Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

Arthritis and Rheumatism

Volumn 64, Issue 8, 2012, Pages 2568-2578

  Oh, Hwanhee ^a   Chun, Churl Hong ^b   Chun, Jang Soo ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Wonkwang University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECANASE 1; COLLAGENASE 3; DICKKOPF 1 PROTEIN; DICKKOPF 2 PROTEIN; GLYCOPROTEIN; MESSENGER RNA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ADENOVIRUS; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; KNEE MENISCUS; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; OSTEOPHYTE; OSTEOSCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE;

AGED; ANIMALS; APOPTOSIS; CARTILAGE; CHONDROCYTES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MENISCI, TIBIAL; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MIDDLE AGED; OSTEOARTHRITIS; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 84864470588     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34481     Document Type: Article

References (41)

1. Goldring MB, Goldring SR,. Osteoarthritis. J Cell Physiol 2007; 213: 626-34.
2. Hashimoto M, Nakasa T, Hikata T, Asahara H,. Molecular network of cartilage homeostasis and osteoarthritis. Med Res Rev 2008; 28: 464-81.
3. Corr M,. Wnt-β-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol 2008; 4: 550-6.
4. Blom AB, van Lent PL, van der Kraan PM, van den Berg WB,. To seek shelter from the Wnt in osteoarthritis? Wnt-signaling as a target for osteoarthritis therapy. Curr Drug Targets 2010; 11: 620-9.
5. Zhu M, Chen M, Zuscik M, Wu Q, Wang YJ, Rosier RN, et al. Inhibition of β-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum 2008; 58: 2053-64.
6. Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, et al. Activation of β-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult β-catenin conditional activation mice. J Bone Miner Res 2009; 24: 12-21.
7. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J,. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 2008; 121: 737-46.
8. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A 2004; 101: 9757-62.
9. Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, et al. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum 2005; 52: 1077-80.
10. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 2007; 56: 4095-103.
11. Niehrs C,. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006; 25: 7469-81.
12. Chan TF, Couchourel D, Abed E, Delalandre A, Duval N, Lajeunesse D,. Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts. J Bone Miner Res 2011; 26: 1399-410.
13. Wu W, Glinka A, Delius H, Niehrs C,. Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling. Curr Biol 2000; 10: 1611-4.
14. Mao B, Niehrs C,. Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene 2003; 302: 179-83.
15. Lane NE, Nevitt MC, Lui LY, de Leon P, Corr M, for the Study of Osteoporotic Fractures Research Group. Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum 2007; 56: 3319-25.
16. Voorzanger-Rousselot N, Ben-Tabassi NC, Garnero P,. Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with rheumatoid arthritis and knee osteoarthritis. Ann Rheum Dis 2009; 68: 1513-4.
17. Honsawek S, Tanavalee A, Yuktanandana P, Ngarmukos S, Saetan N, Tantavisut S,. Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients. BMC Musculoskelet Disord 2010; 11: 257.
18. Weng LH, Wang CJ, Ko JY, Sun YC, Su YS, Wang FS,. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Osteoarthritis Cartilage 2009; 17: 933-43.
19. Weng LH, Wang CJ, Ko JY, Sun YC, Wang FS,. Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Arthritis Rheum 2010; 62: 1393-402.
20. Mukhopadhyay M, Shtrom S, Rodriguez-Esteban C, Chen L, Tsukui T, Gomer L, et al. Dickkopf-1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell 2001; 1: 423-34.
21. Yang S, Kim J, Ryu JH, Oh H, Chun CH, Kim BJ, et al. Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010; 16: 687-93.
22. Mainil-Varlet P, Aigner T, Brittberg M, Bullough P, Hollander A, Hunziker E, et al. Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am 2003; 85A Suppl 2: 1-141.
23. Kleemann RU, Krocker D, Cedraro A, Tuischer J, Duda GN,. Altered cartilage mechanics and histology in knee osteoarthritis: relation to clinical assessment (ICRS Grade). Osteoarthritis Cartilage 2005; 13: 958-63.
24. Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT,. The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthritis Cartilage 2001; 9: 85-91.
25. Glasson SS, Blanchet TJ, Morris EA,. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007; 15: 1061-9.
26. Mankin HJ, Dorfman H, Lippiello L, Zarins A,. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971; 53: 523-37.
27. Glasson SS, Chambers MG, van den Berg WB, Little CB,. The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010; 18 Suppl 3: S17-23.
28. Ryu JH, Yang S, Shin Y, Rhee J, Chun CH, Chun JS,. Interleukin 6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum 2011; 63: 2732-43.
29. Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 2009; 60: 3723-33.
30. Tokuda M,. Histological study of spontaneous osteoarthritis in the knee joint of guinea pigs. J Orthop Sci 1997; 2: 248-58
31. Kim JS, Ryoo ZY, Chun JS,. Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J Biol Chem 2007; 282: 29359-67.
32. -/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction. J Biol Chem 2011; 286: 27206-13.
33. Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, et al. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 2007; 56: 575-85.
34. Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med 2007; 13: 156-63.
35. Oh H, Ryu JH, Jeon J, Yang S, Chun CH, Park H, et al. Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification. J Bone Miner Res 2012; 27: 1335-44.
36. Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS,. Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death Differ 2011; 19: 440-50.
37. Dell'Accio F, De Bari C, Eltawil NM, Vanhummelen P, Pitzalis C,. Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum 2008; 58: 1410-21.
38. Blom AB, Brockbank SM, van Lent PL, van Beuningen HM, Geurts J, Takahashi N, et al. Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum 2009; 60: 501-12.
39. Shortkroff S, Yates KE,. Alteration of matrix glycosaminoglycans diminishes articular chondrocytes response to a canonical Wnt signal. Osteoarthritis Cartilage 2007; 15: 147-54.
40. Yuasa T, Otani T, Koike T, Iwamoto M, Enomoto-Iwamoto M,. Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest 2008; 88: 264-74.
41. Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 2004; 50: 2547-58.