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Volumn 6, Issue 5, 2010, Pages 1-

Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres

Author keywords

[No Author keywords available]

Indexed keywords

EXONUCLEASE; PROTEIN RIF1; PROTEIN RIF2; PROTEIN YKU; RAP1 PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SHELTERIN LIKE PROTEIN; UNCLASSIFIED DRUG;

EID: 77953245442     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000966     Document Type: Article
Times cited : (88)

References (43)
  • 1
    • 38349073475 scopus 로고    scopus 로고
    • DNA damage response at functional and dysfunctional telomeres
    • Longhese MP (2008) DNA damage response at functional and dysfunctional telomeres. Genes Dev 22: 125-140.
    • (2008) Genes Dev , vol.22 , pp. 125-140
    • Longhese, M.P.1
  • 2
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou EP, Symington LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 3
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z, Chung WH, Shim EY, Lee SE, Ira G (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 4
    • 67649653968 scopus 로고    scopus 로고
    • Multiple pathways regulate 39 overhang generation at S. cerevisiae telomeres
    • Bonetti D, Martina M, Clerici M, Lucchini G, Longhese MP (2009) Multiple pathways regulate 39 overhang generation at S. cerevisiae telomeres. Mol Cell 35: 70-81.
    • (2009) Mol Cell , vol.35 , pp. 70-81
    • Bonetti, D.1    Martina, M.2    Clerici, M.3    Lucchini, G.4    Longhese, M.P.5
  • 5
    • 7244220162 scopus 로고    scopus 로고
    • DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
    • Ira G, Pellicioli A, Balijja A, Wang X, Fiorani S, et al. (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431: 1011-1017.
    • (2004) Nature , vol.431 , pp. 1011-1017
    • Ira, G.1    Pellicioli, A.2    Balijja, A.3    Wang, X.4    Fiorani, S.5
  • 6
    • 33750431337 scopus 로고    scopus 로고
    • Regulation of telomere elongation by the cyclin-dependent kinase CDK1
    • Frank CJ, Hyde M, Greider CW (2006) Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol Cell 24: 423-432.
    • (2006) Mol Cell , vol.24 , pp. 423-432
    • Frank, C.J.1    Hyde, M.2    Greider, C.W.3
  • 7
    • 33749059184 scopus 로고    scopus 로고
    • DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase
    • Vodenicharov MD, Wellinger RJ (2006) DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase. Mol Cell 24: 127-137.
    • (2006) Mol Cell , vol.24 , pp. 127-137
    • Vodenicharov, M.D.1    Wellinger, R.J.2
  • 9
    • 46949098616 scopus 로고    scopus 로고
    • Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
    • Zierhut C, Diffley JF (2008) Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J 27: 1875-1885.
    • (2008) EMBO J , vol.27 , pp. 1875-1885
    • Zierhut, C.1    Diffley, J.F.2
  • 10
    • 2942644725 scopus 로고    scopus 로고
    • The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex
    • Larrivée M, LeBel C, Wellinger RJ (2004) The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev 18: 1391-1396.
    • (2004) Genes Dev , vol.18 , pp. 1391-1396
    • Larrivée, M.1    le Bel, C.2    Wellinger, R.J.3
  • 11
    • 27644578165 scopus 로고    scopus 로고
    • A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint
    • Michelson RJ, Rosenstein S, Weinert T (2005) A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint. Genes Dev 19: 2546-2559.
    • (2005) Genes Dev , vol.19 , pp. 2546-2559
    • Michelson, R.J.1    Rosenstein, S.2    Weinert, T.3
  • 12
    • 34250348765 scopus 로고    scopus 로고
    • Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends
    • Hirano Y, Sugimoto K (2007) Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends. Mol Biol Cell 18: 2026-2036.
    • (2007) Mol Biol Cell , vol.18 , pp. 2026-2036
    • Hirano, Y.1    Sugimoto, K.2
  • 13
    • 0032076127 scopus 로고    scopus 로고
    • Yeast Ku as a regulator of chromosomal DNA end structure
    • Gravel S, Larrivée M, Labrecque P, Wellinger RJ (1998) Yeast Ku as a regulator of chromosomal DNA end structure. Science 280: 741-744.
    • (1998) Science , vol.280 , pp. 741-744
    • Gravel, S.1    Larrivée, M.2    Labrecque, P.3    Wellinger, R.J.4
  • 14
    • 0032474732 scopus 로고    scopus 로고
    • The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
    • Polotnianka RM, Li J, Lustig AJ (1998) The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr Biol 8: 831-834.
