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Volumn 7, Issue 1, 2011, Pages 23-32

Genetic epidemiology of hip and knee osteoarthritis

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECANASE 2; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; CALCITONIN; CALMODULIN; CATECHOL METHYLTRANSFERASE; COLLAGEN TYPE 10; COLLAGEN TYPE 2; DIPEPTIDYL CARBOXYPEPTIDASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GROWTH DIFFERENTIATION FACTOR 5; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; KLOTHO PROTEIN; LEPTIN; MESSENGER RNA; PITUITARY HOMEOBOX 1; PROSTAGLANDIN E2; SMAD3 PROTEIN; SODIUM CHANNEL NAV1.7; THYROXINE DEIODINASE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; TYPE II IODOTHYRONINE DEIODINASE; TYPE III IODOTHYRONINE DEIODINASE; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 78650977864     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2010.191     Document Type: Review
Times cited : (204)

References (116)
  • 1
    • 15844390942 scopus 로고    scopus 로고
    • Pathogenesis and management of pain in osteoarthritis
    • Dieppe, P. A. & Lohmander, L. S. Pathogenesis and management of pain in osteoarthritis. Lancet 365, 965-973 (2005).
    • (2005) Lancet , vol.365 , pp. 965-973
    • Dieppe, P.A.1    Lohmander, L.S.2
  • 2
    • 38149052992 scopus 로고    scopus 로고
    • Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II
    • Lawrence, R. C. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58, 26-35 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 26-35
    • Lawrence, R.C.1
  • 3
    • 32544454827 scopus 로고    scopus 로고
    • Total joint replacement in osteoarthritis
    • Katz, J. N. Total joint replacement in osteoarthritis. Best Pract. Res. Clin. Rheumatol. 20, 145-153 (2006).
    • (2006) Best Pract. Res. Clin. Rheumatol. , vol.20 , pp. 145-153
    • Katz, J.N.1
  • 4
    • 84924833491 scopus 로고
    • Osteoarthritis of the hip: A study of the nature and evolution of the disease
    • Harrison, M. H., Shajowicz, F. & Trueta, J. Osteoarthritis of the hip: a study of the nature and evolution of the disease. J. Bone Joint Surg. Br. 35B, 598-626 (1953).
    • (1953) J. Bone Joint Surg. Br. , vol.35 B , pp. 598-626
    • Harrison, M.H.1    Shajowicz, F.2    Trueta, J.3
  • 5
    • 58849145676 scopus 로고    scopus 로고
    • Finding genes underlying human disease
    • Stein, C. M. & Elston, R. C. Finding genes underlying human disease. Clin. Genet. 75, 101-106 (2009).
    • (2009) Clin. Genet. , vol.75 , pp. 101-106
    • Stein, C.M.1    Elston, R.C.2
  • 6
    • 77956361934 scopus 로고    scopus 로고
    • Involvement of different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes
    • Valdes, A. M. et al. Involvement of different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. Arthritis Rheum. 62, 2688-2695 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 2688-2695
    • Valdes, A.M.1
  • 7
    • 59649093445 scopus 로고    scopus 로고
    • A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain
    • van Meurs, J. B. et al. A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. Arthritis Rheum. 60, 628-629 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 628-629
    • Van Meurs, J.B.1
  • 8
    • 75749110202 scopus 로고    scopus 로고
    • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22
    • Kerkhof, H. J. et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 62, 499-510 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 499-510
    • Kerkhof, H.J.1
  • 9
    • 54949138784 scopus 로고    scopus 로고
    • Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty
    • Gordon, A., Kiss-Toth, E., Stockley, I., Eastell, R. & Wilkinson, J. M. Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. Arthritis Rheum. 58, 3157-3165 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 3157-3165
    • Gordon, A.1    Kiss-Toth, E.2    Stockley, I.3    Eastell, R.4    Wilkinson, J.M.5
  • 10
    • 77951758095 scopus 로고    scopus 로고
    • Report of the American College of Rheumatology Pain Management Task Force
    • Borenstein, D. et al. Report of the American College of Rheumatology Pain Management Task Force. Arthritis Care Res. 62, 590-599 (2010).
    • (2010) Arthritis Care Res. , vol.62 , pp. 590-599
    • Borenstein, D.1
  • 12
    • 77950429077 scopus 로고    scopus 로고
    • Pain perception is altered by a nucleotide polymorphism in SCN9A
    • Reimann, F. et al. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc. Natl Acad. Sci. USA 107, 5148-5153 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 5148-5153
    • Reimann, F.1
  • 13
    • 0344237255 scopus 로고    scopus 로고
    • Genetic contribution to cartilage volume in women: A classical twin study
    • Hunter, D. J., Snieder, H., March, L. & Sambrook, P. N. Genetic contribution to cartilage volume in women: a classical twin study. Rheumatology (Oxford) 42, 1495-1500 (2003).
