Adhesion of transplanted chondrocytes onto cartilage in vitro and in vivo

Journal of Rheumatology

Volumn 27, Issue 7, 2000, Pages 1725-1731

  Doherty, Paul J ^b   Zhang, Hongwei ^b   Manolopoulos, Vaselios ^b   Trogadis, Judy ^b   Tremblay, Louise ^b   Marshall, K Wayne ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b NONE

Author keywords

Cartilage; Chondrocytes; Gene transfer; Osteoarthritis

Indexed keywords

BETA ACTIN; BETA GALACTOSIDASE; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARTILAGE CELL; CELL ADHESION; CELL TRANSPLANTATION; ENHANCER REGION; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROMOTER REGION; VIRUS REPLICATION;

ANIMALS; CARBOCYANINES; CARTILAGE; CATTLE; CHONDROCYTES; DOGS; FLUORESCENT DYES; GENE THERAPY; GENES, REPORTER; INJECTIONS, INTRA-ARTICULAR; LAC OPERON; OSTEOARTHRITIS; TRANSFECTION;

EID: 0033925453     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Minas T, Nehrer S. Current concepts in the treatment of articular cartilage defects. Orthopedics 1997;20:525-38.
2. Chen AC, Nagrampa JP, Schinagl RM, Lottman LM, Sah RL. Chondrocyte transplantation to articular cartilage explants in vitro. J Orthop Res 1997;15:791-802.
3. Manolopoulos V, Marshall KW, Zhang H, Trogadis J, Tremblay L, Doherty PJ. Factors affecting the efficacy of bovine chondrocyte transplantation in vitro. Osteoarthritis Cartilage 1999;7:453-60.
4. Brittberg M, Nilsson A, Lindahl A, Ohlsson C, Peterson L. Rabbit articular cartilage defects treated with autologous cultured chondrocytes. Clin Orthop Rel Res 1996;326:270-83.
5. Grande DA, Pitman MI, Peterson L, Menche D, Klein M. The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. J Orthop Res 1989;7:208-18.
6. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994;331:889-95.
7. Hendrickson DA, Nixon AJ, Grande DA, et al. Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res 1994;12:485-97.
8. Wakitani S, Kimura T, Hirooka A, et al. Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel. J Bone Joint Surg 1989;71B:74-80.
9. Schuman L, Buma P, Versleyen D, de Man B, van der Kraan PM, Homminga GN. Chondrocyte behaviour within different types of collagen gel in vitro. Biomaterials 1995;16:809-14.
10. Baragi VM, Renkiewicz RR, Jordan H, Bonadio J, Hartman JW. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J Clin Invest 1995;96:2454-60.
11. O'Driscoll SW, Salter RB. The repair of major osteochondral defects in joint surfaces by neochondrogenesis with autogenous osteoperiosteal grafts stimulated by continuous passive motion. Clin Orthop Rel Res 1986;208:131-40.
12. Homminga GN, Bulstra S, Bouwmeester P, Linden A. Perichondrial grafting for cartilage lesions of the knee. J Bone Joint Surg 1990;72B:1003-7.
13. Messner K, Lohmander LS, Gilquist J. Neocartilage after artificial cartilage repair in the rabbit: histology and proteoglycan fragments in joint fluid. J Biomed Mater Res 1993;27:949-54.
14. Wakitani S, Goto T, Pineda SJ, et al. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg 1994;76A:579-92.
15. Baragi VM, Renkiewicz RR, Qiu L, et al. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo. Osteoarthritis Cart 1997;5:275-82.
16. Kang R, Marui T, Ghivizzani SC, et al. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasilibity study. Osteoarthritis Cart 1997;5:139-43.
17. Mason JM, Grande DA, Barcia M, Grant R, Pergolizzi RG, Breitbart AS. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair. Gene Therapy 1998;5:1098-104.
18. Chang MW, Barr E, Lu MM, Barton K, Leiden JM. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest 1995;96:2260-8.
19. Doherty PJ, Zhang H, Tremblay L, Manolopoulos V, Marshall KW. Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro. Osteoarthritis Cart 1998;6:153-60.
20. Venn G, Billingham MEJ, Hardingham TE. Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype. Arthritis Rheum 1995;38:525-32.