메뉴 건너뛰기




Volumn 52, Issue 3, 2011, Pages 245-261

Clinical potential and challenges of using genetically modified cells for articular cartilage repair

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT PROTEIN; RECOMBINANT SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR; VASCULOTROPIN RECEPTOR 1;

EID: 80051921186     PISSN: 03539504     EISSN: 13328166     Source Type: Journal    
DOI: 10.3325/cmj.2011.52.245     Document Type: Article
Times cited : (42)

References (145)
  • 1
    • 19144364120 scopus 로고    scopus 로고
    • Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis
    • Evans CH, Robbins PD, Ghivizzani SC, Herndon JH, Kang R, Bahnson AB, et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther. 1996;7:1261-80.
    • (1996) Hum Gene Ther , vol.7 , pp. 1261-1280
    • Evans, C.H.1    Robbins, P.D.2    Ghivizzani, S.C.3    Herndon, J.H.4    Kang, R.5    Bahnson, A.B.6
  • 5
    • 0034792028 scopus 로고    scopus 로고
    • Symptomatic articular cartilage degeneration: the impact in the new millennium
    • Jackson DW, Simon TM, Aberman HM. Symptomatic articular cartilage degeneration: the impact in the new millennium. Clin Orthop Relat Res. 2001;(Suppl):S14-25.
    • (2001) Clin Orthop Relat Res , Issue.SUPPL.
    • Jackson, D.W.1    Simon, T.M.2    Aberman, H.M.3
  • 7
    • 29744465669 scopus 로고    scopus 로고
    • Gene therapy for cartilage defects
    • Cucchiarini M, Madry H. Gene therapy for cartilage defects. J Gene Med. 2005;7:1495-509.
    • (2005) J Gene Med , vol.7 , pp. 1495-1509
    • Cucchiarini, M.1    Madry, H.2
  • 9
    • 31644440253 scopus 로고    scopus 로고
    • Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo
    • Kaul G, Cucchiarini M, Arntzen D, Zurakowski D, Menger MD, Kohn D, et al. Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo. J Gene Med. 2006;8:100-11.
    • (2006) J Gene Med , vol.8 , pp. 100-111
    • Kaul, G.1    Cucchiarini, M.2    Arntzen, D.3    Zurakowski, D.4    Menger, M.D.5    Kohn, D.6
  • 10
    • 23744467071 scopus 로고    scopus 로고
    • Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I)
    • Madry H, Kaul G, Cucchiarini M, Stein U, Zurakowski D, Remberger K, et al. Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther. 2005;12:1171-9.
    • (2005) Gene Ther , vol.12 , pp. 1171-1179
    • Madry, H.1    Kaul, G.2    Cucchiarini, M.3    Stein, U.4    Zurakowski, D.5    Remberger, K.6
  • 12
    • 4644244444 scopus 로고    scopus 로고
    • Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Emkey G, Zurakowski D, Trippel SB. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. J Gene Med. 2004;6:238-45.
    • (2004) J Gene Med , vol.6 , pp. 238-245
    • Madry, H.1    Emkey, G.2    Zurakowski, D.3    Trippel, S.B.4
  • 13
    • 0036124068 scopus 로고    scopus 로고
    • Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis
    • Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res. 2002;20:169-73.
    • (2002) J Orthop Res , vol.20 , pp. 169-173
    • Goater, J.J.1    O'Keefe, R.J.2    Rosier, R.N.3    Puzas, J.E.4    Schwarz, E.M.5
  • 14
    • 0036227368 scopus 로고    scopus 로고
    • Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle
    • Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, et al. Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther. 2002;9:372-80.
    • (2002) Gene Ther , vol.9 , pp. 372-380
    • Taniyama, Y.1    Tachibana, K.2    Hiraoka, K.3    Aoki, M.4    Yamamoto, S.5    Matsumoto, K.6
  • 15
    • 0037423736 scopus 로고    scopus 로고
    • Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells
    • Tsuchiya H, Kitoh H, Sugiura F, Ishiguro N. Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun. 2003;301:338-43.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 338-343
    • Tsuchiya, H.1    Kitoh, H.2    Sugiura, F.3    Ishiguro, N.4
  • 16
    • 30744436362 scopus 로고    scopus 로고
    • Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis
    • Grossin L, Cournil-Henrionnet C, Pinzano A, Gaborit N, Dumas D, Etienne S, et al. Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis. FASEB J. 2006;20:65-75.
    • (2006) FASEB J , vol.20 , pp. 65-75
    • Grossin, L.1    Cournil-Henrionnet, C.2    Pinzano, A.3    Gaborit, N.4    Dumas, D.5    Etienne, S.6
  • 17
    • 32144438313 scopus 로고    scopus 로고
    • Co-transfection with the osteogenic protein (OP)-1 gene and the insulin-like growth factor (IGF)-I gene enhanced osteoblastic cell differentiation
    • Yeh LC, Lee JC. Co-transfection with the osteogenic protein (OP)-1 gene and the insulin-like growth factor (IGF)-I gene enhanced osteoblastic cell differentiation. Biochim Biophys Acta. 2006;1763:57-63.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 57-63
    • Yeh, L.C.1    Lee, J.C.2
  • 18
    • 70449529723 scopus 로고    scopus 로고
    • Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome
    • Zhang HN, Leng P, Wang YZ, Zhang J. Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome. Clin Orthop Relat Res. 2009;467:3175-82.
    • (2009) Clin Orthop Relat Res , vol.467 , pp. 3175-3182
    • Zhang, H.N.1    Leng, P.2    Wang, Y.Z.3    Zhang, J.4
  • 19
    • 77952541151 scopus 로고    scopus 로고
    • Coexpression of insulin-like growth factor-1 and interleukin-4 in an in vitro inflammatory model
    • Manning K, Rachakonda PS, Rai MF, Schmidt MF. Coexpression of insulin-like growth factor-1 and interleukin-4 in an in vitro inflammatory model. Cytokine. 2010;50:297-305.
    • (2010) Cytokine , vol.50 , pp. 297-305
    • Manning, K.1    Rachakonda, P.S.2    Rai, M.F.3    Schmidt, M.F.4
  • 20
    • 0034782732 scopus 로고    scopus 로고
    • Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation
    • Madry H, Zurakowski D, Trippel SB. Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Ther. 2001;8:1443-9.
    • (2001) Gene Ther , vol.8 , pp. 1443-1449
    • Madry, H.1    Zurakowski, D.2    Trippel, S.B.3
  • 21
    • 2342511482 scopus 로고    scopus 로고
    • Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9
    • Li Y, Tew SR, Russell AM, Gonzalez KR, Hardingham TE, Hawkins RE. Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Eng. 2004;10:575-84.