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 1495-1500
    • Hunter, D.J.1    Snieder, H.2    March, L.3    Sambrook, P.N.4
  • 14
    • 25444491939 scopus 로고    scopus 로고
    • The genetic contribution to longitudinal changes in knee structure and muscle strength: A sibpair study
    • Zhai, G., Ding, C., Stankovich, J., Cicuttini, F. & Jones, G. The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study. Arthritis Rheum. 52, 2830-2834 (2005).
    • (2005) Arthritis Rheum. , vol.52 , pp. 2830-2834
    • Zhai, G.1    Ding, C.2    Stankovich, J.3    Cicuttini, F.4    Jones, G.5
  • 15
    • 33846401119 scopus 로고    scopus 로고
    • Genetic influence on the progression of radiographic knee osteoarthritis, a longitudinal twin study
    • Zhai, G., Hart, D. J., Kato, B. S., MacGregor, A. & Spector, T. D. Genetic influence on the progression of radiographic knee osteoarthritis, a longitudinal twin study. Osteoarthritis Cartilage 15, 222-225 (2007).
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 222-225
    • Zhai, G.1    Hart, D.J.2    Kato, B.S.3    MacGregor, A.4    Spector, T.D.5
  • 16
    • 0034638651 scopus 로고    scopus 로고
    • Assessment of a genetic contribution to osteoarthritis of the hip: Sibling study
    • Lanyon, P., Muir, K., Doherty, S. & Doherty, M. Assessment of a genetic contribution to osteoarthritis of the hip: sibling study. BMJ 321, 1179-1183 (2000).
    • (2000) BMJ , vol.321 , pp. 1179-1183
    • Lanyon, P.1    Muir, K.2    Doherty, S.3    Doherty, M.4
  • 17
    • 4344697342 scopus 로고    scopus 로고
    • Genetic risk of knee osteoarthritis, a sibling study
    • Neame, R. L., Muir, K., Doherty, S. & Doherty, M. Genetic risk of knee osteoarthritis, a sibling study. Ann. Rheum. Dis. 63, 1022-1027 (2004).
    • (2004) Ann. Rheum. Dis. , vol.63 , pp. 1022-1027
    • Neame, R.L.1    Muir, K.2    Doherty, S.3    Doherty, M.4
  • 18
    • 0030786608 scopus 로고    scopus 로고
    • Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis
    • Chitnavis, J. et al. Genetic influences in end-stage osteoarthritis. Sibling risks of hip and knee replacement for idiopathic osteoarthritis. J. Bone Joint Surg. Br. 79, 660-664 (1997).
    • (1997) J. Bone Joint Surg. Br. , vol.79 , pp. 660-664
    • Chitnavis, J.1
  • 19
    • 35848934474 scopus 로고    scopus 로고
    • Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families
    • Bukulmez, H. et al. Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families. Arthritis Res. Ther. 8, R25 (2006).
    • (2006) Arthritis Res. Ther. , vol.8
    • Bukulmez, H.1
  • 20
    • 34548213205 scopus 로고    scopus 로고
    • Genetic influences in the aetiology of anteromedial osteoarthritis of the knee
    • McDonnell, S. M., Sinsheimer, J., Price, A. J. & Carr, A. J. Genetic influences in the aetiology of anteromedial osteoarthritis of the knee. J. Bone Joint Surg. Br. 89, 901-903 (2007).
    • (2007) J. Bone Joint Surg. Br. , vol.89 , pp. 901-903
    • McDonnell, S.M.1    Sinsheimer, J.2    Price, A.J.3    Carr, A.J.4
  • 21
    • 33748685243 scopus 로고    scopus 로고
    • Osteoarthritis susceptibility loci defined by genome scan meta-analysis
    • Lee, Y. H., Rho, Y. H., Choi, S. J., Ji, J. D. & Song, G. G. Osteoarthritis susceptibility loci defined by genome scan meta-analysis. Rheumatol. Int. 26, 996-1000 (2006).
    • (2006) Rheumatol. Int. , vol.26 , pp. 996-1000
    • Lee, Y.H.1    Rho, Y.H.2    Choi, S.J.3    Ji, J.D.4    Song, G.G.5
  • 22
    • 44849113821 scopus 로고    scopus 로고
    • Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis
    • Meulenbelt, I. et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum. Mol. Genet. 17, 1867-1875 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 1867-1875
    • Meulenbelt, I.1
  • 24
    • 77951237955 scopus 로고    scopus 로고
    • Genetics in neuroendocrine immunology: Implications for rheumatoid arthritis and osteoarthritis
    • Stark, K., Straub, R. H., Blazicková, S., Hengstenberg, C. & Rovenský, J. Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis. Ann. NY Acad. Sci. 1193, 10-14 (2010).
