Adeno-associated vector mediated gene transfer of transforming growth factor - β1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism

European Cells and Materials

Volumn 10, Issue , 2005, Pages 40-50

  Ulrich Vinther, M ^a   Stengaard, C ^a   Schwarz, E M ^b   Goldring, M B ^c   Soballe, K ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Adeno Associated Virus; Cartilage; Gene therapy; Osteoarthritis; Transforming Growth Factor 1

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; ENHANCED GREEN FLUORESCENT PROTEIN; MESSENGER RNA; PARVOVIRUS VECTOR; STROMELYSIN; TRANSFORMING GROWTH FACTOR BETA1;

ADENO ASSOCIATED VIRUS; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL LINE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; NONHUMAN; OSTEOARTHRITIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REDUCTION; REPORTER GENE; TOTAL KNEE REPLACEMENT;

EID: 28444460380     PISSN: 14732262     EISSN: 14732262     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Alleyne KR, Galloway MT (2001) Management of osteochondral injuries of the knee. Clin Sports Med 20: 343-364.
2. Alsalameh S, Amin R, Gemba T, Lotz M (2004) Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum 50: 1522-1532.
3. Andrews HJ, Edwards TA, Cawston TE, Hazleman BL (1989) Transforming growth factor-β1 causes partial inhibition of interleukin 1-stimulated cartilage degradation in vitro. Biochem Biophys Res Commun 162: 144-150.
4. Arai Y, Kubo T, Fushiki S, Mazda O, Nakai H, Iwaki Y, Imanishi J, Hirasawa Y (2000) Gene delivery to human chondrocytes by an adeno associated virus vector. J Rheumatol 27: 979-982.
5. Arai Y, Kubo T, Kobayashi K, Takeshita K, Takahashi K, Ikeda T, Imanishi J, Takigawa M, Hirasawa Y (1997) Adenovirus vector-mediated gene transduction to chondrocytes: in vitro evaluation of therapeutic efficacy of transforming growth factor-β1 and heat shock protein 70 gene transduction. J Rheumatol 24:1787-1795.
6. Baragi VM, Renkiewicz RR, Qiu L, Brammer D, Riley JM, Sigler RE, Frenkel SR, Amin A, Abramson SB, Roessler BJ (1997) Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo. Osteoarthritis Cartilage 5: 275-282.
7. Blumenfeld I, Laufer D, Livne E (1997) Effects of transforming growth factor-β1 and interleukin-1 α on matrix synthesis in osteoarthritic cartilage of the temporomandibular joint in aged mice. Mech Ageing Dev 95: 101-111.
8. Browne JE, Branch TP (2000) Surgical alternatives for treatment of articular cartilage lesions. J Am Acad Orthop Surg 8: 180-189.
9. Buckwalter JA, Mankin HJ (1998) Articular cartilage repair and transplantation. Arthritis Rheum 41: 1331-1342.
10. Bustin SA (2000) Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25:169-193.
11. Doherty PJ, Zhang H, Tremblay L, Manolopoulos V, Marshall KW (1998) Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro. Osteoarthritis Cartilage 6:153-159.
12. Dowthwaite GP, Bishop JC, Redman SN, Khan IM, Rooney P, Evans DJ, Haughton L, Bayram Z, Boyer S, Thomson B, Wolfe MS, Archer CW (2004) The surface of articular cartilage contains a progenitor cell population. J Cell Sci 117: 889-897.
13. Ellsworth JL, Berry J, Bukowski T, Claus J, Feldhaus A, Holderman S, Holdren MS, Lum KD, Moore EE, Raymond F, Ren H, Shea P, Sprecher C, Storey H, Thompson DL, Waggie K, Yao L, Fernandes RJ, Eyre DR, Hughes SD (2002) Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors. Osteoarthritis Cartilage 10: 308-320.
14. Fortier LA, Mohammed HO, Lust G, Nixon AJ (2002) Insulin-like growth factor-I enhances cell-based repair of articular cartilage. J Bone Joint Surg Br 84: 276-288.
15. Frenkel SR, Di Cesare PE (1999) Degradation and repair of articular cartilage. Front Biosci 4: D671-D685.
16. Gelse K, von der MK, Schneider H (2003) Cartilage regeneration by gene therapy. Curr Gene Ther 3: 305-317.
