Torchilin, V. Intracellular transduction using cell-penetrating peptides Mol. BioSyst. 2010, 6 (4) 628-40
    • (2010) Mol. BioSyst. , vol.6 , Issue.4 , pp. 628-640
    • Sawant, R.1    Torchilin, V.2
  • 101
    • 78149467932 scopus 로고    scopus 로고
    • Targeted nanoparticles deliver siRNA to melanoma
    • Chen, Y.; Bathula, S. R.; Yang, Q.; Huang, L. Targeted nanoparticles deliver siRNA to melanoma J. Invest. Dermatol. 2010, 130 (12) 2790-8
    • (2010) J. Invest. Dermatol. , vol.130 , Issue.12 , pp. 2790-2798
    • Chen, Y.1    Bathula, S.R.2    Yang, Q.3    Huang, L.4
  • 103
    • 37549032712 scopus 로고    scopus 로고
    • Breaking the bonds: Non-viral vectors become chemically dynamic
    • Wolff, J. A.; Rozema, D. B. Breaking the bonds: non-viral vectors become chemically dynamic Mol. Ther. 2008, 16 (1) 8-15
    • (2008) Mol. Ther. , vol.16 , Issue.1 , pp. 8-15
    • Wolff, J.A.1    Rozema, D.B.2
  • 104
    • 5444236205 scopus 로고    scopus 로고
    • Challenges and strategies: The immune responses in gene therapy
    • Zhou, H. S.; Liu, D. P.; Liang, C. C. Challenges and strategies: the immune responses in gene therapy Med. Res. Rev. 2004, 24 (6) 748-61
    • (2004) Med. Res. Rev. , vol.24 , Issue.6 , pp. 748-761
    • Zhou, H.S.1    Liu, D.P.2    Liang, C.C.3
  • 105
    • 84878526418 scopus 로고    scopus 로고
    • Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis
    • El-Sayed, A.; Harashima, H. Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis Mol. Ther. 2013, 21 (6) 1118-30
    • (2013) Mol. Ther. , vol.21 , Issue.6 , pp. 1118-1130
    • El-Sayed, A.1    Harashima, H.2
  • 108
    • 84871918550 scopus 로고    scopus 로고
    • The Possible "proton Sponge" Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH
    • Benjaminsen, R. V.; Mattebjerg, M. A.; Henriksen, J. R.; Moghimi, S. M.; Andresen, T. L. The Possible "Proton Sponge" Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH Mol. Ther. 2013, 21 (1) 149-57
    • (2013) Mol. Ther. , vol.21 , Issue.1 , pp. 149-157
    • Benjaminsen, R.V.1    Mattebjerg, M.A.2    Henriksen, J.R.3    Moghimi, S.M.4    Andresen, T.L.5
  • 110
    • 84878295483 scopus 로고    scopus 로고
    • Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis
    • Rehman, Z. u.; Hoekstra, D.; Zuhorn, I. S. Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis ACS Nano 2013, 7 (5) 3767-77
    • (2013) ACS Nano , vol.7 , Issue.5 , pp. 3767-3777
    • Rehman, Z.U.1    Hoekstra, D.2    Zuhorn, I.S.3
  • 111
    • 52949131846 scopus 로고    scopus 로고
    • A high-throughput comparison of recombinant gene expression parameters for E. Coli-mediated gene transfer to P388D1 macrophage cells
    • Parsa, S.; Wang, Y.; Rines, K.; Pfeifer, B. A. A high-throughput comparison of recombinant gene expression parameters for E. coli-mediated gene transfer to P388D1 macrophage cells J. Biotechnol. 2008, 137 (1-4) 59-64
    • (2008) J. Biotechnol. , vol.137 , Issue.14 , pp. 59-64
    • Parsa, S.1    Wang, Y.2    Rines, K.3    Pfeifer, B.A.4
  • 112
    • 42049096359 scopus 로고    scopus 로고
    • A Comparison between Polymeric Microsphere and Bacterial Vectors for Macrophage P388D1 Gene Delivery
    • Parsa, S.; Wang, Y.; Fuller, J.; Langer, R.; Pfeifer, B. A. A Comparison Between Polymeric Microsphere and Bacterial Vectors for Macrophage P388D1 Gene Delivery Pharm. Res. 2008, 25, 1202-1208
    • (2008) Pharm. Res. , vol.25 , pp. 1202-1208
    • Parsa, S.1    Wang, Y.2    Fuller, J.3    Langer, R.4    Pfeifer, B.A.5
  • 113
    • 77349109732 scopus 로고    scopus 로고
    • Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    • Li, J.; Chen, Y. C.; Tseng, Y. C.; Mozumdar, S.; Huang, L. Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery J. Controlled Release 2010, 142 (3) 416-21
    • (2010) J. Controlled Release , vol.142 , Issue.3 , pp. 416-421
