Formation and intracellular trafficking of lipoplexes and polyplexes

Molecular Therapy

Volumn 11, Issue 3, 2005, Pages 336-347

  Elouahabi, Abdelatif ^a   Ruysschaert, Jean Marie ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; AMIDINE; CYTOCHALASIN B; LIPOFECTAMINE; LIPOPLEX; PLASMID DNA; POLYAMINE DERIVATIVE; POLYETHYLENEIMINE; POLYLYSINE; POLYMER; POLYPLEX; UNCLASSIFIED DRUG; VIRUS VECTOR;

BINDING KINETICS; CELL TRANSPORT; CHEMICAL STRUCTURE; COMPLEX FORMATION; DNA TRANSFER; DNA VECTOR; ENDOCYTOSIS; ENDOSOME; GENE TARGETING; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PARTICLE SIZE; PROCESS OPTIMIZATION; REVIEW; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CATIONS; CELL NUCLEUS; CHO CELLS; CRICETINAE; CRICETULUS; DNA; ENDOSOMES; GENETIC VECTORS; LIPID METABOLISM; TRANSFECTION;

EID: 14044250982     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.12.006     Document Type: Review

References (98)

1. P.L. Felgner et al. Lipofection: A highly efficient lipid-mediated DNA-transfection procedure Proc. Natl. Acad. Sci. USA 84 1987 7413-7417
2. G.Y. Wu C.H. Wu Receptor-mediated in vitro gene transformation by a soluble DNA carrier system J. Biol. Chem. 262 1987 4429-4432
3. K.L. Brigham B. Meyrick B. Christman M. Magnuson G. King L.C. Berry Jr. In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle Am. J. Med. Sci. 298 1989 278-281
4. G.J. Nabel et al. Direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans Proc. Natl. Acad. Sci. USA 90 1993 11307-11311
5. O. Boussif et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine Proc. Natl. Acad. Sci. USA 92 1995 7297-7301
6. I.S. Zuhorn D. Hoekstra On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: Is that the question? J. Membr. Biol. 189 2002 167-179
7. J.M. Ruysschaert et al. A novel cationic amphiphile for transfection of mammalian cells Biochem. Biophys. Res. Commun. 203 1994 1622-1628
8. F. Sakurai et al. Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression J. Controlled Release 66 2000 255-269
9. P. Pires S. Simoes S. Nir R. Gaspar N. Duzgunes M.C. Pedroso de Lima Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells Biochim. Biophys. Acta 1418 1999 71-84
10. S.J. Eastman C. Siegel J. Tousignant A.E. Smith S.H. Cheng R.K. Scheule Biophysical characterization of cationic lipid:DNA complexes Biochim. Biophys. Acta 1325 1997 41-62
11. D.D. Lasic H. Strey M.C.A. Stuart R. Podgornik P.M. Frederik The structure of DNA-liposome complexes J. Am. Chem. Soc. 119 1997 832-833
12. J.O. Radler I. Koltover T. Salditt C.R. Safinya Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes Science 275 1997 810-814
13. C. Kawaura A. Noguchi T. Furuno M. Nakanishi Atomic force microscopy for studying gene transfection mediated by cationic liposomes with a cationic cholesterol derivative FEBS Lett. 421 1998 69-72
14. P.C. Ross S.W. Hui Lipoplex size is a major determinant of in vitro lipofection efficiency Gene Ther. 6 1999 651-659
15. Y. Xu S.W. Hui P. Frederik F.C. Szoka Jr. Physicochemical characterization and purification of cationic lipoplexes Biophys. J. 77 1999 341-353
16. H. Gershon R. Ghirlando S.B. Guttman A. Minsky Mode of formation and structural features of DNA-cationic liposome complexes used for transfection Biochemistry 32 1993 7143-7151
17. M. Ruponen S. Yla-Herttuala A. Urtti Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies Biochim. Biophys. Acta 1415 1999 331-341
18. B. Sternberg F.L. Sorgi L. Huang New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy FEBS Lett. 356 1994 361-366
19. A. El Ouahabi et al. Intracellular visualization of BrdU-labeled plasmid DNA/cationic liposome complexes J. Histochem. Cytochem. 47 1999 1159-1166
20. J. Gustafsson G. Arvidson G. Karlsson M. Almgren Complexes between cationic liposomes and DNA visualized by cryo-TEM Biochim. Biophys. Acta 1235 1995 305-312
21. S. Huebner B.J. Battersby R. Grimm G. Cevc Lipid-DNA complex formation: reorganization and rupture of lipid vesicles in the presence of DNA as observed by cryoelectron microscopy Biophys. J. 76 1999 3158-3166
