Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery

Journal of Controlled Release

Volumn 164, Issue 1, 2012, Pages 41-48

  Fields, Rachel J ^a   Cheng, Christopher J ^a   Quijano, Elias ^a   Weller, Caroline ^a   Kristofik, Nina ^a   Duong, Nha ^a   Hoimes, Christopher ^a   Egan, Marie E ^b   Saltzman, W Mark ^a  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Cell penetrating peptide; Cystic fibrosis; Gene therapy; Nanoparticles; pDNA; Poly(beta amino) ester

Indexed keywords

AMINO ESTERS; CELL-PENETRATING PEPTIDE; CELLULAR INTERNALIZATION; CELLULAR TOXICITIES; COATED NANOPARTICLES; CYSTIC FIBROSIS; CYTOTOXIC EFFECTS; ENGINEERING CHALLENGES; GENE DELIVERY; INTRACELLULAR UPTAKE; PDNA; PLASMID DNA; PLASMID DNA (PDNA); POLY LACTIC-CO-GLYCOLIC ACID; SURFACE COATINGS; SURFACE-MODIFIED; TRANSFECTION EFFICIENCY;

BIOMOLECULES; CELLS; COPOLYMERS; CYTOLOGY; CYTOTOXICITY; DRUG THERAPY; ESTERIFICATION; ESTERS; GENE THERAPY; GENE TRANSFER; NANOPARTICLES; PEPTIDES; PHOSPHOLIPIDS;

PLASTIC COATINGS;

CELL PENETRATING PEPTIDE; MACROGOL 2000; MPG PEPTIDE; MTAT PEPTIDE; NANOPARTICLE; PBRPP PEPTIDE; PLASMID DNA; POLY(BETA AMINO)ESTER; POLYGLACTIN; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; DNA TRANSFECTION; DRUG CYTOTOXICITY; GENE TARGETING; INTERNALIZATION; PRIORITY JOURNAL; SURFACE CHARGE; SURFACE PROPERTY;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; DRUG CARRIERS; EPITHELIAL CELLS; GREEN FLUORESCENT PROTEINS; HUMANS; LUCIFERASES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PLASMIDS; POLYMERS; SOLUBILITY; SURFACE PROPERTIES; TRANSFECTION;

EID: 84868260770     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.09.020     Document Type: Article

References (32)

