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Volumn 56, Issue 1, 2007, Pages 158-167

Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; COMPLEMENTARY DNA; PARVOVIRUS VECTOR; PROTEOGLYCAN; TRANSCRIPTION FACTOR SOX9;

EID: 33846208305     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22299     Document Type: Article
Times cited : (139)

References (49)
  • 1
    • 0033569188 scopus 로고    scopus 로고
    • An introduction to the pathophysiology of osteoarthritis
    • Poole AR. An introduction to the pathophysiology of osteoarthritis. Front Biosci 1999;4:D662-70.
    • (1999) Front Biosci , vol.4
    • Poole, A.R.1
  • 3
    • 0030936759 scopus 로고    scopus 로고
    • Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage
    • Aigner T, Vornehm SI, Zeiler G, Dudhia J, von der Mark K, Bayliss MT. Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage. Arthritis Rheum 1997;40:562-9.
    • (1997) Arthritis Rheum , vol.40 , pp. 562-569
    • Aigner, T.1    Vornehm, S.I.2    Zeiler, G.3    Dudhia, J.4    von der Mark, K.5    Bayliss, M.T.6
  • 4
    • 0000263201 scopus 로고    scopus 로고
    • Degradative enzymes in osteoarthritis
    • Smith RL. Degradative enzymes in osteoarthritis. Front Biosci 1999;4:D704-12.
    • (1999) Front Biosci , vol.4
    • Smith, R.L.1
  • 5
    • 0028799826 scopus 로고
    • Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation
    • Baragi VM, Renkiewicz RR, Jordan H, Bonadio J, Hartman JW, Roessler BJ. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J Clin Invest 1995;96:2454-60.
    • (1995) J Clin Invest , vol.96 , pp. 2454-2460
    • Baragi, V.M.1    Renkiewicz, R.R.2    Jordan, H.3    Bonadio, J.4    Hartman, J.W.5    Roessler, B.J.6
  • 6
    • 13244269894 scopus 로고    scopus 로고
    • Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy
    • Nixon AJ, Haupt JL, Frisbie DD, Morisset SS, McIlwraith CW, Robbins PD, et al. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther 2005;12:177-86.
    • (2005) Gene Ther , vol.12 , pp. 177-186
    • Nixon, A.J.1    Haupt, J.L.2    Frisbie, D.D.3    Morisset, S.S.4    McIlwraith, C.W.5    Robbins, P.D.6
  • 7
    • 0030961873 scopus 로고    scopus 로고
    • In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
    • Pelletier JP, Caron JP, Evans C, Robbins PD, Georgescu HI, Jovanovic D, et al. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum 1997;40:1012-9.
    • (1997) Arthritis Rheum , vol.40 , pp. 1012-1019
    • Pelletier, J.P.1    Caron, J.P.2    Evans, C.3    Robbins, P.D.4    Georgescu, H.I.5    Jovanovic, D.6
  • 8
    • 85047697321 scopus 로고    scopus 로고
    • Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene
    • Frisbie DD, Ghivizzani CS, Robbins PD, Evans CH, McIlwraith CW. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 2002;9:12-20.
    • (2002) Gene Ther , vol.9 , pp. 12-20
    • Frisbie, D.D.1    Ghivizzani, C.S.2    Robbins, P.D.3    Evans, C.H.4    McIlwraith, C.W.5
  • 9
    • 30744436362 scopus 로고    scopus 로고
    • Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis
    • Grossin L, Cournil-Henrionnet C, Pinzano A, Gaborit N, Dumas D, Etienne S, et al. Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis. FASEB J 2006;20:65-75.
    • (2006) FASEB J , vol.20 , pp. 65-75
    • Grossin, L.1    Cournil-Henrionnet, C.2    Pinzano, A.3    Gaborit, N.4    Dumas, D.5    Etienne, S.6
  • 10
    • 0034782732 scopus 로고    scopus 로고
    • Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Zurakowski D, Trippel SB. Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Ther 2001;8:1443-9.
