Nucleocytoplasmic transport

Science

Volumn 271, Issue 5255, 1996, Pages 1513-1518

  Görlich, Dirk ^a,b,d   Mattaj, Iain W ^c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RNA;

ACTIVE TRANSPORT; ARTICLE; CELL MEMBRANE TRANSPORT; CELL NUCLEUS MEMBRANE; CYTOPLASM; EUKARYOTIC CELL; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

EUKARYOTA; METAZOA;

EID: 0029984570     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5255.1513     Document Type: Article

References (97)

1. C M. Feldherr, E. Kallenbach, N. Schultz, J Cell Biol 99, 2216 (1984); C. M Feldherr, ibid. 14, 65 (1962).
2. C M. Feldherr, E. Kallenbach, N. Schultz, J Cell Biol 99, 2216 (1984); C. M Feldherr, ibid. 14, 65 (1962).
3. M. P. Rout and S. R. Wente, Trends Cell Biol. 4, 357 (1994),
4. L. I. Davis, Annu Rev. Biochem. 64, 865 (1995).
5. E Fabre and E. C. Hurt, Cyrr. Opin. Cell Biol 6, 335 (1994).
6. Single-letter abbreviations for the amino acid residues are as follows: A, Ala, C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, lle; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp, and Y, Tyr.
7. W. M. Bonner, in The Cell Nucleus, H. Busch, Ed. (Academic Press, New York, 1978), vol. 6, part C, pp. 97-148.
8. M. Breeuwer and D. Goldfarb, Cell 60, 999 (1990)
9. D. D. Newmeyer, J. M. Lucocq, T. R. Bürglin, E M. De Robertis, EMBO J. 5, 501 (1986).
10. M. Zasloff, Proc. Natl. Acad Sci U.S.A. 80, 6436 (1983).
11. C. Dingwall and R. A. Laskey, Trends Biochem. Sci. 16, 478 (1991).
12. D. S. Goldfarb, J. Gariepy, G. Schoolnik, R. D. Komberg, Nature 322, 641 (1986).
13. E Izaurralde and I. W Mattaj, Semin. Cell Biol. 3, 279 (1992).
14. V C. Ware and A. Khanna-Gupta, Nucleocytoplasmic Transport of Ribosomal Subunits, W. E. Hill et al., Eds., The Ribosome: Structure, Function and Evolution (American Society for Microbiology, Washington, DC, 1991).
15. C Dingwall, S. V. Shamick, R. A Laskey, Cell 30, 449 (1982); J. Robbins, S. M. Dilworth, R. A. Laskey, C. Dingwall, ibid. 64, 615 (1991)
16. C Dingwall, S. V. Shamick, R. A Laskey, Cell 30, 449 (1982); J. Robbins, S. M. Dilworth, R. A. Laskey, C. Dingwall, ibid. 64, 615 (1991)
17. R. E. Lanford and J. S. Butel, ibid 37, 801 (1984); D Kalderon, W. D. Richardson, A. F. Markham, A. E. Smith, Nature 311, 33 (1984)
18. R. E. Lanford and J. S. Butel, ibid 37, 801 (1984); D Kalderon, W. D. Richardson, A. F. Markham, A. E. Smith, Nature 311, 33 (1984)
19. R Lanford, P. Kanda, R. C. Kennedy, Cell 46, 575 (1986).
20. N Michaud and D.S. Goldfarb, J. Cell Biol. 112, 215 (1991).
21. D Görlich, S. Prehn, R. A. Laskey, E. Hartmann, Cell 79, 767 (1994).
22. K. Weis, I. W. Mattaj, A. I Lamond, Science 268, 1049 (1995).
23. U Fischer et al., J. Cell Biol. 113, 705 (1991).
24. U. Fischer, J. Huber, W C Boelens, I. W. Mattaj, R. Lührmann, Cell 82, 475 (1995).
