메뉴 건너뛰기




Volumn 15, Issue 10, 2013, Pages 343-355

Advances and challenges in gene-based approaches for osteoarthritis

Author keywords

Clinical trials; Gene therapy; Human osteoarthritis

Indexed keywords

ADENOVIRUS VECTOR; BONE MORPHOGENETIC PROTEIN 4; PARVOVIRUS VECTOR; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; RETROVIRUS VECTOR;

EID: 84885925103     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.2741     Document Type: Article
Times cited : (42)

References (159)
  • 1
    • 0141920503 scopus 로고    scopus 로고
    • Burden of major musculoskeletal conditions
    • Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003; 81: 646-656.
    • (2003) Bull World Health Organ , vol.81 , pp. 646-656
    • Woolf, A.D.1    Pfleger, B.2
  • 2
    • 84883356204 scopus 로고    scopus 로고
    • The global economic cost of osteoarthritis: how the UK compares
    • Chen A, Gupte C, Akhtar K, et al. The global economic cost of osteoarthritis: how the UK compares. Arthritis 2012; 2012: 698709-698714.
    • (2012) Arthritis , vol.2012 , pp. 698709-698714
    • Chen, A.1    Gupte, C.2    Akhtar, K.3
  • 3
    • 29244433028 scopus 로고    scopus 로고
    • Financial cost of osteoarthritis in France. The 'COART' France study
    • Le Pen C, Reygrobellet C, Gerentes I. Financial cost of osteoarthritis in France. The 'COART' France study. Joint Bone Spine 2005; 72: 567-570.
    • (2005) Joint Bone Spine , vol.72 , pp. 567-570
    • Le Pen, C.1    Reygrobellet, C.2    Gerentes, I.3
  • 5
    • 77950021805 scopus 로고    scopus 로고
    • OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009
    • Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010; 18: 476-499.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 476-499
    • Zhang, W.1    Nuki, G.2    Moskowitz, R.W.3
  • 6
    • 58849159153 scopus 로고    scopus 로고
    • Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis
    • Wehling P, Reinecke J, Baltzer AW, et al. Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Hum Gene Ther 2009; 20: 97-101.
    • (2009) Hum Gene Ther , vol.20 , pp. 97-101
    • Wehling, P.1    Reinecke, J.2    Baltzer, A.W.3
  • 7
    • 84862934902 scopus 로고    scopus 로고
    • Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients
    • Ha CW, Noh MJ, Choi KB, et al. Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients. Cytotherapy 2012; 14: 247-256.
    • (2012) Cytotherapy , vol.14 , pp. 247-256
    • Ha, C.W.1    Noh, M.J.2    Choi, K.B.3
  • 8
    • 0034041974 scopus 로고    scopus 로고
    • Gene delivery to human chondrocytes by an adeno-associated virus vector
    • Arai Y, Kubo T, Fushiki S, et al. Gene delivery to human chondrocytes by an adeno-associated virus vector. J Rheumatol 2000; 27: 979-982.
    • (2000) J Rheumatol , vol.27 , pp. 979-982
    • Arai, Y.1    Kubo, T.2    Fushiki, S.3
  • 9
    • 0037338160 scopus 로고    scopus 로고
    • Efficient and persistent gene transfer into articular cartilage using recombinant adeno-associated virus vectors in vitro and in vivo
    • Madry H, Cucchiarini M, Terwilliger EF, et al. Efficient and persistent gene transfer into articular cartilage using recombinant adeno-associated virus vectors in vitro and in vivo. Human Gene Ther 2003; 14: 393-402.
    • (2003) Human Gene Ther , vol.14 , pp. 393-402
    • Madry, H.1    Cucchiarini, M.2    Terwilliger, E.F.3
  • 10
    • 84868657138 scopus 로고    scopus 로고
    • Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis
    • Goldring MB. Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis 2012; 4: 269-285.
    • (2012) Ther Adv Musculoskelet Dis , vol.4 , pp. 269-285
    • Goldring, M.B.1
  • 11
    • 78650983649 scopus 로고    scopus 로고
    • Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
    • Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 2010; 7: 33-42.
    • (2010) Nat Rev Rheumatol , vol.7 , pp. 33-42
    • Kapoor, M.1    Martel-Pelletier, J.2    Lajeunesse, D.3
  • 13
    • 84856620553 scopus 로고    scopus 로고
    • Aetiology of osteoarthritis: genetics and synovial joint development
    • Sandell LJ. Aetiology of osteoarthritis: genetics and synovial joint development. Nat Rev Rheumatol 2012; 8: 77-89.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 77-89
    • Sandell, L.J.1
  • 14
    • 78650977864 scopus 로고    scopus 로고
    • Genetic epidemiology of hip and knee osteoarthritis
    • Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol 2011; 7: 23-32.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 23-32
    • Valdes, A.M.1    Spector, T.D.2
  • 15
    • 84855993582 scopus 로고    scopus 로고
    • Biomechanical factors in osteoarthritis
    • Guilak F. Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol 2012; 25: 815-823.
    • (2012) Best Pract Res Clin Rheumatol , vol.25 , pp. 815-823
    • Guilak, F.1
  • 16
    • 83755186543 scopus 로고    scopus 로고
    • Mechanotransduction and cartilage integrity
    • Leong DJ, Hardin JA, Cobelli NJ, et al. Mechanotransduction and cartilage integrity. Ann NY Acad Sci 2011; 1240: 32-37.
    • (2011) Ann NY Acad Sci , vol.1240 , pp. 32-37
    • Leong, D.J.1    Hardin, J.A.2    Cobelli, N.J.3
  • 17
    • 84861994775 scopus 로고    scopus 로고
    • Effects of ageing on articular cartilage homeostasis
    • Lotz M, Loeser RF. Effects of ageing on articular cartilage homeostasis. Bone 2012; 51: 241-248.
    • (2012) Bone , vol.51 , pp. 241-248
    • Lotz, M.1    Loeser, R.F.2
  • 18
    • 79952814836 scopus 로고    scopus 로고
    • Osteoarthritis year 2010 in review: pathomechanisms
    • van den Berg WB. Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthritis Cartilage 2011; 19: 338-341.
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 338-341
    • van den Berg, W.B.1
  • 19
    • 84856667040 scopus 로고    scopus 로고
    • Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis
    • Goldring MB, Marcu KB. Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. Trends Mol Med 2011; 18: 109-118.
    • (2011) Trends Mol Med , vol.18 , pp. 109-118
    • Goldring, M.B.1    Marcu, K.B.2
  • 20
    • 70249083400 scopus 로고    scopus 로고
    • The elusive path to cartilage regeneration
    • Hunziker EB. The elusive path to cartilage regeneration. Adv Mater 2009; 21: 3419-3424.
    • (2009) Adv Mater , vol.21 , pp. 3419-3424
    • Hunziker, E.B.1
  • 21
    • 72949105817 scopus 로고    scopus 로고
    • Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer
    • Cucchiarini M, Terwilliger EF, Kohn D, et al. Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer. J Cell Mol Med 2009; 13: 2476-2488.
