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Volumn 6, Issue 8, 2010, Pages

Dynamics of RAD9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 1; HISTONE; PROTEIN DPB11; PROTEIN RAD9; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

EID: 77957368466     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001047     Document Type: Article
Times cited : (57)

References (76)
  • 1
    • 68249091647 scopus 로고    scopus 로고
    • Checkpoint mechanisms at the intersection between DNA damage and repair
    • Amst
    • Lazzaro F, Giannattasio M, Puddu F, Granata M, Pellicioli A, et al. (2009) Checkpoint mechanisms at the intersection between DNA damage and repair. DNA Repair (Amst) 8: 1055-1067.
    • (2009) DNA Repair , vol.8 , pp. 1055-1067
    • Lazzaro, F.1    Giannattasio, M.2    Puddu, F.3    Granata, M.4    Pellicioli, A.5
  • 2
    • 68349095151 scopus 로고    scopus 로고
    • Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
    • Amst
    • Kerzendorfer C, O'Driscoll M (2009) Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency. DNA Repair (Amst) 8: 1139-1152.
    • (2009) DNA Repair , vol.8 , pp. 1139-1152
    • Kerzendorfer, C.1    O'Driscoll, M.2
  • 3
    • 0036531901 scopus 로고    scopus 로고
    • A unified view of the DNA-damage checkpoint
    • Melo J, Toczyski D (2002) A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol 14: 237-245.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 237-245
    • Melo, J.1    Toczyski, D.2
  • 4
    • 33751419716 scopus 로고    scopus 로고
    • Surviving the breakup: The DNA damage checkpoint
    • Harrison JC, Haber JE (2006) Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 40: 209-235.
    • (2006) Annu Rev Genet , vol.40 , pp. 209-235
    • Harrison, J.C.1    Haber, J.E.2
  • 6
    • 0035313706 scopus 로고    scopus 로고
    • DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
    • Durocher D, Jackson SP (2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol 13: 225-231.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 225-231
    • Durocher, D.1    Jackson, S.P.2
  • 7
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti V, Clerici M, Lucchini G, Longhese MP (2000) The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev 14: 2046-2059.
    • (2000) Genes Dev , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 8
    • 0034329474 scopus 로고    scopus 로고
    • LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
    • Rouse J, Jackson SP (2000) LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J 19: 5801-5812.
    • (2000) EMBO J , vol.19 , pp. 5801-5812
    • Rouse, J.1    Jackson, S.P.2
  • 9
    • 0035138557 scopus 로고    scopus 로고
    • Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
    • Wakayama T, Kondo T, Ando S, Matsumoto K, Sugimoto K (2001) Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol 21: 755-764.
    • (2001) Mol Cell Biol , vol.21 , pp. 755-764
    • Wakayama, T.1    Kondo, T.2    Ando, S.3    Matsumoto, K.4    Sugimoto, K.5
  • 10
    • 0034700511 scopus 로고    scopus 로고
    • A role for Saccharomyces cerevisiae histone H2A in DNA repair
    • Downs JA, Lowndes NF, Jackson SP (2000) A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 408: 1001-1004.
    • (2000) Nature , vol.408 , pp. 1001-1004
    • Downs, J.A.1    Lowndes, N.F.2    Jackson, S.P.3
  • 11
    • 0032527776 scopus 로고    scopus 로고
    • Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
    • Paciotti V, Lucchini G, Plevani P, Longhese MP (1998) Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J 17: 4199-4209.
    • (1998) EMBO J , vol.17 , pp. 4199-4209
    • Paciotti, V.1    Lucchini, G.2    Plevani, P.3    Longhese, M.P.4
  • 12
    • 0032133216 scopus 로고    scopus 로고
    • MEC1-dependent phosphorylation of Rad9p in response to DNA damage
    • Emili A (1998) MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Mol Cell 2: 183-189.
    • (1998) Mol Cell , vol.2 , pp. 183-189
    • Emili, A.1
  • 13
    • 0032189952 scopus 로고    scopus 로고
    • The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
    • Vialard JE, Gilbert CS, Green CM, Lowndes NF (1998) The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J 17: 5679-5688.