    • (2004) Tissue Eng , vol.10 , pp. 575-584
    • Li, Y.1    Tew, S.R.2    Russell, A.M.3    Gonzalez, K.R.4    Hardingham, T.E.5    Hawkins, R.E.6
  • 22
    • 0037083347 scopus 로고    scopus 로고
    • Functional genomic analysis of type II IL-1beta decoy receptor: potential for gene therapy in human arthritis and inflammation
    • Attur MG, Dave MN, Leung MY, Cipolletta C, Meseck M, Woo SL, et al. Functional genomic analysis of type II IL-1beta decoy receptor: potential for gene therapy in human arthritis and inflammation. J Immunol. 2002;168:2001-10.
    • (2002) J Immunol , vol.168 , pp. 2001-2010
    • Attur, M.G.1    Dave, M.N.2    Leung, M.Y.3    Cipolletta, C.4    Meseck, M.5    Woo, S.L.6
  • 23
    • 0034091315 scopus 로고    scopus 로고
    • Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1
    • Smith P, Shuler FD, Georgescu HI, Ghivizzani SC, Johnstone B, Niyibizi C, et al. Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum. 2000;43:1156-64.
    • (2000) Arthritis Rheum , vol.43 , pp. 1156-1164
    • Smith, P.1    Shuler, F.D.2    Georgescu, H.I.3    Ghivizzani, S.C.4    Johnstone, B.5    Niyibizi, C.6
  • 25
    • 0030478862 scopus 로고    scopus 로고
    • Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing
    • Gerich TG, Kang R, Fu FH, Robbins PD, Evans CH. Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing. Gene Ther. 1996;3:1089-93.
    • (1996) Gene Ther , vol.3 , pp. 1089-1093
    • Gerich, T.G.1    Kang, R.2    Fu, F.H.3    Robbins, P.D.4    Evans, C.H.5
  • 26
    • 0031278167 scopus 로고    scopus 로고
    • In vivo gene transfer and overexpression of focal adhesion kinase (pp125 FAK) mediated by recombinant adenovirus-induced tendon adhesion formation and epitenon cell change
    • Lou J, Kubota H, Hotokezaka S, Ludwig FJ, Manske PR. In vivo gene transfer and overexpression of focal adhesion kinase (pp125 FAK) mediated by recombinant adenovirus-induced tendon adhesion formation and epitenon cell change. J Orthop Res. 1997;15:911-8.
    • (1997) J Orthop Res , vol.15 , pp. 911-918
    • Lou, J.1    Kubota, H.2    Hotokezaka, S.3    Ludwig, F.J.4    Manske, P.R.5
  • 29
    • 0034232660 scopus 로고    scopus 로고
    • Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes
    • Shuler FD, Georgescu HI, Niyibizi C, Studer RK, Mi Z, Johnstone B, et al. Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes. J Orthop Res. 2000;18:585-92.
    • (2000) J Orthop Res , vol.18 , pp. 585-592
    • Shuler, F.D.1    Georgescu, H.I.2    Niyibizi, C.3    Studer, R.K.4    Mi, Z.5    Johnstone, B.6
  • 30
    • 0035915777 scopus 로고    scopus 로고
    • Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function
    • B rower-Toland BD, Saxer RA, Goodrich LR, Mi Z, Robbins PD, Evans CH, et al. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther. 2001;12:117-29.
    • (2001) Hum Gene Ther , vol.12 , pp. 117-129
    • brower-Toland, B.D.1    Saxer, R.A.2    Goodrich, L.R.3    Mi, Z.4    Robbins, P.D.5    Evans, C.H.6
  • 31
    • 0034885826 scopus 로고    scopus 로고
    • Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer
    • Gelse K, Jiang QJ, Aigner T, Ritter T, Wagner K, Poschl E, et al. Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer. Arthritis Rheum. 2001;44:1943-53.
    • (2001) Arthritis Rheum , vol.44 , pp. 1943-1953
    • Gelse, K.1    Jiang, Q.J.2    Aigner, T.3    Ritter, T.4    Wagner, K.5    Poschl, E.6
  • 34
    • 8444233948 scopus 로고    scopus 로고
    • The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage
    • Ikeda T, Kamekura S, Mabuchi A, Kou I, Seki S, Takato T, et al. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum. 2004;50:3561-73.
    • (2004) Arthritis Rheum , vol.50 , pp. 3561-3573
    • Ikeda, T.1    Kamekura, S.2    Mabuchi, A.3    Kou, I.4    Seki, S.5    Takato, T.6
  • 35
    • 11044221899 scopus 로고    scopus 로고
    • Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model
    • Haupt JL, Frisbie DD, McIlwraith CW, Robbins PD, Ghivizzani S, Evans CH, et al. Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J Orthop Res. 2005;23:118-26.
    • (2005) J Orthop Res , vol.23 , pp. 118-126
    • Haupt, J.L.1    Frisbie, D.D.2    McIlwraith, C.W.3    Robbins, P.D.4    Ghivizzani, S.5    Evans, C.H.6
  • 36
    • 13244269894 scopus 로고    scopus 로고
    • Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy
    • Nixon AJ, Haupt JL, Frisbie DD, Morisset SS, McIlwraith CW, Robbins PD, et al. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther. 2005;12:177-86.
    • (2005) Gene Ther , vol.12 , pp. 177-186
    • Nixon, A.J.1    Haupt, J.L.2    Frisbie, D.D.3    Morisset, S.S.4    McIlwraith, C.W.5    Robbins, P.D.6
  • 37
    • 34548644074 scopus 로고    scopus 로고
    • Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid
    • Steinert AF, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, et al. Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid. Tissue Eng. 2007;13:2227-37.
    • (2007) Tissue Eng , vol.13 , pp. 2227-2237
    • Steinert, A.F.1    Palmer, G.D.2    Capito, R.3    Hofstaetter, J.G.4    Pilapil, C.5    Ghivizzani, S.C.6
  • 38
    • 75649099043 scopus 로고    scopus 로고
    • Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer
    • Steinert AF, Proffen B, Kunz M, Hendrich C, Ghivizzani SC, Noth U, et al. Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther. 2009;11:R148.
    • (2009) Arthritis Res Ther , vol.11
    • Steinert, A.F.1    Proffen, B.2    Kunz, M.3    Hendrich, C.4    Ghivizzani, S.C.5    Noth, U.6
  • 40
    • 0029133070 scopus 로고
    • Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector
    • Roessler BJ, Hartman JW, Vallance DK, Latta JM, Janich SL, Davidson BL. Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector. Hum Gene Ther. 1995;6:307-16.