    • Ann. NY Acad. Sci. , vol.1193 , pp. 10-14
    • Stark, K.1    Straub, R.H.2    Blazicková, S.3    Hengstenberg, C.4    Rovenský, J.5
  • 25
    • 64349091037 scopus 로고    scopus 로고
    • SNP imputation in association studies
    • Halperin, E. & Stephan, D. A. SNP imputation in association studies. Nat. Biotechnol. 27, 349-351 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 349-351
    • Halperin, E.1    Stephan, D.A.2
  • 26
    • 60549083544 scopus 로고    scopus 로고
    • An open access database of genome-wide association results
    • Johnson, A. D. & ODonnell, C. J. An open access database of genome-wide association results. BMC Med. Genet. 10, 6 (2009).
    • (2009) BMC Med. Genet. , vol.10 , pp. 6
    • Johnson, A.D.1    Odonnell, C.J.2
  • 27
    • 77951702343 scopus 로고    scopus 로고
    • Genetic heterogeneity in human disease
    • McClellan, J. & King, M. C. Genetic heterogeneity in human disease. Cell 141, 210-217 (2010).
    • (2010) Cell , vol.141 , pp. 210-217
    • McClellan, J.1    King, M.C.2
  • 30
    • 59949097546 scopus 로고    scopus 로고
    • HuGE Navigator [online]
    • HuGE literature finder. HuGE Navigator [online], http://hugenavigator. net/HuGENavigator/ startPagePubLit.do (2010)
    • (2010) HuGE Literature Finder
  • 31
    • 51449114435 scopus 로고    scopus 로고
    • Calibration of credibility of agnostic genome-wide associations
    • Ioannidis, J. P. Calibration of credibility of agnostic genome-wide associations. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B, 964-972 (2008).
    • (2008) Am. J. Med. Genet. B Neuropsychiatr. Genet. , vol.147 B , pp. 964-972
    • Ioannidis, J.P.1
  • 32
    • 42949118331 scopus 로고    scopus 로고
    • Joint homeostasis, restoration, and remodeling in osteoarthritis
    • Lories, R. J. Joint homeostasis, restoration, and remodeling in osteoarthritis. Best Pract. Res. Clin. Rheumatol. 22, 209-220 (2008).
    • (2008) Best Pract. Res. Clin. Rheumatol. , vol.22 , pp. 209-220
    • Lories, R.J.1
  • 33
    • 0032905901 scopus 로고    scopus 로고
    • Mechanisms of GDF-5 action during skeletal development
    • Francis-West, P. H. et al. Mechanisms of GDF-5 action during skeletal development. Development 126, 1305-1315 (1999).
    • (1999) Development , vol.126 , pp. 1305-1315
    • Francis-West, P.H.1
  • 34
    • 34047103363 scopus 로고    scopus 로고
    • A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis
    • Miyamoto, Y. et al. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat. Genet. 39, 529-533 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 529-533
    • Miyamoto, Y.1
  • 35
    • 67650074525 scopus 로고    scopus 로고
    • Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism
    • Egli, R. J. et al. Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. Arthritis Rheum. 60, 2055-2064 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 2055-2064
    • Egli, R.J.1
  • 36
    • 72249115093 scopus 로고    scopus 로고
    • Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations
    • Valdes, A. M. et al. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann. Rheum. Dis. 68, 1916-1920 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1916-1920
    • Valdes, A.M.1
  • 37
    • 66449089103 scopus 로고    scopus 로고
    • Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand
    • Evangelou, E. et al. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum. 60, 1710-1721 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 1710-1721
    • Evangelou, E.1
  • 38
    • 43049122786 scopus 로고    scopus 로고
    • A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5′ UTR of GDF5 with osteoarthritis susceptibility
    • Chapman, K. et al. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5′ UTR of GDF5 with osteoarthritis susceptibility. Hum. Mol. Genet. 17, 1497-1504 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 1497-1504
    • Chapman, K.1
  • 39
    • 70449729925 scopus 로고    scopus 로고
    • Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: The Rotterdam study
    • Vaes, R. B. et al. Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study. Ann. Rheum. Dis. 68, 1754-1760 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1754-1760
    • Vaes, R.B.1
  • 40
    • 78650988509 scopus 로고    scopus 로고
    • The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance
    • doi:10.1136/ard.2010.134155
    • Valdes, A. M. et al. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann. Rheum. Dis. doi:10.1136/ ard.2010.134155.
    • Ann. Rheum. Dis.
    • Valdes, A.M.1
  • 41
    • 44949190537 scopus 로고    scopus 로고
    • Lessons from animal models of osteoarthritis
    • van den Berg, W. B. Lessons from animal models of osteoarthritis. Curr. Rheumatol. Rep. 10, 26-29 (2008).