    • (1998) EMBO J , vol.17 , pp. 5679-5688
    • Vialard, J.E.1    Gilbert, C.S.2    Green, C.M.3    Lowndes, N.F.4
  • 14
    • 0034881760 scopus 로고    scopus 로고
    • Budding yeast Rad9 is an ATPdependent Rad53 activating machine
    • Gilbert CS, Green CM, Lowndes NF (2001) Budding yeast Rad9 is an ATPdependent Rad53 activating machine. Mol Cell 8: 129-136.
    • (2001) Mol Cell , vol.8 , pp. 129-136
    • Gilbert, C.S.1    Green, C.M.2    Lowndes, N.F.3
  • 15
    • 0036281710 scopus 로고    scopus 로고
    • Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint
    • Schwartz MF, Duong JK, Sun Z, Morrow JS, Pradhan D, et al. (2002) Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell 9: 1055-1065.
    • (2002) Mol Cell , vol.9 , pp. 1055-1065
    • Schwartz, M.F.1    Duong, J.K.2    Sun, Z.3    Morrow, J.S.4    Pradhan, D.5
  • 16
    • 23244444605 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation
    • Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, et al. (2005) Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol 15: 1364-1375.
    • (2005) Curr Biol , vol.15 , pp. 1364-1375
    • Sweeney, F.D.1    Yang, F.2    Chi, A.3    Shabanowitz, J.4    Hunt, D.F.5
  • 17
    • 0033570894 scopus 로고    scopus 로고
    • Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
    • Pellicioli A, Lucca C, Liberi G, Marini F, Lopes M, et al. (1999) Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J 18: 6561-6572.
    • (1999) EMBO J , vol.18 , pp. 6561-6572
    • Pellicioli, A.1    Lucca, C.2    Liberi, G.3    Marini, F.4    Lopes, M.5
  • 18
    • 0023712476 scopus 로고
    • The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
    • Weinert TA, Hartwell LH (1988) The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.
    • (1988) Science , vol.241 , pp. 317-322
    • Weinert, T.A.1    Hartwell, L.H.2
  • 19
    • 0025222637 scopus 로고
    • Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage
    • Weinert TA, Hartwell LH (1990) Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage. Mol Cell Biol 10: 6554-6564.
    • (1990) Mol Cell Biol , vol.10 , pp. 6554-6564
    • Weinert, T.A.1    Hartwell, L.H.2
  • 20
    • 0027338038 scopus 로고
    • RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae
    • Siede W, Friedberg AS, Friedberg EC (1993) RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 90: 7985-7989.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7985-7989
    • Siede, W.1    Friedberg, A.S.2    Friedberg, E.C.3
  • 21
    • 0033587049 scopus 로고    scopus 로고
    • The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage
    • Soulier J, Lowndes NF (1999) The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage. Curr Biol 9: 551-554.
    • (1999) Curr Biol , vol.9 , pp. 551-554
    • Soulier, J.1    Lowndes, N.F.2
  • 22
    • 35548970638 scopus 로고    scopus 로고
    • Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast
    • Hammet A, Magill C, Heierhorst J, Jackson SP (2007) Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep 8: 851-857.
    • (2007) EMBO Rep , vol.8 , pp. 851-857
    • Hammet, A.1    Magill, C.2    Heierhorst, J.3    Jackson, S.P.4
  • 23
    • 70450221911 scopus 로고    scopus 로고
    • Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping
    • Nnakwe CC, Altaf M, Cote J, Kron SJ (2009) Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping. DNA Repair (Amst) 8: 1452-1461.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 1452-1461
    • Nnakwe, C.C.1    Altaf, M.2    Cote, J.3    Kron, S.J.4
  • 24
    • 0037328929 scopus 로고    scopus 로고
    • Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage
    • Toh GW-L, Lowndes NF (2003) Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans 31: 242-246.
    • (2003) Biochem Soc Trans , vol.31 , pp. 242-246
    • Toh, G.W.-L.1    Lowndes, N.F.2
  • 25
    • 0032504069 scopus 로고    scopus 로고
    • Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
    • Sun Z, Hsiao J, Fay DS, Stern DF (1998) Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281: 272-274.