    • (1995) Hum Gene Ther , vol.6 , pp. 307-316
    • Roessler, B.J.1    Hartman, J.W.2    Vallance, D.K.3    Latta, J.M.4    Janich, S.L.5    Davidson, B.L.6
  • 42
    • 0033016094 scopus 로고    scopus 로고
    • Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury
    • Hildebrand KA, Deie M, Allen CR, Smith DW, Georgescu HI, Evans CH, et al. Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: the use of different viral vectors and the effects of injury. J Orthop Res. 1999;17:37-42.
    • (1999) J Orthop Res , vol.17 , pp. 37-42
    • Hildebrand, K.A.1    Deie, M.2    Allen, C.R.3    Smith, D.W.4    Georgescu, H.I.5    Evans, C.H.6
  • 43
    • 0033862014 scopus 로고    scopus 로고
    • Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1) gene
    • Goto H, Shuler FD, Niyibizi C, Fu FH, Robbins PD, Evans CH. Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1) gene. Osteoarthritis Cartilage. 2000;8:266-71.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 266-271
    • Goto, H.1    Shuler, F.D.2    Niyibizi, C.3    Fu, F.H.4    Robbins, P.D.5    Evans, C.H.6
  • 44
    • 12144276564 scopus 로고    scopus 로고
    • Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes
    • Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE. Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthritis Cartilage. 2005;13:80-9.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 80-89
    • Tew, S.R.1    Li, Y.2    Pothacharoen, P.3    Tweats, L.M.4    Hawkins, R.E.5    Hardingham, T.E.6
  • 45
    • 22644436809 scopus 로고    scopus 로고
    • Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2
    • Cucchiarini M, Madry H, Ma C, Thurn T, Zurakowski D, Menger MD, et al. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther. 2005;12:229-38.
    • (2005) Mol Ther , vol.12 , pp. 229-238
    • Cucchiarini, M.1    Madry, H.2    Ma, C.3    Thurn, T.4    Zurakowski, D.5    Menger, M.D.6
  • 46
    • 34248181957 scopus 로고    scopus 로고
    • Adeno associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair
    • Pagnotto MR, Wang Z, Karpie JC, Ferretti M, Xiao X, Chu CR. Adeno associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair. Gene Ther. 2007;14:804-13.
    • (2007) Gene Ther , vol.14 , pp. 804-813
    • Pagnotto, M.R.1    Wang, Z.2    Karpie, J.C.3    Ferretti, M.4    Xiao, X.5    Chu, C.R.6
  • 47
    • 0037338160 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage
    • Madry H, Cucchiarini M, Terwilliger EF, Trippel SB. Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther. 2003;14:393-402.
    • (2003) Hum Gene Ther , vol.14 , pp. 393-402
    • Madry, H.1    Cucchiarini, M.2    Terwilliger, E.F.3    Trippel, S.B.4
  • 48
    • 12344321351 scopus 로고    scopus 로고
    • Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector
    • Yokoo N, Saito T, Uesugi M, Kobayashi N, Xin KQ, Okuda K, et al. Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector. Arthritis Rheum. 2005;52:164-70.
    • (2005) Arthritis Rheum , vol.52 , pp. 164-170
    • Yokoo, N.1    Saito, T.2    Uesugi, M.3    Kobayashi, N.4    Xin, K.Q.5    Okuda, K.6
  • 49
    • 20144377839 scopus 로고    scopus 로고
    • Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo
    • Jennings K, Miyamae T, Traister R, Marinov A, Katakura S, Sowders D, et al. Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo. Mol Ther. 2005;11:600-7.
    • (2005) Mol Ther , vol.11 , pp. 600-607
    • Jennings, K.1    Miyamae, T.2    Traister, R.3    Marinov, A.4    Katakura, S.5    Sowders, D.6
  • 50
    • 0343618533 scopus 로고    scopus 로고
    • Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis
    • Goater J, Muller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, et al. Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. J Rheumatol. 2000;27:983-9.
    • (2000) J Rheumatol , vol.27 , pp. 983-989
    • Goater, J.1    Muller, R.2    Kollias, G.3    Firestein, G.S.4    Sanz, I.5    O'Keefe, R.J.6
  • 51
    • 0034693936 scopus 로고    scopus 로고
    • Adenoassociated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor alpha and reduces arthritis
    • Zhang HG, Xie J, Yang P, Wang Y, Xu L, Liu D, et al. Adenoassociated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor alpha and reduces arthritis. Hum Gene Ther. 2000;11:2431-42.
    • (2000) Hum Gene Ther , vol.11 , pp. 2431-2442
    • Zhang, H.G.1    Xie, J.2    Yang, P.3    Wang, Y.4    Xu, L.5    Liu, D.6
  • 52
    • 29244437207 scopus 로고    scopus 로고
    • Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector
    • Hiraide A, Yokoo N, Xin KQ, Okuda K, Mizukami H, Ozawa K, et al. Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector. Hum Gene Ther. 2005;16:1413-21.
    • (2005) Hum Gene Ther , vol.16 , pp. 1413-1421
    • Hiraide, A.1    Yokoo, N.2    Xin, K.Q.3    Okuda, K.4    Mizukami, H.5    Ozawa, K.6
  • 53
    • 0036019191 scopus 로고    scopus 로고
    • Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis
    • Apparailly F, Millet V, Noel D, Jacquet C, Sany J, Jorgensen C. Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum Gene Ther. 2002;13:1179-88.
    • (2002) Hum Gene Ther , vol.13 , pp. 1179-1188
    • Apparailly, F.1    Millet, V.2    Noel, D.3    Jacquet, C.4    Sany, J.5    Jorgensen, C.6
  • 54
    • 0034041974 scopus 로고    scopus 로고
    • Gene delivery to human chondrocytes by an adeno associated virus vector
    • Arai Y, Kubo T, Fushiki S, Mazda O, Nakai H, Iwaki Y, et al. Gene delivery to human chondrocytes by an adeno associated virus vector. J Rheumatol. 2000;27:979-82.
    • (2000) J Rheumatol , vol.27 , pp. 979-982
    • Arai, Y.1    Kubo, T.2    Fushiki, S.3    Mazda, O.4    Nakai, H.5    Iwaki, Y.6
  • 55
    • 0036677129 scopus 로고    scopus 로고
    • Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes
    • Ulrich-Vinther M, Maloney MD, Goater JJ, Soballe K, Goldring MB, O'Keefe RJ, et al. Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheum. 2002;46:2095-104.