    • (2001) Gene Ther , vol.8 , pp. 1443-1449
    • Madry, H.1    Zurakowski, D.2    Trippel, S.B.3
  • 11
    • 4644244444 scopus 로고    scopus 로고
    • Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Emkey G, Zurakowski D, Trippel SB. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. J Gene Med 2004;6:238-45.
    • (2004) J Gene Med , vol.6 , pp. 238-245
    • Madry, H.1    Emkey, G.2    Zurakowski, D.3    Trippel, S.B.4
  • 12
    • 0034858445 scopus 로고    scopus 로고
    • Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7
    • Hidaka C, Quitoriano M, Warren RF, Crystal RG. Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7. J Orthop Res 2001;19:751-8.
    • (2001) J Orthop Res , vol.19 , pp. 751-758
    • Hidaka, C.1    Quitoriano, M.2    Warren, R.F.3    Crystal, R.G.4
  • 13
    • 28444460380 scopus 로고    scopus 로고
    • Adeno-associated vector mediated gene transfer of transforming growth factor-β1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism
    • Ulrich-Vinther M, Stengaard C, Schwarz EM, Goldring MB, Soballe K. Adeno-associated vector mediated gene transfer of transforming growth factor-β1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism. Eur Cell Mater 2005; 10:40-59.
    • (2005) Eur Cell Mater , vol.10 , pp. 40-59
    • Ulrich-Vinther, M.1    Stengaard, C.2    Schwarz, E.M.3    Goldring, M.B.4    Soballe, K.5
  • 14
    • 11144240780 scopus 로고    scopus 로고
    • Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair
    • Venkatesan N, Barre L, Benani A, Netter P, Magdalou J, Fournel-Gigleux S, et al. Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair. Proc Natl Acad Sci U S A 2004;101:18087-92.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18087-18092
    • Venkatesan, N.1    Barre, L.2    Benani, A.3    Netter, P.4    Magdalou, J.5    Fournel-Gigleux, S.6
  • 16
    • 8444233948 scopus 로고    scopus 로고
    • The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage
    • Ikeda T, Kamekura S, Mabuchi A, Kou I, Seki S, Takato T, et al. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum 2004;50:3561-73.
    • (2004) Arthritis Rheum , vol.50 , pp. 3561-3573
    • Ikeda, T.1    Kamekura, S.2    Mabuchi, A.3    Kou, I.4    Seki, S.5    Takato, T.6
  • 18
    • 0030899814 scopus 로고    scopus 로고
    • SOX9 is a potent activator of the chondrocyte-specific enhancer of the proα1(II) collagen gene
    • Lefebvre V, Huang W, Harley VR, Goodfellow PN, de Crombrugghe B. SOX9 is a potent activator of the chondrocyte-specific enhancer of the proα1(II) collagen gene. Mol Cell Biol 1997;17: 2336-46.
    • (1997) Mol Cell Biol , vol.17 , pp. 2336-2346
    • Lefebvre, V.1    Huang, W.2    Harley, V.R.3    Goodfellow, P.N.4    de Crombrugghe, B.5
  • 19
    • 0031104994 scopus 로고    scopus 로고
    • SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
    • Ng LJ, Wheatley S, Muscat GE, Conway-Campbell J, Bowles J, Wright E, et al. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol 1997;183:108-21.
    • (1997) Dev Biol , vol.183 , pp. 108-121
    • LJ, N.1    Wheatley, S.2    Muscat, G.E.3    Conway-Campbell, J.4    Bowles, J.5    Wright, E.6
  • 20
    • 0032922670 scopus 로고    scopus 로고
    • Transactivation of the mouse cartilage-derived retinoic acid-sensitive protein gene by Sox9
    • Xie WF, Zhang X, Sakano S, Lefebvre V, Sandell LJ. Transactivation of the mouse cartilage-derived retinoic acid-sensitive protein gene by Sox9. J Bone Miner Res 1999;14:757-63.