    • (2008) Curr. Rheumatol. Rep. , vol.10 , pp. 26-29
    • Van Den Berg, W.B.1
  • 42
    • 13944259791 scopus 로고    scopus 로고
    • An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis
    • Kizawa, H. et al. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat. Genet. 37, 138-144 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 138-144
    • Kizawa, H.1
  • 43
    • 33751300226 scopus 로고    scopus 로고
    • Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese
    • Jiang, Q. et al. Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese. J. Hum. Genet. 51, 1068-1072 (2006).
    • (2006) J. Hum. Genet. , vol.51 , pp. 1068-1072
    • Jiang, Q.1
  • 44
    • 34547093391 scopus 로고    scopus 로고
    • Association of the aspartic acidrepeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population
    • Shi, D. et al. Association of the aspartic acidrepeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population. J. Hum. Genet. 52, 664-667 (2007).
    • (2007) J. Hum. Genet. , vol.52 , pp. 664-667
    • Shi, D.1
  • 45
    • 42749087329 scopus 로고    scopus 로고
    • Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population
    • Song, J. H. et al. Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population. Knee 15, 191-195 (2008).
    • (2008) Knee , vol.15 , pp. 191-195
    • Song, J.H.1
  • 46
    • 50949126590 scopus 로고    scopus 로고
    • Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians
    • Atif, U. et al. Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. Osteoarthritis Cartilage 16, 1174-1177 (2008).
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1174-1177
    • Atif, U.1
  • 47
    • 34547790324 scopus 로고    scopus 로고
    • Meta-analysis of association between the ASPN D-repeat and osteoarthritis
    • Nakamura, T. et al. Meta-analysis of association between the ASPN D-repeat and osteoarthritis. Hum. Mol. Genet. 16, 1676-1681 (2007).
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 1676-1681
    • Nakamura, T.1
  • 48
    • 0035795409 scopus 로고    scopus 로고
    • TGF-α/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • Yang, X. et al. TGF-α/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J. Cell Biol. 153, 35-46 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 35-46
    • Yang, X.1
  • 49
    • 77955365705 scopus 로고    scopus 로고
    • Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis
    • Valdes, A. M. et al. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum. 62, 2347-2352 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 2347-2352
    • Valdes, A.M.1
  • 50
    • 29644432280 scopus 로고    scopus 로고
    • Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation
    • Li, T. F. et al. Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J. Bone Miner. Res. 21, 4-16 (2006).
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 4-16
    • Li, T.F.1
  • 51
    • 59649110626 scopus 로고    scopus 로고
    • TSH-based protocol, tablet instability, and absorption effects on L-T4 bioequivalence
    • Eisenberg, M. & Distefano, J. J. TSH-based protocol, tablet instability, and absorption effects on L-T4 bioequivalence. Thyroid 19, 103-110 (2009).
    • (2009) Thyroid , vol.19 , pp. 103-110
    • Eisenberg, M.1    Distefano, J.J.2
  • 52
    • 78650667173 scopus 로고    scopus 로고
    • Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility
    • doi:10.1136/ard.2010.133660
    • Meulenbelt, I. et al. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. Ann. Rheum. Dis. doi:10.1136/ard.2010.133660.
    • Ann. Rheum. Dis.
    • Meulenbelt, I.1
  • 53
    • 27744597628 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase and oxidant damage in osteoarthritis
    • Regan, E. et al. Extracellular superoxide dismutase and oxidant damage in osteoarthritis. Arthritis Rheum. 52, 3479-3491 (2005).
    • (2005) Arthritis Rheum. , vol.52 , pp. 3479-3491
    • Regan, E.1
  • 54
    • 33847194975 scopus 로고    scopus 로고
    • Cell death and apoptosis in osteoarthritic cartilage
    • Kim, H. A. & Blanco, F. J. Cell death and apoptosis in osteoarthritic cartilage. Curr. Drug Targets 8, 333-345 (2007).
    • (2007) Curr. Drug Targets , vol.8 , pp. 333-345
    • Kim, H.A.1    Blanco, F.J.2
  • 55
    • 67650065023 scopus 로고    scopus 로고
    • Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women
    • Valdes, A. M. et al. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. Arthritis Rheum. 60, 2046-2054 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 2046-2054
    • Valdes, A.M.1
  • 56
    • 73449139779 scopus 로고    scopus 로고
    • The role of European mtDNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain
    • Rego, I. et al. The role of European mtDNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain. Ann. Rheum. Dis. 69, 210-213 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 210-213
    • Rego, I.1
  • 58
    • 77954411692 scopus 로고    scopus 로고
    • A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population
    • Gálvez-Rosas, A. et al. A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. Rheumatol. Int. 30, 1035-1039 (2010)
    • (2010) Rheumatol. Int. , vol.30 , pp. 1035-1039
    • Gálvez-Rosas, A.1
  • 59
    • 77957263965 scopus 로고    scopus 로고
    • Large-scale gene expression in bone marrow mesenchymal stem cells: A putative role for COL10A1 in osteoarthritis
    • Lamas, J. R. et al. Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis. Ann. Rheum. Dis. 69, 1880-1885 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1880-1885
    • Lamas, J.R.1
  • 60
    • 69949143486 scopus 로고    scopus 로고
    • The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5′ part of the split COL6A4 gene
    • Wagener, R., Gara, S. K., Kobbe, B., Paulsson, M. & Zaucke, F. The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5′ part of the split COL6A4 gene. Matrix Biol. 28, 307-310 (2009).