    • (2002) Arthritis Rheum , vol.46 , pp. 2095-2104
    • Ulrich-Vinther, M.1    Maloney, M.D.2    Goater, J.J.3    Soballe, K.4    Goldring, M.B.5    O'Keefe, R.J.6
  • 56
    • 33846208305 scopus 로고    scopus 로고
    • Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9
    • Cucchiarini M, Thurn T, Weimer A, Kohn D, Terwilliger EF, Madry H. Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9. Arthritis Rheum. 2007;56:158-67.
    • (2007) Arthritis Rheum , vol.56 , pp. 158-167
    • Cucchiarini, M.1    Thurn, T.2    Weimer, A.3    Kohn, D.4    Terwilliger, E.F.5    Madry, H.6
  • 57
    • 72949105817 scopus 로고    scopus 로고
    • Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer
    • Cucchiarini M, Terwilliger EF, Kohn D, Madry H. Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer. J Cell Mol Med. 2009;13:2476-88.
    • (2009) J Cell Mol Med , vol.13 , pp. 2476-2488
    • Cucchiarini, M.1    Terwilliger, E.F.2    Kohn, D.3    Madry, H.4
  • 59
    • 1642514749 scopus 로고    scopus 로고
    • Light-activated gene transduction of recombinant adenoassociated virus in human mesenchymal stem cells
    • Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM. Light-activated gene transduction of recombinant adenoassociated virus in human mesenchymal stem cells. Gene Ther. 2004;11:34-41.
    • (2004) Gene Ther , vol.11 , pp. 34-41
    • Ito, H.1    Goater, J.J.2    Tiyapatanaputi, P.3    Rubery, P.T.4    O'Keefe, R.J.5    Schwarz, E.M.6
  • 60
    • 39849105677 scopus 로고    scopus 로고
    • Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery
    • B asile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Soballe K, et al. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther. 2008;16:466-73.
    • (2008) Mol Ther , vol.16 , pp. 466-473
    • Basile, P.1    Dadali, T.2    Jacobson, T.3    Hasslund, S.4    Ulrich-Vinther, M.5    Soballe, K.6
  • 62
    • 9244245810 scopus 로고    scopus 로고
    • Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo
    • Madry H, Cucchiarini M, Kaul G, Kohn D, Terwilliger EF, Trippel SB. Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo. Am J Sports Med. 2004;32:1860-5.
    • (2004) Am J Sports Med , vol.32 , pp. 1860-1865
    • Madry, H.1    Cucchiarini, M.2    Kaul, G.3    Kohn, D.4    Terwilliger, E.F.5    Trippel, S.B.6
  • 63
    • 20144387650 scopus 로고    scopus 로고
    • Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
    • Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, et al. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med. 2005;11:291-7.
    • (2005) Nat Med , vol.11 , pp. 291-297
    • Ito, H.1    Koefoed, M.2    Tiyapatanaputi, P.3    Gromov, K.4    Goater, J.J.5    Carmouche, J.6
  • 64
    • 28844494049 scopus 로고    scopus 로고
    • Tendon healing in vitro: bFGF gene transfer to tenocytes by adeno-associated viral vectors promotes expression of collagen genes
    • Wang XT, Liu PY, Xin KQ, Tang JB. Tendon healing in vitro: bFGF gene transfer to tenocytes by adeno-associated viral vectors promotes expression of collagen genes. J Hand Surg Am. 2005;30:1255-61.
    • (2005) J Hand Surg Am , vol.30 , pp. 1255-1261
    • Wang, X.T.1    Liu, P.Y.2    Xin, K.Q.3    Tang, J.B.4
  • 65
    • 43049100347 scopus 로고    scopus 로고
    • Adeno-associated virus-2-mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength. an in vivo study
    • Tang JB, Cao Y, Zhu B, Xin KQ, Wang XT, Liu PY. Adeno-associated virus-2-mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength. an in vivo study. J Bone Joint Surg Am. 2008;90:1078-89.
    • (2008) J Bone Joint Surg Am , vol.90 , pp. 1078-1089
    • Tang, J.B.1    Cao, Y.2    Zhu, B.3    Xin, K.Q.4    Wang, X.T.5    Liu, P.Y.6
  • 66
    • 70449720789 scopus 로고    scopus 로고
    • rAAVmediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions
    • Cucchiarini M, Schetting S, Terwilliger EF, Kohn D, Madry H. rAAVmediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions. Gene Ther. 2009;16:1363-72.
    • (2009) Gene Ther , vol.16 , pp. 1363-1372
    • Cucchiarini, M.1    Schetting, S.2    Terwilliger, E.F.3    Kohn, D.4    Madry, H.5
  • 67
    • 0029843596 scopus 로고    scopus 로고
    • Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector
    • Xiao X, Li J, Samulski RJ. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol. 1996;70:8098-108.
    • (1996) J Virol , vol.70 , pp. 8098-8108
    • Xiao, X.1    Li, J.2    Samulski, R.J.3
  • 68
    • 20244384369 scopus 로고    scopus 로고
    • Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach
    • Kafienah W, Al-Fayez F, Hollander AP, Barker MD. Inhibition of cartilage degradation: a combined tissue engineering and gene therapy approach. Arthritis Rheum. 2003;48:709-18.
    • (2003) Arthritis Rheum , vol.48 , pp. 709-718
    • Kafienah, W.1    Al-Fayez, F.2    Hollander, A.P.3    Barker, M.D.4
  • 69
    • 33847686338 scopus 로고    scopus 로고
    • Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent
    • Bondeson J, Lauder S, Wainwright S, Amos N, Evans A, Hughes C, et al. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. J Rheumatol. 2007;34:523-33.
    • (2007) J Rheumatol , vol.34 , pp. 523-533
    • Bondeson, J.1    Lauder, S.2    Wainwright, S.3    Amos, N.4    Evans, A.5    Hughes, C.6
  • 70
    • 0028799826 scopus 로고
    • Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation
    • Baragi VM, Renkiewicz RR, Jordan H, Bonadio J, Hartman JW, Roessler BJ. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J Clin Invest. 1995;96:2454-60.
    • (1995) J Clin Invest , vol.96 , pp. 2454-2460
    • Baragi, V.M.1    Renkiewicz, R.R.2    Jordan, H.3    Bonadio, J.4    Hartman, J.W.5    Roessler, B.J.6
  • 71
    • 0035284837 scopus 로고    scopus 로고
    • Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4
    • Kim SH, Kim S, Evans CH, Ghivizzani SC, Oligino T, Robbins PD. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol. 2001;166:3499-505.
