Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA

Journal of Controlled Release

Volumn 149, Issue 1, 2011, Pages 2-7

  Kano, Arihiro ^a   Moriyama, Kenji ^a   Yamano, Takeshi ^a   Nakamura, Izumi ^a   Shimada, Naohiko ^a   Maruyama, Atsushi ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Enhanced permeability and retention; Pegylation; Poly lysine

Indexed keywords

BIODISTRIBUTIONS; BLOOD CIRCULATION; CATIONIC CHARGES; ENHANCED PERMEABILITY AND RETENTIONS; IN-VIVO; LIFE-TIMES; MASKING EFFECT; MULTIANGLE LASER LIGHT SCATTERING; NEW SERIES; PEGYLATION; POLY-L-LYSINE; POLYLYSINE; SIDE CHAINS; SMALL INTERFERING RNA (SIRNA);

AMINO ACIDS; BLOOD; ETHYLENE; ETHYLENE GLYCOL; LIGHT SCATTERING; NUCLEIC ACIDS; POLYETHYLENE OXIDES; RNA; TUMORS;

POLYETHYLENE GLYCOLS;

MACROGOL; POLYLYSINE; SMALL INTERFERING RNA;

AMINATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCULATION; CONJUGATION; DRUG DISTRIBUTION; LUNG TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; DRUG CARRIERS; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE TRANSFER TECHNIQUES; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POLYLYSINE; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 78651246499     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.12.007     Document Type: Article

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