Continuous transforming growth factor β1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation

Tissue Engineering

Volumn 11, Issue 1-2, 2005, Pages 310-318

  Lee, Dug Keun ^a,d   Choi, Kyoung Baek ^b   Oh, In Suk ^b   Song, Sun U ^c   Hwang, Sally ^a   Lim, Chae Lyul ^b   Hyun, Jong Pil ^b   Lee, Hyeon Youl ^b   Chi, Guang Fan ^b   Yi, Youngsuk ^a   Yip, Vivian ^a   Kim, Jeannie ^a   Lee, Eun Byul ^a   Noh, Moon Jong ^a   Lee, Kwan Hee ^a,b,d  

^a TissueGene   (United States)

^b Tissue Gene Asia   (South Korea)

^c Inha University School of Medicine   (South Korea)

^d GeneDx Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE; COLLAGEN; DATA REDUCTION; GROWTH KINETICS; VECTORS;

CELL-MEDIATED GENE THERAPY; CHONDROCYTE REDIFFERENTIATION; HUMAN CHONDROCYTES; RETROVIRAL VECTORS;

GENES;

RETROVIRUS VECTOR; RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; WESTERN BLOTTING;

ANIMALS; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; FEASIBILITY STUDIES; GENE THERAPY; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; RETROVIRIDAE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSGENES; TRANSPLANTATION, HETEROLOGOUS;

EID: 20244375123     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2005.11.310     Document Type: Article

References (41)

