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Volumn 17, Issue 15-16, 2011, Pages 1921-1933

Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIALS; CARTILAGE; CELL PROLIFERATION; COLLAGEN; DEFECTS; FIBROBLASTS; FLOWCHARTING; GENE THERAPY; GENE TRANSFER; MONOLAYERS; PEPTIDES; PHOSPHATASES; STEM CELLS; TRANSCRIPTION; TRANSCRIPTION FACTORS; VIRUSES;

EID: 79960793071     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2011.0018     Document Type: Article
Times cited : (83)

References (75)
  • 1
    • 0031856463 scopus 로고    scopus 로고
    • Articular cartilage repair and transplantation
    • Buckwalter, J.A., and Mankin, H.J. Articular cartilage repair and transplantation. Arthritis Rheum 41, 1331, 1998.
    • (1998) Arthritis Rheum , vol.41 , pp. 1331
    • Buckwalter, J.A.1    Mankin, H.J.2
  • 2
    • 0032425951 scopus 로고    scopus 로고
    • The healing and regeneration of articular cartilage
    • O'Driscoll, S.W. The healing and regeneration of articular cartilage. J Bone Joint Surg Am 80, 1795, 1998.
    • (1998) J Bone Joint Surg Am , vol.80 , pp. 1795
    • O'Driscoll, S.W.1
  • 6
    • 0035882056 scopus 로고    scopus 로고
    • Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components
    • Barry, F., Boynton, R.E., Liu, B., and Murphy, J.M. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation- dependent gene expression of matrix components. Exp Cell Res 268, 189, 2001.
    • (2001) Exp Cell Res , vol.268 , pp. 189
    • Barry, F.1    Boynton, R.E.2    Liu, B.3    Murphy, J.M.4
  • 8
    • 0017355018 scopus 로고
    • The progeny of rabbit articular chondrocytes synthesize collagen types i and III and type i trimer, but not type II. Verifications by cyanogen bromide peptide analysis
    • Benya, P.D., Padilla, S.R., and Nimni, M.E. The progeny of rabbit articular chondrocytes synthesize collagen types I and III and type I trimer, but not type II. Verifications by cyanogen bromide peptide analysis. Biochemistry 16, 865, 1977.
    • (1977) Biochemistry , vol.16 , pp. 865
    • Benya, P.D.1    Padilla, S.R.2    Nimni, M.E.3
  • 9
    • 0017723046 scopus 로고
    • Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture
    • von der Mark, K., Gauss, V., von der Mark, H., and Muller, P. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature 267, 531, 1977.
    • (1977) Nature , vol.267 , pp. 531
    • Von Der Mark, K.1    Gauss, V.2    Von Der Mark, H.3    Muller, P.4
  • 10
    • 33750289940 scopus 로고    scopus 로고
    • Stemming cartilage degeneration: Adult mesenchymal stem cells as a cell source for articular cartilage tissue engineering
    • Tuan, R.S. Stemming cartilage degeneration: adult mesenchymal stem cells as a cell source for articular cartilage tissue engineering. Arthritis Rheum 54, 3075, 2006.
    • (2006) Arthritis Rheum , vol.54 , pp. 3075
    • Tuan, R.S.1
  • 12
    • 43949115205 scopus 로고    scopus 로고
    • Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells
    • Mueller, M.B., and Tuan, R.S. Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis Rheum 58, 1377, 2008.
    • (2008) Arthritis Rheum , vol.58 , pp. 1377
    • Mueller, M.B.1    Tuan, R.S.2
  • 13
    • 39749185584 scopus 로고    scopus 로고
    • The use ofmesenchymal stem cells for chondrogenesis
    • Pelttari, K., Steck, E., and Richter,W. The use ofmesenchymal stem cells for chondrogenesis. Injury 39 Suppl 1, S58, 2008.
    • (2008) Injury , vol.39 , Issue.SUPPL.1
    • Pelttari, K.1    Steck, E.2    Richter, W.3
  • 14
    • 29744465669 scopus 로고    scopus 로고
    • Gene therapy for cartilage defects
    • Cucchiarini, M., and Madry, H. Gene therapy for cartilage defects. J Gene Med 7, 1495, 2005.