    • (1998) Science , vol.281 , pp. 272-274
    • Sun, Z.1    Hsiao, J.2    Fay, D.S.3    Stern, D.F.4
  • 26
    • 0033197541 scopus 로고    scopus 로고
    • The FHA domain is a modular phosphopeptide recognition motif
    • Durocher D, Henckel J, Fersht AR, Jackson SP (1999) The FHA domain is a modular phosphopeptide recognition motif. Mol Cell 4: 387-394.
    • (1999) Mol Cell , vol.4 , pp. 387-394
    • Durocher, D.1    Henckel, J.2    Fersht, A.R.3    Jackson, S.P.4
  • 27
    • 58649097740 scopus 로고    scopus 로고
    • Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization
    • Usui T, Foster SS, Petrini JHJ (2009) Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell 33: 147-159.
    • (2009) Mol Cell , vol.33 , pp. 147-159
    • Usui, T.1    Foster, S.S.2    Petrini, J.H.J.3
  • 28
    • 4644283204 scopus 로고    scopus 로고
    • Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2
    • Du L-L, Moser BA, Russell P (2004) Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2. J Biol Chem 279: 38409-38414.
    • (2004) J Biol Chem , vol.279 , pp. 38409-38414
    • Du, L.-L.1    Moser, B.A.2    Russell, P.3
  • 29
    • 33846015507 scopus 로고    scopus 로고
    • The tandem BRCT domain of 53BP1 is not required for its repair function
    • Ward I, Kim J-E, Minn K, Chini CC, Mer G, et al. (2006) The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem 281: 38472-38477.
    • (2006) J Biol Chem , vol.281 , pp. 38472-38477
    • Ward, I.1    Kim, J.-E.2    Minn, K.3    Chini, C.C.4    Mer, G.5
  • 30
    • 59449094470 scopus 로고    scopus 로고
    • An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks
    • Zgheib O, Pataky K, Brugger J, Halazonetis TD (2009) An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol 29: 1050-1058.
    • (2009) Mol Cell Biol , vol.29 , pp. 1050-1058
    • Zgheib, O.1    Pataky, K.2    Brugger, J.3    Halazonetis, T.D.4
  • 31
    • 48749102974 scopus 로고    scopus 로고
    • Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair
    • Kilkenny ML, Doré AS, Roe SM, Nestoras K, Ho JCY, et al. (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes Dev 22: 2034-2047.
    • (2008) Genes Dev , vol.22 , pp. 2034-2047
    • Kilkenny, M.L.1    Doré, A.S.2    Roe, S.M.3    Nestoras, K.4    Ho, J.C.Y.5
  • 32
    • 65149084552 scopus 로고    scopus 로고
    • Crosstalk between histone modifications during the DNA damage response
    • van Attikum H, Gasser SM (2009) Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol 19: 207-217.
    • (2009) Trends Cell Biol , vol.19 , pp. 207-217
    • van Attikum, H.1    Gasser, S.M.2
  • 33
    • 15444373985 scopus 로고    scopus 로고
    • The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1
    • Giannattasio M, Lazzaro F, Plevani P, Muzi-falconi M (2005) The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem 280: 9879-9886.
    • (2005) J Biol Chem , vol.280 , pp. 9879-9886
    • Giannattasio, M.1    Lazzaro, F.2    Plevani, P.3    Muzi-falconi, M.4
  • 34
    • 9244252580 scopus 로고    scopus 로고
    • Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
    • Huyen Y, Zgheib O, Ditullio RA, Gorgoulis VG, Zacharatos P, et al. (2004) Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432: 406-411.
    • (2004) Nature , vol.432 , pp. 406-411
    • Huyen, Y.1    Zgheib, O.2    Ditullio, R.A.3    Gorgoulis, V.G.4    Zacharatos, P.5
  • 35
    • 33745924670 scopus 로고    scopus 로고
    • Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation
    • Grenon M, Magill CP, Lowndes NF, Jackson SP (2006) Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation. FEMS Yeast Res 6: 836-847.
    • (2006) FEMS Yeast Res , vol.6 , pp. 836-847
    • Grenon, M.1    Magill, C.P.2    Lowndes, N.F.3    Jackson, S.P.4
  • 36
    • 8844248619 scopus 로고    scopus 로고
    • Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage
    • Sanders SL, Portoso M, Mata J, Bähler J, Allshire RC, et al. (2004) Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell 119: 603-614.
