Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro

Osteoarthritis and Cartilage

Volumn 6, Issue 3, 1998, Pages 153-159

  Doherty, Paul J ^a   Zhang, Hongwei ^a   Tremblay, Louise ^a   Manolopoulos, Vaselios ^a   Marshall, K Wayne ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Adenovirus; Cartilage; Chondrocytes; galactosidase

Indexed keywords

BETA GALACTOSIDASE; VIRUS VECTOR;

ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; GENE EXPRESSION; GENETICS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TISSUE TRANSPLANTATION;

EID: 0032076306     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1998.0107     Document Type: Article

References (17)

1. 1. Heinegard D, Oldberg A. Structure and biology of cartilage and bone matrix noncollagenous macromolecules. Faseb J 1989;3:2042-51.
2. 2. Mankin HJ, Brandt KD. Pathogenesis of Osteoarthritis. In: Kelley, WN, Harris, ED, Ruddy, S, Sledge, CB, Eds. Pathogenesis of Osteoarthritis, 3rded. Philadelphia, PA: W.B. Saunders 1989: 1469-79.
3. 3. Venn G, Billingham MEJ, Hardingham TE. Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype. Arthritis Rheum 1995;38:525-32.
4. 4. van der Kraan PM, Glansbeek HL, Vitters EL, van den Berg WB. Early elevation of transforming growth factor-β, decorin, and biglycan mRNA levels during cartilage matrix restoration after mild proteoglycan depletion. J Rheumatol 1997; 24:543-9.
5. 5. Erlacher L, Maier R, Ullrich R et al. Differential expression of the protooncogene bcl-2 in normal and osteo arthritic human articular cartilage. J Rheumatol 1995;22:926-31.
6. 6. Cs-Szabo G, Melching LI, Roughley PJ, Glant TT. Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples. Arthritis Rheum 1997;40:1037-45.
7. 7. Lefkoe TP, Nalin AM, Clark JM, Reife RA, Sugai J, Sandell LJ. Gene expression of collagen types IIA and IX correlates with ultrastructural events in early osteoarthritis: New applications of the rabbit meniscectomy model. J Rheumatol 1997;24: 1155-63.
8. 8. Okimura A, Okada Y, Makihira S et al. Enhancement of cartilage matrix protein synthesis in arthritic cartilage. Arthritis Rheum 1997;40: 1029-36.
9. 9. Poole AR, Ionescu M, Swan A, Dieppe PA. Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. J Clin Invest 1994;94:25-33.
10. 10. Chang MW, Barr E, Lu MM, Barton K, Leiden JM. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest 1995;96:2260-8.
11. 11. Hauselmann HJ, Aydelotte MB, Schumacher BL, Kuettner KE, Gitelis SH, Thonari J-MA. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. Matrix 1992;12:116-29.
12. 12. Sun D, Aydelotte B, Maldonado B, Kuettner KE, Kimura JH. Clonal analysis of the population of chondrocytes from the Swarm rat chondrosarcoma in agarose cultures. J Orthop Res 1986;4:427-36.
13. 13. Guo J, Jourdian GW, MacCallum DK. Culture and growth characteristics of chondrocytes encapsulated in alginate beads. Conn Tiss Res 1989;19:277-97.
14. 14. Baragi VM, Renkiewicz RR, Jordan H, Bonadio J, Hartman JW. Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. J Clin Invest 1996;96:2454-60.
15. 15. Baragi VM, Renkiewicz RR, Qiu L et al. Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo. Osteoarthritis Cart 1997;5: 275-82.
16. 16. Kang R, Marui T, Ghivizzani SC et al. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study. Osteoarthritis Cart 1997;5:139-43.
17. 17. Elima K, Vuorio E. Expression of mRNAs for collagens and other matrix components in dedifferentiating and redifferentiating human chondrocytes in culture. FEBS Letters 1989;258: 195-8.