25. W. Wen, J L Meinkoth, R. Y Tsien, S. S. Taylor, ibid., p. 463.
26. R. A Fridell et al., Proc. Natl. Acad. Sci. U S.A., in press.
27. L Gerace, Cell 82, 341 (1995).
28. W M. Michael, M Choi, G Dreyfuss, ibid. 83, 415 (1995).
29. P. Legrain and M. Rosbash, ibid. 57, 573 (1989).
30. E Izaurralde and I. W. Mattaj, ibid. 81, 153 (1995).
31. A. Jarmolowski, W. C. Boelens, E. Izaurralde, I. W. Maltaj, J Cell Biol. 124, 627 (1994).
32. W D Richardson, A. D Mills, S. M. Dilworth, R A. Laskey, C. Dingwall, Cell 52, 655 (1988); D D. Newmeyer and D. J. Forbes, ibid., p. 641.
33. W D Richardson, A. D Mills, S. M. Dilworth, R A. Laskey, C. Dingwall, Cell 52, 655 (1988); D D. Newmeyer and D. J. Forbes, ibid., p. 641.
34. S. A. Adam, R Sterne-Marr, L. Gerace, J. Cell Biol 111, 807 (1990)
35. M. S. Moore and G. Blobel, Cell 69, 939 (1992).
36. N. Imamoto et al., EMBO J. 14, 3617 (1995); S. A. Adam and L Gerace, Cell 66, 837 (1991).
37. N. Imamoto et al., EMBO J. 14, 3617 (1995); S. A. Adam and L Gerace, Cell 66, 837 (1991).
38. J. Moroianu, M. Hijikata, G. Blobel, A. Radu, Proc. Natl Acad. Sci. U.S.A 92, 6532 (1995).
39. E. J. Adam and S. A. Adam, J Cell Biol. 125, 547 (1994), A. Radu, G. Blobel, M. S. Moore, Proc. Natl. Acad. Sci U S A. 92, 1769 (1995); N C. Chi, E J. Adarn, S. A Adam, J. Cell Biol. 130, 265 (1995); N. Imamoto et al., FEBS Lett. 368, 415 (1995).
40. E. J. Adam and S. A. Adam, J Cell Biol. 125, 547 (1994), A. Radu, G. Blobel, M. S. Moore, Proc. Natl. Acad. Sci U S A. 92, 1769 (1995); N C. Chi, E J. Adarn, S. A Adam, J. Cell Biol. 130, 265 (1995); N. Imamoto et al., FEBS Lett. 368, 415 (1995).
41. E. J. Adam and S. A. Adam, J Cell Biol. 125, 547 (1994), A. Radu, G. Blobel, M. S. Moore, Proc. Natl. Acad. Sci U S A. 92, 1769 (1995); N C. Chi, E J. Adarn, S. A Adam, J. Cell Biol. 130, 265 (1995); N. Imamoto et al., FEBS Lett. 368, 415 (1995).
42. E. J. Adam and S. A. Adam, J Cell Biol. 125, 547 (1994), A. Radu, G. Blobel, M. S. Moore, Proc. Natl. Acad. Sci U S A. 92, 1769 (1995); N C. Chi, E J. Adarn, S. A Adam, J. Cell Biol. 130, 265 (1995); N. Imamoto et al., FEBS Lett. 368, 415 (1995).
43. D. Gorlich et al., Curr. Biol 5, 383 (1995).
44. G. T Drivas, A. Shin, E. Coutavas, M. G. Rush, P. D'Eustachio, Mol. Cell. Biol. 10, 1793 (1990); F. R. Bischoff and H. Ponstingl, Proc. Natl. Acad. Sci. U.S.A. 88, 10830 (1991).
45. G. T Drivas, A. Shin, E. Coutavas, M. G. Rush, P. D'Eustachio, Mol. Cell. Biol. 10, 1793 (1990); F. R. Bischoff and H. Ponstingl, Proc. Natl. Acad. Sci. U.S.A. 88, 10830 (1991).
46. M. S. Moore and G. Blobel, Nature 365, 661 (1993); F. Melchior, B. Paschal, E Evans, L. Gerace, J. Cell Biol. 123, 1649 (1993).
47. M. S. Moore and G. Blobel, Nature 365, 661 (1993); F. Melchior, B. Paschal, E Evans, L. Gerace, J. Cell Biol. 123, 1649 (1993).
