Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: Real-time visualization of transient membrane destabilization without endosomal lysis

ACS Nano

Volumn 7, Issue 5, 2013, Pages 3767-3777

  Rehman, Zia Ur ^a   Hoekstra, Dick ^a   Zuhorn, Inge S ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

endosomal escape; flip flop mechanism; lipoplexes; live cell imaging; polyplexes; proton sponge effect

Indexed keywords

ENDOSOMAL ESCAPES; FLIP-FLOP MECHANISM; LIPOPLEXES; LIVE-CELL IMAGING; POLYPLEXES; PROTON SPONGE;

CYTOLOGY; LIPOSOMES; MEMBRANES; NUCLEIC ACIDS; POLYOLS;

BIOMOLECULES;

DNA; DRUG CARRIER; LIPID; POLYETHYLENEIMINE; RNA;

ARTICLE; CELL MEMBRANE; CHEMISTRY; ENDOSOME; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; METABOLISM; TIME;

CELL MEMBRANE; DNA; DRUG CARRIERS; ENDOSOMES; HELA CELLS; HUMANS; LIPIDS; POLYETHYLENEIMINE; RNA; TIME FACTORS; TRANSFECTION;

EID: 84878295483     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn3049494     Document Type: Article

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