    • Li, J.1    Chen, Y.C.2    Tseng, Y.C.3    Mozumdar, S.4    Huang, L.5
  • 116
    • 0035871674 scopus 로고    scopus 로고
    • Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: Differential circulation in mice and rats and the implications for human gene therapy
    • Ward, C. M.; Read, M. L.; Seymour, L. W. Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy Blood 2001, 97 (8) 2221-9
    • (2001) Blood , vol.97 , Issue.8 , pp. 2221-2229
    • Ward, C.M.1    Read, M.L.2    Seymour, L.W.3
  • 118
    • 0034717044 scopus 로고    scopus 로고
    • Gatekeepers of the nucleus
    • Wente, S. R. Gatekeepers of the nucleus Science 2000, 288 (5470) 1374-7
    • (2000) Science , vol.288 , Issue.5470 , pp. 1374-1377
    • Wente, S.R.1
  • 119
    • 0029984570 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport
    • Gorlich, D.; Mattaj, I. W. Nucleocytoplasmic transport Science 1996, 271 (5255) 1513-8
    • (1996) Science , vol.271 , Issue.5255 , pp. 1513-1518
    • Gorlich, D.1    Mattaj, I.W.2
  • 120
    • 0033524453 scopus 로고    scopus 로고
    • Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus
    • Zanta, M. A.; Belguise-Valladier, P.; Behr, J. P. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus Proc. Natl. Acad. Sci. U.S.A. 1999, 96 (1) 91-6
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , Issue.1 , pp. 91-96
    • Zanta, M.A.1    Belguise-Valladier, P.2    Behr, J.P.3
  • 121
    • 0036190843 scopus 로고    scopus 로고
    • Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems
    • Cartier, R.; Reszka, R. Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems Gene Ther. 2002, 9 (3) 157-67
    • (2002) Gene Ther. , vol.9 , Issue.3 , pp. 157-167
    • Cartier, R.1    Reszka, R.2
  • 122
    • 0032859928 scopus 로고    scopus 로고
    • A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA
    • Branden, L. J.; Mohamed, A. J.; Smith, C. I. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA Nat. Biotechnol. 1999, 17 (8) 784-7
    • (1999) Nat. Biotechnol. , vol.17 , Issue.8 , pp. 784-787
    • Branden, L.J.1    Mohamed, A.J.2    Smith, C.I.3
  • 123
    • 0030786458 scopus 로고    scopus 로고
    • Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrier
    • Baker, A.; Cotten, M. Delivery of bacterial artificial chromosomes into mammalian cells with psoralen-inactivated adenovirus carrier Nucleic Acids Res. 1997, 25 (10) 1950-6
    • (1997) Nucleic Acids Res. , vol.25 , Issue.10 , pp. 1950-1956
    • Baker, A.1    Cotten, M.2
  • 124
    • 80052401275 scopus 로고    scopus 로고
    • Human artificial chromosomes for gene delivery and the development of animal models
    • Kazuki, Y.; Oshimura, M. Human artificial chromosomes for gene delivery and the development of animal models Mol. Ther. 2011, 19 (9) 1591-601
    • (2011) Mol. Ther. , vol.19 , Issue.9 , pp. 1591-1601
    • Kazuki, Y.1    Oshimura, M.2
  • 125
    • 0000015743 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Basic concepts and mechanisms
    • Dias, N.; Stein, C. A. Antisense oligonucleotides: basic concepts and mechanisms Mol. Cancer Ther. 2002, 1 (5) 347-55
    • (2002) Mol. Cancer Ther. , vol.1 , Issue.5 , pp. 347-355
    • Dias, N.1    Stein, C.A.2
  • 127
    • 0037138413 scopus 로고    scopus 로고
    • Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer
    • Noss, K. R.; Wolfe, S. A.; Grimes, S. R. Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer Gene 2002, 285 (1-2) 247-56
    • (2002) Gene , vol.285 , Issue.12 , pp. 247-256
    • Noss, K.R.1    Wolfe, S.A.2    Grimes, S.R.3
  • 128
    • 84877015804 scopus 로고    scopus 로고
    • A Mini-intronic Plasmid (MIP): A Novel Robust Transgene Expression Vector in Vivo and in Vitro
    • Lu, J.; Zhang, F.; Kay, M. A. A Mini-intronic Plasmid (MIP): A Novel Robust Transgene Expression Vector In Vivo and In Vitro Mol. Ther. 2013, 21 (5) 954-63
