-
1
-
-
36749022214
-
The DNA damage response: Ten years after
-
Harper JW, Elledge SJ (2007) The DNA damage response: Ten years after. Mol Cell 28:739-745.
-
(2007)
Mol Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
2
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
Cimprich KA, Cortez D (2008) ATR: An essential regulator of genome integrity Nat Rev Mol Cell Biol 9:616-627.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
3
-
-
34547499407
-
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases
-
Smolka MB, Albuquerque CP, Chen SH, Zhou H (2007) Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc Natl Acad Sci USA 104:10364-10369.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10364-10369
-
-
Smolka, M.B.1
Albuquerque, C.P.2
Chen, S.H.3
Zhou, H.4
-
4
-
-
0034663809
-
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
-
Paciotti V, Clerici M, Lucchini G, Longhese MP (2000) The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev 14:2046-2059.
-
(2000)
Genes Dev
, vol.14
, pp. 2046-2059
-
-
Paciotti, V.1
Clerici, M.2
Lucchini, G.3
Longhese, M.P.4
-
5
-
-
0034329474
-
LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
-
Rouse J, Jackson SP (2000) LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J 19:5801-5812.
-
(2000)
EMBO J
, vol.19
, pp. 5801-5812
-
-
Rouse, J.1
Jackson, S.P.2
-
6
-
-
0035138557
-
Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
-
Wakayama T, Kondo T, Ando S, Matsumoto K, Sugimoto K (2001) Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol 21:755-764.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 755-764
-
-
Wakayama, T.1
Kondo, T.2
Ando, S.3
Matsumoto, K.4
Sugimoto, K.5
-
7
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L, Elledge SJ (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300:1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
8
-
-
0035498938
-
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
-
Melo JA, Cohen J, Toczyski DP (2001) Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev 15:2809-2821.
-
(2001)
Genes Dev
, vol.15
, pp. 2809-2821
-
-
Melo, J.A.1
Cohen, J.2
Toczyski, D.P.3
-
9
-
-
0035955398
-
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
-
Kondo T, Wakayama T, Naiki T, Matsumoto K, Sugimoto K (2001) Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294:867-870.
-
(2001)
Science
, vol.294
, pp. 867-870
-
-
Kondo, T.1
Wakayama, T.2
Naiki, T.3
Matsumoto, K.4
Sugimoto, K.5
-
10
-
-
0037418195
-
Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
-
Majka J, Burgers PM (2003) Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci USA 100:2249-2254.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2249-2254
-
-
Majka, J.1
Burgers, P.M.2
-
11
-
-
42949130159
-
Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
-
Bonilla CY, Melo JA, Toczyski DP (2008) Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell 30:267-276.
-
(2008)
Mol Cell
, vol.30
, pp. 267-276
-
-
Bonilla, C.Y.1
Melo, J.A.2
Toczyski, D.P.3
-
12
-
-
33845607102
-
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
-
Majka J, Niedziela-Majka A, Burgers PM (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell 24:891-901.
-
(2006)
Mol Cell
, vol.24
, pp. 891-901
-
-
Majka, J.1
Niedziela-Majka, A.2
Burgers, P.M.3
-
13
-
-
0036237806
-
Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway
-
Wang H, Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160:1295-1304.
-
(2002)
Genetics
, vol.160
, pp. 1295-1304
-
-
Wang, H.1
Elledge, S.J.2
-
14
-
-
0029592020
-
Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
-
Araki H, Leem SH, Phongdara A, Sugino A (1995) Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc Natl Acad Sci USA 92:11791-11795.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11791-11795
-
-
Araki, H.1
Leem, S.H.2
Phongdara, A.3
Sugino, A.4
-
15
-
-
27544460716
-
Identification and functional analysis of TopBP1 and its homologs
-
Garcia V, Furuya K, Carr AM (2005) Identification and functional analysis of TopBP1 and its homologs. DNA Repair 4:1227-1239.
-
(2005)
DNA Repair
, vol.4
, pp. 1227-1239
-
-
Garcia, V.1
Furuya, K.2
Carr, A.M.3
-
16
-
-
33846330909
-
CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
-
Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445:328-332.
