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Volumn 20, Issue 7, 2012, Pages 1298-1304

In vivo gene delivery by nonviral vectors: Overcoming hurdles

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; DIOLEOYLPHOSPHATIDIC ACID; GOLD NANOPARTICLE; LIPOPLEX; LIPOPOLYPLEX; LIPOSOME; MACROGOL; PLASMID DNA; POLYGLACTIN; POLYPLEX; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 84863485635     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.79     Document Type: Review
Times cited : (317)

References (71)
  • 1
    • 79953774326 scopus 로고    scopus 로고
    • Non-viral nucleic acid delivery: Key challenges and future directions
    • Elsabahy, M, Nazarali, A and Foldvari, M (2011). Non-viral nucleic acid delivery: key challenges and future directions. Curr Drug Deliv 8: 235-244.
    • (2011) Curr Drug Deliv , vol.8 , pp. 235-244
    • Elsabahy, M.1    Nazarali, A.2    Foldvari, M.3
  • 2
    • 79957671438 scopus 로고    scopus 로고
    • RNA interference therapy via functionalized scaffolds
    • Monaghan, M and Pandit, A (2011). RNA interference therapy via functionalized scaffolds. Adv Drug Deliv Rev 63: 197-208.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 197-208
    • Monaghan, M.1    Pandit, A.2
  • 3
    • 73349086270 scopus 로고    scopus 로고
    • Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1
    • Vickers, TA, Lima, WF, Wu, H, Nichols, JG, Linsley, PS and Crooke, ST (2009). Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1. Nucleic Acids Res 37: 6927-6941.
    • (2009) Nucleic Acids Res , vol.37 , pp. 6927-6941
    • Vickers, T.A.1    Lima, W.F.2    Wu, H.3    Nichols, J.G.4    Linsley, P.S.5    Crooke, S.T.6
  • 7
    • 85027933914 scopus 로고    scopus 로고
    • RNAi-based therapeutic strategies for metabolic disease
    • Czech, MP, Aouadi, M and Tesz, GJ (2011). RNAi-based therapeutic strategies for metabolic disease. Nat Rev Endocrinol 7: 473-484.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 473-484
    • Czech, M.P.1    Aouadi, M.2    Tesz, G.J.3
  • 8
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • DOI 10.1016/j.ymthe.2005.11.002, PII S1525001605016746
    • Judge, AD, Bola, G, Lee, AC and MacLachlan, I (2006). Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 13: 494-505. (Pubitemid 43257617)
    • (2006) Molecular Therapy , vol.13 , Issue.3 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.H.3    MacLachlan, I.4
  • 9
    • 80155147118 scopus 로고    scopus 로고
    • Research progress on siRNA delivery with nonviral carriers
    • Gao, Y, Liu, XL and Li, XR (2011). Research progress on siRNA delivery with nonviral carriers. Int J Nanomedicine 6: 1017-1025.
    • (2011) Int J Nanomedicine , vol.6 , pp. 1017-1025
    • Gao, Y.1    Liu, X.L.2    Li, X.R.3
  • 10
    • 80054684446 scopus 로고    scopus 로고
    • Tumor-targeted RNAinterference: Functional non-viral nanovectors
    • Pan, X, Thompson, R, Meng, X, Wu, D and Xu, L (2011). Tumor-targeted RNAinterference: functional non-viral nanovectors. Am J Cancer Res 1: 25-42.
    • (2011) Am J Cancer Res , vol.1 , pp. 25-42
    • Pan, X.1    Thompson, R.2    Meng, X.3    Wu, D.4    Xu, L.5
  • 11
    • 37549032712 scopus 로고    scopus 로고
    • Breaking the bonds: Non-viral vectors become chemically dynamic
    • Wolff, JA and Rozema, DB (2008). Breaking the bonds: non-viral vectors become chemically dynamic. Mol Ther 16: 8-15.
    • (2008) Mol Ther , vol.16 , pp. 8-15
    • Wolff, J.A.1    Rozema, D.B.2
  • 12
    • 77954313055 scopus 로고    scopus 로고
    • Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting
    • Li, SD and Huang, L (2010). Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting. J Control Release 145: 178-181.
    • (2010) J Control Release , vol.145 , pp. 178-181
    • Li, S.D.1    Huang, L.2
  • 14
    • 58149465608 scopus 로고    scopus 로고
    • Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice
    • Schipper, ML, Iyer, G, Koh, AL, Cheng, Z, Ebenstein, Y, Aharoni, A et al. (2009). Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small 5: 126-134.