    • (2004) Cell , vol.119 , pp. 603-614
    • Sanders, S.L.1    Portoso, M.2    Mata, J.3    Bähler, J.4    Allshire, R.C.5
  • 37
    • 33745137149 scopus 로고    scopus 로고
    • Histone modification-dependent and - independent pathways for recruitment of checkpoint protein Crb2 to doublestrand breaks
    • Du L-L, Nakamura TM, Russell P (2006) Histone modification-dependent and - independent pathways for recruitment of checkpoint protein Crb2 to doublestrand breaks. Genes Dev 20: 1583-1596.
    • (2006) Genes Dev , vol.20 , pp. 1583-1596
    • Du, L.-L.1    Nakamura, T.M.2    Russell, P.3
  • 38
    • 33845666681 scopus 로고    scopus 로고
    • Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
    • Botuyan MV, Lee J, Ward IM, Kim J-E, Thompson JR, et al. (2006) Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127: 1361-1373.
    • (2006) Cell , vol.127 , pp. 1361-1373
    • Botuyan, M.V.1    Lee, J.2    Ward, I.M.3    Kim, J.-E.4    Thompson, J.R.5
  • 39
    • 48749102722 scopus 로고    scopus 로고
    • A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
    • Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, et al. (2008) A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev 22: 2048-2061.
    • (2008) Genes Dev , vol.22 , pp. 2048-2061
    • Schotta, G.1    Sengupta, R.2    Kubicek, S.3    Malin, S.4    Kauer, M.5
  • 40
    • 33748807217 scopus 로고    scopus 로고
    • Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling
    • Javaheri A, Wysocki R, Jobin-Robitaille O, Altaf M, Cote J, et al. (2006) Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proc Natl Acad Sci USA 103: 13771-13776.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13771-13776
    • Javaheri, A.1    Wysocki, R.2    Jobin-Robitaille, O.3    Altaf, M.4    Cote, J.5
  • 41
    • 33646777111 scopus 로고    scopus 로고
    • Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation
    • Amst
    • Toh GW-L, O'shaughnessy AM, Jimeno S, Dobbie IM, Grenon M, et al. (2006) Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation. DNA Repair (Amst) 5: 693-703.
    • (2006) DNA Repair , vol.5 , pp. 693-703
    • Toh, G.W.-L.1    O'Shaughnessy, A.M.2    Jimeno, S.3    Dobbie, I.M.4    Grenon, M.5
  • 42
    • 3042793923 scopus 로고    scopus 로고
    • Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast
    • Nakamura TM, Du L-L, Redon C, Russell P (2004) Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol Cell Biol 24: 6215-6230.
    • (2004) Mol Cell Biol , vol.24 , pp. 6215-6230
    • Nakamura, T.M.1    Du, L.-L.2    Redon, C.3    Russell, P.4
  • 43
    • 0141815630 scopus 로고    scopus 로고
    • Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
    • Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, et al. (2003) Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem 278: 36487-36495.
    • (2003) J Biol Chem , vol.278 , pp. 36487-36495
    • Iwabuchi, K.1    Basu, B.P.2    Kysela, B.3    Kurihara, T.4    Shibata, M.5
  • 44
    • 19444363834 scopus 로고    scopus 로고
    • 53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin
    • Pryde F, Khalili S, Robertson K, Selfridge J, Ritchie A-M, et al. (2005) 53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin. J Cell Sci 118: 2043-2055.
    • (2005) J Cell Sci , vol.118 , pp. 2043-2055
    • Pryde, F.1    Khalili, S.2    Robertson, K.3    Selfridge, J.4    Ritchie, A.-M.5
  • 45
    • 0038143321 scopus 로고    scopus 로고
    • Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
    • Ward IM, Minn K, Jorda KG, Chen J (2003) Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 278: 19579-19582.
    • (2003) J Biol Chem , vol.278 , pp. 19579-19582
    • Ward, I.M.1    Minn, K.2    Jorda, K.G.3    Chen, J.4
  • 46
    • 36249031962 scopus 로고    scopus 로고
    • RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
    • Huen MSY, Grant R, Manke I, Minn K, Yu X, et al. (2007) RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131: 901-914.