    • (2001) J Immunol , vol.166 , pp. 3499-3505
    • Kim, S.H.1    Kim, S.2    Evans, C.H.3    Ghivizzani, S.C.4    Oligino, T.5    Robbins, P.D.6
  • 72
    • 22944436822 scopus 로고    scopus 로고
    • Stimulation of chondrocytes in vitro by gene transfer with plasmids coding for epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF)
    • Schmal H, Mehlhorn AT, Zwingmann J, Muller CA, Stark GB, Sudkamp NP. Stimulation of chondrocytes in vitro by gene transfer with plasmids coding for epidermal growth factor (hEGF) and basic fibroblast growth factor (bFGF). Cytotherapy. 2005;7:292-300.
    • (2005) Cytotherapy , vol.7 , pp. 292-300
    • Schmal, H.1    Mehlhorn, A.T.2    Zwingmann, J.3    Muller, C.A.4    Stark, G.B.5    Sudkamp, N.P.6
  • 73
    • 20244375123 scopus 로고    scopus 로고
    • Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation
    • Lee DK, Choi KB, Oh IS, Song SU, Hwang S, Lim CL, et al. Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation. Tissue Eng. 2005;11:310-8.
    • (2005) Tissue Eng , vol.11 , pp. 310-318
    • Lee, D.K.1    Choi, K.B.2    Oh, I.S.3    Song, S.U.4    Hwang, S.5    Lim, C.L.6
  • 74
    • 33845764391 scopus 로고    scopus 로고
    • Antiapoptotic Bcl-2 gene transfection of human articular chondrocytes protects against nitric oxide-induced apoptosis
    • Surendran S, Kim SH, Jee BK, Ahn SH, Gopinathan P, Han CW. Antiapoptotic Bcl-2 gene transfection of human articular chondrocytes protects against nitric oxide-induced apoptosis. J Bone Joint Surg Br. 2006;88:1660-5.
    • (2006) J Bone Joint Surg Br , vol.88 , pp. 1660-1665
    • Surendran, S.1    Kim, S.H.2    Jee, B.K.3    Ahn, S.H.4    Gopinathan, P.5    Han, C.W.6
  • 75
    • 0036187950 scopus 로고    scopus 로고
    • Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase
    • Piera-Velazquez S, Jimenez SA, Stokes D. Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum. 2002;46:683-93.
    • (2002) Arthritis Rheum , vol.46 , pp. 683-693
    • Piera-Velazquez, S.1    Jimenez, S.A.2    Stokes, D.3
  • 76
    • 77957371019 scopus 로고    scopus 로고
    • Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo
    • Madry H, Orth P, Kaul G, Zurakowski D, Menger MD, Kohn D, et al. Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo. Arch Orthop Trauma Surg. 2010;130:1311-22.
    • (2010) Arch Orthop Trauma Surg , vol.130 , pp. 1311-1322
    • Madry, H.1    Orth, P.2    Kaul, G.3    Zurakowski, D.4    Menger, M.D.5    Kohn, D.6
  • 77
    • 0033510413 scopus 로고    scopus 로고
    • Stable transfection of human fetal chondrocytes with a type II procollagen minigene: expression of the mutant protein and alterations in the structure of the extracellular matrix in vitro
    • Dharmavaram RM, Liu G, Tuan RS, Stokes DG, Jimenez SA. Stable transfection of human fetal chondrocytes with a type II procollagen minigene: expression of the mutant protein and alterations in the structure of the extracellular matrix in vitro. Arthritis Rheum. 1999;42:1433-42.
    • (1999) Arthritis Rheum , vol.42 , pp. 1433-1442
    • Dharmavaram, R.M.1    Liu, G.2    Tuan, R.S.3    Stokes, D.G.4    Jimenez, S.A.5
  • 78
    • 11144240780 scopus 로고    scopus 로고
    • Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair
    • Venkatesan N, Barre L, Benani A, Netter P, Magdalou J, Fournel-Gigleux S, et al. Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair. Proc Natl Acad Sci U S A. 2004;101:18087-92.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18087-18092
    • Venkatesan, N.1    Barre, L.2    Benani, A.3    Netter, P.4    Magdalou, J.5    Fournel-Gigleux, S.6
  • 80
    • 0034858445 scopus 로고    scopus 로고
    • Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7
    • Hidaka C, Quitoriano M, Warren RF, Crystal RG. Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7. J Orthop Res. 2001;19:751-8.
    • (2001) J Orthop Res , vol.19 , pp. 751-758
    • Hidaka, C.1    Quitoriano, M.2    Warren, R.F.3    Crystal, R.G.4
  • 81
    • 0033994254 scopus 로고    scopus 로고
    • Efficient lipid-mediated gene transfer to articular chondrocytes
    • Madry H, Trippel SB. Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Ther. 2000;7:286-91.
    • (2000) Gene Ther , vol.7 , pp. 286-291
    • Madry, H.1    Trippel, S.B.2
  • 83
    • 0034004658 scopus 로고    scopus 로고
    • Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate
    • Fragonas E, Valente M, Pozzi-Mucelli M, Toffanin R, Rizzo R, Silvestri F, et al. Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate. Biomaterials. 2000;21:795-801.
    • (2000) Biomaterials , vol.21 , pp. 795-801
    • Fragonas, E.1    Valente, M.2    Pozzi-Mucelli, M.3    Toffanin, R.4    Rizzo, R.5    Silvestri, F.6
  • 85
    • 3042774899 scopus 로고    scopus 로고
    • Maturation and integration of tissue-engineered cartilages within an in vitro defect repair model
    • Hunter CJ, Levenston ME. Maturation and integration of tissue-engineered cartilages within an in vitro defect repair model. Tissue Eng. 2004;10:736-46.
    • (2004) Tissue Eng , vol.10 , pp. 736-746
    • Hunter, C.J.1    Levenston, M.E.2
  • 86
    • 0031905173 scopus 로고    scopus 로고
    • Articular cartilage repair Rabbit experiments with a collagen gel-biomatrix and chondrocytes cultured in it
    • Kawamura S, Wakitani S, Kimura T, Maeda A, Caplan AI, Shino K, et al. Articular cartilage repair. Rabbit experiments with a collagen gel-biomatrix and chondrocytes cultured in it. Acta Orthop Scand. 1998;69:56-62.
    • (1998) Acta Orthop Scand , vol.69 , pp. 56-62
    • Kawamura, S.1    Wakitani, S.2    Kimura, T.3    Maeda, A.4    Caplan, A.I.5    Shino, K.6
  • 87
    • 16744364788 scopus 로고    scopus 로고
    • Ex vivo gene delivery using an adenovirus vector in treatment for cartilage defects
    • Ikeda T, Kubo T, Nakanishi T, Arai Y, Kobayashi K, Mazda O, et al. Ex vivo gene delivery using an adenovirus vector in treatment for cartilage defects. J Rheumatol. 2000;27:990-6.