    • (1998) Curr Biol , vol.8 , pp. 831-834
    • Polotnianka, R.M.1    Li, J.2    Lustig, A.J.3
  • 15
    • 0036682516 scopus 로고    scopus 로고
    • EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70D mutants
    • Maringele L, Lydall D (2002) EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70D mutants. Genes Dev 16: 1919-1933.
    • (2002) Genes Dev , vol.16 , pp. 1919-1933
    • Maringele, L.1    Lydall, D.2
  • 16
    • 2442520305 scopus 로고    scopus 로고
    • EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae
    • Bertuch AA, Lundblad V (2004) EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. Genetics 166: 1651-1659.
    • (2004) Genetics , vol.166 , pp. 1651-1659
    • Bertuch, A.A.1    Lundblad, V.2
  • 17
    • 0031037649 scopus 로고    scopus 로고
    • DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae
    • Barnes G, Rio D (1997) DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae. Proc Natl Acad Sci USA 94: 867-872.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 867-872
    • Barnes, G.1    Rio, D.2
  • 18
    • 0028822203 scopus 로고
    • Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
    • Garvik B, Carson M, Hartwell L (1995) Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol 15: 6128-6138.
    • (1995) Mol Cell Biol , vol.15 , pp. 6128-6138
    • Garvik, B.1    Carson, M.2    Hartwell, L.3
  • 19
    • 0029845892 scopus 로고    scopus 로고
    • Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
    • Nugent CI, Hughes TR, Lue NF, Lundblad V (1996) Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274: 249-252.
    • (1996) Science , vol.274 , pp. 249-252
    • Nugent, C.I.1    Hughes, T.R.2    Lue, N.F.3    Lundblad, V.4
  • 20
    • 0035504409 scopus 로고    scopus 로고
    • Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction
    • Booth C, Griffith E, Brady G, Lydall D (2001) Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction. Nucleic Acids Res 29: 4414-4422.
    • (2001) Nucleic Acids Res , vol.29 , pp. 4414-4422
    • Booth, C.1    Griffith, E.2    Brady, G.3    Lydall, D.4
  • 22
    • 0031036351 scopus 로고    scopus 로고
    • A protein-counting mechanism for telomere length regulation in yeast
    • Marcand S, Gilson E, Shore D (1997) A protein-counting mechanism for telomere length regulation in yeast. Science 275: 986-990.
    • (1997) Science , vol.275 , pp. 986-990
    • Marcand, S.1    Gilson, E.2    Shore, D.3
  • 23
    • 10044265469 scopus 로고    scopus 로고
    • Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length
    • Levy DL, Blackburn EH (2004) Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Mol Cell Biol 24: 10857-10867.
    • (2004) Mol Cell Biol , vol.24 , pp. 10857-10867
    • Levy, D.L.1    Blackburn, E.H.2
  • 24
    • 0026623241 scopus 로고
    • A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
    • Hardy CF, Sussel L, Shore D (1992) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6: 801-814.
    • (1992) Genes Dev , vol.6 , pp. 801-814
    • Hardy, C.F.1    Sussel, L.2    Shore, D.3
  • 25
    • 0028004378 scopus 로고
    • Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
    • Moretti P, Freeman K, Coodly L, Shore D (1994) Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev 8: 2257-2269.
    • (1994) Genes Dev , vol.8 , pp. 2257-2269
    • Moretti, P.1    Freeman, K.2    Coodly, L.3    Shore, D.4
  • 26
    • 0030995534 scopus 로고    scopus 로고
    • A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
    • Wotton D, Shore D (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11: 748-760.
    • (1997) Genes Dev , vol.11 , pp. 748-760
    • Wotton, D.1    Shore, D.2
  • 27
    • 0031038170 scopus 로고    scopus 로고
    • Regulation of telomere length and function by a Myb-domain protein in fission yeast
    • Cooper JP, Nimmo ER, Allshire RC, Cech TR (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385: 744-747.
    • (1997) Nature , vol.385 , pp. 744-747
    • Cooper, J.P.1    Nimmo, E.R.2    Allshire, R.C.3    Cech, T.R.4
  • 28
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes & Dev 19: 2100-2110.
    • (2005) Genes & Dev , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 29
    • 0035806955 scopus 로고    scopus 로고
    • Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere
    • Diede SJ, Gottschling DE (2001) Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere. Curr Biol 11: 1336-1340.