    • (2009) Matrix Biol. , vol.28 , pp. 307-310
    • Wagener, R.1    Gara, S.K.2    Kobbe, B.3    Paulsson, M.4    Zaucke, F.5
  • 61
    • 48349105759 scopus 로고    scopus 로고
    • Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis
    • Miyamoto, Y. et al. Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nat. Genet. 40, 994-998 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 994-998
    • Miyamoto, Y.1
  • 62
    • 64549151355 scopus 로고    scopus 로고
    • Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations
    • Meulenbelt, I. et al. Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations. Hum. Mol. Genet. 18, 1518-1523 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1518-1523
    • Meulenbelt, I.1
  • 63
    • 66149180583 scopus 로고    scopus 로고
    • Developments in the scientific understanding of osteoarthritis
    • Abramson, S. B. & Attur, M. Developments in the scientific understanding of osteoarthritis. Arthritis Res. Ther. 11, 227 (2009).
    • (2009) Arthritis Res. Ther. , vol.11 , pp. 227
    • Abramson, S.B.1    Attur, M.2
  • 64
    • 57049092882 scopus 로고    scopus 로고
    • The contribution of genes to osteoarthritis
    • Valdes, A. M. & Spector, T. D. The contribution of genes to osteoarthritis. Med. Clin. North Am. 93, 45-66 (2009).
    • (2009) Med. Clin. North Am. , vol.93 , pp. 45-66
    • Valdes, A.M.1    Spector, T.D.2
  • 65
    • 77952551250 scopus 로고    scopus 로고
    • A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis
    • Valdes, A. M. et al. A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. Osteoarthritis Cartilage 18, 699-704 (2010).
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 699-704
    • Valdes, A.M.1
  • 66
    • 77951590246 scopus 로고    scopus 로고
    • Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
    • Attur, M. et al. Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. Ann. Rheum. Dis. 69, 856-861 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 856-861
    • Attur, M.1
  • 67
    • 35148849760 scopus 로고    scopus 로고
    • Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients
    • Sezgin, M. et al. Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients. Clin. Invest. Med. 30, E86-E92 (2007).
    • (2007) Clin. Invest. Med. , vol.30
    • Sezgin, M.1
  • 68
    • 41849104564 scopus 로고    scopus 로고
    • Interleukin-1beta gene polymorphism associated with radiographic signs of osteoarthritis of the knee
    • Kanoh, T. et al. Interleukin-1beta gene polymorphism associated with radiographic signs of osteoarthritis of the knee. J. Orthop. Sci. 13, 97-100 (2008).
    • (2008) J. Orthop. Sci. , vol.13 , pp. 97-100
    • Kanoh, T.1
  • 69
    • 69049113951 scopus 로고    scopus 로고
    • Genetic polymorphisms of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86-bpVNTR) in susceptibility to knee osteoarthritis in a Chinese Han population
    • Ni, H. et al. Genetic polymorphisms of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86-bpVNTR) in susceptibility to knee osteoarthritis in a Chinese Han population. Rheumatol. Int. 29, 1301-1305 (2009).
    • (2009) Rheumatol. Int. , vol.29 , pp. 1301-1305
    • Ni, H.1
  • 70
    • 44449153906 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    • Valdes, A. M. et al. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am. J. Hum. Genet. 82, 1231-1240 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 1231-1240
    • Valdes, A.M.1
  • 71
    • 78650968063 scopus 로고    scopus 로고
    • The (-765 G-> C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis
    • doi:10.1136/ard.2009.124040
    • Schneider, E. M. et al. The (-765 G->C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis. Ann. Rheum. Dis. doi:10.1136/ard.2009.124040.
    • Ann. Rheum. Dis.
    • Schneider, E.M.1
  • 72
    • 78149408549 scopus 로고    scopus 로고
    • New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study
    • Nakajima, M. et al. New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. PLoS ONE 5, e9723 (2010).