    • (2009) Small , vol.5 , pp. 126-134
    • Schipper, M.L.1    Iyer, G.2    Koh, A.L.3    Cheng, Z.4    Ebenstein, Y.5    Aharoni, A.6
  • 15
    • 0026694788 scopus 로고
    • Passive tumor targeting of soluble macromolecules and drug conjugates
    • Seymour, LW (1992). Passive tumor targeting of soluble macromolecules and drug conjugates. Crit Rev Ther Drug Carrier Syst 9: 135-187.
    • (1992) Crit Rev Ther Drug Carrier Syst , vol.9 , pp. 135-187
    • Seymour, L.W.1
  • 16
    • 0033752806 scopus 로고    scopus 로고
    • Current status of pH-sensitive liposomes in drug delivery
    • Drummond, DC, Zignani, M and Leroux, J (2000). Current status of pH-sensitive liposomes in drug delivery. Prog Lipid Res 39: 409-460.
    • (2000) Prog Lipid Res , vol.39 , pp. 409-460
    • Drummond, D.C.1    Zignani, M.2    Leroux, J.3
  • 17
    • 0035078410 scopus 로고    scopus 로고
    • Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG - Diortho ester - Lipid conjugate
    • DOI 10.1021/bc000110v
    • Guo, X and Szoka, FC Jr (2001). Steric stabilization of fusogenic liposomes by a lowpH sensitive PEG-diortho ester-lipid conjugate. Bioconjug Chem 12: 291-300. (Pubitemid 32235482)
    • (2001) Bioconjugate Chemistry , vol.12 , Issue.2 , pp. 291-300
    • Guo, X.1    Szoka, Jr.F.C.2
  • 18
    • 14044252938 scopus 로고    scopus 로고
    • Toward synthetic viruses: Endosomal pH-Triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
    • DOI 10.1016/j.ymthe.2004.11.006, PII S1525001604015321
    • Walker, GF, Fella, C, Pelisek, J, Fahrmeir, J, Boeckle, S, Ogris, M et al. (2005). Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. Mol Ther 11: 418-425. (Pubitemid 40277318)
    • (2005) Molecular Therapy , vol.11 , Issue.3 , pp. 418-425
    • Walker, G.F.1    Fella, C.2    Pelisek, J.3    Fahrmeir, J.4    Boeckle, S.5    Ogris, M.6    Wagner, E.7
  • 19
    • 79955084359 scopus 로고    scopus 로고
    • Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumorspecific cleavable PEG-lipid
    • Hatakeyama, H, Akita, H, Ito, E, Hayashi, Y, Oishi, M, Nagasaki, Y et al. (2011). Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumorspecific cleavable PEG-lipid. Biomaterials 32: 4306-4316.
    • (2011) Biomaterials , vol.32 , pp. 4306-4316
    • Hatakeyama, H.1    Akita, H.2    Ito, E.3    Hayashi, Y.4    Oishi, M.5    Nagasaki, Y.6
  • 20
    • 79953066932 scopus 로고    scopus 로고
    • A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma
    • Hatakeyama, H, Akita, H and Harashima, H (2011). A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev 63: 152-160.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 152-160
    • Hatakeyama, H.1    Akita, H.2    Harashima, H.3
  • 22
    • 38049165716 scopus 로고    scopus 로고
    • Sheddable coatings for longcirculating nanoparticles
    • Romberg, B, Hennink, WE and Storm, G (2008). Sheddable coatings for longcirculating nanoparticles. Pharm Res 25: 55-71.
    • (2008) Pharm Res , vol.25 , pp. 55-71
    • Romberg, B.1    Hennink, W.E.2    Storm, G.3
  • 23
    • 79960530841 scopus 로고    scopus 로고
    • In vivo delivery of RNAi with lipid-based nanoparticles
    • Huang, L and Liu, Y (2011). In vivo delivery of RNAi with lipid-based nanoparticles. Annu Rev Biomed Eng 13: 507-530.
    • (2011) Annu Rev Biomed Eng , vol.13 , pp. 507-530
    • Huang, L.1    Liu, Y.2
  • 24
    • 79953732327 scopus 로고    scopus 로고
    • Advances and perspectives in cell-specific aptamers
    • Sun, W, Du, L and Li, M (2011). Advances and perspectives in cell-specific aptamers. Curr Pharm Des 17: 80-91.