    • (2007) Cell , vol.131 , pp. 901-914
    • Huen, M.S.Y.1    Grant, R.2    Manke, I.3    Minn, K.4    Yu, X.5
  • 47
    • 36749084931 scopus 로고    scopus 로고
    • Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
    • Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, et al. (2007) Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318: 1637-1640.
    • (2007) Science , vol.318 , pp. 1637-1640
    • Kolas, N.K.1    Chapman, J.R.2    Nakada, S.3    Ylanko, J.4    Chahwan, R.5
  • 48
    • 36248966246 scopus 로고    scopus 로고
    • RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    • Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, et al. (2007) RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131: 887-900.
    • (2007) Cell , vol.131 , pp. 887-900
    • Mailand, N.1    Bekker-Jensen, S.2    Faustrup, H.3    Melander, F.4    Bartek, J.5
  • 49
    • 2442646547 scopus 로고    scopus 로고
    • Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with Cterminal BRCT domains of Rad4TOPBP1
    • Furuya K, Poitelea M, Guo L, Caspari T, Carr AM (2004) Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with Cterminal BRCT domains of Rad4TOPBP1. Genes Dev 18: 1154-1164.
    • (2004) Genes Dev , vol.18 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 50
    • 47949109008 scopus 로고    scopus 로고
    • Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
    • Puddu F, Granata M, Nola LD, Balestrini A, Piergiovanni G, et al. (2008) Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol 28: 4782-4793.
    • (2008) Mol Cell Biol , vol.28 , pp. 4782-4793
    • Puddu, F.1    Granata, M.2    Nola, L.D.3    Balestrini, A.4    Piergiovanni, G.5
  • 51
    • 33746948393 scopus 로고    scopus 로고
    • Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
    • Liu S, Bekker-Jensen S, Mailand N, Lukas C, Bartek J, et al. (2006) Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Mol Cell Biol 26: 6056-6064.
    • (2006) Mol Cell Biol , vol.26 , pp. 6056-6064
    • Liu, S.1    Bekker-Jensen, S.2    Mailand, N.3    Lukas, C.4    Bartek, J.5
  • 52
    • 0027434814 scopus 로고
    • Biochemical properties of cloned glutathione S-transferases from Schistosoma mansoni and Schistosoma japonicum
    • Walker J, Crowley P, Moreman AD, Barrett J (1993) Biochemical properties of cloned glutathione S-transferases from Schistosoma mansoni and Schistosoma japonicum. Mol Biochem Parasitol 61: 255-264.
    • (1993) Mol Biochem Parasitol , vol.61 , pp. 255-264
    • Walker, J.1    Crowley, P.2    Moreman, A.D.3    Barrett, J.4
  • 53
    • 0030815533 scopus 로고    scopus 로고
    • Ste5 RING-H2 domain: Role in Ste4-promoted oligomerization for yeast pheromone signaling
    • Inouye C, Dhillon N, Thorner J (1997) Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science 278: 103-106.
    • (1997) Science , vol.278 , pp. 103-106
    • Inouye, C.1    Dhillon, N.2    Thorner, J.3
  • 54
    • 13144276290 scopus 로고    scopus 로고
    • Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity
    • Clackson T, Yang W, Rozamus LW, Hatada M, Amara JF, et al. (1998) Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci USA 95: 10437-10442.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10437-10442
    • Clackson, T.1    Yang, W.2    Rozamus, L.W.3    Hatada, M.4    Amara, J.F.5
  • 55
    • 0031438163 scopus 로고    scopus 로고
    • Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
    • Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M (1997) Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev 11: 3387-3400.
    • (1997) Genes Dev , vol.11 , pp. 3387-3400
    • Saka, Y.1    Esashi, F.2    Matsusaka, T.3    Mochida, S.4    Yanagida, M.5
  • 56
    • 0034699382 scopus 로고    scopus 로고
    • A chemical switch for inhibitor-sensitive alleles of any protein kinase
    • Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, et al. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407: 395-401.