22. I. Koltover T. Salditt J.O. Radler C.R. Safinya An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery Science 281 1998 78-81
23. I. Koltover T. Salditt C.R. Safinya Phase diagram, stability, and overcharging of lamellar cationic lipid-DNA self-assembled complexes Biophys. J. 77 1999 915-924
24. V. Cherezov H. Qiu V. Pector M. Vandenbranden J.-M. Ruysschaert M. Caffrey Biophysical and transfection studies of the diC(14)-amidine/DNA complex Biophys. J. 82 2002 3105-3117
25. T. Stegmann J.-Y. Legendre Gene transfer mediated by cationic lipids: lack of a correlation between lipid mixing and transfection Biochim. Biophys. Acta 1325 1997 71-79
26. V. Pector J. Backmann D. Maes M. Vandenbranden J.M. Ruysschaert Biophysical and structural properties of DNA-cationic liposome complexes: Influence of the DNA/lipid ratio J. Biol. Chem. 275 2000 29533-29538
27. J. Zabner A.J. Fasbender T. Moninger K.A. Poellinger M.J. Welsh Cellular and molecular barriers to gene transfer by a cationic lipid J. Biol. Chem. 270 1995 18997-19007
28. K. Kunath et al. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: Comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine J. Controlled Release 89 2003 113-125
29. D.D. Dunlap A. Maggi M.R. Soria L. Monaco Nanoscopic structure of DNA condensed for gene delivery Nucleic Acids Res. 25 1997 3095-3101
30. S. Choosakoonkriang B.A. Lobo G.S. Koe J.G. Koe C.R. Middaugh Biophysical characterization of PEI/DNA complexes J. Pharm. Sci. 92 2003 1710-1722
31. H. Arima Y. Aramaki S. Tsuchiya Contribution of trypsin-sensitive proteins to binding of cationic liposomes to the mouse macrophage-like cell line RAW264.7 J. Pharm. Sci. 86 1997 786-790
32. P. Chenevier B. Veyret D. Roux N. Henry-Toulme Interaction of cationic colloids at the surface of J774 cells: A kinetic analysis Biophys. J. 79 2000 1298-1309
33. F. Labat-Moleur et al. An electron microscopy study into the mechanism of gene transfer with lipopolyamines Gene Ther. 3 1996 1010-1017
34. K.A. Mislick J.D. Baldeschwieler Evidence for the role of proteoglycans in cation-mediated gene transfer Proc. Natl. Acad. Sci. USA 93 1996 12349-12354
35. M. Ruponen S. Ronkko P. Honkakoski J. Pelkonen M. Tammi A. Urtti Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes J. Biol. Chem. 276 2001 33875-33880
36. C.M. Wiethoff J.G. Smith G.S. Koe C.R. Middaugh The potential role of proteoglycans in cationic lipid-mediated gene delivery: Studies of the interaction of cationic lipid-DNA complexes with model glycosaminoglycans J. Biol. Chem. 276 2001 32806-32813
37. M. Belting P. Petersson Intracellular accumulation of secreted proteoglycans inhibits cationic lipid-mediated gene transfer: co-transfer of glycosaminoglycans to the nucleus J. Biol. Chem. 274 1999 19375-19382
38. A. Elouahabi M. Thiry V. Pector J.M. Ruysschaert M. Vandenbranden Calorimetry of cationic liposome-DNA complex and intracellular visualization of the complexes Methods Enzymol. 373 2003 313-332
39. A. El Ouahabi M. Thiry V. Pector R. Fuks J.M. Ruysschaert M. Vandenbranden The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids FEBS Lett. 414 1997 187-192
40. H. Hagerstrand et al. Liposomes composed of a double-chain cationic amphiphile (vectamidine) induce their own encapsulation into human erythrocytes Biochim. Biophys. Acta 1421 1999 125-130
41. X. Zhou L. Huang DNA transfection mediated by cationic liposomes containing lipopolylysine: Characterization and mechanism of action Biochim. Biophys. Acta 1189 1994 195-203
42. D.S. Friend D. Papahadjopoulos R.J. Debs Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes Biochim. Biophys. Acta 1278 1996 41-50
43. M. Ogris P. Steinlein S. Carotta S. Brunner E. Wagner DNA/ polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression AAPS PharmSci. 3 2001 E21
44. A. Remy-Kristensen J.P. Clamme C. Vuilleumier J.G. Kuhry Y. Mely Role of endocytosis in the transfection of L929 fibroblasts by polyethylenimine/ DNA complexes Biochim. Biophys. Acta 1514 2001 21-32
45. T. Bieber W. Meissner S. Kostin A. Niemann H.P. Elsasser Intracellular route and transcriptional competence of polyethylenimine-DNA complexes J. Controlled Release 82 2002 441-454