    • (2011) Curr Pharm des , vol.17 , pp. 80-91
    • Sun, W.1    Du, L.2    Li, M.3
  • 25
    • 77949741829 scopus 로고    scopus 로고
    • Intracellular transduction using cell-penetrating peptides
    • Sawant, R and Torchilin, V (2010). Intracellular transduction using cell-penetrating peptides. Mol Biosyst 6: 628-640.
    • (2010) Mol Biosyst , vol.6 , pp. 628-640
    • Sawant, R.1    Torchilin, V.2
  • 26
    • 79951944060 scopus 로고    scopus 로고
    • Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor
    • Manjappa, AS, Chaudhari, KR, Venkataraju, MP, Dantuluri, P, Nanda, B, Sidda, C et al. (2011). Antibody derivatization and conjugation strategies: application in preparation of stealth immunoliposome to target chemotherapeutics to tumor. J Control Release 150: 2-22.
    • (2011) J Control Release , vol.150 , pp. 2-22
    • Manjappa, A.S.1    Chaudhari, K.R.2    Venkataraju, M.P.3    Dantuluri, P.4    Nanda, B.5    Sidda, C.6
  • 27
    • 77950516882 scopus 로고    scopus 로고
    • Nanoparticles targeted with NGR motif deliver c-myc siRNA and doxorubicin for anticancer therapy
    • Chen, Y, Wu, JJ and Huang, L (2010). Nanoparticles targeted with NGR motif deliver c-myc siRNA and doxorubicin for anticancer therapy. Mol Ther 18: 828-834.
    • (2010) Mol Ther , vol.18 , pp. 828-834
    • Chen, Y.1    Wu, J.J.2    Huang, L.3
  • 28
    • 78149467932 scopus 로고    scopus 로고
    • Targeted nanoparticles deliver siRNA to melanoma
    • Chen, Y, Bathula, SR, Yang, Q and Huang, L (2010). Targeted nanoparticles deliver siRNA to melanoma. J Invest Dermatol 130: 2790-2798.
    • (2010) J Invest Dermatol , vol.130 , pp. 2790-2798
    • Chen, Y.1    Bathula, S.R.2    Yang, Q.3    Huang, L.4
  • 29
    • 79960561767 scopus 로고    scopus 로고
    • Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma
    • Huang, S, Li, J, Han, L, Liu, S, Ma, H, Huang, R et al. (2011). Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma. Biomaterials 32: 6832-6838.
    • (2011) Biomaterials , vol.32 , pp. 6832-6838
    • Huang, S.1    Li, J.2    Han, L.3    Liu, S.4    Ma, H.5    Huang, R.6
  • 30
    • 59449091692 scopus 로고    scopus 로고
    • In vivo targeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma
    • Díez, S, Navarro, G and de ILarduya, CT (2009). In vivo targeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma. J Gene Med 11: 38-45.
    • (2009) J Gene Med , vol.11 , pp. 38-45
    • Díez, S.1    Navarro, G.2    De Ilarduya, C.T.3
  • 31
    • 0034882516 scopus 로고    scopus 로고
    • On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
    • DOI 10.1038/sj.gt.3301506
    • Hafez, IM, Maurer, N and Cullis, PR (2001). On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Ther 8: 1188-1196. (Pubitemid 32776393)
    • (2001) Gene Therapy , vol.8 , Issue.15 , pp. 1188-1196
    • Hafez, I.M.1    Maurer, N.2    Cullis, P.R.3
  • 33
    • 77954243341 scopus 로고    scopus 로고
    • Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
    • Akinc, A, Querbes, W, De, S, Qin, J, Frank-Kamenetsky, M, Jayaprakash, KN et al. (2010). Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol Ther 18: 1357-1364.
    • (2010) Mol Ther , vol.18 , pp. 1357-1364
    • Akinc, A.1    Querbes, W.2    De S3    Qin, J.4    Frank-Kamenetsky, M.5    Jayaprakash, K.N.6
  • 34
    • 47249130263 scopus 로고    scopus 로고
    • Amine-reactive pyridylhydrazonebased PEG reagents for pH-reversible PEI polyplex shielding
    • Fella, C, Walker, GF, Ogris, M and Wagner, E (2008). Amine-reactive pyridylhydrazonebased PEG reagents for pH-reversible PEI polyplex shielding. Eur J Pharm Sci 34: 309-320.