1. D. Luo, K. Woodrow-Mumford, N. Belcheva, and W.M. Saltzman Controlled DNA delivery systems Pharm. Res. 16 1999 1300 1308
2. T. Wang, J.R. Upponi, and V.P. Torchilin Design of multifunctional non-viral gene vectors to overcome physiological barriers: dilemmas and strategies Int. J. Pharm. 427 1 2012 3 20
3. A.K. Jain, M. Das, N.K. Swarnakar, and S. Jain Engineered PLGA nanoparticles: an emerging delivery tool in cancer therapeutics Crit. Rev. Ther. Drug Carrier Syst. 28 2011 1 45
4. M. Conese, F. Ascenzioni, A.C. Boyd, C. Coutelle, I. De Fino, S. De Smedt, J. Rejman, J. Rosenecker, D. Schindelhauer, and B.J. Scholte Gene and cell therapy for cystic fibrosis: from bench to bedside J. Cyst. Fibros. 10 Suppl. 2 2011 S114 S128
5. J. Blum, and W. Saltzman High loading efficiency and tunable release of plasmid DNA encapsulated in submicron particles fabricated from PLGA conjugated with poly-l-lysine J. Control. Release 129 2008 66 72
6. D.M. Lynn Degradable poly(B-amino esters): synthesis, characterization, and self-assembly with plasmid DNA R. Langer, J. Am. Chem. Soc. 2000 10761 10768
7. J. Green, R. Langer, and D. Anderson A combinatorial polymer library approach yields insight into nonviral gene delivery Acc. Chem. Res. 41 6 2008 749 759
8. S.R. Little, D.M. Lynn, Q. Ge, D.G. Anderson, S.V. Puram, J. Chen, H.N. Eisen, and R. Langer Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines Proc. Natl. Acad. Sci. U. S. A. 101 2004 9534 9539
9. S.R. Little, D.M. Lynn, S.V. Puram, and R. Langer Formulation and characterization of poly(beta amino ester) microparticles for genetic vaccine delivery J. Control. Release 107 2005 449 462
10. C. Yu, Y. Hu, J. Duan, W. Yuan, C. Wang, H. Xu, and X.D. Yang Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro PLoS One 6 2011 e24077
11. Y. Cu, C.J. Booth, and W.M. Saltzman In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery J. Control. Release 156 2011 258 264
12. H. Nie, S.T. Khew, L.Y. Lee, K.L. Poh, Y.W. Tong, and C.H. Wang Lysine-based peptide-functionalized PLGA foams for controlled DNA delivery J. Control. Release 138 2009 64 70
13. L.J. Cruz, P.J. Tacken, R. Fokkink, B. Joosten, M.C. Stuart, F. Albericio, R. Torensma, and C.G. Figdor Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro J. Control. Release 144 2010 118 126
14. J.P. Bertram, S.M. Jay, S.R. Hynes, R. Robinson, J.M. Criscione, and E.B. Lavik Functionalized poly(lactic-co-glycolic acid) enhances drug delivery and provides chemical moieties for surface engineering while preserving biocompatibility Acta Biomater. 5 2009 2860 2871
15. T. Fahmy, R. Samstein, C. Harness, and W. Mark Saltzman Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting Biomaterials 26 2005 5727 5736
16. Y. Cu, C. LeMoëllic, M. Caplan, and W. Saltzman Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency Nanomedicine 6 2010 334 343
17. C.J. Cheng, and W.M. Saltzman Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides Biomaterials 32 2011 6194 6203
18. D.C. Gruenert, M. Willems, J.J. Cassiman, and R.A. Frizzell Established cell lines used in cystic fibrosis research J. Cyst. Fibros. 3 Suppl. 2 2004 191 196
19. D.N. Nguyen, J.J. Green, J.M. Chan, R. Langer, and D.G. Anderson Polymeric Materials for Gene Delivery and DNA Vaccination Adv. Mater. 21 2009 847 867
20. T. Endoh, and T. Ohtsuki Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape Adv. Drug Deliv. Rev. 61 2009 704 709
21. M. Magzoub, S. Sandgren, P. Lundberg, K. Oglecka, J. Lilja, A. Wittrup, L.E. Göran Eriksson, U. Langel, M. Belting, and A. Gräslund N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis Biochem. Biophys. Res. Commun. 348 2006 379 385
22. J. Zhou, T.R. Patel, M. Fu, J.P. Bertram, and W.M. Saltzman Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors Biomaterials 33 2012 583 591
23. S. Yamano, J. Dai, C. Yuvienco, S. Khapli, A.M. Moursi, and J.K. Montclare Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis J. Control. Release 152 2011 278 285
24. E. Rytting, J. Nguyen, X. Wang, and T. Kissel Biodegradable polymeric nanocarriers for pulmonary drug delivery Expert Opin. Drug Deliv. 5 2008 629 639
25. M.T. Tse, C. Blatchford, and H. Oya Alpar Evaluation of different buffers on plasmid DNA encapsulation into PLGA microparticles Int. J. Pharm. 370 2009 33 40
26. A.C. Hunter, and S.M. Moghimi Cationic carriers of genetic material and cell death: a mitochondrial tale Biochim. Biophys. Acta 1797 2010 1203 1209
27. Y. Cu, and W. Saltzman Drug delivery: stealth particles give mucus the slip Nat. Mater. 8 2009 11 13
28. J.S. Suk, S.K. Lai, Y.Y. Wang, L.M. Ensign, P.L. Zeitlin, M.P. Boyle, and J. Hanes The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles Biomaterials 30 2009 2591 2597
29. J. Nguyen, X. Xie, M. Neu, R. Dumitrascu, R. Reul, J. Sitterberg, U. Bakowsky, R. Schermuly, L. Fink, T. Schmehl, T. Gessler, W. Seeger, and T. Kissel Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs J. Genet. Med. 10 2008 1236 1246
30. G. Kibria, H. Hatakeyama, N. Ohga, K. Hida, and H. Harashima Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery J. Control. Release 153 2011 141 148
31. K. Oglecka, P. Lundberg, M. Magzoub, L.E. Göran Eriksson, U. Langel, and A. Gräslund Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects Biochim. Biophys. Acta 1778 2008 206 213
32. R. Sawant, and V. Torchilin Intracellular transduction using cell-penetrating peptides Mol. Biosyst. 6 2010 628 640