    • (2000) Nature , vol.407 , pp. 395-401
    • Bishop, A.C.1    Ubersax, J.A.2    Petsch, D.T.3    Matheos, D.P.4    Gray, N.S.5
  • 57
    • 42949130159 scopus 로고    scopus 로고
    • Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
    • Bonilla CY, Melo JA, Toczyski DP (2008) Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell 30: 267-276.
    • (2008) Mol Cell , vol.30 , pp. 267-276
    • Bonilla, C.Y.1    Melo, J.A.2    Toczyski, D.P.3
  • 58
    • 1242351988 scopus 로고    scopus 로고
    • A domain of Rad9 specifically required for activation of Chk1 in budding yeast
    • Blankley RT, Lydall D (2004) A domain of Rad9 specifically required for activation of Chk1 in budding yeast. J Cell Sci 117: 601-608.
    • (2004) J Cell Sci , vol.117 , pp. 601-608
    • Blankley, R.T.1    Lydall, D.2
  • 59
    • 24944451331 scopus 로고    scopus 로고
    • Dynamic changes in protein-protein interaction and protein phosphorylation probed with amine-reactive isotope tag
    • Smolka MB, Albuquerque CP, Chen SH, Schmidt KH, Wei XX, et al. (2005) Dynamic changes in protein-protein interaction and protein phosphorylation probed with amine-reactive isotope tag. Mol Cell Proteomics 4: 1358-1369.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 1358-1369
    • Smolka, M.B.1    Albuquerque, C.P.2    Chen, S.H.3    Schmidt, K.H.4    Wei, X.X.5
  • 60
    • 33847247383 scopus 로고    scopus 로고
    • Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain
    • Grenon M, Costelloe T, Jimeno S, O'shaughnessy A, Fitzgerald J, et al. (2007) Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain. Yeast 24: 105-119.
    • (2007) Yeast , vol.24 , pp. 105-119
    • Grenon, M.1    Costelloe, T.2    Jimeno, S.3    O'Shaughnessy, A.4    Fitzgerald, J.5
  • 61
    • 24944575222 scopus 로고    scopus 로고
    • Signal transduction: How rad53 kinase is activated
    • Pellicioli A, Foiani M (2005) Signal transduction: how rad53 kinase is activated. Curr Biol 15: R769-R771.
    • (2005) Curr Biol , vol.15
    • Pellicioli, A.1    Foiani, M.2
  • 62
    • 25444466892 scopus 로고    scopus 로고
    • Role of Dot1- dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9
    • Wysocki R, Javaheri A, Allard S, Sha F, Côté J, et al. (2005) Role of Dot1- dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol 25: 8430-8443.
    • (2005) Mol Cell Biol , vol.25 , pp. 8430-8443
    • Wysocki, R.1    Javaheri, A.2    Allard, S.3    Sha, F.4    Côté, J.5
  • 63
    • 7244220162 scopus 로고    scopus 로고
    • DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
    • Ira G, Pellicioli A, Balijja A, Wang X, Fiorani S, et al. (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431: 1011-1017.
    • (2004) Nature , vol.431 , pp. 1011-1017
    • Ira, G.1    Pellicioli, A.2    Balijja, A.3    Wang, X.4    Fiorani, S.5
  • 64
    • 11244269445 scopus 로고    scopus 로고
    • The CDK regulates repair of doublestrand breaks by homologous recombination during the cell cycle
    • Aylon Y, Liefshitz B, Kupiec M (2004) The CDK regulates repair of doublestrand breaks by homologous recombination during the cell cycle. EMBO J 23: 4868-4875.
    • (2004) EMBO J , vol.23 , pp. 4868-4875
    • Aylon, Y.1    Liefshitz, B.2    Kupiec, M.3
  • 65
    • 39549114009 scopus 로고    scopus 로고
    • Differential regulation of the cellular response to DNA double-strand breaks in G1
    • Barlow JH, Lisby M, Rothstein R (2008) Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol Cell 30: 73-85.