    • (2005) J Gene Med , vol.7 , pp. 1495
    • Cucchiarini, M.1    Madry, H.2
  • 15
    • 0037297421 scopus 로고    scopus 로고
    • In vitro chondrogenesis of human bone marrow-derived mesenchymal progenitor cells in monolayer culture: Activation by transfection with TGF-beta2
    • Wang, W.G., Lou, S.Q., Ju, X.D., Xia, K., and Xia, J.H. In vitro chondrogenesis of human bone marrow-derived mesenchymal progenitor cells in monolayer culture: activation by transfection with TGF-beta2. Tissue Cell 35, 69, 2003.
    • (2003) Tissue Cell , vol.35 , pp. 69
    • Wang, W.G.1    Lou, S.Q.2    Ju, X.D.3    Xia, K.4    Xia, J.H.5
  • 16
    • 22144463885 scopus 로고    scopus 로고
    • Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures
    • Kawamura, K., Chu, C.R., Sobajima, S., Robbins, P.D., Fu, F.H., Izzo, N.J., and Niyibizi, C. Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures. Exp Hematol 33, 865, 2005.
    • (2005) Exp Hematol , vol.33 , pp. 865
    • Kawamura, K.1    Chu, C.R.2    Sobajima, S.3    Robbins, P.D.4    Fu, F.H.5    Izzo, N.J.6    Niyibizi, C.7
  • 18
    • 34248181957 scopus 로고    scopus 로고
    • Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair
    • Pagnotto, M.R., Wang, Z., Karpie, J.C., Ferretti, M., Xiao, X., and Chu, C.R. Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair. Gene Ther 14, 804, 2007.
    • (2007) Gene Ther , vol.14 , pp. 804
    • Pagnotto, M.R.1    Wang, Z.2    Karpie, J.C.3    Ferretti, M.4    Xiao, X.5    Chu, C.R.6
  • 20
    • 31644434203 scopus 로고    scopus 로고
    • Transgene-activated mesenchymal cells for articular cartilage repair: A comparison of primary bone marrow-, perichondrium/periosteum-and fat-derived cells
    • Park, J., Gelse, K., Frank, S., von der Mark, K., Aigner, T., and Schneider, H. Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum-and fat-derived cells. J Gene Med 8, 112, 2006.
    • (2006) J Gene Med , vol.8 , pp. 112
    • Park, J.1    Gelse, K.2    Frank, S.3    Von Der Mark, K.4    Aigner, T.5    Schneider, H.6
  • 21
    • 75749116750 scopus 로고    scopus 로고
    • Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells
    • Weiss, S., Hennig, T., Bock, R., Steck, E., and Richter, W. Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells. J Cell Physiol 223, 84, 2010.
    • (2010) J Cell Physiol , vol.223 , pp. 84
    • Weiss, S.1    Hennig, T.2    Bock, R.3    Steck, E.4    Richter, W.5
  • 24
    • 18144391965 scopus 로고    scopus 로고
    • FGF signaling in the developing endochondral skeleton
    • Ornitz, D.M. FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev 16, 205, 2005.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 205
    • Ornitz, D.M.1
  • 25
    • 16344377055 scopus 로고    scopus 로고
    • FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells
    • Solchaga, L.A., Penick, K., Goldberg, V.M., Caplan, A.I., and Welter, J.F. FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol 203, 398, 2005.
    • (2005) J Cell Physiol , vol.203 , pp. 398
    • Solchaga, L.A.1    Penick, K.2    Goldberg, V.M.3    Caplan, A.I.4    Welter, J.F.5
  • 26
    • 77649243276 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells
    • Solchaga, L.A., Penick, K., Goldberg, V.M., Caplan, A.I., and Welter, J.F. Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. Tissue Eng Part A 16, 1009, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 1009
    • Solchaga, L.A.1    Penick, K.2    Goldberg, V.M.3    Caplan, A.I.4    Welter, J.F.5
  • 27
    • 0037423736 scopus 로고    scopus 로고
    • Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells
    • Tsuchiya, H., Kitoh, H., Sugiura, F., and Ishiguro, N. Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 301, 338, 2003.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 338
    • Tsuchiya, H.1    Kitoh, H.2    Sugiura, F.3    Ishiguro, N.4
  • 29
    • 35348942941 scopus 로고    scopus 로고
    • Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis using "beadin-bead" polysaccharide capsules
    • Babister, J.C., Tare, R.S., Green, D.W., Inglis, S., Mann, S., and Oreffo, R.O. Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis using "beadin-bead" polysaccharide capsules. Biomaterials 29, 58, 2008.