46. I.S. Zuhorn R. Kalicharan D. Hoekstra Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis J. Biol. Chem. 277 2002 18021-18028
47. H. Matsui L.G. Johnson S.H. Randel R.C. Boucher Loss of binding and entry of liposomes-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells J. Biol. Chem. 272 1997 1117-1126
48. S. Simoes V. Slepushkin P. Pires R. Gaspar M.C. Pedroso de Lima N. Duzgunes Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum Biochim. Biophys. Acta 1463 2000 459-469
49. A. Fasbender J. Zabner B.G. Zeiher M.J. Welsh A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia Gene Ther. 4 1997 1173-1180
50. Q. Chu et al. Binding and uptake of cationic lipid:pDNA complexes by polarized airway epithelial cells Hum. Gene Ther. 10 1999 25-36
51. V. Escriou C. Ciolina F. Lacroix G. Byk D. Scherman P. Wils Cationic lipid-mediated gene transfer: Effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes Biochim. Biophys. Acta 1368 1998 276-288
52. I.S. Zuhorn W.H. Visser U. Bakowsky J.B. Engberts D. Hoekstra Interference of serum with lipoplex-cell interaction: Modulation of intracellular processing Biochim. Biophys. Acta 1560 2002 25-36
53. T. Boukhnikachvili O. Aguerre-Chariol M. Airiau S. Lesieur M. Ollivon J. Vacus Structure of in-serum transfecting DNA-cationic lipid complexes FEBS Lett. 409 1997 188-194
54. J.P. Yang L. Huang Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA Gene Ther. 4 1997 950-960
55. B.M. Tandia M. Vandenbranden R. Wattiez Z. Lakhdar J.M. Ruysschaert A. Elouahabi Identification of human plasma proteins that bind to cationic lipid/DNA complex and analysis of their effects on transfection efficiency: Implications for intravenous gene transfer Mol. Ther. 8 2003 264-273
56. J.W. McLean et al. Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice Am. J. Physiol. 273 1997 H387-H404
57. L.S. Uyechi L. Gagne G. Thurston F.C. Szoka Jr. Mechanism of lipoplex gene delivery in mouse lung: Binding and internalization of fluorescent lipid and DNA components Gene Ther. 8 2001 828-836
58. J.H. Felgner et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations J. Biol. Chem. 269 1994 2550-2561
59. H. Farhood N. Serbina L. Huang The role of dioleoyl phosphatidylethanolamine in cationic liposome-mediated gene transfer Biochim. Biophys. Acta 1235 1995 289-295
60. A. Fasbender J. Marshall T.O. Moninger T. Grunst S. Cheng M.J. Welsh Effect of co-lipids in enhancing cationic-lipid mediated gene transfer in vitro and in vivo Gene Ther. 4 1997 716-725
61. K.W. Mok P.R. Cullis Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA Biophys. J. 73 1997 2534-2545
62. I. Wrobel D. Collins Fusion of cationic liposomes with mammalian cells occurs after endocytosis Biochim. Biophys. Acta 1235 1995 296-304
63. M. Nakanishi A. Noguchi Confocal and probe microscopy to study gene transfection mediated by cationic liposomes with a cationic cholesterol derivative Adv. Drug Delivery Rev. 52 2001 197-207
64. Y. Xu F.C. Szoka Jr. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection Biochemistry 35 1996 5616-5623
65. S. Cornelis M. Vandenbranden J.M. Ruysschaert A. Elouahabi Role of intracellular cationic liposome-DNA complex dissociation in transfection mediated by cationic lipids DNA Cell Biol. 21 2002 91-97
66. A. Coonrod F.-Q. Li M. Horwitz On the mechanism of DNA transfection: efficient gene transfer without viruses Gene Ther. 4 1997 1313-1321
67. D.T. Curiel S. Agarwal E. Wagner M. Cotten Adenovirus enhancement of transferrin-polylysine-mediated gene delivery Proc. Natl. Acad. Sci. USA 88 1991 8850-8854
68. D.T. Curiel et al. High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes Hum. Gene Ther. 3 1992 147-154
69. E. Wagner et al. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes Proc. Natl. Acad. Sci. USA 89 1992 6099-6103
70. E. Wagner C. Plank K. Zatloukal M. Cotten M.L. Birnstiel Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle Proc. Natl. Acad. Sci. USA 89 1992 798-7934
71. Y.W. Cho J.D. Kim K. Park Polycation gene delivery systems: Escape from endosomes to cytosol J. Pharm. Pharmacol. 55 2003 721-734