    • (2008) Eur J Pharm Sci , vol.34 , pp. 309-320
    • Fella, C.1    Walker, G.F.2    Ogris, M.3    Wagner, E.4
  • 35
    • 56049093896 scopus 로고    scopus 로고
    • Carboxymethyl poly(Lhistidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery
    • Asayama, S, Sudo, M, Nagaoka, S and Kawakami, H (2008). Carboxymethyl poly(Lhistidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery. Mol Pharm 5: 898-901.
    • (2008) Mol Pharm , vol.5 , pp. 898-901
    • Asayama, S.1    Sudo, M.2    Nagaoka, S.3    Kawakami, H.4
  • 36
    • 24144489048 scopus 로고    scopus 로고
    • Reversible covalent chemistry in drug delivery
    • DOI 10.2174/1570163054866882
    • West, KR and Otto, S (2005). Reversible covalent chemistry in drug delivery. Curr Drug Discov Technol 2: 123-160. (Pubitemid 41242960)
    • (2005) Current Drug Discovery Technologies , vol.2 , Issue.3 , pp. 123-160
    • West, K.R.1    Otto, S.2
  • 37
    • 0033199557 scopus 로고    scopus 로고
    • New detachable poly(ethylene glycol) conjugates: Cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamine
    • DOI 10.1021/bc990031n
    • Zalipsky, S, Qazen, M, Walker, JA 2nd, Mullah, N, Quinn, YP and Huang, SK (1999). New detachable poly(ethylene glycol) conjugates: cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamine. Bioconjug Chem 10: 703-707. (Pubitemid 29456355)
    • (1999) Bioconjugate Chemistry , vol.10 , Issue.5 , pp. 703-707
    • Zalipsky, S.1    Qazen, M.2    Walker II, J.A.3    Mullah, N.4    Quinn, Y.P.5    Huang, S.K.6
  • 38
    • 78649962007 scopus 로고    scopus 로고
    • PH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells
    • Mok, H, Veiseh, O, Fang, C, Kievit, FM, Wang, FY, Park, JO et al. (2010). pH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells. Mol Pharm 7: 1930-1939.
    • (2010) Mol Pharm , vol.7 , pp. 1930-1939
    • Mok, H.1    Veiseh, O.2    Fang, C.3    Kievit, F.M.4    Wang, F.Y.5    Park, J.O.6
  • 40
    • 69949155656 scopus 로고    scopus 로고
    • A pHsensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
    • Hatakeyama, H, Ito, E, Akita, H, Oishi, M, Nagasaki, Y, Futaki, S et al. (2009). A pHsensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J Control Release 139: 127-132.
    • (2009) J Control Release , vol.139 , pp. 127-132
    • Hatakeyama, H.1    Ito, E.2    Akita, H.3    Oishi, M.4    Nagasaki, Y.5    Futaki, S.6
  • 41
    • 79957912413 scopus 로고    scopus 로고
    • Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA
    • Sakurai, Y, Hatakeyama, H, Sato, Y, Akita, H, Takayama, K, Kobayashi, S et al. (2011). Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA. Biomaterials 32: 5733-5742.
    • (2011) Biomaterials , vol.32 , pp. 5733-5742
    • Sakurai, Y.1    Hatakeyama, H.2    Sato, Y.3    Akita, H.4    Takayama, K.5    Kobayashi, S.6
  • 42
    • 77349109732 scopus 로고    scopus 로고
    • Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    • Li, J, Chen, YC, Tseng, YC, Mozumdar, S and Huang, L (2010). Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery. J Control Release 142: 416-421.
    • (2010) J Control Release , vol.142 , pp. 416-421
    • Li, J.1    Chen, Y.C.2    Tseng, Y.C.3    Mozumdar, S.4    Huang, L.5
  • 43
    • 84857771152 scopus 로고    scopus 로고
    • Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer
    • Bolhassani, A (2011). Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer. Biochim Biophys Acta 1816: 232-246.