    • (2008) Biomaterials , vol.29 , pp. 58
    • Babister, J.C.1    Tare, R.S.2    Green, D.W.3    Inglis, S.4    Mann, S.5    Oreffo, R.O.6
  • 30
    • 77953351772 scopus 로고    scopus 로고
    • Improving chondrogenesis: Potential and limitations of SOX9 gene transfer and mechanical stimulation for cartilage tissue engineering
    • Kupcsik, L., Stoddart, M.J., Li, Z., Benneker, L.M., and Alini, M. Improving chondrogenesis: potential and limitations of SOX9 gene transfer and mechanical stimulation for cartilage tissue engineering. Tissue Eng Part A 16, 1845, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 1845
    • Kupcsik, L.1    Stoddart, M.J.2    Li, Z.3    Benneker, L.M.4    Alini, M.5
  • 31
    • 0035984714 scopus 로고    scopus 로고
    • Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
    • Simonsen, J.L., Rosada, C., Serakinci, N., Justesen, J., Stenderup, K., Rattan, S.I., Jensen, T.G., and Kassem, M. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol 20, 592, 2002.
    • (2002) Nat Biotechnol , vol.20 , pp. 592
    • Simonsen, J.L.1    Rosada, C.2    Serakinci, N.3    Justesen, J.4    Stenderup, K.5    Rattan, S.I.6    Jensen, T.G.7    Kassem, M.8
  • 32
    • 77649217768 scopus 로고    scopus 로고
    • Enhanced treatment of articular cartilage defect of the knee by intra-articular injection of Bcl-xL-engineered mesenchymal stem cells in rabbit model
    • Hu, B., Ren, J.L., Zhang, J.R., Ma, Q., Liu, Y.P., and Mao, T.Q. Enhanced treatment of articular cartilage defect of the knee by intra-articular injection of Bcl-xL-engineered mesenchymal stem cells in rabbit model. J Tissue Eng Regen Med 4, 105, 2010.
    • (2010) J Tissue Eng Regen Med , vol.4 , pp. 105
    • Hu, B.1    Ren, J.L.2    Zhang, J.R.3    Ma, Q.4    Liu, Y.P.5    Mao, T.Q.6
  • 35
    • 0001592496 scopus 로고
    • Adenovirus-associated defective virus particles
    • Atchison, R.W., Casto, B.C., and Hammon, W.M. Adenovirus-associated defective virus particles. Science 149, 754, 1965.
    • (1965) Science , vol.149 , pp. 754
    • Atchison, R.W.1    Casto, B.C.2    Hammon, W.M.3
  • 36
    • 0034241592 scopus 로고    scopus 로고
    • Adeno-associated virus mediates longterm gene transfer and delivery of chondroprotective IL-4 to murine synovium
    • Watanabe, S., Imagawa, T., Boivin, G.P., Gao, G., Wilson, J.M., and Hirsch, R. Adeno-associated virus mediates longterm gene transfer and delivery of chondroprotective IL-4 to murine synovium. Mol Ther 2, 147, 2000.
    • (2000) Mol Ther , vol.2 , pp. 147
    • Watanabe, S.1    Imagawa, T.2    Boivin, G.P.3    Gao, G.4    Wilson, J.M.5    Hirsch, R.6
  • 37
    • 22644436809 scopus 로고    scopus 로고
    • Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2
    • Cucchiarini, M., Madry, H., Ma, C., Thurn, T., Zurakowski, D., Menger, M.D., Kohn, D., Trippel, S.B., and Terwilliger, E.F. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 12, 229, 2005.
    • (2005) Mol Ther , vol.12 , pp. 229
    • Cucchiarini, M.1    Madry, H.2    Ma, C.3    Thurn, T.4    Zurakowski, D.5    Menger, M.D.6    Kohn, D.7    Trippel, S.B.8    Terwilliger, E.F.9
  • 38
    • 29244437207 scopus 로고    scopus 로고
    • Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector
    • Hiraide, A., Yokoo, N., Xin, K.Q., Okuda, K., Mizukami, H., Ozawa, K., and Saito, T. Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector. Hum Gene Ther 16, 1413, 2005.