    • (2000) J Rheumatol , vol.27 , pp. 990-996
    • Ikeda, T.1    Kubo, T.2    Nakanishi, T.3    Arai, Y.4    Kobayashi, K.5    Mazda, O.6
  • 88
    • 0033800499 scopus 로고    scopus 로고
    • The influence of transforming growth factor beta1 on mesenchymal cell repair of full-thickness cartilage defects
    • Perka C, Schultz O, Spitzer RS, Lindenhayn K. The influence of transforming growth factor beta1 on mesenchymal cell repair of full-thickness cartilage defects. J Biomed Mater Res. 2000;52:543-52.
    • (2000) J Biomed Mater Res , vol.52 , pp. 543-552
    • Perka, C.1    Schultz, O.2    Spitzer, R.S.3    Lindenhayn, K.4
  • 89
    • 0034319252 scopus 로고    scopus 로고
    • Delamination rates of tissue flaps used in articular cartilage repair
    • Driesang IM, Hunziker EB. Delamination rates of tissue flaps used in articular cartilage repair. J Orthop Res. 2000;18:909-11.
    • (2000) J Orthop Res , vol.18 , pp. 909-911
    • Driesang, I.M.1    Hunziker, E.B.2
  • 93
    • 0030893301 scopus 로고    scopus 로고
    • Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study
    • Kang R, Marui T, Ghivizzani SC, Nita IM, Georgescu HI, Suh JK, et al. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study. Osteoarthritis Cartilage. 1997;5:139-43.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 139-143
    • Kang, R.1    Marui, T.2    Ghivizzani, S.C.3    Nita, I.M.4    Georgescu, H.I.5    Suh, J.K.6
  • 94
    • 1342342795 scopus 로고    scopus 로고
    • Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipidmediated gene transfer in a gel suspension delivery system
    • Madry H, Cucchiarini M, Stein U, Remberger K, Menger MD, Kohn D, et al. Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipidmediated gene transfer in a gel suspension delivery system. J Gene Med. 2003;5:502-9.
    • (2003) J Gene Med , vol.5 , pp. 502-509
    • Madry, H.1    Cucchiarini, M.2    Stein, U.3    Remberger, K.4    Menger, M.D.5    Kohn, D.6
  • 95
    • 0035040091 scopus 로고    scopus 로고
    • High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects
    • Goomer RS, Deftos LJ, Terkeltaub R, Maris T, Lee MC, Harwood FL, et al. High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects. Osteoarthritis Cartilage. 2001;9:248-56.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. 248-256
    • Goomer, R.S.1    Deftos, L.J.2    Terkeltaub, R.3    Maris, T.4    Lee, M.C.5    Harwood, F.L.6
  • 97
    • 0031718624 scopus 로고    scopus 로고
    • Expression of human bone morphogenic protein in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair
    • Mason JM, Grande DA, Barcia M, Grant R, Pergolizzi RG, Breitbart AS. Expression of human bone morphogenic protein in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair. Gene Ther. 1998;5:1098-104.
    • (1998) Gene Ther , vol.5 , pp. 1098-1104
    • Mason, J.M.1    Grande, D.A.2    Barcia, M.3    Grant, R.4    Pergolizzi, R.G.5    Breitbart, A.S.6
  • 98
    • 0036731957 scopus 로고    scopus 로고
    • Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects
    • Adachi N, Sato K, Usas A, Fu FH, Ochi M, Han CW, et al. Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects. J Rheumatol. 2002;29:1920-30.
    • (2002) J Rheumatol , vol.29 , pp. 1920-1930
    • Adachi, N.1    Sato, K.2    Usas, A.3    Fu, F.H.4    Ochi, M.5    Han, C.W.6
  • 101
    • 0036789813 scopus 로고    scopus 로고
    • Gene marking in adeno-associated virus vector infected periosteum derived cells for cartilage repair
    • Kobayashi N, Koshino T, Uesugi M, Yokoo N, Xin KQ, Okuda K, et al. Gene marking in adeno-associated virus vector infected periosteum derived cells for cartilage repair. J Rheumatol. 2002;29:2176-80.
    • (2002) J Rheumatol , vol.29 , pp. 2176-2180
    • Kobayashi, N.1    Koshino, T.2    Uesugi, M.3    Yokoo, N.4    Xin, K.Q.5    Okuda, K.6
  • 102
    • 0037869555 scopus 로고    scopus 로고
    • Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7
    • Hidaka C, Goodrich LR, Chen CT, Warren RF, Crystal RG, Nixon AJ. Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7. J Orthop Res. 2003;21:573-83.
    • (2003) J Orthop Res , vol.21 , pp. 573-583
    • Hidaka, C.1    Goodrich, L.R.2    Chen, C.T.3    Warren, R.F.4    Crystal, R.G.5    Nixon, A.J.6
  • 103
    • 0030740745 scopus 로고    scopus 로고
    • Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo
    • B aragi VM, Renkiewicz RR, Qiu L, Brammer D, Riley JM, Sigler RE, et al. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo. Osteoarthritis Cartilage. 1997;5:275-82.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 275-282
    • Baragi, V.M.1    Renkiewicz, R.R.2    Qiu, L.3    Brammer, D.4    Riley, J.M.5    Sigler, R.E.6
  • 104
    • 0034812672 scopus 로고    scopus 로고
    • Regeneration of hyaline cartilage by cell-mediated gene therapy using transforming growth factor beta 1-producing fibroblasts
    • Lee KH, Song SU, Hwang TS, Yi Y, Oh IS, Lee JY, et al. Regeneration of hyaline cartilage by cell-mediated gene therapy using transforming growth factor beta 1-producing fibroblasts. Hum Gene Ther. 2001;12:1805-13.
    • (2001) Hum Gene Ther , vol.12 , pp. 1805-1813
    • Lee, K.H.1    Song, S.U.2    Hwang, T.S.3    Yi, Y.4    Oh, I.S.5    Lee, J.Y.6
  • 105
    • 0026439964 scopus 로고
    • Overexpression of ovine insulin-like growth factor-I stimulates autonomous autocrine or paracrine growth in bovine mammary-derived epithelial cells
    • Romagnolo D, Akers RM, Wong EA, Boyle PL, McFadden TB, Turner JD. Overexpression of ovine insulin-like growth factor-I stimulates autonomous autocrine or paracrine growth in bovine mammary-derived epithelial cells. Mol Endocrinol. 1992;6:1774-80.