72. K. Rittner et al. New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo Mol. Ther. 5 2002 104-114
73. M.X. Tang C.T. Redemann F.C. Szoka Jr. In vitro gene delivery by degraded polyamidoamine dendrimers Bioconjugate Chem. 7 1996 703-714
74. A. Kichler C. Leborgne E. Coeytaux O. Danos Polyethylenimine-mediated gene delivery: A mechanistic study J. Gene Med. 3 2001 135-144
75. N.D. Sonawane F.C. Szoka Jr. A.S. Verkman Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes J. Biol. Chem. 278 2003 44826-44831
76. M. Ogris R.C. Carlisle T. Bettinger L.W. Seymour Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors J. Biol. Chem. 276 2001 47550-47555
77. D.V. Schaffer N.A. Fidelman N. Dan D.A. Lauffenburger Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery Biotechnol. Bioeng. 67 2000 598-606
78. M.L. Read K.H. Bremner D. Oupicky N.K. Green P.F. Searle L.W. Seymour Vectors based on reducible polycations facilitate intracellular release of nucleic acids J. Gene Med. 5 2003 232-245
79. M.B. James T.D. Giorgio Nuclear-associated plasmid, but not cell-associated plasmid, is correlated with transgene expression in cultured mammalian cells Mol. Ther. 1 2000 339-346
80. R. Tachibana et al. Quantitative analysis of correlation between number of nuclear plasmids and gene expression activity after transfection with cationic liposomes Pharm. Res. 19 2002 377-381
81. O. Zelphati X. Liang P. Hobart P.L. Felgner Gene chemistry: Functionally and conformationally intact fluorescent plasmid DNA Hum. Gene Ther. 10 1999 15-24
82. D. Lechardeur et al. Metabolic instability of plasmid DNA in the cytosol: A potential barrier to gene transfer Gene Ther. 6 1999 482-497
83. 2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids J. Gene Med. 3 2001 153-164
84. H. Pollard J.S. Remy G. Loussouarn S. Demolombe J.P. Behr D. Escande Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells J. Biol. Chem. 273 1998 7507-7511
85. C. Neves V. Escriou G. Byk D. Scherman P. Wils Intracellular fate and nuclear targeting of plasmid DNA Cell Biol. Toxicol. 15 1999 193-202
86. M.E. Dowty P. Williams G. Zhang J.E. Hagstrom J.A. Wolff Plasmid DNA entry into postmitotic nuclei of primary rat myotubes Proc. Natl. Acad. Sci. USA 92 1995 4572-4576
87. H. Kamiya Y. Fujimura I. Matsuoka H. Harashima Visualization of intracellular trafficking of exogenous DNA delivered by cationic liposomes Biochem. Biophys. Res. Commun. 298 2002 591-597
88. S. Brunner T. Sauer S. Carotta M. Cotton M. Saltik E. Wagner Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus Gene Ther. 7 2000 401-407
89. S. Brunner E. Furtbauer T. Sauer M. Kursa E. Wagner Overcoming the nuclear barrier: Cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation Mol. Ther. 5 2002 80-86
90. M. Wilke E. Fortunati M. van den Broek A.T. Hoogeveen B.J. Scholte Efficacy of a peptide-based gene delivery system depends on mitotic activity Gene Ther. 3 1996 1133-1142
91. W.C. Tseng F.R. Haselton T.D. Giorgio Mitosis enhances transgene expression of plasmid delivered by cationic liposomes Biochim. Biophys. Acta 1445 1999 53-64
92. I. Mortimer P. Tam I. MacLachlan R.W. Graham E.G. Saravolac P.B. Joshi Cationic lipid-mediated transfection of cells in culture requires mitotic activity Gene Ther. 6 1999 403-411
93. J.E. Hagstrom J.J. Ludtke M.C. Bassik M.G. Sebestyen S.A. Adam J.A. Wolff Nuclear import of DNA in digitonin-permeabilized cells J. Cell Sci. 110 1997 2323-2331
94. G.L. Wilson B.S. Dean G. Wang D.A. Dean Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences J. Biol. Chem. 274 1999 22025-22032
95. D.A. Dean Import of plasmid DNA into the nucleus is sequence specific Exp. Cell Res. 230 1997 293-302
96. J. Vacik B.S. Dean W.E. Zimmer D.A. Dean Cell-specific nuclear import of plasmid DNA Gene Ther. 6 1999 1006-1014
97. A. Subramanian P. Ranganathan S.L. Diamond Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells Nat. Biotechnol. 17 1999 873-877
98. L.J. Branden A.J. Mohamed C.I. Smith A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA Nat. Biotechnol. 17 1999 784-787