    • (2013) Mol. Ther. , vol.21 , Issue.5 , pp. 954-963
    • Lu, J.1    Zhang, F.2    Kay, M.A.3
  • 129
    • 84869086449 scopus 로고    scopus 로고
    • The extragenic spacer length between the 5′ and 3′ ends of the transgene expression cassette affects transgene silencing from plasmid-based vectors
    • Lu, J.; Zhang, F.; Xu, S.; Fire, A. Z.; Kay, M. A. The extragenic spacer length between the 5′ and 3′ ends of the transgene expression cassette affects transgene silencing from plasmid-based vectors Mol. Ther. 2012, 20 (11) 2111-9
    • (2012) Mol. Ther. , vol.20 , Issue.11 , pp. 2111-2119
    • Lu, J.1    Zhang, F.2    Xu, S.3    Fire, A.Z.4    Kay, M.A.5
  • 130
    • 0041315884 scopus 로고    scopus 로고
    • Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo
    • Chen, Z. Y.; He, C. Y.; Ehrhardt, A.; Kay, M. A. Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo Mol Ther 2003, 8 (3) 495-500
    • (2003) Mol Ther , vol.8 , Issue.3 , pp. 495-500
    • Chen, Z.Y.1    He, C.Y.2    Ehrhardt, A.3    Kay, M.A.4
  • 131
    • 84861830264 scopus 로고    scopus 로고
    • A minicircle DNA vector-mediated siRNA to stably suppress hepatitis B virus replication and expression
    • Liu, X.; Yang, Z.; Feng, T. [A minicircle DNA vector-mediated siRNA to stably suppress hepatitis B virus replication and expression] Acta Microbiol. Sin. 2012, 52 (2) 191-7
    • (2012) Acta Microbiol. Sin. , vol.52 , Issue.2 , pp. 191-197
    • Liu, X.1    Yang, Z.2    Feng, T.3
  • 132
    • 78650028269 scopus 로고    scopus 로고
    • A robust system for production of minicircle DNA vectors
    • Kay, M. A.; He, C. Y.; Chen, Z. Y. A robust system for production of minicircle DNA vectors Nat. Biotechnol. 2010, 28 (12) 1287-9
    • (2010) Nat. Biotechnol. , vol.28 , Issue.12 , pp. 1287-1289
    • Kay, M.A.1    He, C.Y.2    Chen, Z.Y.3
  • 133
    • 34248562970 scopus 로고    scopus 로고
    • Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos
    • Morcos, P. A. Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos Biochem. Biophys. Res. Commun. 2007, 358 (2) 521-7
    • (2007) Biochem. Biophys. Res. Commun. , vol.358 , Issue.2 , pp. 521-527
    • Morcos, P.A.1
  • 134
    • 84877261475 scopus 로고    scopus 로고
    • Efficient and specific gene knockdown by small interfering RNAs produced in bacteria
    • Huang, L.; Jin, J.; Deighan, P.; Kiner, E.; McReynolds, L.; Lieberman, J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria Nat. Biotechnol. 2013, 31 (4) 350-6
    • (2013) Nat. Biotechnol. , vol.31 , Issue.4 , pp. 350-356
    • Huang, L.1    Jin, J.2    Deighan, P.3    Kiner, E.4    McReynolds, L.5    Lieberman, J.6
  • 135
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga, C.; Tomari, Y.; Shin, C.; Bartel, D. P.; Zamore, P. D. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes Cell 2005, 123 (4) 607-20
    • (2005) Cell , vol.123 , Issue.4 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 136
    • 27744537851 scopus 로고    scopus 로고
    • Human RISC couples microRNA biogenesis and posttranscriptional gene silencing
    • Gregory, R. I.; Chendrimada, T. P.; Cooch, N.; Shiekhattar, R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing Cell 2005, 123 (4) 631-40
    • (2005) Cell , vol.123 , Issue.4 , pp. 631-640
    • Gregory, R.I.1    Chendrimada, T.P.2    Cooch, N.3    Shiekhattar, R.4
  • 138
    • 33745085925 scopus 로고    scopus 로고
    • Short hairpin RNA-expressing bacteria elicit RNA interference in mammals
    • Xiang, S.; Fruehauf, J.; Li, C. J. Short hairpin RNA-expressing bacteria elicit RNA interference in mammals Nat. Biotechnol. 2006, 24 (6) 697-702
    • (2006) Nat. Biotechnol. , vol.24 , Issue.6 , pp. 697-702
    • Xiang, S.1    Fruehauf, J.2    Li, C.J.3


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