48. M. S. Moore and G. Blobel, Proc. Natl. Acad Sci. U.S.A 91, 10212 (1994), B. M. Paschal and L. Gerace, J. Cell Biol. 129, 925 (1995).
49. M. S. Moore and G. Blobel, Proc. Natl. Acad Sci. U.S.A 91, 10212 (1994), B. M. Paschal and L. Gerace, J. Cell Biol. 129, 925 (1995).
50. Importin is also called karyopherin. The term NLS receptor is also used for the α subunit. Importin-α was onginally isolated from Xenopus lacvis. The S cerevisiae homolog is SRP1p. Higher eukaryotes have multiple α subunits; for example, human SRP1p (Npilp) and human Rch1p (hSRP1α1). OHO31p (pendulin) is one family member in Drosophila. The β subunit is also called p97 or PTAC97. pp15 has also been termed p10 and NTF2
51. C. M. Feldherr and D. Akin, Exp Cell Res. 205, 179 (1993)
52. N Imamoto, T. Tachibana, M. Matsubae, Y. Yoneda, J. Biol. Chem. 270, 8559 (1995).
53. D. Görlich, F. Vogel, A. D. Mills, E. Hartmann, R. A. Laskey, Nature 377, 246 (1995).
54. M. Perfer, S Berg, A. B Reynolds, Cell 76, 789 (1994).
55. P. Bork and M. A Andrade, Nature Genet 11, 115 (1995).
56. P. Cortes, Z. S. Ye, D. Baltimore, Proc Natl. Acad. Sci. U.S.A. 91, 7633 (1994)
57. K. Weis, unpublished material
58. R. Yano, M. Oakes, M. Yamagishi, L. Vu, M Nomura, Mol. Cell Biol 12, 5640 (1992).
59. C. A. Cuomo, S. A Kirch, J. Gyuris, R. Brent, M A Oettinger, Proc Natl. Acad. Sci. U.S.A 91, 6156 (1994).
60. I. Torok et al., J. Cell Biol. 129, 1473 (1995); P. Kussel and M Frasoh, ibid., p. 1491.
61. I. Torok et al., J. Cell Biol. 129, 1473 (1995); P. Kussel and M Frasoh, ibid., p. 1491.
62. D. Gorlich, P Henklein, R. A. Laskey, E Hartmann, EMBO J., in press.
63. K. Weis, U Ryder, A. I. Lamond. ibid , in press
64. D. M. Kraemer, C. Strambio-de-Castillia, G. Blobel, M. P. Rout, J. Biol. Chem. 270, 19017 (1995), M. K. lovine, J. L. Watkins, S R. Wente, J. Cell Biol. 131, 1699 (1995).
65. D. M. Kraemer, C. Strambio-de-Castillia, G. Blobel, M. P. Rout, J. Biol. Chem. 270, 19017 (1995), M. K. lovine, J. L. Watkins, S R. Wente, J. Cell Biol. 131, 1699 (1995).
66. A. Radu, M. S Moore, G. Blobel, Cell 81, 215 (1995).
67. M. Rexach and G Blobel, ibid. 83, 683 (1995)
68. K. Svoboda, C. F. Schmidt, B. Schnapp, S. M. Block, Nature 365, 721 (1993).
69. J. T. Finer, R. M. Simmons, J. A Spudich, ibid 368, 113 (1994).
70. F. R. Bischoff and H Ponstingl, ibid. 354, 80 (1991).
71. F R. Bischoff, H. Krebber, T. Kempf, I. Hermes, H. Ponstingl, Proc. Natl. Acad Sci. U.S.A. 92, 1749 (1995)
72. F. Melchior, T. Guan, N Yokoyama, T. Nishimoto, L. Gerace, J. Cell Biol 131, 571 (1995).
73. N Yokoyama et al., Nature 376, 184 (1995); J. Wu, M J. Matunis, D Kraemer, G. Blobel, E. Coutavas, J. Biol. Chem. 270, 14209 (1995); F. R. Bischoff, H. Krebber, E. Smimova, W. H. Dong. H. Ponstingl, EMBO J. 14, 705 (1995), C. Dingwall, S. Kandels-Lewis, B. Seraph in, Proc. Natl. Acad. Sci. U S.A 92, 7525 (1995).
