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Volumn 24, Issue 6, 2006, Pages 891-901

The Checkpoint Clamp Activates Mec1 Kinase during Initiation of the DNA Damage Checkpoint

Author keywords

DNA

Indexed keywords

ATR PROTEIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 2; DNA BINDING PROTEIN; DOUBLE STRANDED DNA; FUNGAL ENZYME; HETERODIMER; PROTEIN DDC1; PROTEIN DDC2; PROTEIN KINASE; PROTEIN MEC1; PROTEIN MEC3; PROTEIN RAD17; PROTEIN RAD24; PROTEIN RPA1; PROTEIN RPA2; PROTEIN SUBUNIT; REPLICATION FACTOR C;

EID: 33845607102     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.11.027     Document Type: Article
Times cited : (162)

References (37)
  • 1
    • 2942744563 scopus 로고    scopus 로고
    • DNA stimulates Mec1-mediated phosphorylation of replication protein A
    • Bartrand A.J., Iyasu D., and Brush G.S. DNA stimulates Mec1-mediated phosphorylation of replication protein A. J. Biol. Chem. 279 (2004) 26762-26767
    • (2004) J. Biol. Chem. , vol.279 , pp. 26762-26767
    • Bartrand, A.J.1    Iyasu, D.2    Brush, G.S.3
  • 2
    • 0041966011 scopus 로고    scopus 로고
    • Elg1 forms an alternative RFC complex important for DNA replication and genome integrity
    • Bellaoui M., Chang M., Ou J., Xu H., Boone C., and Brown G.W. Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J. 22 (2003) 4304-4313
    • (2003) EMBO J. , vol.22 , pp. 4304-4313
    • Bellaoui, M.1    Chang, M.2    Ou, J.3    Xu, H.4    Boone, C.5    Brown, G.W.6
  • 3
    • 3442896884 scopus 로고    scopus 로고
    • Replication protein A phosphorylation and the cellular response to DNA damage
    • Binz S.K., Sheehan A.M., and Wold M.S. Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair (Amst.) 3 (2004) 1015-1024
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1015-1024
    • Binz, S.K.1    Sheehan, A.M.2    Wold, M.S.3
  • 4
    • 0034307720 scopus 로고    scopus 로고
    • Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response
    • Brush G.S., and Kelly T.J. Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response. Nucleic Acids Res. 28 (2000) 3725-3732
    • (2000) Nucleic Acids Res. , vol.28 , pp. 3725-3732
    • Brush, G.S.1    Kelly, T.J.2
  • 5
    • 0030479885 scopus 로고    scopus 로고
    • The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
    • Brush G.S., Morrow D.M., Hieter P., and Kelly T.J. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc. Natl. Acad. Sci. USA 93 (1996) 15075-15080
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15075-15080
    • Brush, G.S.1    Morrow, D.M.2    Hieter, P.3    Kelly, T.J.4
  • 6
    • 20744435871 scopus 로고    scopus 로고
    • Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex
    • Bylund G.O., and Burgers P.M. Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex. Mol. Cell. Biol. 25 (2005) 5445-5455
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5445-5455
    • Bylund, G.O.1    Burgers, P.M.2
  • 7
    • 0037027880 scopus 로고    scopus 로고
    • DNA structure dependent checkpoints as regulators of DNA repair
    • Carr A.M. DNA structure dependent checkpoints as regulators of DNA repair. DNA Repair (Amst.) 1 (2002) 983-994
    • (2002) DNA Repair (Amst.) , vol.1 , pp. 983-994
    • Carr, A.M.1
  • 8
    • 4243156107 scopus 로고    scopus 로고
    • Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA
    • Ellison V., and Stillman B. Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA. PLoS Biol. 1 (2003) 231-243
    • (2003) PLoS Biol. , vol.1 , pp. 231-243
    • Ellison, V.1    Stillman, B.2
  • 9
    • 2442646547 scopus 로고    scopus 로고
    • Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
    • Furuya K., Poitelea M., Guo L., Caspari T., and Carr A.M. Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev. 18 (2004) 1154-1164
    • (2004) Genes Dev. , vol.18 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 10
    • 1542320702 scopus 로고    scopus 로고
    • Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint
    • Giannattasio M., Lazzaro F., Longhese M.P., Plevani P., and Muzi-Falconi M. Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J. 23 (2004) 429-438
    • (2004) EMBO J. , vol.23 , pp. 429-438
    • Giannattasio, M.1    Lazzaro, F.2    Longhese, M.P.3    Plevani, P.4    Muzi-Falconi, M.5
  • 11
    • 0034881760 scopus 로고    scopus 로고
    • Budding yeast Rad9 is an ATP-dependent Rad53 activating machine