    • (2009) J Cell Mol Med , vol.13 , pp. 2476-2488
    • Cucchiarini, M.1    Terwilliger, E.F.2    Kohn, D.3
  • 22
    • 33846208305 scopus 로고    scopus 로고
    • Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9
    • Cucchiarini M, Thurn T, Weimer A, et al. Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9. Arthritis Rheum 2007; 56: 158-167.
    • (2007) Arthritis Rheum , vol.56 , pp. 158-167
    • Cucchiarini, M.1    Thurn, T.2    Weimer, A.3
  • 23
    • 84860467045 scopus 로고    scopus 로고
    • Benefits of rAAV-mediated IGF-I overexpression for the long term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis
    • Weimer A, Madry H, Venkatesan JK, et al. Benefits of rAAV-mediated IGF-I overexpression for the long term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis. Mol Med 2012; 18: 346-358.
    • (2012) Mol Med , vol.18 , pp. 346-358
    • Weimer, A.1    Madry, H.2    Venkatesan, J.K.3
  • 24
    • 84875186059 scopus 로고    scopus 로고
    • Arthritis gene therapy and its tortuous path into the clinic
    • Evans CH, Ghivizzani SC, Robbins PD. Arthritis gene therapy and its tortuous path into the clinic. Transl Res 2013; 161: 205-216.
    • (2013) Transl Res , vol.161 , pp. 205-216
    • Evans, C.H.1    Ghivizzani, S.C.2    Robbins, P.D.3
  • 25
    • 0028031550 scopus 로고
    • Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
    • Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994; 331: 889-895.
    • (1994) N Engl J Med , vol.331 , pp. 889-895
    • Brittberg, M.1    Lindahl, A.2    Nilsson, A.3
  • 26
    • 80051921186 scopus 로고    scopus 로고
    • Clinical potential and challenges of using genetically modified cells for articular cartilage repair
    • Madry H, Cucchiarini M. Clinical potential and challenges of using genetically modified cells for articular cartilage repair. Croat Med J 2011; 52: 245-261.
    • (2011) Croat Med J , vol.52 , pp. 245-261
    • Madry, H.1    Cucchiarini, M.2
  • 27
    • 29744465669 scopus 로고    scopus 로고
    • Gene therapy for cartilage defects
    • Cucchiarini M, Madry H. Gene therapy for cartilage defects. J Gene Med 2005; 7: 1495-1509.
    • (2005) J Gene Med , vol.7 , pp. 1495-1509
    • Cucchiarini, M.1    Madry, H.2
  • 28
    • 84867858047 scopus 로고    scopus 로고
    • Failed cartilage repair for early osteoarthritis defects: a biochemical, histological and immunohistochemical analysis of the repair tissue after treatment with marrow-stimulation techniques
    • Kaul G, Cucchiarini M, Remberger K, et al. Failed cartilage repair for early osteoarthritis defects: a biochemical, histological and immunohistochemical analysis of the repair tissue after treatment with marrow-stimulation techniques. Knee Surg Sports Traumatol Arthrosc 2012; 20: 2315-2324.
    • (2012) Knee Surg Sports Traumatol Arthrosc , vol.20 , pp. 2315-2324
    • Kaul, G.1    Cucchiarini, M.2    Remberger, K.3
  • 29
    • 81855214340 scopus 로고    scopus 로고
    • Gene therapy for cartilage repair
    • Madry H, Orth P, Cucchiarini M. Gene therapy for cartilage repair. Cartilage 2011; 2: 201-225.
    • (2011) Cartilage , vol.2 , pp. 201-225
    • Madry, H.1    Orth, P.2    Cucchiarini, M.3
  • 30
    • 0016819815 scopus 로고
    • Maturation of the adrenal medulla-IV. Effects of morphine
    • Anderson TR, Slotkin TA. Maturation of the adrenal medulla-IV. Effects of morphine. Biochem Pharmacol 1975; 24: 1469-1474.
    • (1975) Biochem Pharmacol , vol.24 , pp. 1469-1474
    • Anderson, T.R.1    Slotkin, T.A.2
  • 31
    • 0035915777 scopus 로고    scopus 로고
    • Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function
    • Brower-Toland BD, Saxer RA, Goodrich LR, et al. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther 2001; 12: 117-129.
    • (2001) Hum Gene Ther , vol.12 , pp. 117-129
    • Brower-Toland, B.D.1    Saxer, R.A.2    Goodrich, L.R.3
  • 32
    • 0033925453 scopus 로고    scopus 로고
    • Adhesion of transplanted chondrocytes onto cartilage in vitro and in vivo
    • Doherty PJ, Zhang H, Manolopoulos V, et al. Adhesion of transplanted chondrocytes onto cartilage in vitro and in vivo. J Rheumatol 2000; 27: 1725-1731.
    • (2000) J Rheumatol , vol.27 , pp. 1725-1731
    • Doherty, P.J.1    Zhang, H.2    Manolopoulos, V.3
  • 33
    • 0032076306 scopus 로고    scopus 로고
    • Resurfacing of articular cartilage explants with genetically modified human chondrocytes in vitro
    • Doherty PJ, Zhang H, Tremblay L, et al. Resurfacing of articular cartilage explants with genetically modified human chondrocytes in vitro. Osteoarthritis Cartilage 1998; 6: 153-159.
    • (1998) Osteoarthritis Cartilage , vol.6 , pp. 153-159
    • Doherty, P.J.1    Zhang, H.2    Tremblay, L.3
  • 34
    • 0032838797 scopus 로고    scopus 로고
    • Transfer of lacZ marker gene to the meniscus
    • Goto H, Shuler FD, Lamsam C, et al. Transfer of lacZ marker gene to the meniscus. J Bone Joint Surg Am 1999; 81: 918-925.
    • (1999) J Bone Joint Surg Am , vol.81 , pp. 918-925
    • Goto, H.1    Shuler, F.D.2    Lamsam, C.3
  • 35
    • 0033862014 scopus 로고    scopus 로고
    • Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene
    • Goto H, Shuler FD, Niyibizi C, et al. Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene. Osteoarthritis Cartilage 2000; 8: 266-271.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 266-271
    • Goto, H.1    Shuler, F.D.2    Niyibizi, C.3
  • 36
    • 0036226899 scopus 로고    scopus 로고
    • In vivo gene delivery to synovium by lentiviral vectors
    • Gouze E, Pawliuk R, Pilapil C, et al. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 2002; 5: 397-404.
    • (2002) Mol Ther , vol.5 , pp. 397-404
    • Gouze, E.1    Pawliuk, R.2    Pilapil, C.3
  • 37
    • 2342505985 scopus 로고    scopus 로고
    • A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer
    • Gouze JN, Gouze E, Palmer GD, et al. A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer. Arthritis Res Ther 2003; 5: R301-R309.
    • (2003) Arthritis Res Ther , vol.5
    • Gouze, J.N.1    Gouze, E.2    Palmer, G.D.3
  • 38
    • 0033016094 scopus 로고    scopus 로고
    • Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury
    • Hildebrand KA, Deie M, Allen CR, et al. Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury. J Orthop Res 1999; 17: 37-42.