    • (2010) PLoS ONE , vol.5
    • Nakajima, M.1
  • 73
    • 33847059993 scopus 로고    scopus 로고
    • The role of T cells in the pathogenesis of osteoarthritis
    • Sakkas, L. I. & Platsoucas, C. D. The role of T cells in the pathogenesis of osteoarthritis. Arthritis Rheum. 56, 409-424 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 409-424
    • Sakkas, L.I.1    Platsoucas, C.D.2
  • 74
    • 78149489455 scopus 로고    scopus 로고
    • Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index
    • doi:10.1136/ard.2009.125260
    • Kerkhof, H. J. et al. Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann. Rheum. Dis. doi:10.1136/ard.2009.125260.
    • Ann. Rheum. Dis.
    • Kerkhof, H.J.1
  • 75
    • 57249115817 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha -308G/A gene polymorphism: Lack of association with knee osteoarthritis in a Turkish population
    • Sezgin, M. et al. Tumour necrosis factor alpha -308G/A gene polymorphism: lack of association with knee osteoarthritis in a Turkish population. Clin. Exp. Rheumatol. 26, 763-768 (2008).
    • (2008) Clin. Exp. Rheumatol. , vol.26 , pp. 763-768
    • Sezgin, M.1
  • 76
    • 0033864484 scopus 로고    scopus 로고
    • Dual roles of Wnt signaling during chondrogenesis in the chicken limb
    • Hartmann, C. & Tabin, C. J. Dual roles of Wnt signaling during chondrogenesis in the chicken limb. Development 127, 3141-3159 (2000).
    • (2000) Development , vol.127 , pp. 3141-3159
    • Hartmann, C.1    Tabin, C.J.2
  • 77
    • 53849125461 scopus 로고    scopus 로고
    • Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis
    • Corr, M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat. Clin. Pract. Rheumatol. 4, 550-556 (2008).
    • (2008) Nat. Clin. Pract. Rheumatol. , vol.4 , pp. 550-556
    • Corr, M.1
  • 78
    • 20944450269 scopus 로고    scopus 로고
    • Haplotypes of the lowdensity lipoprotein receptor-related protein 5 (LRP5) gene: Are they a risk factor in osteoarthritis?
    • Smith, A. J. et al. Haplotypes of the lowdensity lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis? Osteoarthritis Cartilage 13, 608-613 (2005).
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 608-613
    • Smith, A.J.1
  • 79
    • 48349084103 scopus 로고    scopus 로고
    • Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts
    • Kerkhof, J. M. et al. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis Cartilage 16, 1141-1149 (2008).
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1141-1149
    • Kerkhof, J.M.1
  • 80
    • 33646372430 scopus 로고    scopus 로고
    • Frizzled-related protein variants are risk factors for hip osteoarthritis
    • Lane, N. E. et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum. 54, 1246-1254 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 1246-1254
    • Lane, N.E.1
  • 81
    • 33846236311 scopus 로고    scopus 로고
    • Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee
    • Valdes, A. M. et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum. 56, 137-146 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 137-146
    • Valdes, A.M.1
  • 82
    • 0348111255 scopus 로고    scopus 로고
    • The usual suspects: Verdict not guilty?
    • Tortorella, M. D. & Malfait, A. M. The usual suspects: verdict not guilty? Arthritis Rheum. 48, 3304-3307 (2003).
    • (2003) Arthritis Rheum. , vol.48 , pp. 3304-3307
    • Tortorella, M.D.1    Malfait, A.M.2
  • 83
    • 15844384854 scopus 로고    scopus 로고
    • ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    • Stanton, H. et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434, 648-652 (2005).
    • (2005) Nature , vol.434 , pp. 648-652
    • Stanton, H.1
  • 84
    • 39749178970 scopus 로고    scopus 로고
    • Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis
    • Rodriguez-Lopez, J. et al. Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis. Arthritis Rheum. 58, 435-441 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 435-441
    • Rodriguez-Lopez, J.1
  • 85
    • 60249087668 scopus 로고    scopus 로고
    • Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes
    • Rodriguez-Lopez, J. et al. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis Cartilage 17, 321-327 (2009).
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 321-327
    • Rodriguez-Lopez, J.1
  • 86
    • 59449104607 scopus 로고    scopus 로고
    • Association of (-1, 607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms)
    • Barlas, I. O. et al. Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms). Rheumatol. Int. 29, 383-388 (2009).
    • (2009) Rheumatol. Int. , Issue.29 , pp. 383-388
    • Barlas, I.O.1
  • 87
    • 67650407473 scopus 로고    scopus 로고
    • Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort
    • Kerna, I. et al. Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. Osteoarthritis Cartilage 17, 1093-1098 (2009).