    • Gilbert C.S., Green C.M., and Lowndes N.F. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol. Cell 8 (2001) 129-136
    • (2001) Mol. Cell , vol.8 , pp. 129-136
    • Gilbert, C.S.1    Green, C.M.2    Lowndes, N.F.3
  • 12
    • 0024425887 scopus 로고
    • Checkpoints: controls that ensure the order of cell cycle events
    • Hartwell L.H., and Weinert T.A. Checkpoints: controls that ensure the order of cell cycle events. Science 246 (1989) 629-634
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 13
    • 0035955398 scopus 로고    scopus 로고
    • Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
    • Kondo T., Wakayama T., Naiki T., Matsumoto K., and Sugimoto K. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294 (2001) 867-870
    • (2001) Science , vol.294 , pp. 867-870
    • Kondo, T.1    Wakayama, T.2    Naiki, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 14
    • 33645212498 scopus 로고    scopus 로고
    • Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1
    • Ma J.L., Lee S.J., Duong J.K., and Stern D.F. Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1. J. Biol. Chem. 281 (2006) 3954-3963
    • (2006) J. Biol. Chem. , vol.281 , pp. 3954-3963
    • Ma, J.L.1    Lee, S.J.2    Duong, J.K.3    Stern, D.F.4
  • 15
    • 0037418195 scopus 로고    scopus 로고
    • Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint
    • Majka J., and Burgers P.M. Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc. Natl. Acad. Sci. USA 100 (2003) 2249-2254
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2249-2254
    • Majka, J.1    Burgers, P.M.2
  • 16
    • 11144266855 scopus 로고    scopus 로고
    • The PCNA-RFC families of DNA clamps and clamp loaders
    • Majka J., and Burgers P.M. The PCNA-RFC families of DNA clamps and clamp loaders. Prog. Nucleic Acids Res. Mol. Biol. 78 (2004) 227-260
    • (2004) Prog. Nucleic Acids Res. Mol. Biol. , vol.78 , pp. 227-260
    • Majka, J.1    Burgers, P.M.2
  • 17
    • 24944495500 scopus 로고    scopus 로고
    • Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint
    • Majka J., and Burgers P.M. Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint. DNA Repair (Amst.) 4 (2005) 1189-1194
    • (2005) DNA Repair (Amst.) , vol.4 , pp. 1189-1194
    • Majka, J.1    Burgers, P.M.2
  • 18
    • 2442646313 scopus 로고    scopus 로고
    • Requirement for ATP by the DNA damage checkpoint clamp loader
    • Majka J., Chung B.Y., and Burgers P.M. Requirement for ATP by the DNA damage checkpoint clamp loader. J. Biol. Chem. 279 (2004) 20921-20926
    • (2004) J. Biol. Chem. , vol.279 , pp. 20921-20926
    • Majka, J.1    Chung, B.Y.2    Burgers, P.M.3
  • 19
    • 33748780358 scopus 로고    scopus 로고
    • RPA directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions
    • Majka J., Binz S.K., Wold M.S., and Burgers P.M. RPA directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions. J. Biol. Chem. 281 (2006) 27855-27861
    • (2006) J. Biol. Chem. , vol.281 , pp. 27855-27861
    • Majka, J.1    Binz, S.K.2    Wold, M.S.3    Burgers, P.M.4
  • 20
    • 0035498938 scopus 로고    scopus 로고
    • Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
    • Melo J.A., Cohen J., and Toczyski D.P. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 15 (2001) 2809-2821
    • (2001) Genes Dev. , vol.15 , pp. 2809-2821
    • Melo, J.A.1    Cohen, J.2    Toczyski, D.P.3
  • 21
    • 0033858055 scopus 로고    scopus 로고
    • Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae
    • Naiki T., Shimomura T., Kondo T., Matsumoto K., and Sugimoto K. Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae. Mol. Cell. Biol. 20 (2000) 5888-5896
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5888-5896
    • Naiki, T.1    Shimomura, T.2    Kondo, T.3    Matsumoto, K.4    Sugimoto, K.5
  • 22
    • 0032527776 scopus 로고    scopus 로고
    • Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
    • Paciotti V., Lucchini G., Plevani P., and Longhese M.P. Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p. EMBO J. 17 (1998) 4199-4209
    • (1998) EMBO J. , vol.17 , pp. 4199-4209
    • Paciotti, V.1    Lucchini, G.2    Plevani, P.3    Longhese, M.P.4
  • 23
    • 0034663809 scopus 로고    scopus 로고
    • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
    • Paciotti V., Clerici M., Lucchini G., and Longhese M.P. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev. 14 (2000) 2046-2059