    • (1999) J Bone Miner Res , vol.14 , pp. 757-763
    • Xie, W.F.1    Zhang, X.2    Sakano, S.3    Lefebvre, V.4    Sandell, L.J.5
  • 21
    • 0035045680 scopus 로고    scopus 로고
    • Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in a transgenic mouse model of osteoarthritis
    • Salminen H, Vuorio E, Saamanen AM. Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in a transgenic mouse model of osteoarthritis. Arthritis Rheum 2001;44:947-55.
    • (2001) Arthritis Rheum , vol.44 , pp. 947-955
    • Salminen, H.1    Vuorio, E.2    Saamanen, A.M.3
  • 22
    • 0041662164 scopus 로고    scopus 로고
    • SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes
    • Aigner T, Gebhard PM, Schmid E, Bau B, Harley V, Poschl E. SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes. Matrix Biol 2003;22:363-72.
    • (2003) Matrix Biol , vol.22 , pp. 363-372
    • Aigner, T.1    Gebhard, P.M.2    Schmid, E.3    Bau, B.4    Harley, V.5    Poschl, E.6
  • 23
    • 0034041974 scopus 로고    scopus 로고
    • Gene delivery to human chondrocytes by an adeno associated virus vector
    • Arai Y, Kubo T, Fushiki S, Mazda O, Nakai H, Iwaki Y, et al. Gene delivery to human chondrocytes by an adeno associated virus vector. J Rheumatol 2000;27:979-82.
    • (2000) J Rheumatol , vol.27 , pp. 979-982
    • Arai, Y.1    Kubo, T.2    Fushiki, S.3    Mazda, O.4    Nakai, H.5    Iwaki, Y.6
  • 24
    • 0037338160 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage
    • Madry H, Cucchiarini M, Terwilliger EF, Trippel SB. Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther 2003;14:393-402.
    • (2003) Hum Gene Ther , vol.14 , pp. 393-402
    • Madry, H.1    Cucchiarini, M.2    Terwilliger, E.F.3    Trippel, S.B.4
  • 25
    • 22644436809 scopus 로고    scopus 로고
    • Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2
    • Cucchiarini M, Madry H, Ma C, Thurn T, Zurakowski D, Menger MD, et al. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 2005;12:229-38.
    • (2005) Mol Ther , vol.12 , pp. 229-238
    • Cucchiarini, M.1    Madry, H.2    Ma, C.3    Thurn, T.4    Zurakowski, D.5    Menger, M.D.6
  • 26
    • 0029843596 scopus 로고    scopus 로고
    • Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector
    • Xiao X, Li J, Samulski RJ. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol 1996;70:8098-108.
    • (1996) J Virol , vol.70 , pp. 8098-8108
    • Xiao, X.1    Li, J.2    Samulski, R.J.3
  • 27
    • 29744465669 scopus 로고    scopus 로고
    • Gene therapy for cartilage defects
    • Cucchiarini M, Madry H. Gene therapy for cartilage defects. J Gene Med 2005;7:1495-509.
    • (2005) J Gene Med , vol.7 , pp. 1495-1509
    • Cucchiarini, M.1    Madry, H.2
  • 28
    • 0031718624 scopus 로고    scopus 로고
    • Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: Potential utility in gene therapy for osteochondral repair
    • Mason JM, Grande DA, Barcia M, Grant R, Pergolizzi RG, Breitbart AS. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair. Gene Ther 1998;5:1098-104.
    • (1998) Gene Ther , vol.5 , pp. 1098-1104
    • Mason, J.M.1    Grande, D.A.2    Barcia, M.3    Grant, R.4    Pergolizzi, R.G.5    Breitbart, A.S.6
  • 29
    • 0033763544 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints
    • Mi Z, Ghivizzani SC, Lechman ER, Jaffurs D, Glorioso JC, Evans CH, et al. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum 2000;43:2563-70.
    • (2000) Arthritis Rheum , vol.43 , pp. 2563-2570
    • Mi, Z.1    Ghivizzani, S.C.2    Lechman, E.R.3    Jaffurs, D.4    Glorioso, J.C.5    Evans, C.H.6
  • 30
    • 0015046195 scopus 로고
    • Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data
    • Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971;53:523-37.