    • (1999) J Orthop Res , vol.17 , pp. 37-42
    • Hildebrand, K.A.1    Deie, M.2    Allen, C.R.3
  • 39
    • 8444233948 scopus 로고    scopus 로고
    • The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage
    • Ikeda T, Kamekura S, Mabuchi A, et al. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum 2004; 50: 3561-3573.
    • (2004) Arthritis Rheum , vol.50 , pp. 3561-3573
    • Ikeda, T.1    Kamekura, S.2    Mabuchi, A.3
  • 40
    • 2342511482 scopus 로고    scopus 로고
    • Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9
    • Li Y, Tew SR, Russell AM, et al. Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Eng 2004; 10: 575-584.
    • (2004) Tissue Eng , vol.10 , pp. 575-584
    • Li, Y.1    Tew, S.R.2    Russell, A.M.3
  • 41
    • 4644244444 scopus 로고    scopus 로고
    • Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Emkey G, Zurakowski D, et al. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. J Gene Med 2004; 6: 238-245.
    • (2004) J Gene Med , vol.6 , pp. 238-245
    • Madry, H.1    Emkey, G.2    Zurakowski, D.3
  • 42
    • 0034782732 scopus 로고    scopus 로고
    • Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Zurakowski D, Trippel SB. Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Ther 2001; 8: 1443-1449.
    • (2001) Gene Ther , vol.8 , pp. 1443-1449
    • Madry, H.1    Zurakowski, D.2    Trippel, S.B.3
  • 43
    • 0033779509 scopus 로고    scopus 로고
    • Cartilage and bone regeneration using gene-enhanced tissue engineering
    • Mason JM, Breitbart AS, Barcia M, et al. Cartilage and bone regeneration using gene-enhanced tissue engineering. Clin Orthop Relat Res 2000; 379(Suppl): S171-S178.
    • (2000) Clin Orthop Relat Res , vol.379 , Issue.SUPPL
    • Mason, J.M.1    Breitbart, A.S.2    Barcia, M.3
  • 44
    • 0029874283 scopus 로고    scopus 로고
    • Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo
    • Nita I, Ghivizzani SC, Galea-Lauri J, et al. Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 1996; 39: 820-828.
    • (1996) Arthritis Rheum , vol.39 , pp. 820-828
    • Nita, I.1    Ghivizzani, S.C.2    Galea-Lauri, J.3
  • 45
    • 13244269894 scopus 로고    scopus 로고
    • Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy
    • Nixon AJ, Haupt JL, Frisbie DD, et al. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther 2005; 12: 177-186.
    • (2005) Gene Ther , vol.12 , pp. 177-186
    • Nixon, A.J.1    Haupt, J.L.2    Frisbie, D.D.3
  • 46
    • 0030961873 scopus 로고    scopus 로고
    • In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
    • Pelletier JP, Caron JP, Evans C, et al. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 1997; 40: 1012-1019.
    • (1997) Arthritis Rheum , vol.40 , pp. 1012-1019
    • Pelletier, J.P.1    Caron, J.P.2    Evans, C.3
  • 47
    • 0037423736 scopus 로고    scopus 로고
    • Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells
    • Tsuchiya H, Kitoh H, Sugiura F, et al. Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 2003; 301: 338-343.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 338-343
    • Tsuchiya, H.1    Kitoh, H.2    Sugiura, F.3
  • 48
    • 70449529723 scopus 로고    scopus 로고
    • Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome
    • Zhang HN, Leng P, Wang YZ, et al. Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome. Clin Orthop Relat Res 2009; 467: 3175-3182.
    • (2009) Clin Orthop Relat Res , vol.467 , pp. 3175-3182
    • Zhang, H.N.1    Leng, P.2    Wang, Y.Z.3
  • 49
    • 2942555576 scopus 로고    scopus 로고
    • Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10
    • Zhang X, Mao Z, Yu C. Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J Orthop Res 2004; 22: 742-750.
    • (2004) J Orthop Res , vol.22 , pp. 742-750
    • Zhang, X.1    Mao, Z.2    Yu, C.3
  • 50
    • 0343618533 scopus 로고    scopus 로고
    • Empirical advantages of adeno-associated viral vectors in vivo gene therapy for arthritis
    • Goater J, Muller R, Kollias G, et al. Empirical advantages of adeno-associated viral vectors in vivo gene therapy for arthritis. J Rheumatol 2000; 27: 983-989.
    • (2000) J Rheumatol , vol.27 , pp. 983-989
    • Goater, J.1    Muller, R.2    Kollias, G.3
  • 51
    • 1642514749 scopus 로고    scopus 로고
    • Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells
    • Ito H, Goater JJ, Tiyapatanaputi P, et al. Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells. Gene Ther 2004; 11: 34-41.
    • (2004) Gene Ther , vol.11 , pp. 34-41
    • Ito, H.1    Goater, J.J.2    Tiyapatanaputi, P.3
  • 52
    • 20144387650 scopus 로고    scopus 로고
    • Remodelling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
    • Ito H, Koefoed M, Tiyapatanaputi P, et al. Remodelling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med 2005; 11: 291-297.
    • (2005) Nat Med , vol.11 , pp. 291-297
    • Ito, H.1    Koefoed, M.2    Tiyapatanaputi, P.3
  • 53
    • 34248181957 scopus 로고    scopus 로고
    • Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair
    • Pagnotto MR, Wang Z, Karpie JC, et al. Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair. Gene Ther 2007; 14: 804-813.
    • (2007) Gene Ther , vol.14 , pp. 804-813
    • Pagnotto, M.R.1    Wang, Z.2    Karpie, J.C.3
  • 54
    • 34249987137 scopus 로고    scopus 로고
    • Adeno-associated viral vector transduction of human mesenchymal stem cells
    • Stender S, Murphy M, O'Brien T, et al. Adeno-associated viral vector transduction of human mesenchymal stem cells. Eur Cell Mater 2007; 13: 93-99.
    • (2007) Eur Cell Mater , vol.13 , pp. 93-99
    • Stender, S.1    Murphy, M.2    O'Brien, T.3
  • 55
    • 28444460380 scopus 로고    scopus 로고
    • Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism
    • Ulrich-Vinther M, Stengaard C, Schwarz EM, et al. Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism. Eur Cell Mater 2005; 10: 40-50.
    • (2005) Eur Cell Mater , vol.10 , pp. 40-50
    • Ulrich-Vinther, M.1    Stengaard, C.2    Schwarz, E.M.3
  • 56
    • 84864767326 scopus 로고    scopus 로고
    • SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
    • Venkatesan JK, Ekici M, Madry H, et al. SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells. Stem Cell Res Ther 2012; 3: 22-36.
    • (2012) Stem Cell Res Ther , vol.3 , pp. 22-36
    • Venkatesan, J.K.1    Ekici, M.2    Madry, H.3
  • 57
    • 9244245810 scopus 로고    scopus 로고
    • Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo
    • Madry H, Cucchiarini M, Kaul G, et al. Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo. Am J Sports Med 2004; 32: 1860-1865.
    • (2004) Am J Sports Med , vol.32 , pp. 1860-1865
    • Madry, H.1    Cucchiarini, M.2    Kaul, G.3
  • 58
    • 84885901252 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vectors efficiently transduce human menisci
    • Madry H, Cucchiarini M, Kohn D, et al. Recombinant adeno-associated virus vectors efficiently transduce human menisci. Trans Orthop Res Soc 2002; 48: 0274.