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1093-1098
    • Kerna, I.1
  • 88
    • 32444433647 scopus 로고    scopus 로고
    • Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women
    • Valdes, A. M. et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum. 54, 533-539 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 533-539
    • Valdes, A.M.1
  • 89
    • 17044364069 scopus 로고    scopus 로고
    • Estrogen receptor-alpha gene haplotype is associated with primary knee osteoarthritis in Korean population
    • Jin, S. Y. et al. Estrogen receptor-alpha gene haplotype is associated with primary knee osteoarthritis in Korean population. Arthritis Res. Ther. 6, R415-R421 (2004).
    • (2004) Arthritis Res. Ther. , vol.6
    • Jin, S.Y.1
  • 91
    • 34547676850 scopus 로고    scopus 로고
    • Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women
    • Lian, K. et al. Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women. Osteoarthritis Cartilage 15, 972-978 (2007).
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 972-978
    • Lian, K.1
  • 92
    • 67349122665 scopus 로고    scopus 로고
    • Attempt to replicate published genetic associations in a large, welldefined osteoarthritis case-control population (the GOAL study)
    • Limer, K. L. et al. Attempt to replicate published genetic associations in a large, welldefined osteoarthritis case-control population (the GOAL study). Osteoarthritis Cartilage 17, 782-789 (2009).
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 782-789
    • Limer, K.L.1
  • 93
    • 44849087738 scopus 로고    scopus 로고
    • A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese
    • Mototani, H. et al. A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Hum. Mol. Genet. 17, 1790-1797 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 1790-1797
    • Mototani, H.1
  • 94
    • 67449128720 scopus 로고    scopus 로고
    • Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections
    • Dieguez-Gonzalez, R. et al. Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections. Ann. Rheum. Dis. 68, 1017-1021 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1017-1021
    • Dieguez-Gonzalez, R.1
  • 95
    • 55449101697 scopus 로고    scopus 로고
    • Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population
    • Tsezou, A. et al. Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population. J. Orthop. Res. 26, 1466-1470 (2008).
    • (2008) J. Orthop. Res. , vol.26 , pp. 1466-1470
    • Tsezou, A.1
  • 97
    • 78650977422 scopus 로고    scopus 로고
    • Genetic polymorphism of PITX1 in susceptibility to knee osteoarthritis in a Chinese Han population: A case-control study
    • doi:10.1007/s00296-009-1341-5
    • Fan, J. et al. Genetic polymorphism of PITX1 in susceptibility to knee osteoarthritis in a Chinese Han population: a case-control study. Rheumatol. Int. doi:10.1007/s00296-009- 1341-5.
    • Rheumatol. Int.
    • Fan, J.1
  • 98
    • 20244378239 scopus 로고    scopus 로고
    • A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese
    • Mototani, H. et al. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum. Mol. Genet. 14, 1009-1017 (2005).
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 1009-1017
    • Mototani, H.1
  • 99
    • 45549102864 scopus 로고    scopus 로고
    • Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin
    • Poulou, M. et al. Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin. Genet. Test. 12, 263-265 (2008).
    • (2008) Genet. Test. , vol.12 , pp. 263-265
    • Poulou, M.1
  • 100
    • 55349091075 scopus 로고    scopus 로고
    • Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population
    • Shi, D. et al. Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population. BMC Med. Genet. 9, 91 (2008).
    • (2008) BMC Med. Genet. , vol.9 , pp. 91
    • Shi, D.1
  • 101
    • 77956929106 scopus 로고    scopus 로고
    • Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population
    • Mototani, H., Iida, A., Nakamura, Y. & Ikegawa, S. Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population. J. Bone Miner. Metab. 28, 547-553 (2010).
    • (2010) J. Bone Miner. Metab. , vol.28 , pp. 547-553
    • Mototani, H.1    Iida, A.2    Nakamura, Y.3    Ikegawa, S.4
  • 102
    • 0037927980 scopus 로고    scopus 로고
    • Angiotensin converting enzyme gene polymorphism in Korean patients with primary knee osteoarthritis
    • Hong, S. J. et al. Angiotensin converting enzyme gene polymorphism in Korean patients with primary knee osteoarthritis. Exp. Mol. Med. 35, 189-195 (2003).
    • (2003) Exp. Mol. Med. , vol.35 , pp. 189-195
    • Hong, S.J.1
  • 103
    • 79951577923 scopus 로고    scopus 로고
    • DD genotype of ace gene I/D polymorphism is associated in a Turkish study population with osteoarthritis
    • doi:10.1007/s11033-010-0284-y
    • Bayram, B. et al. DD genotype of ace gene I/D polymorphism is associated in a Turkish study population with osteoarthritis. Mol. Biol. Rep. doi:10.1007/s11033-010-0284-y.
    • Mol. Biol. Rep.
    • Bayram, B.1
  • 104
    • 43349083503 scopus 로고    scopus 로고
    • Prevalence of angiotensinconverting enzyme gene insertion-deletion polymorphism in patients with primary knee osteoarthritis
    • Shehab, D. K. et al. Prevalence of angiotensinconverting enzyme gene insertion-deletion polymorphism in patients with primary knee osteoarthritis. Clin. Exp. Rheumatol. 26, 305-310 (2008).