    • (2000) Genes Dev. , vol.14 , pp. 2046-2059
    • Paciotti, V.1    Clerici, M.2    Lucchini, G.3    Longhese, M.P.4
  • 24
    • 0035818485 scopus 로고    scopus 로고
    • Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage
    • Post S., Weng Y.C., Cimprich K., Chen L.B., Xu Y., and Lee E.Y. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proc. Natl. Acad. Sci. USA 98 (2001) 13102-13107
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13102-13107
    • Post, S.1    Weng, Y.C.2    Cimprich, K.3    Chen, L.B.4    Xu, Y.5    Lee, E.Y.6
  • 25
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse J., and Jackson S.P. Interfaces between the detection, signaling, and repair of DNA damage. Science 297 (2002) 547-551
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 26
    • 0036241880 scopus 로고    scopus 로고
    • Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo
    • Rouse J., and Jackson S.P. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol. Cell 9 (2002) 857-869
    • (2002) Mol. Cell , vol.9 , pp. 857-869
    • Rouse, J.1    Jackson, S.P.2
  • 27
    • 0029928222 scopus 로고    scopus 로고
    • Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways
    • Sun Z., Fay D.S., Marini F., Foiani M., and Stern D.F. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10 (1996) 395-406
    • (1996) Genes Dev. , vol.10 , pp. 395-406
    • Sun, Z.1    Fay, D.S.2    Marini, F.3    Foiani, M.4    Stern, D.F.5
  • 28
    • 23244444605 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation
    • Sweeney F.D., Yang F., Chi A., Shabanowitz J., Hunt D.F., and Durocher D. Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr. Biol. 15 (2005) 1364-1375
    • (2005) Curr. Biol. , vol.15 , pp. 1364-1375
    • Sweeney, F.D.1    Yang, F.2    Chi, A.3    Shabanowitz, J.4    Hunt, D.F.5    Durocher, D.6
  • 29
    • 0033582906 scopus 로고    scopus 로고
    • A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins
    • Thelen M.P., Venclovas C., and Fidelis K. A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins. Cell 96 (1999) 769-770
    • (1999) Cell , vol.96 , pp. 769-770
    • Thelen, M.P.1    Venclovas, C.2    Fidelis, K.3
  • 30
    • 1342325347 scopus 로고    scopus 로고
    • Replication protein A (RPA) phosphorylation prevents RPA association with replication centers
    • Vassin V.M., Wold M.S., and Borowiec J.A. Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol. Cell. Biol. 24 (2004) 1930-1943
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1930-1943
    • Vassin, V.M.1    Wold, M.S.2    Borowiec, J.A.3
  • 31
    • 0032189952 scopus 로고    scopus 로고
    • The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
    • Vialard J.E., Gilbert C.S., Green C.M., and Lowndes N.F. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J. 17 (1998) 5679-5688
    • (1998) EMBO J. , vol.17 , pp. 5679-5688
    • Vialard, J.E.1    Gilbert, C.S.2    Green, C.M.3    Lowndes, N.F.4
  • 33
    • 22744449724 scopus 로고    scopus 로고
    • Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
    • Wu X., Shell S.M., and Zou Y. Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. Oncogene 24 (2005) 4728-4735
    • (2005) Oncogene , vol.24 , pp. 4728-4735
    • Wu, X.1    Shell, S.M.2    Zou, Y.3
  • 34
    • 0033662156 scopus 로고    scopus 로고
    • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
    • Yang D.Q., and Kastan M.B. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat. Cell Biol. 2 (2000) 893-898
    • (2000) Nat. Cell Biol. , vol.2 , pp. 893-898
    • Yang, D.Q.1    Kastan, M.B.2
  • 35
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L., and Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300 (2003) 1542-1548
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 36
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • Zou L., Liu D., and Elledge S.J. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA 100 (2003) 13827-13832
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3
  • 37
    • 5144219712 scopus 로고    scopus 로고
    • Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants
    • Zubko M.K., Guillard S., and Lydall D. Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics 168 (2004) 103-115
    • (2004) Genetics , vol.168 , pp. 103-115
    • Zubko, M.K.1    Guillard, S.2    Lydall, D.3


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