    • (2002) Trans Orthop Res Soc , vol.48 , pp. 0274
    • Madry, H.1    Cucchiarini, M.2    Kohn, D.3
  • 59
    • 79960793071 scopus 로고    scopus 로고
    • Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2
    • Cucchiarini M, Ekici M, Schetting S, et al. Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2. Tissue Eng Part A 2011; 17: 1921-1933.
    • (2011) Tissue Eng Part A , vol.17 , pp. 1921-1933
    • Cucchiarini, M.1    Ekici, M.2    Schetting, S.3
  • 60
    • 70449720789 scopus 로고    scopus 로고
    • rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions
    • Cucchiarini M, Schetting S, Terwilliger EF, et al. rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions. Gene Ther 2009; 16: 1363-1372.
    • (2009) Gene Ther , vol.16 , pp. 1363-1372
    • Cucchiarini, M.1    Schetting, S.2    Terwilliger, E.F.3
  • 61
    • 22644436809 scopus 로고    scopus 로고
    • Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2
    • Cucchiarini M, Madry H, Ma C, et al. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 2005; 12: 229-238.
    • (2005) Mol Ther , vol.12 , pp. 229-238
    • Cucchiarini, M.1    Madry, H.2    Ma, C.3
  • 62
    • 31644440253 scopus 로고    scopus 로고
    • Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo
    • Kaul G, Cucchiarini M, Arntzen D, et al. Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo. J Gene Med 2006; 8: 100-111.
    • (2006) J Gene Med , vol.8 , pp. 100-111
    • Kaul, G.1    Cucchiarini, M.2    Arntzen, D.3
  • 63
    • 22944436822 scopus 로고    scopus 로고
    • Stimulation of chondrocytes in vitro by gene transfer with plasmids coding for epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF)
    • Schmal H, Mehlhorn AT, Zwingmann J, et al. Stimulation of chondrocytes in vitro by gene transfer with plasmids coding for epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF). Cytotherapy 2005; 7: 292-300.
    • (2005) Cytotherapy , vol.7 , pp. 292-300
    • Schmal, H.1    Mehlhorn, A.T.2    Zwingmann, J.3
  • 64
    • 0036187950 scopus 로고    scopus 로고
    • Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase
    • Piera-Velazquez S, Jimenez SA, Stokes D. Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum 2002; 46: 683-693.
    • (2002) Arthritis Rheum , vol.46 , pp. 683-693
    • Piera-Velazquez, S.1    Jimenez, S.A.2    Stokes, D.3
  • 65
    • 84873693621 scopus 로고    scopus 로고
    • Growth factor transgenes interactively regulate articular chondrocytes
    • Shi S, Mercer S, Eckert GJ, et al. Growth factor transgenes interactively regulate articular chondrocytes. J Cell Biochem 2012; 114: 908-919.
    • (2012) J Cell Biochem , vol.114 , pp. 908-919
    • Shi, S.1    Mercer, S.2    Eckert, G.J.3
  • 66
    • 33845764391 scopus 로고    scopus 로고
    • Anti-apoptotic Bcl-2 gene transfection of human articular chondrocytes protects against nitric oxide-induced apoptosis
    • Surendran S, Kim SH, Jee BK, et al. Anti-apoptotic Bcl-2 gene transfection of human articular chondrocytes protects against nitric oxide-induced apoptosis. J Bone Joint Surg Br 2006; 88: 1660-1665.
    • (2006) J Bone Joint Surg Br , vol.88 , pp. 1660-1665
    • Surendran, S.1    Kim, S.H.2    Jee, B.K.3
  • 67
    • 30744436362 scopus 로고    scopus 로고
    • Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis
    • Grossin L, Cournil-Henrionnet C, Pinzano A, et al. Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis. FASEB J 2006; 20: 65-75.
    • (2006) FASEB J , vol.20 , pp. 65-75
    • Grossin, L.1    Cournil-Henrionnet, C.2    Pinzano, A.3
  • 68
    • 34347239641 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vector hybrids efficiently target different skeletal cells
    • Dai J, Rabie AB. Recombinant adeno-associated virus vector hybrids efficiently target different skeletal cells. Front Biosci 2007; 12: 4280-4287.
    • (2007) Front Biosci , vol.12 , pp. 4280-4287
    • Dai, J.1    Rabie, A.B.2
  • 69
    • 33749587067 scopus 로고    scopus 로고
    • Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent
    • Amos N, Lauder S, Evans A, et al. Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent. Rheumatology (Oxford) 2006; 45: 1201-1209.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1201-1209
    • Amos, N.1    Lauder, S.2    Evans, A.3
  • 70
    • 79959502791 scopus 로고    scopus 로고
    • Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts
    • Chan TF, Couchourel D, Abed E, et al. Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts. J Bone Miner Res 2011; 26: 1399-1410.
    • (2011) J Bone Miner Res , vol.26 , pp. 1399-1410
    • Chan, T.F.1    Couchourel, D.2    Abed, E.3
  • 71
    • 84864470588 scopus 로고    scopus 로고
    • Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice
    • Oh H, Chun CH, Chun JS. Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum 2012; 64: 2568-2578.
    • (2012) Arthritis Rheum , vol.64 , pp. 2568-2578
    • Oh, H.1    Chun, C.H.2    Chun, J.S.3
  • 72
    • 84859517028 scopus 로고    scopus 로고
    • alpha-Catenin inhibits beta-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.alpha-catenin.beta-catenin ternary complex
    • Rhee J, Ryu JH, Kim JH, et al. alpha-Catenin inhibits beta-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.alpha-catenin.beta-catenin ternary complex. J Biol Chem 2012; 287: 11751-11760.
    • (2012) J Biol Chem , vol.287 , pp. 11751-11760
    • Rhee, J.1    Ryu, J.H.2    Kim, J.H.3
  • 73
    • 11144240780 scopus 로고    scopus 로고
    • Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair
    • Venkatesan N, Barre L, Benani A, et al. Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair. Proc Natl Acad Sci U S A 2004; 101: 18087-18092.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18087-18092
    • Venkatesan, N.1    Barre, L.2    Benani, A.3
  • 74
    • 0035915777 scopus 로고    scopus 로고
    • Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function
    • Brower-Toland BD, Saxer RA, Goodrich LR, et al. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther 2001; 12: 117-129.
    • (2001) Hum Gene Ther , vol.12 , pp. 117-129
    • Brower-Toland, B.D.1    Saxer, R.A.2    Goodrich, L.R.3
  • 75
    • 78149265290 scopus 로고    scopus 로고
    • Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits
    • Chen B, Qin J, Wang H, et al. Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits. Exp Mol Med 2010; 42: 684-695.
    • (2010) Exp Mol Med , vol.42 , pp. 684-695
    • Chen, B.1    Qin, J.2    Wang, H.3
  • 76
    • 11044221899 scopus 로고    scopus 로고
    • Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model
    • Haupt JL, Frisbie DD, McIlwraith CW, et al. Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J Orthop Res 2005; 23: 118-126.