-
(2007)
Nature
, vol.445
, pp. 328-332
-
-
Tanaka, S.1
-
17
-
-
33846328709
-
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
-
Zegerman P, Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445:281-285.
-
(2007)
Nature
, vol.445
, pp. 281-285
-
-
Zegerman, P.1
Diffley, J.F.2
-
18
-
-
0033616679
-
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae
-
Wang H, Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 96:3824-3829.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3824-3829
-
-
Wang, H.1
Elledge, S.J.2
-
20
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
Mordes DA, Glick GG, Zhao R, Cortez D (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev 22:1478-1489.
-
(2008)
Genes Dev
, vol.22
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
Cortez, D.4
-
21
-
-
0031658237
-
Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication
-
Kamimura Y, Masumoto H, Sugino A, Araki H (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18:6102-6109.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6102-6109
-
-
Kamimura, Y.1
Masumoto, H.2
Sugino, A.3
Araki, H.4
-
22
-
-
3042798440
-
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
-
Cortez D, Glick G, Elledge SJ (2004) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci USA 101:10078-10083.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10078-10083
-
-
Cortez, D.1
Glick, G.2
Elledge, S.J.3
-
23
-
-
11144227916
-
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
-
Yoo HY, Shevchenko A, Dunphy WG (2004) Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem 279:53353-53364.
-
(2004)
J Biol Chem
, vol.279
, pp. 53353-53364
-
-
Yoo, H.Y.1
Shevchenko, A.2
Dunphy, W.G.3
-
24
-
-
0033199892
-
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
-
Sarkaria JN, et al. (1999) Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59:4375-4382.
-
(1999)
Cancer Res
, vol.59
, pp. 4375-4382
-
-
Sarkaria, J.N.1
-
25
-
-
0033621392
-
Substrate specificities and identification of putative substrates of ATM kinase family members
-
Kim ST, Lim DS, Canman CE, Kastan MB (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 274:37538-37543.
-
(1999)
J Biol Chem
, vol.274
, pp. 37538-37543
-
-
Kim, S.T.1
Lim, D.S.2
Canman, C.E.3
Kastan, M.B.4
-
26
-
-
0036134979
-
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival
-
Yamane K, Wu X, Chen J (2002) A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 22:555-566.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 555-566
-
-
Yamane, K.1
Wu, X.2
Chen, J.3
-
27
-
-
34547115962
-
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM
-
Yoo HY, Kumagai A, Shevchenko A, Dunphy WG (2007) Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem 282:17501-17506.
-
(2007)
J Biol Chem
, vol.282
, pp. 17501-17506
-
-
Yoo, H.Y.1
Kumagai, A.2
Shevchenko, A.3
Dunphy, W.G.4
-
28
-
-
0036241880
-
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo
-
Rouse J, Jackson SP (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 9:857-869.
-
(2002)
Mol Cell
, vol.9
, pp. 857-869
-
-
Rouse, J.1
Jackson, S.P.2
-
29
-
-
47949109008
-
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
-
Puddu F, et al. (2008) Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol 28:4782-4793.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4782-4793
-
-
Puddu, F.1
-
30
-
-
47949109008
-
Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
-
Puddu F, et al. (2008) Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol 28:4782-4793.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4782-4793
-
-
Puddu, F.1
-
31
-
-
39549114009
-
Differential regulation of the cellular response to DNA double-strand breaks in G1
-
Barlow JH, Lisby M, Rothstein R (2008) Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol Cell 30:73-85.
-
(2008)
Mol Cell
, vol.30
, pp. 73-85
-
-
Barlow, J.H.1
Lisby, M.2
Rothstein, R.3
-
32
-
-
0345293222
-
MEC1-dependent phosphorylation of yeast RPA1 in vitro
-
Kim HS, Brill SJ (2003) MEC1-dependent phosphorylation of yeast RPA1 in vitro. DNA Repair 2:1321-1335.
-
(2003)
DNA Repair
, vol.2
, pp. 1321-1335
-
-
Kim, H.S.1
Brill, S.J.2
|