    • (2011) Biochim Biophys Acta , vol.1816 , pp. 232-246
    • Bolhassani, A.1
  • 44
    • 0029908918 scopus 로고    scopus 로고
    • Nuclear localization signal of SV40 T antigen directs import of plasmid DNA into sea urchin male pronuclei in vitro
    • DOI 10.1002/(SICI)1098-2795 (199612)45:4<431::AID-MRD4>3.0.CO;2-S
    • Collas, P and Aleström, P (1996). Nuclear localization signal of SV40 T antigen directs import of plasmid DNA into sea urchin male pronuclei in vitro. Mol Reprod Dev 45: 431-438. (Pubitemid 26408782)
    • (1996) Molecular Reproduction and Development , vol.45 , Issue.4 , pp. 431-438
    • Collas, P.1    Alestrom, P.2
  • 45
    • 0033047861 scopus 로고    scopus 로고
    • Cell-specific nuclear import of plasmid DNA
    • DOI 10.1038/sj.gt.3300924
    • Vacik, J, Dean, BS, Zimmer, WE and Dean, DA (1999). Cell-specific nuclear import of plasmid DNA. Gene Ther 6: 1006-1014. (Pubitemid 29295205)
    • (1999) Gene Therapy , vol.6 , Issue.6 , pp. 1006-1014
    • Vacik, J.1    Dean, B.S.2    Zimmer, W.E.3    Dean, D.A.4
  • 46
    • 84863285543 scopus 로고    scopus 로고
    • Membrane and nuclear permeabilization by polymeric pDNA vehicles: Efficient method for gene delivery or mechanism of cytotoxicity?
    • Grandinetti, G, Smith, AE and Reineke, TM (2012). Membrane and nuclear permeabilization by polymeric pDNA vehicles: efficient method for gene delivery or mechanism of cytotoxicity? Mol Pharm 9: 523-538.
    • (2012) Mol Pharm , vol.9 , pp. 523-538
    • Grandinetti, G.1    Smith, A.E.2    Reineke, T.M.3
  • 47
    • 80053481644 scopus 로고    scopus 로고
    • Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: Implications for a mechanism of cytotoxicity
    • Grandinetti, G, Ingle, NP and Reineke, TM (2011). Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: implications for a mechanism of cytotoxicity. Mol Pharm 8: 1709-1719.
    • (2011) Mol Pharm , vol.8 , pp. 1709-1719
    • Grandinetti, G.1    Ingle, N.P.2    Reineke, T.M.3
  • 48
    • 78449309070 scopus 로고    scopus 로고
    • Efficient and targeted delivery of siRNA in vivo
    • Shim, MS and Kwon, YJ (2010). Efficient and targeted delivery of siRNA in vivo. FEBS J 277: 4814-4827.
    • (2010) FEBS J , vol.277 , pp. 4814-4827
    • Shim, M.S.1    Kwon, Y.J.2
  • 49
    • 79952107509 scopus 로고    scopus 로고
    • A singlemonomer derived linear-like PEI-co-PEG for siRNA delivery and silencing
    • Tsai, LR, Chen, MH, Chien, CT, Chen, MK, Lin, FS, Lin, KM et al. (2011). A singlemonomer derived linear-like PEI-co-PEG for siRNA delivery and silencing. Biomaterials 32: 3647-3653.
    • (2011) Biomaterials , vol.32 , pp. 3647-3653
    • Tsai, L.R.1    Chen, M.H.2    Chien, C.T.3    Chen, M.K.4    Lin, F.S.5    Lin, K.M.6
  • 50
    • 79955482854 scopus 로고    scopus 로고
    • Bioreducible poly (ß-amino esters)/shRNA complex nanoparticles for efficient RNA delivery
    • Yin, Q, Gao, Y, Zhang, Z, Zhang, P and Li, Y (2011). Bioreducible poly (ß-amino esters)/shRNA complex nanoparticles for efficient RNA delivery. J Control Release 151: 35-44.
    • (2011) J Control Release , vol.151 , pp. 35-44
    • Yin, Q.1    Gao, Y.2    Zhang, Z.3    Zhang, P.4    Li, Y.5
  • 51
    • 84863479670 scopus 로고    scopus 로고
    • Polymers for siRNA delivery: Inspired by viruses to be targeted, dynamic, and precise
    • epub ahead of print
    • Wagner, E (2011). Polymers for siRNA delivery: inspired by viruses to be targeted, dynamic, and precise. Acc Chem Res (epub ahead of print).
    • (2011) Acc Chem Res
    • Wagner, E.1
  • 52
    • 80052596798 scopus 로고    scopus 로고
    • Solid-phase synthesis of sequence-defined T-, i-, and U-shape polymers for pDNA and siRNA delivery
    • Schaffert, D, Troiber, C, Salcher, EE, Fröhlich, T, Martin, I, Badgujar, N et al. (2011). Solid-phase synthesis of sequence-defined T-, i-, and U-shape polymers for pDNA and siRNA delivery. Angew Chem Int Ed Engl 50: 8986-8989.