    • (2005) J Orthop Res , vol.23 , pp. 118-126
    • Haupt, J.L.1    Frisbie, D.D.2    McIlwraith, C.W.3
  • 77
    • 20244375123 scopus 로고    scopus 로고
    • Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation
    • Lee DK, Choi KB, Oh IS, et al. Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation. Tissue Eng 2005; 11: 310-318.
    • (2005) Tissue Eng , vol.11 , pp. 310-318
    • Lee, D.K.1    Choi, K.B.2    Oh, I.S.3
  • 78
    • 4644244444 scopus 로고    scopus 로고
    • Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Emkey G, Zurakowski D, et al. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. J Gene Med 2004; 6: 238-245.
    • (2004) J Gene Med , vol.6 , pp. 238-245
    • Madry, H.1    Emkey, G.2    Zurakowski, D.3
  • 79
    • 0035036445 scopus 로고    scopus 로고
    • Efficacy of cationic-liposome mediated gene transfer to mesangial cells in vitro and in vivo
    • Madry H, Reszka R, Bohlender J, et al. Efficacy of cationic-liposome mediated gene transfer to mesangial cells in vitro and in vivo. J Mol Med 2001; 79: 184-189.
    • (2001) J Mol Med , vol.79 , pp. 184-189
    • Madry, H.1    Reszka, R.2    Bohlender, J.3
  • 80
    • 0033779712 scopus 로고    scopus 로고
    • Insulin-like growth factor-I gene therapy applications for cartilage repair
    • Nixon AJ, Brower-Toland BD, Bent SJ, et al. Insulin-like growth factor-I gene therapy applications for cartilage repair. Clin Orthop Relat Res 2000; 43: S201-213.
    • (2000) Clin Orthop Relat Res , vol.43
    • Nixon, A.J.1    Brower-Toland, B.D.2    Bent, S.J.3
  • 81
    • 0034871638 scopus 로고    scopus 로고
    • Gene mediated insulin-like growth factor-I delivery to the synovium
    • Saxer RA, Bent SJ, Brower-Toland BD, et al. Gene mediated insulin-like growth factor-I delivery to the synovium. J Orthop Res 2001; 19: 759-767.
    • (2001) J Orthop Res , vol.19 , pp. 759-767
    • Saxer, R.A.1    Bent, S.J.2    Brower-Toland, B.D.3
  • 82
    • 0034232660 scopus 로고    scopus 로고
    • Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes
    • Shuler FD, Georgescu HI, Niyibizi C, et al. Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes. J Orthop Res 2000; 18: 585-592.
    • (2000) J Orthop Res , vol.18 , pp. 585-592
    • Shuler, F.D.1    Georgescu, H.I.2    Niyibizi, C.3
  • 83
    • 0034091315 scopus 로고    scopus 로고
    • Genetic enhancement of matrix synthesis by articular chondrocytes
    • Smith P, Shuler FD, Georgescu HI, et al. Genetic enhancement of matrix synthesis by articular chondrocytes. J Rheumatol 2000; 43: 1156-1164.
    • (2000) J Rheumatol , vol.43 , pp. 1156-1164
    • Smith, P.1    Shuler, F.D.2    Georgescu, H.I.3
  • 84
    • 28444460380 scopus 로고    scopus 로고
    • Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism
    • Ulrich-Vinther M, Stengaard C, Schwarz EM, et al. Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism. Eur Cell Mater 2005; 10: 40-59.
    • (2005) Eur Cell Mater , vol.10 , pp. 40-59
    • Ulrich-Vinther, M.1    Stengaard, C.2    Schwarz, E.M.3
  • 85
    • 0033763544 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints
    • Mi Z, Ghivizzani SC, Lechman ER, et al. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum 2000; 43: 2563-2570.
    • (2000) Arthritis Rheum , vol.43 , pp. 2563-2570
    • Mi, Z.1    Ghivizzani, S.C.2    Lechman, E.R.3
  • 86
    • 22644444720 scopus 로고    scopus 로고
    • Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro
    • Palmer GD, Steinert A, Pascher A, et al. Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther 2005; 12: 219-228.
    • (2005) Mol Ther , vol.12 , pp. 219-228
    • Palmer, G.D.1    Steinert, A.2    Pascher, A.3
  • 87
    • 84861098549 scopus 로고    scopus 로고
    • Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer
    • Shi S, Mercer S, Eckert GJ, et al. Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer. J Orthop Res 2011; 30: 1026-1031.
    • (2011) J Orthop Res , vol.30 , pp. 1026-1031
    • Shi, S.1    Mercer, S.2    Eckert, G.J.3
  • 88
    • 12144276564 scopus 로고    scopus 로고
    • Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes
    • Tew SR, Li Y, Pothacharoen P, et al. Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthritis Cartilage 2005; 13: 80-89.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 80-89
    • Tew, S.R.1    Li, Y.2    Pothacharoen, P.3
  • 89
    • 0037423736 scopus 로고    scopus 로고
    • Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells
    • Tsuchiya H, Kitoh H, Sugiura F, et al. Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 2003; 301: 338-343.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 338-343
    • Tsuchiya, H.1    Kitoh, H.2    Sugiura, F.3
  • 90
    • 84855750914 scopus 로고    scopus 로고
    • SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat
    • Lee JM, Im GI. SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat. Biomaterials 2012; 33: 2016-2024.
    • (2012) Biomaterials , vol.33 , pp. 2016-2024
    • Lee, J.M.1    Im, G.I.2
  • 91
    • 84862877054 scopus 로고    scopus 로고
    • Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering
    • Duval E, Bauge C, Andriamanalijaona R, et al. Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering. Biomaterials 2012; 33: 6042-6051.
    • (2012) Biomaterials , vol.33 , pp. 6042-6051
    • Duval, E.1    Bauge, C.2    Andriamanalijaona, R.3
  • 92
    • 61849173539 scopus 로고    scopus 로고
    • The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13
    • Jones SW, Watkins G, Le Good N, et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. Osteoarthritis Cartilage 2009; 17: 464-472.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 464-472
    • Jones, S.W.1    Watkins, G.2    Le Good, N.3
  • 93
    • 73649139221 scopus 로고    scopus 로고
    • Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
    • Tardif G, Hum D, Pelletier JP, et al. Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord 2009; 10: 148-158.
    • (2009) BMC Musculoskelet Disord , vol.10 , pp. 148-158
    • Tardif, G.1    Hum, D.2    Pelletier, J.P.3
  • 94
    • 77953067173 scopus 로고    scopus 로고
    • MicroRNA-140 plays dual roles in both cartilage development and homeostasis
    • Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev 2010; 24: 1173-1185.
    • (2010) Genes Dev , vol.24 , pp. 1173-1185
    • Miyaki, S.1    Sato, T.2    Inoue, A.3
  • 95
    • 77955283528 scopus 로고    scopus 로고
    • Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes
    • Dudek KA, Lafont JE, Martinez-Sanchez A, et al. Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J Biol Chem 2010; 285: 24381-24387.
