Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain

Yeast

Volumn 24, Issue 2, 2007, Pages 105-119

  Grenon, Muriel ^a   Costelloe, Thomas ^a   Jimeno, Sonia ^a   O'Shaughnessy, Aisling ^a   FitzGerald, Jennifer ^a   Zgheib, Omar ^b   Degerth, Linda ^a   Lowndes, Noel F ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

DNA damage checkpoint; Histone H3; Lysine 79; Rad9; Tudor

Indexed keywords

FUNGAL DNA; HISTONE H3; LYSINE DERIVATIVE; METHYLTRANSFERASE; PROTEIN RAD9;

ALLELE; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL INTERACTION; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EPISTASIS; FUNGAL CELL; FUNGAL GENE; FUNGAL STRAIN; GENETIC CODE; GENOME ANALYSIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CHROMATIN; DNA DAMAGE; DNA REPAIR; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; GENES, CDC; HISTONES; METHYLATION; MICROSCOPY, FLUORESCENCE; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 33847247383     PISSN: 0749503X     EISSN: 10970061     Source Type: Journal    
DOI: 10.1002/yea.1441     Document Type: Article

References (49)

1. Blankley RT, Lydall D. 2004. A domain of Rad9 specifically required for activation of Chk1 in budding yeast. J Cell Sci 117: 601-608.
2. D'Amours D, Jackson SP. 2001. The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev 15: 2238-2249.
3. D'Amours D, Jackson SP. 2002. The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat Rev Mol Cell Biol 3: 317-327.
4. Downs JA, Cote J. 2005. Dynamics of chromatin during the repair of DNA double-strand breaks. Cell Cycle 4: 1373-1376.
5. Du LL, Nakamura TM, Russell P. 2006. Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev 20: 1583-1596.
6. Fang J, Feng Q, Ketel CS, et al. 2002. Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol 12: 1086-1099.
7. 1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair. J Cell Sci 115: 1749-1757.
8. Game JC, Williamson MS, Baccari C. 2005. X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity. Genetics 169: 51-63.
9. Game JC, Williamson MS, Spicakova T, Brown JM. 2006. The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18. Genetics 173: 1951-1968.
10. Garcia V, Furuya K, Carr AM. 2005. Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) 4: 1227-1239.
11. Giannattasio M, Lazzaro F, Plevani P, Muzi-Falconi M. 2005. The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem 280: 9879-9886.
12. Gilbert CS, Green CM, Lowndes NF. 2001. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol Cell 8: 129-136.
13. Grenon M, Gilbert C, Lowndes NF. 2001. Checkpoint activation in response to double-strand breaks requires the Mre1 1/Rad50/Xrs2 complex. Nat Cell Biol 3: 844-847.
14. Huyen Y, Zgheib O, Ditullio RA Jr, et al. 2004. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432: 406-411.
15. Lisby M, Barlow JH, Burgess RC, Rothstein R. 2004. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118: 699-713.
16. Lowndes NE, Murguia JR. 2000. Sensing and responding to DNA damage. Curr Opin Gener Dev 10: 17-25.
17. Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ. 1997. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389: 251-260.
18. McGowan CH, Russell P. 2004. The DNA damage response: sensing and signaling. Curr Opin Cell Biol 16: 629-633.
19. Melo JA, Cohen J, Toczyski DP. 2001. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev 15: 2809-2821.
20. Mochan TA, Venere M, DiTullio RA Jr, Halazonetis TD. 2004. 53BP1, an activator of ATM in response to DNA damage. DNA Repair (Amst) 3: 945-952.
21. Mozziconacci J, Victor JM. 2003. Nucleosome gaping supports a functional structure for the 30 nm chromatin fiber. J Struct Biol 143: 72-76.
22. Naiki T, Wakayama T, Nakada D, Matsumoto K, Sugimoto K. 2004. Association of Rad9 with double-strand breaks through a Med-dependent mechanism. Mol Cell Biol 24: 3277-3285.
23. Nakada D, Hirano Y, Sugimoto K. 2004. Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol Cell Biol 24: 10016-10025.
24. Nishioka K, Rice JC, Sarma K, et al. 2002. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell 9: 1201-1213.
25. Nyberg KA, Michelson RJ, Putnam CW, Weinert TA. 2002. Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 36: 617-656.
26. O'Shaughnessy AM, Grenon M, Gilbert C, et al. 2006. Multiple approaches to study S. cerevisiae Rad9, a prototypical checkpoint protein. Methods Enzymol 409: 131-150.
27. Paciotti V, Clerici M, Lucchini G, Longhese MP. 2000. The checkpoint protein Ddc2, functionally related to Sz. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev 14: 2046-2059.
28. Redon C, Pilch DR, Rogakou EP, et al. 2003. Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage. EMBO Rep 4: 678-684.
29. Reid RJ, Lisby M, Rothstein R. 2002. Cloning-free genome alterations in Saccharomyces cerevisiae using adaptamer-mediated PCR. Methods Enzymol 350: 258-277.
30. Rouse J, Jackson SP. 2002. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 9: 857-869.
31. Sanchez Y, Bachant J, Wang H, et al. 1999. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science 286: 1166-1171.
32. Sanders SL, Portoso M, Mata J, et al. 2004. Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell 119: 603-614.
33. Schwartz MF, Duong JK, Sun Z, et al. 2002. Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell 9: 1055-1065.
34. Scully R, Xie A, Nagaraju G. 2004. Molecular functions of BRCA1 in the DNA damage response. Cancer Biol Ther 3: 521-527.
35. Shahbazian MD, Zhang K, Grunstein M. 2005. Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1. Mol Cell 19: 271-277.
36. Shroff R, Arbel-Eden A, Pilch D, et al. 2004. Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol 14: 1703-1711.
37. Stucki M, Clapperton JA, Mohammad D, et al. 2005. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123: 1213-1226.
38. Stucki M, Jackson SP. 2004. MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. DNA Repair (Amst) 3: 953-957.
39. Sweeney FD, Yang F, Chi A, et al. 2005. Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol 15: 1364-1375.
40. Toh GWL, O'Shaughnessy AM, Jimeno S, et al. 2006. Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation. DNA Repair (Amst) 5: 693-703.
41. Usui T, Ogawa H, Petrini JH. 2001. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol Cell 7: 1255-1266.
42. van Leeuwen F, Gafken PR, Gottschling DE. 2002. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109: 745-756.
43. Vialard JE, Gilbert CS, Green CM, Lowndes NF. 1998. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J 17: 5679-5688.
44. Vidanes GM, Bonilla CY, Toczyski DP. 2005. Complicated tails: histone modifications and the DNA damage response. Cell 121: 973-976.
45. Wakayama T, Kondo T, Ando S, Matsumoto K, Sugimoto K. 2001. Piel, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae. Mol Cell Biol 21: 755-764.
46. Weinert TA, Hartwell LH. 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.
47. 1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol 25: 8430-8443.
48. Zhou BB, Elledge SJ. 2000. The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439.
49. Zou L, Elledge SJ. 2003. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300: 1542-1548.