    • (2008) Mol Cell , vol.30 , pp. 73-85
    • Barlow, J.H.1    Lisby, M.2    Rothstein, R.3
  • 66
    • 41149094512 scopus 로고    scopus 로고
    • Regulation of DNA repair throughout the cell cycle
    • Branzei D, Foiani M (2008) Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol 9: 297-308.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 297-308
    • Branzei, D.1    Foiani, M.2
  • 67
    • 44349180168 scopus 로고    scopus 로고
    • Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres
    • Lazzaro F, Sapountzi V, Granata M, Pellicioli A, Vaze M, et al. (2008) Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J 27: 1502-1512.
    • (2008) EMBO J , vol.27 , pp. 1502-1512
    • Lazzaro, F.1    Sapountzi, V.2    Granata, M.3    Pellicioli, A.4    Vaze, M.5
  • 68
    • 68249113358 scopus 로고    scopus 로고
    • A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1
    • Navadgi-Patil VM, Burgers PM (2009) A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair (Amst) 8: 996-1003.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 996-1003
    • Navadgi-Patil, V.M.1    Burgers, P.M.2
  • 69
    • 0027437850 scopus 로고
    • Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
    • Gyuris J, Golemis E, Chertkov H, Brent R (1993) Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75: 791-803.
    • (1993) Cell , vol.75 , pp. 791-803
    • Gyuris, J.1    Golemis, E.2    Chertkov, H.3    Brent, R.4
  • 70
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • Longtine MS, McKenzie A, Demarini DJ, Shah NG, Wach A, et al. (1998) Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953-961.
    • (1998) Yeast , vol.14 , pp. 953-961
    • Longtine, M.S.1    McKenzie, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5
  • 71
    • 0034903337 scopus 로고    scopus 로고
    • In vivo site-directed mutagenesis using oligonucleotides
    • Storici F, Lewis LK, Resnick MA (2001) In vivo site-directed mutagenesis using oligonucleotides. Nat Biotechnol 19: 773-776.
    • (2001) Nat Biotechnol , vol.19 , pp. 773-776
    • Storici, F.1    Lewis, L.K.2    Resnick, M.A.3
  • 72
    • 70450285186 scopus 로고    scopus 로고
    • Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis
    • Diani L, Colombelli C, Nachimuthu BT, Donnianni R, Plevani P, et al. (2009) Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis. J Biol Chem 284: 32627-32634.
    • (2009) J Biol Chem , vol.284 , pp. 32627-32634
    • Diani, L.1    Colombelli, C.2    Nachimuthu, B.T.3    Donnianni, R.4    Plevani, P.5
  • 73
    • 0032873415 scopus 로고    scopus 로고
    • Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae
    • Goldstein AL, McCusker JH (1999) Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast 15: 1541-1553.
    • (1999) Yeast , vol.15 , pp. 1541-1553
    • Goldstein, A.L.1    McCusker, J.H.2
  • 74
    • 0029592020 scopus 로고
    • Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in Sphase progression and at a cell cycle checkpoint
    • Araki H, Leem SH, Phongdara A, Sugino A (1995) Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in Sphase progression and at a cell cycle checkpoint. Proc Natl Acad Sci U S A 92: 11791-11795.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11791-11795
    • Araki, H.1    Leem, S.H.2    Phongdara, A.3    Sugino, A.4
  • 75
    • 0027438020 scopus 로고
    • De novo synthesis of budding yeast DNA polymerase alpha and POL1 transcription at the G1/S boundary are not required for entrance into S phase
    • Muzi Falconi M, Piseri A, Ferrari M, Lucchini G, Plevani P, et al. (1993) De novo synthesis of budding yeast DNA polymerase alpha and POL1 transcription at the G1/S boundary are not required for entrance into S phase. Proc Natl Acad Sci U S A 90: 10519-10523.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10519-10523
    • Falconi, M.M.1    Piseri, A.2    Ferrari, M.3    Lucchini, G.4    Plevani, P.5
  • 76
    • 40549112308 scopus 로고    scopus 로고
    • Characterization of the activation domain of the Rad53 checkpoint kinase
    • Fiorani S, Mimun G, Caleca L, Piccini D, Pellicioli A (2008) Characterization of the activation domain of the Rad53 checkpoint kinase. Cell Cycle 7: 493-499.
    • (2008) Cell Cycle , vol.7 , pp. 493-499
    • Fiorani, S.1    Mimun, G.2    Caleca, L.3    Piccini, D.4    Pellicioli, A.5


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