    • (2010) J Biol Chem , vol.285 , pp. 24381-24387
    • Dudek, K.A.1    Lafont, J.E.2    Martinez-Sanchez, A.3
  • 96
    • 61349159991 scopus 로고    scopus 로고
    • Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase
    • Dvir-Ginzberg M, Gagarina V, Lee EJ, et al. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 2008; 283: 36300-36310.
    • (2008) J Biol Chem , vol.283 , pp. 36300-36310
    • Dvir-Ginzberg, M.1    Gagarina, V.2    Lee, E.J.3
  • 97
    • 20244384369 scopus 로고    scopus 로고
    • Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach
    • Kafienah W, Al-Fayez F, Hollander AP, et al. Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach. Arthritis Rheum 2003; 48: 709-718.
    • (2003) Arthritis Rheum , vol.48 , pp. 709-718
    • Kafienah, W.1    Al-Fayez, F.2    Hollander, A.P.3
  • 98
    • 0029133070 scopus 로고
    • Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector
    • Roessler BJ, Hartman JW, Vallance DK, et al. Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector. Hum Gene Ther 1995; 6: 307-316.
    • (1995) Hum Gene Ther , vol.6 , pp. 307-316
    • Roessler, B.J.1    Hartman, J.W.2    Vallance, D.K.3
  • 99
    • 0028799826 scopus 로고
    • Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation
    • Baragi VM, Renkiewicz RR, Jordan H, et al. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J Clin Invest 1995; 96: 2454-2460.
    • (1995) J Clin Invest , vol.96 , pp. 2454-2460
    • Baragi, V.M.1    Renkiewicz, R.R.2    Jordan, H.3
  • 100
    • 30944445959 scopus 로고    scopus 로고
    • Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo
    • Zhang X, Yu C, Xu S, et al. Direct chitosan-mediated gene delivery to the rabbit knee joints in vitro and in vivo. Biochem Biophys Res Commun 2006; 341: 202-208.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 202-208
    • Zhang, X.1    Yu, C.2    Xu, S.3
  • 101
    • 85047697321 scopus 로고    scopus 로고
    • Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene
    • Frisbie DD, Ghivizzani SC, Robbins PD, et al. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 2002; 9: 12-20.
    • (2002) Gene Ther , vol.9 , pp. 12-20
    • Frisbie, D.D.1    Ghivizzani, S.C.2    Robbins, P.D.3
  • 102
    • 84878834158 scopus 로고    scopus 로고
    • Optimization of scAAVIL-1ra in vitro and in vivo to deliver high levels of therapeutic protein for treatment of osteoarthritis
    • Goodrich LR, Phillips JN, McIlwraith CW, et al. Optimization of scAAVIL-1ra in vitro and in vivo to deliver high levels of therapeutic protein for treatment of osteoarthritis. Mol Ther Nucleic Acids 2013; 2: e70-e79.
    • (2013) Mol Ther Nucleic Acids , vol.2
    • Goodrich, L.R.1    Phillips, J.N.2    McIlwraith, C.W.3
  • 104
    • 0035284837 scopus 로고    scopus 로고
    • Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4
    • Kim SH, Kim S, Evans CH, et al. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol 2001; 166: 3499-3505.
    • (2001) J Immunol , vol.166 , pp. 3499-3505
    • Kim, S.H.1    Kim, S.2    Evans, C.H.3
  • 105
    • 0242606953 scopus 로고    scopus 로고
    • Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis
    • Scharstuhl A, Diepens R, Lensen J, et al. Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis. Osteoarthritis Cartilage 2003; 11: 773-782.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 773-782
    • Scharstuhl, A.1    Diepens, R.2    Lensen, J.3
  • 106
    • 0032924502 scopus 로고    scopus 로고
    • In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression
    • Fernandes J, Tardif G, Martel-Pelletier J, et al. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am J Pathol 1999; 154: 1159-1169.
    • (1999) Am J Pathol , vol.154 , pp. 1159-1169
    • Fernandes, J.1    Tardif, G.2    Martel-Pelletier, J.3
  • 107
    • 77957201321 scopus 로고    scopus 로고
    • Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis
    • Hsieh JL, Shen PC, Shiau AL, et al. Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis. J Orthop Res 2010; 28: 1300-1306.
    • (2010) J Orthop Res , vol.28 , pp. 1300-1306
    • Hsieh, J.L.1    Shen, P.C.2    Shiau, A.L.3
  • 108
    • 66049129631 scopus 로고    scopus 로고
    • Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1
    • Matsumoto T, Cooper GM, Gharaibeh B, et al. Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1. Arthritis Rheum 2009; 60: 1390-1405.
    • (2009) Arthritis Rheum , vol.60 , pp. 1390-1405
    • Matsumoto, T.1    Cooper, G.M.2    Gharaibeh, B.3
  • 109
    • 84855750914 scopus 로고    scopus 로고
    • SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat
    • Lee JM, Im GI. SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat. Biomaterials 2011; 33: 2016-2024.
    • (2011) Biomaterials , vol.33 , pp. 2016-2024
    • Lee, J.M.1    Im, G.I.2
  • 110
    • 81155137913 scopus 로고    scopus 로고
    • Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo
    • Orth P, Kaul G, Cucchiarini M, et al. Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo. Knee Surg Sports Traumatol Arthrosc 2011; 19: 2119-2130.
    • (2011) Knee Surg Sports Traumatol Arthrosc , vol.19 , pp. 2119-2130
    • Orth, P.1    Kaul, G.2    Cucchiarini, M.3
  • 111
    • 84862778885 scopus 로고    scopus 로고
    • Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs
    • Jeon SY, Park JS, Yang HN, et al. Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs. Biomaterials 2012; 33: 4413-4423.
    • (2012) Biomaterials , vol.33 , pp. 4413-4423
    • Jeon, S.Y.1    Park, J.S.2    Yang, H.N.3
  • 112
    • 84941600568 scopus 로고    scopus 로고
    • Co-transduction of lentiviral and adenoviral vectors for co-delivery of growth factor and shRNA genes in mesenchymal stem cells-based chondrogenic system
    • doi:10.1002/term.1656.
    • Zhang F, Yao Y, Su K, et al. Co-transduction of lentiviral and adenoviral vectors for co-delivery of growth factor and shRNA genes in mesenchymal stem cells-based chondrogenic system. J Tissue Eng Regen Med 2012. doi:10.1002/term.1656.
    • (2012) J Tissue Eng Regen Med
    • Zhang, F.1    Yao, Y.2    Su, K.3
  • 113
    • 1342285045 scopus 로고    scopus 로고
    • Osteoarthritis gene therapy
    • Evans CH, Gouze JN, Gouze E, et al. Osteoarthritis gene therapy. Gene Ther 2004; 11: 379-389.
    • (2004) Gene Ther , vol.11 , pp. 379-389
    • Evans, C.H.1    Gouze, J.N.2    Gouze, E.3
  • 114
    • 0033994254 scopus 로고    scopus 로고
    • Efficient lipid-mediated gene transfer to articular chondrocytes
    • Madry H, Trippel SB. Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Ther 2000; 7: 286-291.
    • (2000) Gene Ther , vol.7 , pp. 286-291
    • Madry, H.1    Trippel, S.B.2
  • 115
    • 84864317336 scopus 로고    scopus 로고
    • Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells
    • Elsler S, Schetting S, Schmitt G, et al. Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells. J Gene Med 2012; 14: 501-511.