    • (2008) Clin. Exp. Rheumatol. , vol.26 , pp. 305-310
    • Shehab, D.K.1
  • 105
    • 36549027898 scopus 로고    scopus 로고
    • Calcitonin affects both bone and cartilage: A dual action treatment for osteoarthritis?
    • Karsdal, M. A. et al. Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis? Ann. NY Acad. Sci. 1117, 181-195 (2007).
    • (2007) Ann. NY Acad. Sci. , vol.1117 , pp. 181-195
    • Karsdal, M.A.1
  • 106
    • 75149135554 scopus 로고    scopus 로고
    • Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population
    • Magaña, J. J. et al. Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population. Knee 17, 157-160 (2010).
    • (2010) Knee , vol.17 , pp. 157-160
    • Magaña, J.J.1
  • 107
    • 77955176134 scopus 로고    scopus 로고
    • Getting to the heart of the matter: Osteoarthritis takes its place as part of the metabolic syndrome
    • Katz, J. D., Agrawal, S. & Velasquez, M. Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome. Curr. Opin. Rheumatol. 22, 512-519 (2010)
    • (2010) Curr. Opin. Rheumatol. , vol.22 , pp. 512-519
    • Katz, J.D.1    Agrawal, S.2    Velasquez, M.3
  • 108
    • 77955176027 scopus 로고    scopus 로고
    • Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
    • Mutabaruka, M. S., Aoulad Aissa, M., Delalandre, A., Lavigne, M. & Lajeunesse, D. Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. Arthritis Res. Ther. 12, R20 (2010).
    • (2010) Arthritis Res. Ther. , vol.12
    • Mutabaruka, M.S.1    Aoulad Aissa, M.2    Delalandre, A.3    Lavigne, M.4    Lajeunesse, D.5
  • 109
    • 78049293809 scopus 로고    scopus 로고
    • Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: A case-control study
    • doi:10.1038/jhg.2010.86
    • Qin, J. et al. Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: a case-control study. J. Hum. Genet. doi:10.1038/jhg.2010.86.
    • J. Hum. Genet.
    • Qin, J.1
  • 110
    • 53149094308 scopus 로고    scopus 로고
    • Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: Lack of association with VEGF -460 T/C and +405 C/G polymorphisms
    • Sánchez-Enrquez, S. et al. Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF -460 T/C and +405 C/G polymorphisms. Rheumatol. Int. 29, 63-68 (2008)
    • (2008) Rheumatol. Int. , vol.29 , pp. 63-68
    • Sánchez-Enrquez, S.1
  • 111
    • 44449135139 scopus 로고    scopus 로고
    • Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: Two case-control studies in East Asian populations and a metaanalysis
    • Shi, D. et al. Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a metaanalysis. Arthritis Res. Ther. 10, R54 (2008).
    • (2008) Arthritis Res. Ther. , vol.10
    • Shi, D.1
  • 112
    • 38549178090 scopus 로고    scopus 로고
    • Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility
    • Jiang, Q. et al. Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility. J. Hum. Genet. 53, 42-47 (2008).
    • (2008) J. Hum. Genet. , vol.53 , pp. 42-47
    • Jiang, Q.1
  • 113
    • 78751703383 scopus 로고    scopus 로고
    • Meta-analysis of genomewide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
    • in press
    • Evangelou, E. et al. Meta-analysis of genomewide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann. Rheum. Dis. (in press).
    • Ann. Rheum. Dis.
    • Evangelou, E.1
  • 114
    • 77952557918 scopus 로고    scopus 로고
    • Missing heritability and strategies for finding the underlying causes of complex disease
    • Eichler, E. E. et al. Missing heritability and strategies for finding the underlying causes of complex disease. Nat. Rev. Genet. 11, 446-450 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 446-450
    • Eichler, E.E.1
  • 115
    • 37749024290 scopus 로고    scopus 로고
    • The additive effect of individual genes in predicting risk of knee osteoarthritis
    • Valdes, A. M., Doherty, M. & Spector, T. D. The additive effect of individual genes in predicting risk of knee osteoarthritis. Ann. Rheum. Dis. 67, 124-127 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 124-127
    • Valdes, A.M.1    Doherty, M.2    Spector, T.D.3
  • 116
    • 77957728949 scopus 로고    scopus 로고
    • Prediction model for knee osteoarthritis based on genetic and clinical information
    • Takahashi, H. et al. Prediction model for knee osteoarthritis based on genetic and clinical information. Arthritis Res. Ther. 12, R187 (2010).
    • (2010) Arthritis Res. Ther. , vol.12
    • Takahashi, H.1


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