1. Edwards, D.R., Leco, K.J., Beaudry, P.P., Atadja, P.W., Veillette, C., and Riabowol, K.T. Transforming growth factor β modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J. 6, 1899, 1987.
2. Sporn, M.B., Roberts, A.B., Wakefield, L.M., and de Crombrugghe, B. Some recent advances in the chemistry and biology of transforming growth factor-β. J. Cell Biol. 105, 1039, 1987.
3. Morales, T.I., and Roberts, A.B. Transforming growth factor β regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J. Biol. Chem. 263, 12828, 1988.
4. Redini, F., Daireaux, M., Mauviel, A., Galera, P., Loyau, G., and Pujol, J.P. Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-β (TGF-β). Biochim. Biophys. Acta 1093, 196, 1991.
5. 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells. Endocrinology 132, 1603, 1993.
6. 1 stimulates type II collagen expression in cultured periosteum-derived cells. J. Bone Miner. Res. 7, 115, 1992.
7. O'Driscoll, S.W., Recklies, A.D., and Poole, A.R. Chondrogenesis in periosteal explants: An organ culture model for in vitro study. J. Bone Joint Surg. Am. 76, 1042, 1994.
8. 2. Histochem. J. 27, 505, 1995.
9. Glansbeek, H.L., van Beuningen, H.M., Vitters, E.L., van der Kraan, P.M., and van den Berg, W.B. Expression of recombinant human soluble type II transforming growth factor-β receptor in Pichia pastoris and Escherichia coli: Two powerful systems to express a potent inhibitor of transforming growth factor-β. Protein Expr. Purif. 12, 201, 1998.
10. Lind, M., Schumacker, B., Soballe, K., Keller, J., Melsen, F., and Bunger, C. Transforming growth factor-β enhances fracture healing in rabbit tibiae. Acta Orthop. Scand. 64, 553, 1993.
11. 1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation. J. Bone Miner. Res. 12, 1584, 1997.
12. 1- producing fibroblasts. Hum. Gene Ther. 12, 1805, 2001.
13. Archer, C.W., McDowell, J., Bayliss, M.T., Stephens, M.D., and Bentley, G. Phenotypic modulation in sub-populations of human articular chondrocytes in vitro. J. Cell Sci. 97, 361, 1990.
14. Benya, P.D., Padilla, S.R., and Nimni, M.E. Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture. Cell 15, 1313, 1978.
15. Solursh, M. Differentiation of cartilage and bone. Curr. Opin. Cell Biol. 1, 989, 1989.
16. Sandell, L.J., and Adler, P. Developmental patterns of cartilage. Front. Biosci. 15, 731, 1999.
17. Benya, P.D., Padilla, S.R., and Nimni, M.E. The progeny of rabbit articular chondrocytes synthesize collagen types I and III and type I trimer, but not type II: Verifications by cyanogen bromide peptide analysis. Biochemistry 16, 865, 1977.
18. Lefebvre, V., Peeters-Joris, C., and Vaes, G. Production of collagens, collagenase and collagenase inhibitor during the dedifferentiation of articular chondrocytes by serial subcultures. Biochim. Biophys. Acta. 1051, 266, 1990.
19. Bonaventure, J., Kadhom, N., Cohen-Solal, L., Ng, K.H., Bourguignon, J., Lasselin, C., and Freisinger, P. Reexpression of cartilage-specific genes by dedifferentiated human articular chondrocytes cultured in alginate beads. Exp. Cell Res. 212, 97, 1994.
20. van der Kraan, P.M., Buma, P., van Kuppeveit, T., and van den Berg, W.B. Interaction of chondrocytes, extracellular matrix and growth factors: Relevance for articular cartilage tissue engineering. Osteoarthritis Cartilage 10, 631, 2002.
21. Benya, P.D., and Shaffer, J.D. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30, 215, 1982.
22. Thenet, S., Benya, P.D., Demignot, S., Feunteun, J., and Adolphe, M. SV40-immortalization of rabbit articular chondrocytes: Alteration of differentiated functions. J. Cell. Physiol. 150, 158, 1992.
23. Loty, S., Sautier, J.M., Loty, C., Boulekbache, H., Kokubo, T., and Forest, N. Cartilage formation by fetal rat chondrocytes cultured in alginate beads: A proposed model for investigating tissue-biomaterial interactions. J. Biomed. Mater. Res. 42, 213, 1998.
24. Demoor-Fossard, M., Redini, F., Boittin, M., and Pujol, J.P. Expression of decorin and biglycan by rabbit articular chondrocytes: Effects of cytokines and phenotypic modulation. Biochim. Biophys. Acta. 1398, 179, 1998.
25. Martin, J.A., and Buckwalter, J.A. Effects of fibronectin on articular cartilage chondrocyte proteoglycan synthesis and response to insulin-like growth factor-I. J. Orthop. Res. 16, 752, 1996.
26. Yaeger, P.C., Masi, T.L., de Ortiz, J.L, Binette, F., Tubo, R., and McPherson, J.M. Synergistic action of transforming growth factor-β and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes. Exp. Cell Res. 237, 318, 1997.
27. Van Suisante, J.L., Bump, P., van Beunigen, H.M., van den Berg, W.B., and Veth, R. Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentration. J. Orthop. Res. 18, 68, 2000.
28. Weiser, L., Bhargava, M., Attia, E., and Torzilli, P.A. Effect of serum and platelet-derived growth factor on chondrocytes grown in collagen gels. Tissue Eng. 5, 533, 1999.
29. Martin, I., Vunjak-Novakovic, G., Yang, J., Langer, R., and Freed, L.E. Mammalian chondrocytes expanded in the presence of fibroblast growth factor-2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue. Exp. Cell Res. 15, 681, 1999.
30. Fernandes, J., Tardif, G., Martel-Pelletier, J., Lascau-Coman, V., Dupuis, M., Moldovan, F., Sheppard, M., Krishnan, B.R., and Pelletier, J.P. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: Prevention of osteoarthritis progression. Am. J. Pathol. 154, 1159, 1999.
31. Iwamoto, M., Sato, K., Nakashima, K., Fuchihata, H., Suzuki, F., and Kato, Y. Regulation of colony formation of differentiated chondrocytes in soft agar by transforming growth factor-β. Biochem. Biophys. Res. Commun. 159, 1006, 1989.
32. 1 modulation of rat periosteal cell chondrogenesis. J. Cell Biochem. 81, 284, 2001.
33. 1 enhances periosteal chondrogenesis in vitro: A preliminary report. J. Bone Joint Surg. Am. 84, 793, 2002.
34. 1 to promote bone repair in skull defects in rabbits. Biomaterials 23, 1003, 2002.
35. Sellers, R.S., Peluso, D., and Morris, E.A. The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage. J. Bone Joint Surg. Am. 79, 1452, 1997.
36. Madry, H., Padera, R., Seidel, J., Langer, R., Freed, L.E., Trippel, S.B., and Vunjak-Novakovic, G. Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum. Gene Ther. 13, 1621, 2002.
37. Sittinger, M., Reitzel, D., Dauner, M., Hierlemann, H., Hammer, C., Kastenbauer, E., Planck, H., Burmester, G.R., and Bujia, J. Resorbable polyesters in cartilage engineering: Affinity and biocompatibility of polymer fiber structures to chondrocytes. J. Biomed. Mater. Res. 33, 57, 1996.
38. Homminga, G.N., Buma, P., Koot, H.W., van der Kraan, P.M., and van den Berg, W.B. Chondrocyte behavior in fibrin glue in vitro. Acta Orthop. Scand. 64, 441, 1993.
39. Brittberg, M., Lindahl, A., Nilsson, A., Ohlsson, C., Isaksson, O., and Peterson, L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N. Engl. J. Med. 331, 889, 1994.
40. Hacein-Bey-Abina, S., von Kalle, C., Schmidt, M., Le Deist, F., Wulffraat, N., McIntyre, E., Radford, I., Villeval, J.L., Fraser, C.C., Cavazzana-Calyo, M., and Fisher, A. A serious adverse event after successful gene therapy for X-linked severe combined immunodifficiency. N. Engl. J. Med. 348, 255, 2003.
41. Kaiser, J. Gene therapy. Seeking the cause of induced leukemias in X-SCID trial. Science 299, 495, 2003.