17. Goater J, Muller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM (2000) Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. J Rheumatol 27: 983-989.
18. Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM (2002) Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res 20:169-173.
19. Gouttenoire J, Valcourt U, Ronziere MC, Aubert-Foucher E, Mallein-Gerin F, Herbage D (2004) Modulation of collagen synthesis in normal and osteoarthritic cartilage. Biorheology 41: 535-542.
20. Grimaud E, Heymann D, Redini F (2002) Recent advances in TGF-β1 effects on chondrocyte metabolism. Potential therapeutic roles of TGF-β1 in cartilage disorders. Cytokine Growth Factor Rev 13: 241-257.
21. Hill DJ, Logan A (1992) Peptide growth factors and their interactions during chondrogenesis. Prog Growth Factor Res 4: 45-68.
22. Hyder SM, Huang JC, Nawaz Z, Boettger-Tong H, Makela S, Chiappetta C, Stancel GM (2000) Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environ Health Perspect 108 Suppl 5: 785-790.
23. Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM (2004) Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells. Gene Ther 11: 34-41.
24. Izumi T, Scully SP, Heydemann A, Bolander ME (1992) Transforming growth factor-β1 stimulates type II collagen expression in cultured periosteum-derived cells. J Bone Miner Res 7: 115-121.
25. Joyce ME, Roberts AB, Sporn MB, Bolander ME (1990) Transforming growth factor-β1 and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 110: 2195-2207.
26. Kaiser M, Haag J, Soder S, Bau B, Aigner T (2004) Bone morphogenetic protein and transforming growth factor-β1 inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1. Arthritis Rheum 50: 3535-3540.
27. Kang R, Marui T, Ghivizzani SC, Nita IM, Georgescu HI, Suh JK, Robbins PD, Evans CH (1997) Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study. Osteoarthritis Cartilage 5: 139-143.
28. Kish G, Modis L, Hangody L (1999) Osteochondral mosaicplasty for the treatment of focal chondral and osteochondral lesions of the knee and talus in the athlete. Rationale, indications, techniques, and results. Clin Sports Med 18: 45-66.
29. Lafeber FP, van Roy HL, van der Kraan PM, van den Berg WB, Bijlsma JW (1997) Transforming growth factor-β1 predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage. J Rheumatol 24: 536-542.
30. Lewandoski M (2001) Conditional control of gene expression in the mouse. Nat Rev Genet 2:743-755.
31. Livne E (1994) In vitro response of articular cartilage from mature mice to human transforming growth factor-β1. Acta Anat (Basel) 149: 185-194.
32. Lum ZP, Hakala BE, Mort JS, Recklies AD (1996) Modulation of the catabolic effects of interleukin-1 on human articular chondrocytes by transforming growth factor-β1. J Cell Physiol 166: 351-359.
33. Madry H, Cucchiarini M, Terwilliger EF, Trippel SB (2003) Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther 14: 393-402.
34. Malemud CJ, Goldberg VM (1999) Future directions for research and treatment of osteoarthritis. Front Biosci 4: D762-D771.
35. Martinek V, Fu FH, Lee CW, Huard J (2001) Treatment of osteochondral injuries. Genetic engineering. Clin Sports Med 20: 403-416.
36. Moses HL, Serra R (1996) Regulation of differentiation by TGF-β1. Curr Opin Genet Dev 6: 581-586.
37. Moulharat N, Lesur C, Thomas M, Rolland-Valognes G, Pastoureau P, Anract P, De Ceuninck F, Sabatini M (2004) Effects of transforming growth factor-β1 on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro. Osteoarthritis Cartilage 12: 296-305.
38. Nixon AJ, Saxer RA, Brower-Toland BD (2001) Exogenous insulin-like growth factor-I stimulates an autoinductive IGF-I autocrine/paracrine response in chondrocytes. J Orthop Res 19: 26-32.
39. Osborn KD, Trippel SB, Mankin HJ (1989) Growth factor stimulation of adult articular cartilage. J Orthop Res 7: 35-42.
40. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