    • (1971) J Bone Joint Surg Am , vol.53 , pp. 523-537
    • Mankin, H.J.1    Dorfman, H.2    Lippiello, L.3    Zarins, A.4
  • 31
    • 0024311525 scopus 로고
    • Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
    • Samulski RJ, Chang LS, Shenk T. Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol 1989;63:3822-8.
    • (1989) J Virol , vol.63 , pp. 3822-3828
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 32
    • 0012296395 scopus 로고    scopus 로고
    • Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors
    • Cucchiarini M, Ren XL, Perides G, Terwilliger EF. Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors. Gene Ther 2003;10:657-67.
    • (2003) Gene Ther , vol.10 , pp. 657-667
    • Cucchiarini, M.1    Ren, X.L.2    Perides, G.3    Terwilliger, E.F.4
  • 33
    • 0029977067 scopus 로고    scopus 로고
    • Sex reversal by loss of the C-terminal transactivation domain of human SOX9
    • Sudbeck P, Schmitz ML, Baeuerle PA, Scherer G. Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat Genet 1996;13:230-2.
    • (1996) Nat Genet , vol.13 , pp. 230-232
    • Sudbeck, P.1    Schmitz, M.L.2    Baeuerle, P.A.3    Scherer, G.4
  • 34
    • 0033994254 scopus 로고    scopus 로고
    • Efficient lipid-mediated gene transfer to articular chondrocytes
    • Madry H, Trippel SB. Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Ther 2000;7:286-91.
    • (2000) Gene Ther , vol.7 , pp. 286-291
    • Madry, H.1    Trippel, S.B.2
  • 35
    • 0041633625 scopus 로고    scopus 로고
    • Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage
    • Merrihew C, Soeder S, Rueger DC, Kuettner KE, Chubinskaya S. Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. J Bone Joint Surg Am 2003;85-A Suppl 3:67-74.
    • (2003) J Bone Joint Surg Am , vol.85-A , Issue.SUPPL. 3 , pp. 67-74
    • Merrihew, C.1    Soeder, S.2    Rueger, D.C.3    Kuettner, K.E.4    Chubinskaya, S.5
  • 36
    • 1342342795 scopus 로고    scopus 로고
    • Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system
    • Madry H, Cucchiarini M, Stein U, Remberger K, Menger MD, Kohn D, et al. Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. J Gene Med 2003;5:502-9.
    • (2003) J Gene Med , vol.5 , pp. 502-509
    • Madry, H.1    Cucchiarini, M.2    Stein, U.3    Remberger, K.4    Menger, M.D.5    Kohn, D.6
  • 37
    • 0242606952 scopus 로고    scopus 로고
    • Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro
    • Wang J, Verdonk P, Elewaut D, Veys Em, Verbruggen G. Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro. Osteoarthritis Cartilage 2003;11:801-9.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 801-809
    • Wang, J.1    Verdonk, P.2    Elewaut, D.3    Veys, E.4    Verbruggen, G.5
  • 38
    • 0041571728 scopus 로고    scopus 로고
    • The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes
    • Loeser RF, Pacione CA, Chubinskaya S. The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. Arthritis Rheum 2003;48: 2188-96.
    • (2003) Arthritis Rheum , vol.48 , pp. 2188-2196
    • Loeser, R.F.1    Pacione, C.A.2    Chubinskaya, S.3
  • 39
    • 0026729099 scopus 로고
    • Type X collagen synthesis in human osteoarthritic cartilage: Indication of chondrocyte hypertrophy
    • Von der Mark K, Kirsch T, Nerlich A, Kuss A, Weseloh G, Gluckert K, et al. Type X collagen synthesis in human osteoarthritic cartilage: indication of chondrocyte hypertrophy. Arthritis Rheum 1992;35:806-11.