74. N Yokoyama et al., Nature 376, 184 (1995); J. Wu, M J. Matunis, D Kraemer, G. Blobel, E. Coutavas, J. Biol. Chem. 270, 14209 (1995); F. R. Bischoff, H. Krebber, E. Smimova, W. H. Dong. H. Ponstingl, EMBO J. 14, 705 (1995), C. Dingwall, S. Kandels-Lewis, B. Seraph in, Proc. Natl. Acad. Sci. U S.A 92, 7525 (1995).
75. N Yokoyama et al., Nature 376, 184 (1995); J. Wu, M J. Matunis, D Kraemer, G. Blobel, E. Coutavas, J. Biol. Chem. 270, 14209 (1995); F. R. Bischoff, H. Krebber, E. Smimova, W. H. Dong. H. Ponstingl, EMBO J. 14, 705 (1995), C. Dingwall, S. Kandels-Lewis, B. Seraph in, Proc. Natl. Acad. Sci. U S.A 92, 7525 (1995).
76. N Yokoyama et al., Nature 376, 184 (1995); J. Wu, M J. Matunis, D Kraemer, G. Blobel, E. Coutavas, J. Biol. Chem. 270, 14209 (1995); F. R. Bischoff, H. Krebber, E. Smimova, W. H. Dong. H. Ponstingl, EMBO J. 14, 705 (1995), C. Dingwall, S. Kandels-Lewis, B. Seraph in, Proc. Natl. Acad. Sci. U S.A 92, 7525 (1995).
77. S. A. Richards, K. M. Lounsbury, I. G. Macara, J Biol. Chem 270, 14405 (1995).
78. D Görlich, F. R. Bischoff, H. Ponstingl, unpublished material.
79. B. R. Cüllen and M. H Malim, Trends Biochem Sci. 16, 346 (1991)
80. C. C. Fritz, M L. Zapp, M R Green, Nature 376, 530 (1995).
81. H. P. Bogerd, R. A Fridell, S. Madore, B. R. Cullen. Cell 82, 485 (1995).
82. F. Stutz and M. Rosbash, EMBO J 13, 4096 (1994).
83. F Stutz, M Neville, M. Rosbash, Cell 82, 495 (1995).
84. M. von Lindem et al., Mol. Cell. Biol 12, 3346 (1992); D. Kraemer, R. W. Wozniak, G. Blobel, A Radu, Proc. Natl. Acad Sci. U S.A 91, 1519 (1994).
85. M. von Lindem et al., Mol. Cell. Biol 12, 3346 (1992); D. Kraemer, R. W. Wozniak, G. Blobel, A Radu, Proc. Natl. Acad Sci. U S.A 91, 1519 (1994).
86. L C Gorsch, T. C. Dockendorff, C. N. Cole, J. Cell Biol. 129, 939 (1995).
87. N. J. Pokrywka and D. S Goldfarb, J. Biol. Chem 270, 3619 (1995)
88. U Guddat, A. H. Bakken, T. Pieler, Cell 60, 619 (1990).
89. E Izaurralde et al., Nature 376, 709 (1995)
90. A. J Shatkin, Cell 9, 645 (1976).
91. E Izaurralde et al., ibid. 78, 657 (1994)
92. N. Visa, E. Izaurralde, J. Ferreira, B. Daneholt, I W Mattaj, J. Cell Biol., in press.
93. S. Piñol-Roma and G. Dreyfuss, Science 253, 312 (1991); Nature 355, 730 (1992).
94. S. Piñol-Roma and G. Dreyfuss, Science 253, 312 (1991); Nature 355, 730 (1992).
95. X. Liu and J. E. Mertz, Genes Dev. 9, 1766 (1995).
96. G. Schlenstedt, C. Saavedra, J. D. J. Loeb, C. N Cole, P A. Silver, Proc. Natl. Acad. Sci. U.S.A. 92, 225 (1995).
97. We thank E. Izaurralde, R A. Laskey, and K. Wois for critical reading of the manuscript. Supported by the Cancer Research Campaign and the Human Frontier Science Programme Organisation.