    • (2012) J Gene Med , vol.14 , pp. 501-511
    • Elsler, S.1    Schetting, S.2    Schmitt, G.3
  • 116
    • 0031786744 scopus 로고    scopus 로고
    • Adenovirus mediated gene delivery to the joints of guinea pigs
    • Ikeda T, Kubo T, Arai Y, et al. Adenovirus mediated gene delivery to the joints of guinea pigs. J Rheumatol 1998; 25: 1666-1673.
    • (1998) J Rheumatol , vol.25 , pp. 1666-1673
    • Ikeda, T.1    Kubo, T.2    Arai, Y.3
  • 117
    • 0030823167 scopus 로고    scopus 로고
    • LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors
    • Allay JA, Dennis JE, Haynesworth SE, et al. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum Gene Ther 1997; 8: 1417-1427.
    • (1997) Hum Gene Ther , vol.8 , pp. 1417-1427
    • Allay, J.A.1    Dennis, J.E.2    Haynesworth, S.E.3
  • 118
    • 0036226899 scopus 로고    scopus 로고
    • In vivo gene delivery to synovium by lentiviral vectors
    • Gouze E, Pawliuk R, Pilapil C, et al. In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 2002; 5: 397-404.
    • (2002) Mol Ther , vol.5 , pp. 397-404
    • Gouze, E.1    Pawliuk, R.2    Pilapil, C.3
  • 119
    • 55049118090 scopus 로고    scopus 로고
    • Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease
    • Meyerrose TE, Roberts M, Ohlemiller KK, et al. Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease. Stem Cells 2008; 26: 1713-1722.
    • (2008) Stem Cells , vol.26 , pp. 1713-1722
    • Meyerrose, T.E.1    Roberts, M.2    Ohlemiller, K.K.3
  • 120
    • 34249987137 scopus 로고    scopus 로고
    • Adeno-associated viral vector transduction of human mesenchymal stem cells
    • Stender S, Murphy M, O'Brien T, et al. Adeno-associated viral vector transduction of human mesenchymal stem cells. Eur Cell Mater 2007; 13: 93-99.
    • (2007) Eur Cell Mater , vol.13 , pp. 93-99
    • Stender, S.1    Murphy, M.2    O'Brien, T.3
  • 121
    • 0034882826 scopus 로고    scopus 로고
    • Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis
    • McCarty DM, Monahan PE, Samulski RJ. Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther 2001; 8: 1248-1254.
    • (2001) Gene Ther , vol.8 , pp. 1248-1254
    • McCarty, D.M.1    Monahan, P.E.2    Samulski, R.J.3
  • 122
    • 82955198421 scopus 로고    scopus 로고
    • Effective reduction of the interleukin-1beta transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis
    • Santangelo KS, Bertone AL. Effective reduction of the interleukin-1beta transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis. Osteoarthritis Cartilage 2011; 19: 1449-1457.
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 1449-1457
    • Santangelo, K.S.1    Bertone, A.L.2
  • 123
    • 84882288958 scopus 로고    scopus 로고
    • scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints
    • Watson RS, Broome TA, Levings PP, et al. scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints. Gene Ther 2013; 20: 670-677.
    • (2013) Gene Ther , vol.20 , pp. 670-677
    • Watson, R.S.1    Broome, T.A.2    Levings, P.P.3
  • 124
    • 84859440283 scopus 로고    scopus 로고
    • The AAV vector toolkit: poised at the clinical crossroads
    • Asokan A, Schaffer DV, Samulski RJ. The AAV vector toolkit: poised at the clinical crossroads. Mol Ther 2012; 20: 699-708.
    • (2012) Mol Ther , vol.20 , pp. 699-708
    • Asokan, A.1    Schaffer, D.V.2    Samulski, R.J.3
  • 125
    • 84857602982 scopus 로고    scopus 로고
    • Adeno-associated virus vectorology, manufacturing, and clinical applications
    • Grieger JC, Samulski RJ. Adeno-associated virus vectorology, manufacturing, and clinical applications. Methods Enzymol 2012; 507: 229-254.
    • (2012) Methods Enzymol , vol.507 , pp. 229-254
    • Grieger, J.C.1    Samulski, R.J.2
  • 126
    • 79954622209 scopus 로고    scopus 로고
    • Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
    • Mingozzi F, High KA. Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges. Nat Rev Genet 2011; 12: 341-355.
    • (2011) Nat Rev Genet , vol.12 , pp. 341-355
    • Mingozzi, F.1    High, K.A.2
  • 127
    • 0033774634 scopus 로고    scopus 로고
    • Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis
    • Frisbie DD, McIlwraith CW. Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis. Clin Orthop Relat Res 2000; 379(Suppl): S273-S287.
    • (2000) Clin Orthop Relat Res , vol.379 , Issue.SUPPL
    • Frisbie, D.D.1    McIlwraith, C.W.2
  • 128
    • 84867863259 scopus 로고    scopus 로고
    • In vivo reduction or blockade of interleukin-1beta in primary osteoarthritis influences expression of mediators implicated in pathogenesis
    • Santangelo KS, Nuovo GJ, Bertone AL. In vivo reduction or blockade of interleukin-1beta in primary osteoarthritis influences expression of mediators implicated in pathogenesis. Osteoarthritis Cartilage 2012; 20: 1610-1618.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 1610-1618
    • Santangelo, K.S.1    Nuovo, G.J.2    Bertone, A.L.3
  • 129
    • 38949205532 scopus 로고    scopus 로고
    • Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA
    • Chen LX, Lin L, Wang HJ, et al. Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA. Osteoarthritis Cartilage 2008; 16: 174-184.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 174-184
    • Chen, L.X.1    Lin, L.2    Wang, H.J.3
  • 130
    • 79953199101 scopus 로고    scopus 로고
    • Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis
    • Shen PC, Shiau AL, Jou IM, et al. Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis. Exp Biol Med (Maywood) 2011; 236: 334-340.
    • (2011) Exp Biol Med (Maywood) , vol.236 , pp. 334-340
    • Shen, P.C.1    Shiau, A.L.2    Jou, I.M.3
  • 131
    • 70349795944 scopus 로고    scopus 로고
    • Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain
    • Yamashita M, Yamauchi K, Suzuki M, et al. Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain. Spine (Phila Pa 1976) 2009; 34: 2270-2277.
    • (2009) Spine (Phila Pa 1976) , vol.34 , pp. 2270-2277
    • Yamashita, M.1    Yamauchi, K.2    Suzuki, M.3
  • 132
    • 66549095444 scopus 로고    scopus 로고
    • TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7
    • Blaney Davidson EN, Vitters EL, van den Berg WB, et al. TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7. Arthritis Res Ther 2006; 8: R65-R72.
    • (2006) Arthritis Res Ther , vol.8
    • Blaney Davidson, E.N.1    Vitters, E.L.2    van den Berg, W.B.3
  • 133
    • 0346220031 scopus 로고    scopus 로고
    • Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis
    • Scharstuhl A, Vitters EL, van der Kraan PM, et al. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis Rheum 2003; 48: 3442-3451.