    • (2011) Angew Chem Int Ed Engl , vol.50 , pp. 8986-8989
    • Schaffert, D.1    Troiber, C.2    Salcher, E.E.3    Fröhlich, T.4    Martin, I.5    Badgujar, N.6
  • 53
    • 33750417183 scopus 로고    scopus 로고
    • Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells
    • DOI 10.1021/mp060039w
    • Li, SD and Huang, L (2006). Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Mol Pharm 3: 579-588. (Pubitemid 44639135)
    • (2006) Molecular Pharmaceutics , vol.3 , Issue.5 , pp. 579-588
    • Li, S.-D.1    Huang, L.2
  • 54
    • 37549004351 scopus 로고    scopus 로고
    • Tumor-targeted delivery of siRNA by self-assembled nanoparticles
    • Li, SD, Chen, YC, Hackett, MJ and Huang, L (2008). Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Mol Ther 16: 163-169.
    • (2008) Mol Ther , vol.16 , pp. 163-169
    • Li, S.D.1    Chen, Y.C.2    Hackett, M.J.3    Huang, L.4
  • 55
    • 42549142820 scopus 로고    scopus 로고
    • Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA
    • DOI 10.1038/mt.2008.51, PII MT200851
    • Li, SD, Chono, S and Huang, L (2008). Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Mol Ther 16: 942-946. (Pubitemid 351587105)
    • (2008) Molecular Therapy , vol.16 , Issue.5 , pp. 942-946
    • Li, S.-D.1    Chono, S.2    Huang, L.3
  • 56
    • 0029932762 scopus 로고    scopus 로고
    • Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer
    • DOI 10.1074/jbc.271.14.8481
    • Lee, RJ and Huang, L (1996). Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J Biol Chem 271: 8481-8487. (Pubitemid 26108687)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.14 , pp. 8481-8487
    • Lee, R.J.1    Huang, L.2
  • 57
    • 52049121804 scopus 로고    scopus 로고
    • An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor
    • Chono, S, Li, SD, Conwell, CC and Huang, L (2008). An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor. J Control Release 131: 64-69.
    • (2008) J Control Release , vol.131 , pp. 64-69
    • Chono, S.1    Li, S.D.2    Conwell, C.C.3    Huang, L.4
  • 58
    • 77956269093 scopus 로고    scopus 로고
    • Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy
    • Chen, Y, Zhu, X, Zhang, X, Liu, B and Huang, L (2010). Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther 18: 1650-1656.
    • (2010) Mol Ther , vol.18 , pp. 1650-1656
    • Chen, Y.1    Zhu, X.2    Zhang, X.3    Liu, B.4    Huang, L.5
  • 59
    • 79960725328 scopus 로고    scopus 로고
    • Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA
    • Perche, F, Benvegnu, T, Berchel, M, Lebegue, L, Pichon, C, Jaffrès, PA et al. (2011). Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA. Nanomedicine 7: 445-453.
    • (2011) Nanomedicine , vol.7 , pp. 445-453
    • Perche, F.1    Benvegnu, T.2    Berchel, M.3    Lebegue, L.4    Pichon, C.5    Jaffrès, P.A.6
  • 61
    • 38949151892 scopus 로고    scopus 로고
    • Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system
    • DOI 10.1016/j.addr.2007.10.007, PII S0169409X07002906
    • Kogure, K, Akita, H, Yamada, Y and Harashima, H (2008). Multifunctional envelopetype nano device (MEND) as a non-viral gene delivery system. Adv Drug Deliv Rev 60: 559-571. (Pubitemid 351215573)
    • (2008) Advanced Drug Delivery Reviews , vol.60 , Issue.4-5 , pp. 559-571
    • Kogure, K.1    Akita, H.2    Yamada, Y.3    Harashima, H.4
  • 62
    • 0027537022 scopus 로고
    • A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA
    • Wang, KY, McCurdy, S, Shea, RG, Swaminathan, S and Bolton, PH (1993). A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA. Biochemistry 32: 1899-1904. (Pubitemid 23086037)
    • (1993) Biochemistry , vol.32 , Issue.8 , pp. 1899-1904
    • Ke Yu Wang1    McCurdy, S.2    Shea, R.G.3    Swaminathan, S.4    Bolton, P.H.5
  • 63
    • 80054825739 scopus 로고    scopus 로고
    • New insight into clinical development of nucleic acid aptamers
    • Esposito, CL, Catuogno, S, de Franciscis, V and Cerchia, L (2011). New insight into clinical development of nucleic acid aptamers. Discov Med 11: 487-496.