    • (1992) Arthritis Rheum , vol.35 , pp. 806-811
    • Von der Mark, K.1    Kirsch, T.2    Nerlich, A.3    Kuss, A.4    Weseloh, G.5    Gluckert, K.6
  • 40
    • 0028328915 scopus 로고
    • Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay
    • Hollander AP, Heathfield TF, Webber C, Iwata Y, Bourne R, Rorabeck C, et al. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest 1994;93:1722-32.
    • (1994) J Clin Invest , vol.93 , pp. 1722-1732
    • Hollander, A.P.1    Heathfield, T.F.2    Webber, C.3    Iwata, Y.4    Bourne, R.5    Rorabeck, C.6
  • 41
    • 0038328937 scopus 로고    scopus 로고
    • The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis
    • Squires GR, Okouneff S, Ionescu M, Poole AR. The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum 2003;48:1261-70.
    • (2003) Arthritis Rheum , vol.48 , pp. 1261-1270
    • Squires, G.R.1    Okouneff, S.2    Ionescu, M.3    Poole, A.R.4
  • 42
    • 1042278739 scopus 로고    scopus 로고
    • Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3
    • Sharif M, Whitehouse A, Sharman P, Perry M, Adams M. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum 2004;50:507-15.
    • (2004) Arthritis Rheum , vol.50 , pp. 507-515
    • Sharif, M.1    Whitehouse, A.2    Sharman, P.3    Perry, M.4    Adams, M.5
  • 43
    • 12144276564 scopus 로고    scopus 로고
    • Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes
    • Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE. Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthritis Cartilage 2005;13:80-9.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 80-89
    • Tew, S.R.1    Li, Y.2    Pothacharoen, P.3    Tweats, L.M.4    Hawkins, R.E.5    Hardingham, T.E.6
  • 44
    • 2342511482 scopus 로고    scopus 로고
    • Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9
    • Li Y, Tew SR, Russell AM, Gonzalez KR, Hardingham TE, Hawkins AR. Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Eng 2004;10: 575-84.
    • (2004) Tissue Eng , vol.10 , pp. 575-584
    • Li, Y.1    Tew, S.R.2    Russell, A.M.3    Gonzalez, K.R.4    Hardingham, T.E.5    Hawkins, A.R.6
  • 46
    • 0037305315 scopus 로고    scopus 로고
    • SOX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation state
    • Kypriotou M, Fossard-Demoor M, Chadjichristos C, Ghayor C, de Crombrugghe B, Pujol JP, et al. SOX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation state. DNA Cell Biol 2003;22: 119-29.
    • (2003) DNA Cell Biol , vol.22 , pp. 119-129
    • Kypriotou, M.1    Fossard-Demoor, M.2    Chadjichristos, C.3    Ghayor, C.4    de Crombrugghe, B.5    Pujol, J.P.6
  • 47
    • 0031879481 scopus 로고    scopus 로고
    • Regulation of gene expression in vivo following transduction by two separate rAAV vectors
    • Rendahl KG, Leff SE, Otten GR, Spratt SK, Bohl D, Van Roey M, et al. Regulation of gene expression in vivo following transduction by two separate rAAV vectors. Nat Biotechnol 1998;16:757-61.
    • (1998) Nat Biotechnol , vol.16 , pp. 757-761
    • Rendahl, K.G.1    Leff, S.E.2    Otten, G.R.3    Spratt, S.K.4    Bohl, D.5    Van Roey, M.6
  • 49
    • 0032170250 scopus 로고    scopus 로고
    • Differentiated cellular function in fetal chondrocytes cultured with insulin-like growth factor-I and transforming growth factor-β
    • Nixon AJ, Lillich JT, Burton-Wurster N, Lust G, Mohammed HO. Differentiated cellular function in fetal chondrocytes cultured with insulin-like growth factor-I and transforming growth factor-β. J Orthop Res 1998;16:531-41.
    • (1998) J Orthop Res , vol.16 , pp. 531-541
    • Nixon, A.J.1    Lillich, J.T.2    Burton-Wurster, N.3    Lust, G.4    Mohammed, H.O.5


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