Gene mediated insulin-like growth factor-I delivery to the synovium

Journal of Orthopaedic Research

Volumn 19, Issue 5, 2001, Pages 759-767

  Saxer, Rachel A ^a   Bent, Stephen J ^a   Brower Toland, Brent D ^a   Mi, Zhibao ^b   Robbins, Paul D ^b   Evans, Christopher H ^c   Nixon, Alan J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; INSULIN; MONOLAYERS; MORPHOLOGY; TISSUE CULTURE;

IN SITU HYBRIDIZATION;

GENETIC ENGINEERING;

BETA GALACTOSIDASE; COLLAGEN TYPE 1; DECORIN; HYALURONIC ACID; PROTEOGLYCAN; RECOMBINANT SOMATOMEDIN C; RNA;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; EXPLANT; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HORSE; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; IN VITRO STUDY; INFECTION; MORPHOLOGY; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RNA TRANSLATION; SYNOVIOCYTE; SYNOVIUM; TISSUE CULTURE; TRANSGENE;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; COLLAGEN; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HORSES; INSULIN-LIKE GROWTH FACTOR I; LIGANDS; PROTEOGLYCANS; RNA, MESSENGER; SYNOVIAL MEMBRANE; TRANSGENES;

EID: 0034871638     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-0266(00)00077-2     Document Type: Article

References (33)

1. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer
2. Long-term transgene expression in fetal rat suprachiasmatic nucleus neurografts following ex vivo adenoviral vector-mediated gene transfer
3. Direct adenovirus-mediated insulin-like growth factor-I gene transfer enhances transplant chondrocyte function
4. Adenovirus-mediated regulable target gene expression in vivo
5. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
6. Insulin-like growth factor-I gene expression patterns during spontaneous repair of acute articular cartilage injury
7. Coordinate upregulation of cartilage matrix synthesis in fibrin cultures supplemented with exogenous insulin-like growth factor-I
8. Construction of adenovirus vectors through Cre-lox recombination
9. Insulin-like growth factor I (IGF-I) enhances hyaluronic acid synthesis in rabbit pericardium
10. Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium
11. How could infectious agents hide in synovial cells? Possible mechanisms of persistent viral infection in a model for the etiopathogenesis of chronic arthritis
12. Effect of growth factors on hyaluronan and proteoglycan synthesis by retroocular tissue fibroblasts of Graves' ophthalmopathy in culture
13. Elongation factor Tu as a control gene for mRNA analysis of lung development and other differentiation and growth-regulated systems
14. Quantitative microanalysis of equine synovial fluid glycosaminoglycan concentration
15. Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants
16. Efficient lipid-mediated gene transfer to articular chondrocytes
17. Quantification of 35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates
18. Biochemical and site-specific effects of insulin-like growth factor I on intrinsic tenocyte activity in equine flexor tendons
19. Influence of exogenous growth factors on the synthesis and secretion of collagen types I and III by explants of normal and healing rabbit ligaments
20. Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis
21. Enhanced repair of extensive articular defects by insulin-like growth factor-I laden fibrin composites
22. Primary nucleotide structure of predominant and alternative splice forms of equine insulin-like growth factor-I and their gene expression patterns in tissues
23. In situ hybridisation for decorin mRNA in rabbit synovium during antigen-induced arthritis
24. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy
25. Estimation of extremely low amounts of single mRNAs by quantitative noncompetitive reverse transcription - Polymerase chain reaction assay in biological specimens from normal and neoplastic cells
26. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
27. Quantitative polymerase chain reaction assay for aggrecan and link protein gene expression in cartilage
28. Adenoviral-mediated gene transfer to rabbit synovium in vivo
29. Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector
30. In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth
31. IGF-1 stimulates synthesis of undersulfated proteoglycans and of hyaluronic acid by peritubular cells from immature rat testis
32. Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines
33. Interleukin-4 adenoviral gene therapy reduces production of inflammatory cytokines and prostaglandin E2 by rheumatoid arthritis synovium ex vivo