41. Redini F, Galera P, Mauviel A, Loyau G, Pujol JP (1988) Transforming growth factor-β1 stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes. FEBS Lett 234: 172-176.
42. Robbins JR, Thomas B, Tan L, Choy B, Arbiser JL, Berenbaum F, Goldring MB (2000) Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1. Arthritis Rheum 43: 2189-2201.
43. Sato K, Urist MR (1984) Bone morphogenetic protein-induced cartilage development in tissue culture. Clin Orthop Relat Res 183: 180-187.
44. Schwarz EM (2000) The adeno-associated virus vector for orthopaedic gene therapy. Clin Orthop Relat Res 379: S31-S39.
45. Sellers RS, Peluso D, Morris EA (1997) The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage. J Bone Joint Surg Am 79: 1452-1463.
46. Shlopov BV, Smith GN, Jr., Cole AA, Hasty KA (1999) Differential patterns of response to doxycycline and transforming growth factor-β1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes. Arthritis Rheum 42: 719-727.
47. Shuler FD, Georgescu HI, Niyibizi C, Studer RK, Mi Z, Johnstone B, Robbins RD, Evans CH (2000) Increased matrix synthesis following adenoviral transfer of a transforming growth factor-β1 gene into articular chondrocytes. J Orthop Res 18: 585-592.
48. Smith P, Shuler FD, Georgescu HI, Ghivizzani SC, Johnstone B, Niyibizi C, Robbins PD, Evans CH (2000) Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum 43: 1156-1164.
49. Su S, Dehnade F, Zafarullah M (1996) Regulation of tissue inhibitor of metalloproteinases-3 gene expression by transforming growth factor-β1 and dexamethasone in bovine and human articular chondrocytes. DNA Cell Biol 15: 1039-1048.
50. Trippel SB, Ghivizzani SC, Nixon AJ (2004) Gene-based approaches for the repair of articular cartilage. Gene Ther 11: 351-359.
51. Ulrich-Vinther M, Carmody EE, Goater JJ, balle S, O'Keefe RJ, Schwarz EM (2002) Recombinant adenoassociated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis. J Bone Joint Surg Am 84: 1405-1412.
52. Ulrich-Vinther M, Duch MR, Soballe K, O'Keefe RJ, Schwarz EM, Pedersen FS (2004) In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector. J Orthop Res 22: 726-734.
53. Ulrich-Vinther M, Maloney MD, Goater JJ, Soballe K, Goldring MB, O'Keefe RJ, Schwarz EM (2002) Lightactivated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheum 46: 2095-2104.
54. Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ (2003) Articular cartilage biology. J Am Acad Orthop Surg 11: 421-430.
55. van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB (2000) Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-β1 injections. Osteoarthritis Cartilage 8: 25-33.
56. van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB (1994) Transforming growth factor-β1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint. Lab Invest 71: 279-290.
57. van der Kraan PM, van den Berg WB (2000) Anabolic and destructive mediators in osteoarthritis. Curr Opin Clin Nutr Metab Care 3: 205-211.
58. Vangsness CT, Jr. (1999) Overview of treatment options for arthritis in the active patient. Clin Sports Med 18:1-11.
59. Wang EA, Rosen V, D'Alessandro JS, Bauduy M, Cordes P, Harada T, Israel DI, Hewick RM, Kerns KM, LaPan P (1990) Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci U S A 87: 2220-2224.
60. Worster AA, Nixon AJ, Brower-Toland BD, Williams J (2000) Effect of transforming growth factor-β1 on chondrogenic differentiation of cultured equine mesenchymal stem cells. Am J Vet Res 61: 1003-1010.
61. Xiao X, Li J, Samulski RJ (1998) Production of hightiter recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol 72: 2224-2232.
62. Ulrich-Vinther M, Maloney MD, Goater JJ, Soballe K, Goldring MB, O'Keefe RJ, Schwarz EM (2002) Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheum 46: 2095-2104.
63. Ulrich-Vinther M, Duch MR, Soballe K, O'Keefe RJ, Schwarz EM, Pedersen FS (2004) In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector. J Orthop Res 22: 726-734.