    • (1992) Mol Endocrinol , vol.6 , pp. 1774-1780
    • Romagnolo, D.1    Akers, R.M.2    Wong, E.A.3    Boyle, P.L.4    McFadden, T.B.5    Turner, J.D.6
  • 106
    • 0030056484 scopus 로고    scopus 로고
    • Targeted expression of insulin-like growth factor to human keratinocytes: modification of the autocrine control of keratinocyte proliferation
    • Eming SA, Snow RG, Yarmush ML, Morgan JR. Targeted expression of insulin-like growth factor to human keratinocytes: modification of the autocrine control of keratinocyte proliferation. J Invest Dermatol. 1996;107:113-20.
    • (1996) J Invest Dermatol , vol.107 , pp. 113-120
    • Eming, S.A.1    Snow, R.G.2    Yarmush, M.L.3    Morgan, J.R.4
  • 107
    • 67650458473 scopus 로고    scopus 로고
    • A localizable, biological-based system for the delivery of bioactive IGF-1 utilizing microencapsulated genetically modified human fibroblasts
    • Patel RS, Temu TM, Jeanbart L, Morgan JR, Lysaght MJ. A localizable, biological-based system for the delivery of bioactive IGF-1 utilizing microencapsulated genetically modified human fibroblasts. ASAIO J. 2009;55:259-65.
    • (2009) ASAIO J , vol.55 , pp. 259-265
    • Patel, R.S.1    Temu, T.M.2    Jeanbart, L.3    Morgan, J.R.4    Lysaght, M.J.5
  • 108
    • 31644434203 scopus 로고    scopus 로고
    • Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/ periosteum- and fat-derived cells
    • Park J, Gelse K, Frank S, von der Mark K, Aigner T, Schneider H. Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/ periosteum- and fat-derived cells. J Gene Med. 2006;8:112-25.
    • (2006) J Gene Med , vol.8 , pp. 112-125
    • Park, J.1    Gelse, K.2    Frank, S.3    von der Mark, K.4    Aigner, T.5    Schneider, H.6
  • 109
    • 0035345628 scopus 로고    scopus 로고
    • Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy
    • Turgeman G, Pittman DD, Muller R, Kurkalli BG, Zhou S, Pelled G, et al. Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med. 2001;3:240-51.
    • (2001) J Gene Med , vol.3 , pp. 240-251
    • Turgeman, G.1    Pittman, D.D.2    Muller, R.3    Kurkalli, B.G.4    Zhou, S.5    Pelled, G.6
  • 110
    • 77951253894 scopus 로고    scopus 로고
    • Application of tissue-engineered cartilage with BMP-7 gene to repair knee joint cartilage injury in rabbits
    • Che JH, Zhang ZR, Li GZ, Tan WH, Bai XD, Qu FJ. Application of tissue-engineered cartilage with BMP-7 gene to repair knee joint cartilage injury in rabbits. Knee Surg Sports Traumatol Arthrosc. 2010;18:496-503.
    • (2010) Knee Surg Sports Traumatol Arthrosc , vol.18 , pp. 496-503
    • Che, J.H.1    Zhang, Z.R.2    Li, G.Z.3    Tan, W.H.4    Bai, X.D.5    Qu, F.J.6
  • 111
    • 39749180922 scopus 로고    scopus 로고
    • Cellbased resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis
    • Gelse K, Muhle C, Franke O, Park J, Jehle M, Durst K, et al. Cellbased resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis. Arthritis Rheum. 2008;58:475-88.
    • (2008) Arthritis Rheum , vol.58 , pp. 475-488
    • Gelse, K.1    Muhle, C.2    Franke, O.3    Park, J.4    Jehle, M.5    Durst, K.6
  • 112
    • 0036046175 scopus 로고    scopus 로고
    • Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats
    • Gysin R, Wergedal JE, Sheng MH, Kasukawa Y, Miyakoshi N, Chen ST, et al. Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats. Gene Ther. 2002;9:991-9.
    • (2002) Gene Ther , vol.9 , pp. 991-999
    • Gysin, R.1    Wergedal, J.E.2    Sheng, M.H.3    Kasukawa, Y.4    Miyakoshi, N.5    Chen, S.T.6
  • 113
    • 60549104556 scopus 로고    scopus 로고
    • The influence of the stable expression of BMP2 in fibrin clots on the remodelling and repair of osteochondral defects
    • Vogt S, Wexel G, Tischer T, Schillinger U, Ueblacker P, Wagner B, et al. The influence of the stable expression of BMP2 in fibrin clots on the remodelling and repair of osteochondral defects. Biomaterials. 2009;30:2385-92.
    • (2009) Biomaterials , vol.30 , pp. 2385-2392
    • Vogt, S.1    Wexel, G.2    Tischer, T.3    Schillinger, U.4    Ueblacker, P.5    Wagner, B.6
  • 114
    • 34250699624 scopus 로고    scopus 로고
    • Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model
    • Goodrich LR, Hidaka C, Robbins PD, Evans CH, Nixon AJ. Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br. 2007;89:672-85.
    • (2007) J Bone Joint Surg Br , vol.89 , pp. 672-685
    • Goodrich, L.R.1    Hidaka, C.2    Robbins, P.D.3    Evans, C.H.4    Nixon, A.J.5
  • 115
    • 32444449516 scopus 로고    scopus 로고
    • Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells
    • Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T, et al. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum. 2006;54:433-42.
    • (2006) Arthritis Rheum , vol.54 , pp. 433-442
    • Kuroda, R.1    Usas, A.2    Kubo, S.3    Corsi, K.4    Peng, H.5    Rose, T.6
  • 116
    • 33846851538 scopus 로고    scopus 로고
    • Repair of full-thickness articular cartilage defects by cultured mesenchymal stem cells transfected with the transforming growth factor beta1 gene
    • Guo X, Zheng Q, Yang S, Shao Z, Yuan Q, Pan Z, et al. Repair of full-thickness articular cartilage defects by cultured mesenchymal stem cells transfected with the transforming growth factor beta1 gene. Biomed Mater. 2006;1:206-15.
    • (2006) Biomed Mater , vol.1 , pp. 206-215
    • Guo, X.1    Zheng, Q.2    Yang, S.3    Shao, Z.4    Yuan, Q.5    Pan, Z.6
  • 117
    • 4344628054 scopus 로고    scopus 로고
    • Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow
    • Katayama R, Wakitani S, Tsumaki N, Morita Y, Matsushita I, Gejo R, et al. Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow. Rheumatology (Oxford). 2004;43:980-5.