    • (2001) Curr Biol , vol.11 , pp. 1336-1340
    • Diede, S.J.1    Gottschling, D.E.2
  • 30
    • 48649086824 scopus 로고    scopus 로고
    • The Yku70- Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
    • Clerici M, Mantiero D, Guerini I, Lucchini G, Longhese MP (2008) The Yku70- Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep 9: 810-818.
    • (2008) EMBO Rep , vol.9 , pp. 810-818
    • Clerici, M.1    Mantiero, D.2    Guerini, I.3    Lucchini, G.4    Longhese, M.P.5
  • 31
    • 0030460748 scopus 로고    scopus 로고
    • Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase
    • Dionne I, Wellinger RJ (1996) Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc Natl Acad Sci USA 93: 13902-13907.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13902-13907
    • Dionne, I.1    Wellinger, R.J.2
  • 32
    • 34547813672 scopus 로고    scopus 로고
    • S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association
    • Goudsouzian LK, Tuzon CT, Zakian VA (2006) S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell 24: 603-610.
    • (2006) Mol Cell , vol.24 , pp. 603-610
    • Goudsouzian, L.K.1    Tuzon, C.T.2    Zakian, V.A.3
  • 33
    • 33845669591 scopus 로고    scopus 로고
    • The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation
    • Tseng SF, Lin JJ, Teng SC (2006) The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res 34: 6327-6336.
    • (2006) Nucleic Acids Res , vol.34 , pp. 6327-6336
    • Tseng, S.F.1    Lin, J.J.2    Teng, S.C.3
  • 34
    • 4944265507 scopus 로고    scopus 로고
    • Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1
    • Bianchi A, Negrini S, Shore D (2004) Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1. Mol Cell 16: 139-146.
    • (2004) Mol Cell , vol.16 , pp. 139-146
    • Bianchi, A.1    Negrini, S.2    Shore, D.3
  • 35
    • 59649083955 scopus 로고    scopus 로고
    • Rif1 and Rif2 inhibit localization of Tel1 to DNA ends
    • Hirano Y, Fukunaga K, Sugimoto K (2009) Rif1 and Rif2 inhibit localization of Tel1 to DNA ends. Mol Cell 33: 312-322.
    • (2009) Mol Cell , vol.33 , pp. 312-322
    • Hirano, Y.1    Fukunaga, K.2    Sugimoto, K.3
  • 36
    • 33846970933 scopus 로고    scopus 로고
    • DNA breaks are masked by multiple Rap1 binding in yeast: Implications for telomere capping and telomerase regulation
    • Negrini S, Ribaud V, Bianchi A, Shore D (2007) DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation. Genes Dev 21: 292-302.
    • (2007) Genes Dev , vol.21 , pp. 292-302
    • Negrini, S.1    Ribaud, V.2    Bianchi, A.3    Shore, D.4
  • 37
    • 27144489538 scopus 로고    scopus 로고
    • Rap1 prevents telomere fusions by nonhomologous end joining
    • Pardo B, Marcand S (2005) Rap1 prevents telomere fusions by nonhomologous end joining. EMBO J 24: 3117-3127.
    • (2005) EMBO J , vol.24 , pp. 3117-3127
    • Pardo, B.1    Marcand, S.2
  • 38
    • 0347416975 scopus 로고    scopus 로고
    • ERCC1/XPF removes the 39 overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes
    • Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T (2003) ERCC1/XPF removes the 39 overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell 2003 12: 1489-1498.
    • (2003) Mol Cell , vol.2003 , Issue.12 , pp. 1489-1498
    • Zhu, X.D.1    Niedernhofer, L.2    Kuster, B.3    Mann, M.4    Hoeijmakers, J.H.5    de Lange, T.6
  • 39
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 40
    • 22144490491 scopus 로고    scopus 로고
    • DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
    • Celli GB, de Lange T (2005) DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol 7: 712-718.
    • (2005) Nat Cell Biol , vol.7 , pp. 712-718
    • Celli, G.B.1    de Lange, T.2
  • 41
    • 34047102946 scopus 로고    scopus 로고
    • Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks
    • Mantiero D, Clerici M, Lucchini G, Longhese MP (2007) Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks. EMBO Rep 8: 380-387.
    • (2007) EMBO Rep , vol.8 , pp. 380-387
    • Mantiero, D.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 42
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti V, Clerici M, Lucchini G, Longhese MP (2000) The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev 14: 2046-2059.
    • (2000) Genes Dev , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4


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