    • (2011) Discov Med , vol.11 , pp. 487-496
    • Esposito, C.L.1    Catuogno, S.2    De Franciscis, V.3    Cerchia, L.4
  • 65
    • 70249110439 scopus 로고    scopus 로고
    • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
    • Dassie, JP, Liu, XY, Thomas, GS, Whitaker, RM, Thiel, KW, Stockdale, KR et al. (2009). Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol 27: 839-849.
    • (2009) Nat Biotechnol , vol.27 , pp. 839-849
    • Dassie, J.P.1    Liu, X.Y.2    Thomas, G.S.3    Whitaker, R.M.4    Thiel, K.W.5    Stockdale, K.R.6
  • 67
    • 76249115458 scopus 로고    scopus 로고
    • Enhanced laminin-derived peptide AG73-mediated liposomal gene transfer by bubble liposomes and ultrasound
    • Negishi, Y, Omata, D, Iijima, H, Takabayashi, Y, Suzuki, K, Endo, Y et al. (2010). Enhanced laminin-derived peptide AG73-mediated liposomal gene transfer by bubble liposomes and ultrasound. Mol Pharm 7: 217-226.
    • (2010) Mol Pharm , vol.7 , pp. 217-226
    • Negishi, Y.1    Omata, D.2    Iijima, H.3    Takabayashi, Y.4    Suzuki, K.5    Endo, Y.6
  • 68
    • 39149137192 scopus 로고    scopus 로고
    • Composition of PLGA and PEI/DNA nanoparticles improves ultrasoundmediated gene delivery in solid tumors in vivo
    • Chumakova, OV, Liopo, AV, Andreev, VG, Cicenaite, I, Evers, BM, Chakrabarty, S et al. (2008). Composition of PLGA and PEI/DNA nanoparticles improves ultrasoundmediated gene delivery in solid tumors in vivo. Cancer Lett 261: 215-225.
    • (2008) Cancer Lett , vol.261 , pp. 215-225
    • Chumakova, O.V.1    Liopo, A.V.2    Andreev, V.G.3    Cicenaite, I.4    Evers, B.M.5    Chakrabarty, S.6
  • 69
    • 80053181578 scopus 로고    scopus 로고
    • Theranostic nanoshells: From probe design to imaging and treatment of cancer
    • Bardhan, R, Lal, S, Joshi, A and Halas, NJ (2011). Theranostic nanoshells: from probe design to imaging and treatment of cancer. Acc Chem Res 44: 936-946.
    • (2011) Acc Chem Res , vol.44 , pp. 936-946
    • Bardhan, R.1    Lal, S.2    Joshi, A.3    Halas, N.J.4
  • 70
    • 79957920185 scopus 로고    scopus 로고
    • Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts
    • Ni, X, Zhang, Y, Ribas, J, Chowdhury, WH, Castanares, M, Zhang, Z et al. (2011). Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts. J Clin Invest 121: 2383-2390.
    • (2011) J Clin Invest , vol.121 , pp. 2383-2390
    • Ni, X.1    Zhang, Y.2    Ribas, J.3    Chowdhury, W.H.4    Castanares, M.5    Zhang, Z.6
  • 71
    • 79960054148 scopus 로고    scopus 로고
    • Tumor-targeting magnetic lipoplex delivery of short hairpin RNA suppresses IGF-1R overexpression of lung adenocarcinoma A549 cells in vitro and in vivo
    • Wang, C, Ding, C, Kong, M, Dong, A, Qian, J, Jiang, D et al. (2011). Tumor-targeting magnetic lipoplex delivery of short hairpin RNA suppresses IGF-1R overexpression of lung adenocarcinoma A549 cells in vitro and in vivo. Biochem Biophys Res Commun 410: 537-542.
    • (2011) Biochem Biophys Res Commun , vol.410 , pp. 537-542
    • Wang, C.1    Ding, C.2    Kong, M.3    Dong, A.4    Qian, J.5    Jiang, D.6


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