The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

Nature

Volumn 489, Issue 7417, 2012, Pages 576-580

  Chen, Xuefeng ^a   Cui, Dandan ^a   Papusha, Alma ^a   Zhang, Xiaotian ^a   Chu, Chia Dwo ^a   Tang, Jiangwu ^a,b   Chen, Kaifu ^a   Pan, Xuewen ^a   Ira, Grzegorz ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b INSTITUTE OF PLANT PROTECTION AND MICROBIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ENZYME; FUN30; HELICASE; HISTONE H3; PROTEIN RAD9; UNCLASSIFIED DRUG;

CHROMOSOME; CYTOLOGY; DNA; ENZYME ACTIVITY; GENETICS; INHIBITION; METHYLATION; PHYSIOLOGY; PROTEIN; SUBSTRATE; YEAST;

ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; HISTONE METHYLATION; NONHUMAN; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

CELL CYCLE PROTEINS; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA, FUNGAL; EXODEOXYRIBONUCLEASES; GENES, FUNGAL; GENOME, FUNGAL; HISTONES; HOMOLOGOUS RECOMBINATION; METHYLATION; NUCLEOSOMES; RECQ HELICASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

EID: 84866954195     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11355     Document Type: Article

References (34)

1. Gravel, S., Chapman, J. R., Magill, C. & Jackson, S. P. DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev. 22, 2767-2772 (2008).
2. Mimitou, E. P. & Symington, L. S. Sae2, Exo1 and Sgs1 collaboratein DNA double-strand break processing. Nature 455, 770-774 (2008).
3. Zhu, Z., Chung, W. H., Shim, E. Y., Lee, S. E. & Ira, G. Sgs1 helicase and two nucleases dna2 and exo1 resect DNA double-strand break ends. Cell 134, 981-994 (2008).
4. Cejka, P. et al. DNA end resectionbyDna2-Sgs1-RPAand its stimulationbyTop3-Rmi1 and Mre11-Rad50-Xrs2. Nature 467, 112-116 (2010).
5. Nicolette, M. L. et al. Mre11-Rad50-Xrs2 and Sae2 promote 59 strand resection of DNA double-strand breaks. Nature Struct. Mol. Biol. 17, 1478-1485 (2010).
6. Niu, H. et al. Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature 467, 108-111 (2010).
7. Awad, S., Ryan, D., Prochasson, P., Owen-Hughes, T. & Hassan, A. H. The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J. Biol. Chem. 285, 9477-9484 (2010).
8. Lazzaro, F. et al. Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J. 27, 1502-1512 (2008).
9. Hammet, A., Magill, C., Heierhorst, J. & Jackson, S. P. Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep. 8, 851-857 (2007).
10. Toh, G. W. et al. Histone H2A phosphorylation andH3methylation are required for a novel Rad9 DSB repair function following checkpoint activation. DNA Repair (Amst.) 5, 693-703 (2006).
11. Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-391 (2002).
12. Chung, W. H., Zhu, Z., Papusha, A., Malkova, A. & Ira, G. Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting. PLoS Genet. 6, e1000948 (2010).
13. Prakash, R. et al. Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev. 23, 67-79 (2009).
14. Flaus, A., Martin, D. M., Barton, G. J. & Owen-Hughes, T. Identification of multiple distinct Snf2 subfamilies with conserved structural motifs. Nucleic Acids Res. 34, 2887-2905 (2006).
15. Neves-Costa, A., Will, W. R., Vetter, A. T., Miller, J. R. & Varga-Weisz, P. The SNF2-familymember Fun30promotesgenesilencinginheterochromaticloci. PLoS ONE 4, e8111 (2009).
16. Yu, Q., Zhang, X. & Bi, X. Rolesofchromatin remodeling factorsinthe formation and maintenance of heterochromatin structure. J. Biol. Chem. 286, 14659-14669 (2011).
17. Vaze, M. et al. Recovery from checkpoint-mediated arrest after repair of a double-strand break requires srs2 helicase. Mol. Cell 10, 373-385 (2002).
18. Kalocsay, M., Hiller, N. J. & Jentsch, S. Chromosome-wide Rad51 spreading and SUMO-H2A. Z-dependent chromosome fixation in response to a persistent DNA double-strand break. Mol. Cell 33, 335-343 (2009).
19. Shim, E. Y. et al. RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatin. Mol. Cell. Biol. 27, 1602-1613 (2007).
20. van Attikum, H., Fritsch, O., Hohn, B. & Gasser, S. M. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. Cell 119, 777-788 (2004).
21. Ira, G., Malkova, A., Liberi, G., Foiani, M. & Haber, J. E. Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repairinyeast. Cell 115, 401-411 (2003).
22. Ira, G. et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431, 1011-1017 (2004).
23. Ivanov, E. L., Sugawara, N., White, C. I., Fabre, F. & Haber, J. E. Mutations inXRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol. Cell. Biol. 14, 3414-3425 (1994).
24. Chen, C. C. et al. Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell 134, 231-243 (2008).
25. Alexeev, A., Mazin, A. & Kowalczykowski, S. C. Rad54 protein possesseschromatin-remodeling activity stimulated by the Rad51-ssDNA nucleoprotein filament. Nature Struct. Biol. 10, 182-186 (2003).
26. Lydall, D. & Weinert, T. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270, 1488-1491 (1995).
27. Bothmer, A. et al. Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol. Cell 42, 319-329 (2011).
28. Bunting, S. F. et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141, 243-254 (2010).
29. Okazaki, N. et al. The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS. J. Mol. Biol. 382, 257-265 (2008).
30. Wach, A., Brachat, A., Pohlmann, R. & Philippsen, P. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808 (1994).
31. Chen, X. et al. Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2phosphorylation. Nature Struct. Mol. Biol. 18, 1015-1019 (2011).
32. Sugawara, N., Wang, X. & Haber, J. E. In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination. Mol. Cell 12, 209-219 (2003).
33. Lambert, J. P. et al. Defining the budding yeast chromatin-associated interactome. Mol. Syst. Biol. 6, 448 (2010).
34. Church, G. M. & Gilbert, W. Genomic sequencing. Proc. Natl Acad. Sci. USA 81, 1991-1995 (1984).