Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer

Journal of Orthopaedic Research

Volumn 30, Issue 7, 2012, Pages 1026-1031

  Shi, Shuiliang ^a   Mercer, Scott ^a   Eckert, George J ^a   Trippel, Stephen B ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

aggrecan; articular chondrocytes; collagen; gene therapy; growth factors

Indexed keywords

AGGRECAN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COLLAGEN TYPE 2; FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; OSTEOGENIC PROTEIN 1; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CARTILAGE MATRIX; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE;

AGGRECANS; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 7; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE I; COLLAGEN TYPE II; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; GENE THERAPY; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; TRANSGENES;

EID: 84861098549     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22036     Document Type: Article

References (37)

1. Chopra R, Anastassiades T,. 1998. Specificity and synergism of polypeptide growth factors in stimulating the synthesis of proteoglycans and a novel high molecular weight anionic glycoprotein by articular chondrocyte cultures. J Rheumatol 25: 1578-1584.
2. Guerne PA, Sublet A, Lotz M,. 1994. Growth factor responsiveness of human articular chondrocytes: distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts. J Cell Physiol 158: 476-484.
3. Trippel SB,. 1995. Growth factor actions on articular cartilage. J Rheumatol Suppl 43: 129-132.
4. Trippel SB, Coutts RD, Einhorn TA, et al. 1996. Growth factor actions on articular cartilage. J Bone Joint Surg 78A: 1272-1286.
5. Henson FM, Bowe EA, Davies ME,. 2005. Promotion of the intrinsic damage-repair response in articular cartilage by fibroblastic growth factor-2. Osteoarthritis Cartilage 13: 537-544.
6. Sah RL, Chen AC, Grodzinsky AJ, et al. 1994. Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants. Arch Biochem Biophys 308: 137-147.
7. Fortier LA, Mohammed HO, Lust G, et al. 2002. Insulin-like growth factor-I enhances cell-based repair of articular cartilage. J Bone Joint Surg Br 84: 276-288.
8. Luyten FP, Hascall VC, Nissley SP, et al. 1988. Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants. Arch Biochem Biophys 267: 416-425.
9. Nixon AJ, Saxer RA, Brower-Toland BD,. 2001. Exogenous insulin-like growth factor-I stimulates an autoinductive IGF-I autocrine/paracrine response in chondrocytes. J Orthop Res 19: 26-32.
10. Eleswarapu SV, Leipzig ND, Athanasiou KA,. 2007. Gene expression of single articular chondrocytes. Cell Tissue Res 327: 43-54.
11. Morales TI, Roberts AB,. 1988. Transforming growth factor beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J Biol Chem 263: 12828-12831.
12. Rosier RN, O'Keefe RJ, Crabb ID, et al. 1989. Transforming growth factor beta: an autocrine regulator of chondrocytes. Connect Tissue Res 20: 295-301.
13. Grunder T, Gaissmaier C, Fritz J, et al. 2004. Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Osteoarthritis Cartilage 12: 559-567.
14. Reddi AH,. 2003. Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration. Ann Rheum Dis 62 (Suppl 2): ii73-ii78.
15. Chubinskaya S, Hakimiyan A, Pacione C, et al. 2007. Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads. Osteoarthritis Cartilage 15: 421-430.
16. Flechtenmacher J, Huch K, Thonar EJ, et al. 1996. Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. Arthritis Rheum 39: 1896-1904.
17. Caldwell JR, Offenberg HL, Ramanathan-Girish S, et al. 2000. A safety, tolerability and pharmacokinetic study of intra-articular recombinant human insulin-like growth factor I (rhIGF-I) in patients with severe osteoarthritis (OA) of the knee. Arthritis Rheum 43: S223.
18. Garcia AM, Szasz N, Trippel SB, et al. 2003. Transport and binding of insulin-like growth factor I through articular cartilage. Arch Biochem Biophys 415: 69-79.
19. Brower-Toland BD, Saxer RA, Goodrich LR, et al. 2001. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther 12: 117-129.
20. Cucchiarini M, Madry H, Ma C, et al. 2005. Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 12: 229-238.
21. Madry H, Zurakowski D, Trippel SB,. 2001. Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation. Gene Ther 8: 1443-1449.
22. Madry H, Kaul G, Cucchiarini M, et al. 2005. Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther 12: 1171-1179.
23. Madry H, Emkey G, Zurakowski D, et al. 2004. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. J Gene Med 6: 238-245.
24. Shuler FD, Georgescu HI, Niyibizi C, et al. 2000. Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes. J Orthop Res 18: 585-592.
25. Yokoo N, Saito T, Uesugi M, et al. 2005. Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector. Arthritis Rheum 52: 164-170.
26. Shi S, Mercer S, Trippel SB,. 2010. Effect of transfection strategy on growth factor overexpression by articular chondrocytes. J Orthop Res 28: 103-109.
27. Evans CH, Ghivizzani SC, Smith P, et al. 2000. Using gene therapy to protect and restore cartilage. Clin Orthop Relat Res 379: S214-S219.
28. Smith P, Shuler FD, Georgescu HI, et al. 2000. Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum 43: 1156-1164.
29. Manning K, Rachakonda PS, Rai MF, et al. 2010. Co-expression of insulin-like growth factor-1 and interleukin-4 in an in vitro inflammatory model. Cytokine 50: 297-305.
30. Cucchiarini M, Terwilliger EF, Kohn D, et al. 2009. Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer. J Cell Mol Med 13: 2476-2488.
31. Orth PKG, Cucchiarini M, Zurakowski D, et al. 2011. Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo. Knee Surg Sports Traumatol Arthrosc 19: 2119-2130.
32. Chen B, Qin J, Wang H, et al. 2010. Effects of adenovirus-mediated bFGF, IL-1Ra and IGF-1 gene transfer on human osteoarthritic chondrocytes and osteoarthritis in rabbits. Exp Mol Med 42: 684-695.
33. ten Dijke P, Korchynskyi O, Valdimarsdottir G, et al. 2003. Controlling cell fate by bone morphogenetic protein receptors. Mol Cell Endocrinol 211: 105-113.
34. Shi Y, Massague J,. 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700.
35. Yakar S, Leroith D, Brodt P,. 2005. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: lessons from animal models. Cytokine Growth Factor Rev 16: 407-420.
36. Szebenyi G, Fallon JF,. 1999. Fibroblast growth factors as multifunctional signaling factors. Int Rev Cytol 185: 45-106.
37. Madry H, Cucchiarini M, Terwilliger EF, et al. 2003. Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther 14: 393-402.