Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis

Molecular Medicine

Volumn 18, Issue 3, 2012, Pages 346-358

  Weimer, Anja ^a   Madry, Henning ^a   Venkatesan, Jagadeesh K ^a   Schmitt, Gertrud ^a   Frisch, Janina ^a   Wezel, Anna ^a   Jung, Jochen ^a   Kohn, Dieter ^a   Terwilliger, Ernest F ^b   Trippel, Stephen B ^c   Cucchiarini, Magali ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARVOVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C RECEPTOR;

AGED; ARTICLE; ARTICULAR CARTILAGE; BONE REMODELING; CARTILAGE CELL; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LONG TERM CARE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TOTAL KNEE REPLACEMENT; TREATMENT RESPONSE;

AGED; CARTILAGE; CELL PROLIFERATION; CHONDROCYTES; DEPENDOVIRUS; GENETIC VECTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOARTHRITIS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTOR, IGF TYPE 1; RECOMBINATION, GENETIC;

EID: 84860467045     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00371     Document Type: Article

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