메뉴 건너뛰기




Volumn 105, Issue 48, 2008, Pages 18730-18734

Dpb11 activates the Mec1-Ddc2 complex

Author keywords

ATR; Checkpoint; DNA damage; TopBP1

Indexed keywords

ATR PROTEIN; DPB11; MEC1 DDC2; PHOSPHOTRANSFERASE; PROTEIN; TOPBP1; UNCLASSIFIED DRUG;

EID: 57749099248     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806621105     Document Type: Article
Times cited : (100)

References (32)
  • 1
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper JW, Elledge SJ (2007) The DNA damage response: Ten years after. Mol Cell 28:739-745.
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 2
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • Cimprich KA, Cortez D (2008) ATR: An essential regulator of genome integrity Nat Rev Mol Cell Biol 9:616-627.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 3
    • 34547499407 scopus 로고    scopus 로고
    • Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases
    • Smolka MB, Albuquerque CP, Chen SH, Zhou H (2007) Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc Natl Acad Sci USA 104:10364-10369.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10364-10369
    • Smolka, M.B.1    Albuquerque, C.P.2    Chen, S.H.3    Zhou, H.4
  • 4
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti V, Clerici M, Lucchini G, Longhese MP (2000) The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev 14:2046-2059.
    • (2000) Genes Dev , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 5
    • 0034329474 scopus 로고    scopus 로고
    • LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
    • Rouse J, Jackson SP (2000) LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J 19:5801-5812.
    • (2000) EMBO J , vol.19 , pp. 5801-5812
    • Rouse, J.1    Jackson, S.P.2
  • 6
    • 0035138557 scopus 로고    scopus 로고
    • Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
    • Wakayama T, Kondo T, Ando S, Matsumoto K, Sugimoto K (2001) Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol 21:755-764.
    • (2001) Mol Cell Biol , vol.21 , pp. 755-764
    • Wakayama, T.1    Kondo, T.2    Ando, S.3    Matsumoto, K.4    Sugimoto, K.5
  • 7
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300:1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 8
    • 0035498938 scopus 로고    scopus 로고
    • Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
    • Melo JA, Cohen J, Toczyski DP (2001) Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev 15:2809-2821.
    • (2001) Genes Dev , vol.15 , pp. 2809-2821
    • Melo, J.A.1    Cohen, J.2    Toczyski, D.P.3
  • 9
    • 0035955398 scopus 로고    scopus 로고
    • Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
    • Kondo T, Wakayama T, Naiki T, Matsumoto K, Sugimoto K (2001) Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294:867-870.
    • (2001) Science , vol.294 , pp. 867-870
    • Kondo, T.1    Wakayama, T.2    Naiki, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 10
    • 0037418195 scopus 로고    scopus 로고
    • Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
    • Majka J, Burgers PM (2003) Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci USA 100:2249-2254.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2249-2254
    • Majka, J.1    Burgers, P.M.2
  • 11
    • 42949130159 scopus 로고    scopus 로고
    • Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage
    • Bonilla CY, Melo JA, Toczyski DP (2008) Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell 30:267-276.
    • (2008) Mol Cell , vol.30 , pp. 267-276
    • Bonilla, C.Y.1    Melo, J.A.2    Toczyski, D.P.3
  • 12
    • 33845607102 scopus 로고    scopus 로고
    • The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
    • Majka J, Niedziela-Majka A, Burgers PM (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol Cell 24:891-901.
    • (2006) Mol Cell , vol.24 , pp. 891-901
    • Majka, J.1    Niedziela-Majka, A.2    Burgers, P.M.3
  • 13
    • 0036237806 scopus 로고    scopus 로고
    • Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway
    • Wang H, Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160:1295-1304.
    • (2002) Genetics , vol.160 , pp. 1295-1304
    • Wang, H.1    Elledge, S.J.2
  • 14
    • 0029592020 scopus 로고
    • Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
    • Araki H, Leem SH, Phongdara A, Sugino A (1995) Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc Natl Acad Sci USA 92:11791-11795.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11791-11795
    • Araki, H.1    Leem, S.H.2    Phongdara, A.3    Sugino, A.4
  • 15
    • 27544460716 scopus 로고    scopus 로고
    • Identification and functional analysis of TopBP1 and its homologs
    • Garcia V, Furuya K, Carr AM (2005) Identification and functional analysis of TopBP1 and its homologs. DNA Repair 4:1227-1239.
    • (2005) DNA Repair , vol.4 , pp. 1227-1239
    • Garcia, V.1    Furuya, K.2    Carr, A.M.3
  • 16
    • 33846330909 scopus 로고    scopus 로고
    • CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
    • Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445:328-332.
    • (2007) Nature , vol.445 , pp. 328-332
    • Tanaka, S.1
  • 17
    • 33846328709 scopus 로고    scopus 로고
    • Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
    • Zegerman P, Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445:281-285.
    • (2007) Nature , vol.445 , pp. 281-285
    • Zegerman, P.1    Diffley, J.F.2
  • 18
    • 0033616679 scopus 로고    scopus 로고
    • DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae
    • Wang H, Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 96:3824-3829.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3824-3829
    • Wang, H.1    Elledge, S.J.2
  • 19
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • Kumagai A, Lee J, Yoo HY, Dunphy WG (2006) TopBP1 activates the ATR-ATRIP complex. Cell 124:943-955.
    • (2006) Cell , vol.124 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 20
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes DA, Glick GG, Zhao R, Cortez D (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev 22:1478-1489.
    • (2008) Genes Dev , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 21
    • 0031658237 scopus 로고    scopus 로고
    • Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication
    • Kamimura Y, Masumoto H, Sugino A, Araki H (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18:6102-6109.
    • (1998) Mol Cell Biol , vol.18 , pp. 6102-6109
    • Kamimura, Y.1    Masumoto, H.2    Sugino, A.3    Araki, H.4
  • 22
    • 3042798440 scopus 로고    scopus 로고
    • Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
    • Cortez D, Glick G, Elledge SJ (2004) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci USA 101:10078-10083.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10078-10083
    • Cortez, D.1    Glick, G.2    Elledge, S.J.3
  • 23
    • 11144227916 scopus 로고    scopus 로고
    • Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
    • Yoo HY, Shevchenko A, Dunphy WG (2004) Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem 279:53353-53364.
    • (2004) J Biol Chem , vol.279 , pp. 53353-53364
    • Yoo, H.Y.1    Shevchenko, A.2    Dunphy, W.G.3
  • 24
    • 0033199892 scopus 로고    scopus 로고
    • Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
    • Sarkaria JN, et al. (1999) Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 59:4375-4382.
    • (1999) Cancer Res , vol.59 , pp. 4375-4382
    • Sarkaria, J.N.1
  • 25
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • Kim ST, Lim DS, Canman CE, Kastan MB (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 274:37538-37543.
    • (1999) J Biol Chem , vol.274 , pp. 37538-37543
    • Kim, S.T.1    Lim, D.S.2    Canman, C.E.3    Kastan, M.B.4
  • 26
    • 0036134979 scopus 로고    scopus 로고
    • A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival
    • Yamane K, Wu X, Chen J (2002) A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 22:555-566.
    • (2002) Mol Cell Biol , vol.22 , pp. 555-566
    • Yamane, K.1    Wu, X.2    Chen, J.3
  • 27
    • 34547115962 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM
    • Yoo HY, Kumagai A, Shevchenko A, Dunphy WG (2007) Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem 282:17501-17506.
    • (2007) J Biol Chem , vol.282 , pp. 17501-17506
    • Yoo, H.Y.1    Kumagai, A.2    Shevchenko, A.3    Dunphy, W.G.4
  • 28
    • 0036241880 scopus 로고    scopus 로고
    • Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo
    • Rouse J, Jackson SP (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 9:857-869.
    • (2002) Mol Cell , vol.9 , pp. 857-869
    • Rouse, J.1    Jackson, S.P.2
  • 29
    • 47949109008 scopus 로고    scopus 로고
    • Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
    • Puddu F, et al. (2008) Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol 28:4782-4793.
    • (2008) Mol Cell Biol , vol.28 , pp. 4782-4793
    • Puddu, F.1
  • 30
    • 47949109008 scopus 로고    scopus 로고
    • Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint
    • Puddu F, et al. (2008) Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint. Mol Cell Biol 28:4782-4793.
    • (2008) Mol Cell Biol , vol.28 , pp. 4782-4793
    • Puddu, F.1
  • 31
    • 39549114009 scopus 로고    scopus 로고
    • Differential regulation of the cellular response to DNA double-strand breaks in G1
    • Barlow JH, Lisby M, Rothstein R (2008) Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol Cell 30:73-85.
    • (2008) Mol Cell , vol.30 , pp. 73-85
    • Barlow, J.H.1    Lisby, M.2    Rothstein, R.3
  • 32
    • 0345293222 scopus 로고    scopus 로고
    • MEC1-dependent phosphorylation of yeast RPA1 in vitro
    • Kim HS, Brill SJ (2003) MEC1-dependent phosphorylation of yeast RPA1 in vitro. DNA Repair 2:1321-1335.
    • (2003) DNA Repair , vol.2 , pp. 1321-1335
    • Kim, H.S.1    Brill, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.