    • (2005) Hum Gene Ther , vol.16 , pp. 1413
    • Hiraide, A.1    Yokoo, N.2    Xin, K.Q.3    Okuda, K.4    Mizukami, H.5    Ozawa, K.6    Saito, T.7
  • 41
    • 77649121784 scopus 로고    scopus 로고
    • Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis
    • Khoury, M., Courties, G., Fabre, S., Bouffi, C., Seemayer, C.A., Vervoordeldonk, M.J., Tak, P.P., Jorgensen, C., and Apparailly, F. Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis. Arthritis Rheum 62, 765, 2010.
    • (2010) Arthritis Rheum , vol.62 , pp. 765
    • Khoury, M.1    Courties, G.2    Fabre, S.3    Bouffi, C.4    Seemayer, C.A.5    Vervoordeldonk, M.J.6    Tak, P.P.7    Jorgensen, C.8    Apparailly, F.9
  • 43
    • 0025253540 scopus 로고
    • Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation
    • Kato, Y., and Iwamoto, M. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. J Biol Chem 265, 5903, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 5903
    • Kato, Y.1    Iwamoto, M.2
  • 44
    • 0028918872 scopus 로고
    • Regulation of proliferation and osteochondrogenic differentiation of periosteum-derived cells by transforming growth factor-beta and basic fibroblast growth factor
    • Iwasaki, M., Nakahara, H., Nakata, K., Nakase, T., Kimura, T., and Ono, K. Regulation of proliferation and osteochondrogenic differentiation of periosteum-derived cells by transforming growth factor-beta and basic fibroblast growth factor. J Bone Joint Surg Am 77, 543, 1995.
    • (1995) J Bone Joint Surg Am , vol.77 , pp. 543
    • Iwasaki, M.1    Nakahara, H.2    Nakata, K.3    Nakase, T.4    Kimura, T.5    Ono, K.6
  • 46
    • 0033084169 scopus 로고    scopus 로고
    • Effects of TGFbeta and bFGF on the differentiation of human bone marrow stromal fibroblasts
    • Locklin, R.M., Oreffo, R.O., and Triffitt, J.T. Effects of TGFbeta and bFGF on the differentiation of human bone marrow stromal fibroblasts. Cell Biol Int 23, 185, 1999.
    • (1999) Cell Biol Int , vol.23 , pp. 185
    • Locklin, R.M.1    Oreffo, R.O.2    Triffitt, J.T.3
  • 47
    • 0025017687 scopus 로고
    • Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta
    • Allen, J.B., Manthey, C.L., Hand, A.R., Ohura, K., Ellingsworth, L., and Wahl, S.M. Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta. J Exp Med 171, 231, 1990.
    • (1990) J Exp Med , vol.171 , pp. 231
    • Allen, J.B.1    Manthey, C.L.2    Hand, A.R.3    Ohura, K.4    Ellingsworth, L.5    Wahl, S.M.6
  • 48
    • 0028169834 scopus 로고
    • Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint
    • van Beuningen, H.M., van der Kraan, P.M., Arntz, O.J., and van den Berg, W.B. Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest 71, 279, 1994.
    • (1994) Lab Invest , vol.71 , pp. 279
    • Van Beuningen, H.M.1    Van Der Kraan, P.M.2    Arntz, O.J.3    Van Den Berg, W.B.4
  • 49
    • 0034790822 scopus 로고    scopus 로고
    • Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily
    • Hunziker, E.B., Driesang, I.M., and Morris, E.A. Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily. Clin Orthop Relat Res 391 Suppl, S171, 2001.
    • (2001) Clin Orthop Relat Res , vol.391 , Issue.SUPPL.
    • Hunziker, E.B.1    Driesang, I.M.2    Morris, E.A.3
  • 50
    • 0042622575 scopus 로고    scopus 로고
    • Adverse effects of adenovirusmediated gene transfer of human transforming growth factor beta 1 into rabbit knees
    • Mi, Z., Ghivizzani, S.C., Lechman, E., Glorioso, J.C., Evans, C.H., and Robbins, P.D. Adverse effects of adenovirusmediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther 5, R132, 2003.
    • (2003) Arthritis Res Ther , vol.5
    • Mi, Z.1    Ghivizzani, S.C.2    Lechman, E.3    Glorioso, J.C.4    Evans, C.H.5    Robbins, P.D.6
  • 51
    • 0023216839 scopus 로고
    • A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication
    • Samulski, R.J., Chang, L.S., and Shenk, T. A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol 61, 3096, 1987.
    • (1987) J Virol , vol.61 , pp. 3096
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 52
    • 0024311525 scopus 로고
    • Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
    • Samulski, R.J., Chang, L.S., and Shenk, T. Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol 63, 3822, 1989.
    • (1989) J Virol , vol.63 , pp. 3822
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 53
    • 0012296395 scopus 로고    scopus 로고
    • Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors
    • Cucchiarini, M., Ren, X.L., Perides, G., and Terwilliger, E.F. Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors. Gene Ther 10, 657, 2003.
    • (2003) Gene Ther , vol.10 , pp. 657
    • Cucchiarini, M.1    Ren, X.L.2    Perides, G.3    Terwilliger, E.F.4
  • 54
    • 0037338160 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage
    • Madry, H., Cucchiarini, M., Terwilliger, E.F., and Trippel, S.B. Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther 14, 393, 2003.
    • (2003) Hum Gene Ther , vol.14 , pp. 393
    • Madry, H.1    Cucchiarini, M.2    Terwilliger, E.F.3    Trippel, S.B.4
  • 55
    • 33846208305 scopus 로고    scopus 로고
    • Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9
    • Cucchiarini, M., Thurn, T., Weimer, A., Kohn, D., Terwilliger, E.F., and Madry, H. Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9. Arthritis Rheum 56, 158, 2007.
    • (2007) Arthritis Rheum , vol.56 , pp. 158
    • Cucchiarini, M.1    Thurn, T.2    Weimer, A.3    Kohn, D.4    Terwilliger, E.F.5    Madry, H.6
  • 56
    • 72949105817 scopus 로고    scopus 로고
    • Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer
    • Cucchiarini, M., Terwilliger, E.F., Kohn, D., and Madry, H. Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer. J Cell Mol Med 13, 2476, 2009.
    • (2009) J Cell Mol Med , vol.13 , pp. 2476
    • Cucchiarini, M.1    Terwilliger, E.F.2    Kohn, D.3    Madry, H.4
  • 57
    • 70449720789 scopus 로고    scopus 로고
    • RAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions
    • Cucchiarini, M., Schetting, S., Terwilliger, E.F., Kohn, D., and Madry, H. rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions. Gene Ther 16, 1363, 2009.
    • (2009) Gene Ther , vol.16 , pp. 1363
    • Cucchiarini, M.1    Schetting, S.2    Terwilliger, E.F.3    Kohn, D.4    Madry, H.5
  • 58
    • 75649099043 scopus 로고    scopus 로고
    • Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer
    • Steinert, A.F., Proffen, B., Kunz, M., Hendrich, C., Ghivizzani, S.C., Nö th, U., Rethwilm, A., Eulert, J., and Evans, C.H. Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther 11, R148, 2009.
    • (2009) Arthritis Res Ther , vol.11
    • Steinert, A.F.1    Proffen, B.2    Kunz, M.3    Hendrich, C.4    Ghivizzani, S.C.5    Nö Th, U.6    Rethwilm, A.7    Eulert, J.8    Evans, C.H.9
  • 59
    • 67649565425 scopus 로고    scopus 로고
    • Gene and protein expression profile of naive and osteo-chondrogenically differentiated rat bone marrow-derived mesenchymal progenitor cells
    • Grä ssel, S., Ahmed, N., Gottl, C., and Grifka, J. Gene and protein expression profile of naive and osteo-chondrogenically differentiated rat bone marrow-derived mesenchymal progenitor cells. Int J MolMed 23, 745, 2009.
    • (2009) Int J MolMed , vol.23 , pp. 745
    • Grä Ssel, S.1    Ahmed, N.2    Gottl, C.3    Grifka, J.4
  • 60
    • 61649106341 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaBdependent pathways
    • Wehling, N., Palmer, G.D., Pilapil, C., Liu, F., Wells, J.W., Mü ller, P.E., Evans, C.H., and Porter, R.M. Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaBdependent pathways. Arthritis Rheum 60, 801, 2009.
    • (2009) Arthritis Rheum , vol.60 , pp. 801
    • Wehling, N.1    Palmer, G.D.2    Pilapil, C.3    Liu, F.4    Wells, J.W.5    Mü Ller, P.E.6    Evans, C.H.7    Porter, R.M.8
  • 62
    • 0028914071 scopus 로고
    • Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation
    • Wroblewski, J., and Edwall-Arvidsson, C. Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation. J Bone Miner Res 10, 735, 1995.