    • (2004) Rheumatology (Oxford) , vol.43 , pp. 980-985
    • Katayama, R.1    Wakitani, S.2    Tsumaki, N.3    Morita, Y.4    Matsushita, I.5    Gejo, R.6
  • 118
    • 77953476884 scopus 로고    scopus 로고
    • Articular cartilage repair by genetically modified bone marrow aspirate in sheep
    • Ivkovic A, Pascher A, Hudetz D, Maticic D, Jelic M, Dickinson S, et al. Articular cartilage repair by genetically modified bone marrow aspirate in sheep. Gene Ther. 2010;17:779-89.
    • (2010) Gene Ther , vol.17 , pp. 779-789
    • Ivkovic, A.1    Pascher, A.2    Hudetz, D.3    Maticic, D.4    Jelic, M.5    Dickinson, S.6
  • 120
    • 0028066146 scopus 로고
    • Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium
    • Hung GL, Galea-Lauri J, Mueller GM, Georgescu HI, Larkin LA, Suchanek MK, et al. Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium. Gene Ther. 1994;1:64-9.
    • (1994) Gene Ther , vol.1 , pp. 64-69
    • Hung, G.L.1    Galea-Lauri, J.2    Mueller, G.M.3    Georgescu, H.I.4    Larkin, L.A.5    Suchanek, M.K.6
  • 123
    • 0030961873 scopus 로고    scopus 로고
    • In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
    • Pelletier JP, Caron JP, Evans C, Robbins PD, Georgescu HI, Jovanovic D, et al. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis Rheum. 1997;40:1012-9.
    • (1997) Arthritis Rheum , vol.40 , pp. 1012-1019
    • Pelletier, J.P.1    Caron, J.P.2    Evans, C.3    Robbins, P.D.4    Georgescu, H.I.5    Jovanovic, D.6
  • 124
    • 2942555576 scopus 로고    scopus 로고
    • Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10
    • Zhang X, Mao Z, Yu C. Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J Orthop Res. 2004;22:742-50.
    • (2004) J Orthop Res , vol.22 , pp. 742-750
    • Zhang, X.1    Mao, Z.2    Yu, C.3
  • 125
    • 0036853027 scopus 로고    scopus 로고
    • Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis
    • Kim SH, Lechman ER, Kim S, Nash J, Oligino TJ, Robbins PD. Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis. Mol Ther. 2002;6:591-600.
    • (2002) Mol Ther , vol.6 , pp. 591-600
    • Kim, S.H.1    Lechman, E.R.2    Kim, S.3    Nash, J.4    Oligino, T.J.5    Robbins, P.D.6
  • 126
    • 66049129631 scopus 로고    scopus 로고
    • Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1
    • Matsumoto T, Cooper GM, Gharaibeh B, Meszaros LB, Li G, Usas A, et al. Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1. Arthritis Rheum. 2009;60:1390-405.
    • (2009) Arthritis Rheum , vol.60 , pp. 1390-1405
    • Matsumoto, T.1    Cooper, G.M.2    Gharaibeh, B.3    Meszaros, L.B.4    Li, G.5    Usas, A.6
  • 132
    • 17144395554 scopus 로고    scopus 로고
    • Gene therapy: what have we accomplished and where do we go from here?
    • Evans CH. Gene therapy: what have we accomplished and where do we go from here? J Rheumatol Suppl. 2005;72:17-20.
    • (2005) J Rheumatol Suppl , vol.72 , pp. 17-20
    • Evans, C.H.1
  • 137
    • 67749084439 scopus 로고    scopus 로고
    • Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study
    • Mease PJ, Hobbs K, Chalmers A, El-Gabalawy H, Bookman A, Keystone E, et al. Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study. Ann Rheum Dis. 2009;68:1247-54.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1247-1254
    • Mease, P.J.1    Hobbs, K.2    Chalmers, A.3    El-Gabalawy, H.4    Bookman, A.5    Keystone, E.6
  • 138
    • 34548045718 scopus 로고    scopus 로고
    • Clinical research. Death prompts a review of gene therapy vector.
    • Kaiser J. Clinical research. Death prompts a review of gene therapy vector. Science. 2007;317:580.
    • (2007) Science , vol.317 , pp. 580
    • Kaiser, J.1
  • 139
    • 36348956106 scopus 로고    scopus 로고
    • RAC reviews serious adverse event associated with AAV therapy trial
    • Williams DA. RAC reviews serious adverse event associated with AAV therapy trial. Mol Ther. 2007;15:2053-4.
    • (2007) Mol Ther , vol.15 , pp. 2053-2054
    • Williams, D.A.1
  • 140
    • 39849105679 scopus 로고    scopus 로고
    • NIH recombinant DNA Advisory Committee continues to ponder adverse event associated with AAV gene therapy trial
    • Williams DA. NIH recombinant DNA Advisory Committee continues to ponder adverse event associated with AAV gene therapy trial. Mol Ther. 2008;16:427-8.
    • (2008) Mol Ther , vol.16 , pp. 427-428
    • Williams, D.A.1
  • 141
    • 77953308051 scopus 로고    scopus 로고
    • Cell carriers as the next generation of cell therapy for cartilage repair: a review of the matrixinduced autologous chondrocyte implantation procedure
    • B rittberg M. Cell carriers as the next generation of cell therapy for cartilage repair: a review of the matrixinduced autologous chondrocyte implantation procedure. Am J Sports Med. 2010;38:1259-71.
    • (2010) Am J Sports Med , vol.38 , pp. 1259-1271
    • Brittberg, M.1
  • 142
    • 0017723046 scopus 로고
    • Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture
    • von der Mark K, Gauss V, von der Mark H, Muller P. Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature. 1977;267:531-2.
    • (1977) Nature , vol.267 , pp. 531-532
    • von der Mark, K.1    Gauss, V.2    von der Mark, H.3    Muller, P.4
  • 143
    • 79954692758 scopus 로고    scopus 로고
    • Ex vivo gene transfer and correction for cell-based therapies
    • Naldini L. Ex vivo gene transfer and correction for cell-based therapies. Nat Rev Genet. 2011;12:301-15.
    • (2011) Nat Rev Genet , vol.12 , pp. 301-315
    • Naldini, L.1
  • 144
    • 33750289940 scopus 로고    scopus 로고
    • Stemming cartilage degeneration: adult mesenchymal stem cells as a cell source for articular cartilage tissue engineering
    • Tuan RS. Stemming cartilage degeneration: adult mesenchymal stem cells as a cell source for articular cartilage tissue engineering. Arthritis Rheum. 2006;54:3075-8.
    • (2006) Arthritis Rheum , vol.54 , pp. 3075-3078
    • Tuan, R.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.