    • (2003) Arthritis Rheum , vol.48 , pp. 3442-3451
    • Scharstuhl, A.1    Vitters, E.L.2    van der Kraan, P.M.3
  • 134
    • 58849111311 scopus 로고    scopus 로고
    • Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection
    • Hsieh JL, Shen PC, Shiau AL, et al. Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection. Hum Gene Ther 2009; 20: 147-158.
    • (2009) Hum Gene Ther , vol.20 , pp. 147-158
    • Hsieh, J.L.1    Shen, P.C.2    Shiau, A.L.3
  • 135
    • 0027435633 scopus 로고
    • Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer
    • Bandara G, Mueller GM, Galea-Lauri J, et al. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci U S A 1993; 90: 10764-10768.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10764-10768
    • Bandara, G.1    Mueller, G.M.2    Galea-Lauri, J.3
  • 136
    • 2942555576 scopus 로고    scopus 로고
    • Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10
    • Zhang X, Mao Z, Yu C. Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J Orthop Res 2004; 22: 742-750.
    • (2004) J Orthop Res , vol.22 , pp. 742-750
    • Zhang, X.1    Mao, Z.2    Yu, C.3
  • 138
    • 19144364120 scopus 로고    scopus 로고
    • Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis
    • Evans CH, Robbins PD, Ghivizzani SC, et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 1996; 7: 1261-1280.
    • (1996) Hum Gene Ther , vol.7 , pp. 1261-1280
    • Evans, C.H.1    Robbins, P.D.2    Ghivizzani, S.C.3
  • 139
    • 2142640339 scopus 로고    scopus 로고
    • Gene therapies for osteoarthritis
    • Evans CH. Gene therapies for osteoarthritis. Curr Rheumatol Rep 2004; 6: 31-40.
    • (2004) Curr Rheumatol Rep , vol.6 , pp. 31-40
    • Evans, C.H.1
  • 140
    • 27544467720 scopus 로고    scopus 로고
    • Gene therapy for the treatment of musculoskeletal diseases
    • Evans CH, Ghivizzani SC, Herndon JH, et al. Gene therapy for the treatment of musculoskeletal diseases. J Am Acad Orthop Surg 2005; 13: 230-242.
    • (2005) J Am Acad Orthop Surg , vol.13 , pp. 230-242
    • Evans, C.H.1    Ghivizzani, S.C.2    Herndon, J.H.3
  • 147
    • 67749084439 scopus 로고    scopus 로고
    • Local delivery of a recombinant adeno-associated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study
    • Mease PJ, Hobbs K, Chalmers A, et al. Local delivery of a recombinant adeno-associated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study. Ann Rheum Dis 2009; 68: 1247-1254.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1247-1254
    • Mease, P.J.1    Hobbs, K.2    Chalmers, A.3
  • 148
    • 77950657693 scopus 로고    scopus 로고
    • Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumour necrosis factor antagonist gene: results of a phase 1/2 Study
    • Mease PJ, Wei N, Fudman EJ, et al. Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumour necrosis factor antagonist gene: results of a phase 1/2 Study. J Rheumatol 2011; 37: 692-703.
    • (2011) J Rheumatol , vol.37 , pp. 692-703
    • Mease, P.J.1    Wei, N.2    Fudman, E.J.3
  • 149
    • 67650497832 scopus 로고    scopus 로고
    • Investigation of the cause of death in a gene-therapy trial
    • Frank KM, Hogarth DK, Miller JL, et al. Investigation of the cause of death in a gene-therapy trial. N Engl J Med 2009; 361: 161-169.
    • (2009) N Engl J Med , vol.361 , pp. 161-169
    • Frank, K.M.1    Hogarth, D.K.2    Miller, J.L.3
  • 150
    • 77956903435 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat
    • Gerwin N, Bendele AM, Glasson S, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat. Osteoarthritis Cartilage 2010; 18(Suppl 3): S24-S34.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Gerwin, N.1    Bendele, A.M.2    Glasson, S.3
  • 151
    • 77956937521 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig
    • Kraus VB, Huebner JL, DeGroot J, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig. Osteoarthritis Cartilage 2010; 18(Suppl 3): S35-S52.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Kraus, V.B.1    Huebner, J.L.2    DeGroot, J.3
  • 152
    • 77956924858 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse
    • Glasson SS, Chambers MG, van den Berg WB, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010; 18(Suppl 3): S17-S23.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Glasson, S.S.1    Chambers, M.G.2    van den Berg, W.B.3
  • 153
    • 77956908666 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rabbit
    • Laverty S, Girard CA, Williams JM, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rabbit. Osteoarthritis Cartilage 2010; 18(Suppl 3): S53-S65.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Laverty, S.1    Girard, C.A.2    Williams, J.M.3
  • 154
    • 16544368753 scopus 로고
    • Hindlimb loading, morphology and biochemistry of articular cartilage in the ACL-deficient cat knee
    • Herzog W, Adams ME, Matyas JR, et al. Hindlimb loading, morphology and biochemistry of articular cartilage in the ACL-deficient cat knee. Osteoarthritis Cartilage 1993; 1: 243-251.
    • (1993) Osteoarthritis Cartilage , vol.1 , pp. 243-251
    • Herzog, W.1    Adams, M.E.2    Matyas, J.R.3
  • 155
    • 77953699197 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog
    • Cook JL, Kuroki K, Visco D, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog. Osteoarthritis Cartilage 2010; 18(Suppl 3): S66-S79.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Cook, J.L.1    Kuroki, K.2    Visco, D.3
  • 156
    • 14044279349 scopus 로고    scopus 로고
    • Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis
    • Boyd SK, Muller R, Leonard T, et al. Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis. Osteoarthritis Cartilage 2005; 13: 235-242.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 235-242
    • Boyd, S.K.1    Muller, R.2    Leonard, T.3
  • 157
    • 84878111948 scopus 로고    scopus 로고
    • Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model
    • Holland JC, Brennan O, Kennedy OD, et al. Examination of osteoarthritis and subchondral bone alterations within the stifle joint of an ovariectomised ovine model. J Anat 2013; 222: 588-597.
    • (2013) J Anat , vol.222 , pp. 588-597
    • Holland, J.C.1    Brennan, O.2    Kennedy, O.D.3
  • 158
    • 77956936940 scopus 로고    scopus 로고
    • Histopathology atlas of animal model systems - overview of guiding principles
    • Aigner T, Cook JL, Gerwin N, et al. Histopathology atlas of animal model systems - overview of guiding principles. Osteoarthritis Cartilage 2010; 18(Suppl 3): S2-S6.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Aigner, T.1    Cook, J.L.2    Gerwin, N.3
  • 159
    • 77956903436 scopus 로고    scopus 로고
    • Recommendations for the use of preclinical models in the study and treatment of osteoarthritis
    • Poole R, Blake S, Buschmann M, et al. Recommendations for the use of preclinical models in the study and treatment of osteoarthritis. Osteoarthritis Cartilage 2010; 18(Suppl 3): S10-S16.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Poole, R.1    Blake, S.2    Buschmann, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.