    • (1995) J Bone Miner Res , vol.10 , pp. 735
    • Wroblewski, J.1    Edwall-Arvidsson, C.2
  • 63
    • 77049109633 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: Relating tissue engineering using adult mesenchymal stem cells to embryonic development
    • Hellingman, C.A., Koevoet, W., Kops, N., Farrell, E., Jahr, H., Liu, W., Baatenburg de Jong, R.J., Frenz, D.A., and von Osch, G.J. Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development. Tissue Eng Part A 16, 545, 2010.
    • (2010) Tissue Eng Part A , vol.16 , pp. 545
    • Hellingman, C.A.1    Koevoet, W.2    Kops, N.3    Farrell, E.4    Jahr, H.5    Liu, W.6    Baatenburg De Jong, R.J.7    Frenz, D.A.8    Von Osch, G.J.9
  • 64
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., and Karsenty, G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747, 1997.
    • (1997) Cell , vol.89 , pp. 747
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 65
    • 4344628054 scopus 로고    scopus 로고
    • Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow
    • Katayama, R., Wakitani, S., Tsumaki, N., Morita, Y., Matsushita, I., Gejo, R., and Kimura, T. Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow. Rheumatology 43, 980, 2004.
    • (2004) Rheumatology , vol.43 , pp. 980
    • Katayama, R.1    Wakitani, S.2    Tsumaki, N.3    Morita, Y.4    Matsushita, I.5    Gejo, R.6    Kimura, T.7
  • 66
    • 77953811664 scopus 로고    scopus 로고
    • In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes
    • Wang, W., Li, B., Li, Y., Jiang, Y., Ouyang, H., and Gao, C. In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes. Biomaterials 31, 5953, 2010.
    • (2010) Biomaterials , vol.31 , pp. 5953
    • Wang, W.1    Li, B.2    Li, Y.3    Jiang, Y.4    Ouyang, H.5    Gao, C.6
  • 67
    • 28244498360 scopus 로고    scopus 로고
    • Determination of osteoprogenitor-specific promoter activity in mouse mesenchymal stem cells by recombinant adeno-associated virus transduction
    • Kumar, S., Mahendra, G., and Ponnazhagan, S. Determination of osteoprogenitor-specific promoter activity in mouse mesenchymal stem cells by recombinant adeno-associated virus transduction. Biochim Biophys Acta 1731, 95, 2005.
    • (2005) Biochim Biophys Acta , vol.1731 , pp. 95
    • Kumar, S.1    Mahendra, G.2    Ponnazhagan, S.3
  • 69
    • 0037331874 scopus 로고    scopus 로고
    • Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells
    • Gelse, K., von der Mark, K., Aigner, T., Park, J., and Schneider, H. Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum 48, 430, 2003.
    • (2003) Arthritis Rheum , vol.48 , pp. 430
    • Gelse, K.1    Von Der Mark, K.2    Aigner, T.3    Park, J.4    Schneider, H.5
  • 70
    • 23744467071 scopus 로고    scopus 로고
    • Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor i (IGF-I)
    • Madry, H., Kaul, G., Cucchiarini, M., Stein, U., Zurakowski, D., Remberger, K., Menger, M.D., Kohn, D., and Trippel, S.B. Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther 12, 1171, 2005.
    • (2005) Gene Ther , vol.12 , pp. 1171
    • Madry, H.1    Kaul, G.2    Cucchiarini, M.3    Stein, U.4    Zurakowski, D.5    Remberger, K.6    Menger, M.D.7    Kohn, D.8    Trippel, S.B.9
  • 72
    • 34250699624 scopus 로고    scopus 로고
    • Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model
    • Goodrich, L.R., Hidaka, C., Robbins, P.D., Evans, C.H., and Nixon, A.J. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br 89, 672, 2007.
    • (2007) J Bone Joint Surg Br , vol.89 , pp. 672
    • Goodrich, L.R.1    Hidaka, C.2    Robbins, P.D.3    Evans, C.H.4    Nixon, A.J.5
  • 74
    • 33744489059 scopus 로고    scopus 로고
    • Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix
    • Di Cesare, P.E., Frenkel, S.R., Carlson, C.S., Fang, C., and Liu, C. Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix. J Orthop Res 24, 1118, 2006.
    • (2006) J Orthop Res , vol.24 , pp. 1118
    • Di Cesare, P.E.1    Frenkel, S.R.2    Carlson, C.S.3    Fang, C.4    Liu, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.