Design, synthesis, and transfection biology of novel cationic glycolipids for use in liposomal gene delivery

Journal of Medicinal Chemistry

Volumn 44, Issue 24, 2001, Pages 4176-4185

  Banerjee, R ^a,c   Mahidhar, Y V ^a   Chaudhuri, A ^a   Gopal, V ^b   Rao, N M ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY 1 [DIHEXADECYL(METHYL)AMMONIO] DEXTRO ARABINITOL; 1 DEOXY 1 [DIHEXADECYL(METHYL)AMMONIO] DEXTRO XYLITOL; 1 DEOXY 1 [METHYL(DIOCTADECYL)AMMONIO] DEXTRO ARABINITOL; 1 DEOXY 1 [METHYL(DITETRADECYL)AMMONIO] DEXTRO ARABINITOL; CATION; CHOLESTEROL; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; ETHIDIUM BROMIDE; GLYCOLIPID; HYDROXYL GROUP; LIPOSOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; GENE TARGETING; GENETIC TRANSFECTION; HYDROPHILICITY; HYDROPHOBICITY; NONHUMAN; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATIONS; CELL SURVIVAL; COS CELLS; DEOXYRIBONUCLEASE I; DNA; DRUG DESIGN; ETHIDIUM; FLUORESCENT DYES; GENE TRANSFER TECHNIQUES; GLYCOLIPIDS; LIPOSOMES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035935745     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000466s     Document Type: Article

References (53)

1. Gene therapy: The first decade
2. Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides
3. Gene transfer with synthetic cationic amphiphiles: Prospects for gene therapy
4. Novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery
5. Potential of cationic liposome-mediated gene delivery by polycations
6. Design, synthesis and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers
7. Novel tetraester construct that reduces cationic lipid-associated cytotoxicity. Implications for the onset of cytotoxicity
8. Cationic liposomes in gene therapy
9. Nonviral gene therapy: Promises and challenges
10. Noninvasive gene targeting to the brain
11. Optimized galenics improve in vitro gene transfer by cationic molecules up to 1000-fold
12. Biophysical characterization of cationic lipid:DNA Complexes
13. Characterization of lipid-DNA interactions: Destabilization of bound lipids and DNA dissociation
14. Physico-chemical characterization and purification of cationic lipoplexes
15. Evidence of interlipidic ion-pairing in anion-induced DNA release from cationic amphiphile-DNA complexes. Mechanistic implications in transaction
16. Lamellarity of cationic liposomes and mode of preparation of lipoplexes affect transaction efficiency
17. Mode of formation and structural features of DNA-cationic liposome complexes used for transfection
18. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes
19. Barriers to gene transfer by a cationic lipid
20. Mechanism of DNA release in cationic liposome/DNA complexes used in cell transfection
21. Metabolic instability of plasmid DNA in the cytosol: A potential barrier to gene transfer
22. DNA vector chemistry: The covalent attachment of signal peptides to plasmid DNA
23. Lipofectin: A highly efficient lipid-mediated DNA transaction procedure
24. Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles
25. Novel cationic liposome reagent for efficient transfection of mammalian cells
26. Gene transfer in vivo with DNA-liposome complexes: Safety and acute toxicity in mice
27. Noninvasive liposome-mediated gene delivery can correct the ion-transport defect in cystic fibrosis mutant mice
28. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations
29. Cationic liposome-mediated intravenous gene delivery in Mice
30. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
31. Novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung
32. Formation of stable cationic lipid/DNA complexes for gene transfer
33. Cationic lipid-mediated gene delivery to murine lung: Correlation of lipid hydration with in vivo transfection activity
34. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
35. Improved DNA:Liposome complexes for increased systemic delivery and gene expression
36. In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector
37. Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery
38. Phospholipids as non-viral vectors for gene therapy
39. New biocompatible cationic amphiphiles derivative from glycine betaine; a novel family of efficient nonviral gene transfer reagent
40. Transfection compound series based on a versatile tris linkage
41. Novel series of non-glycerol-based cationic transfection lipids for use in liposomal gene delivery
42. Properties of novel nontoxic monocationic lipids: Variations of lipid anchor. Spacer and headgroup structure
43. Characterization of three novel cationic lipids as liposomal complexes with DNA
44. Nature of linkage between the cationic headgroup and cholesteryl skeleton controls gene transfection efficiency
45. Reexamination and further development of a precise and rapid dye method for measuring cell growth/cell kill
46. Analysis of cationic liposome-mediated interactions of plasmid DNA with murine and human melanoma cells in vitro
47. Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes
48. Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes
49. Properties of new glycosidic cationic lipids for DNA delivery
50. Mechanism of oligonucleotide release from cationic liposomes
51. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
52. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery