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Volumn 2013, Issue , 2013, Pages

Norcantharidin, derivative of cantharidin, for cancer stem cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BETA CATENIN; CANTHARIDIN; NORCANTHARIDIN; NOTCH RECEPTOR; SONIC HEDGEHOG PROTEIN; WNT PROTEIN;

EID: 84885348916     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/838651     Document Type: Article
Times cited : (36)

References (130)
  • 1
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • DOI 10.1038/nm0797-730
    • Bonnet D., Dick J. E., Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine 1997 3 7 730 737 2-s2.0-0030789242 10.1038/nm0797-730 (Pubitemid 27298715)
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 5
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • DOI 10.1038/nature05372, PII NATURE05372
    • O'Brien C. A., Pollett A., Gallinger S., Dick J. E., A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007 445 7123 106 110 2-s2.0-33846100356 10.1038/nature05372 (Pubitemid 46067310)
    • (2007) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 6
    • 67649969473 scopus 로고    scopus 로고
    • Regulation of mammary stem/progenitor cells by PTEN/Akt/ β -catenin signaling
    • 2-s2.0-67649969473 10.1371/journal.pbio.1000121 e1000121
    • Korkaya H., Paulson A., Charafe-Jauffret E., Ginestier C., Brown M., Dutcher J., Clouthier S. G., Wicha M. S., Regulation of mammary stem/progenitor cells by PTEN/Akt/ β -catenin signaling. PLoS Biology 2009 7 6 2-s2.0-67649969473 10.1371/journal.pbio.1000121 e1000121
    • (2009) PLoS Biology , vol.7 , Issue.6
    • Korkaya, H.1    Paulson, A.2    Charafe-Jauffret, E.3    Ginestier, C.4    Brown, M.5    Dutcher, J.6    Clouthier, S.G.7    Wicha, M.S.8
  • 7
    • 77149138342 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Role of specific chemotherapy agents
    • 2-s2.0-77149138342 10.1097/PPO.0b013e3181d24ff7
    • Isakoff S. J., Triple-negative breast cancer: role of specific chemotherapy agents. Cancer Journal 2010 16 1 53 61 2-s2.0-77149138342 10.1097/PPO.0b013e3181d24ff7
    • (2010) Cancer Journal , vol.16 , Issue.1 , pp. 53-61
    • Isakoff, S.J.1
  • 8
    • 77955872105 scopus 로고    scopus 로고
    • Cancer stem cells: A novel paradigm for cancer prevention and treatment
    • 2-s2.0-77955872105
    • Subramaniam D., Ramalingam S., Houchen C. W., Anant S., Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Reviews in Medicinal Chemistry 2010 10 5 359 371 2-s2.0-77955872105
    • (2010) Mini Reviews in Medicinal Chemistry , vol.10 , Issue.5 , pp. 359-371
    • Subramaniam, D.1    Ramalingam, S.2    Houchen, C.W.3    Anant, S.4
  • 11
    • 33845226457 scopus 로고    scopus 로고
    • Radiation resistance and stem-like cells in brain tumors
    • DOI 10.1016/j.ccr.2006.11.008, PII S1535610806003461
    • Hambardzumyan D., Squartro M., Holland E. C., Radiation resistance and stem-like cells in brain tumors. Cancer Cell 2006 10 6 454 456 2-s2.0-33845226457 10.1016/j.ccr.2006.11.008 (Pubitemid 44854752)
    • (2006) Cancer Cell , vol.10 , Issue.6 , pp. 454-456
    • Hambardzumyan, D.1    Squartro, M.2    Holland, E.C.3
  • 12
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • 2-s2.0-33745728170 10.1158/0008-5472.CAN-06-0054
    • Liu S., Dontu G., Mantle I. D., Patel S., Ahn N.-S., Jackson K. W., Suri P., Wicha M. S., Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research 2006 66 12 6063 6071 2-s2.0-33745728170 10.1158/0008-5472.CAN-06-0054
    • (2006) Cancer Research , vol.66 , Issue.12 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3    Patel, S.4    Ahn, N.-S.5    Jackson, K.W.6    Suri, P.7    Wicha, M.S.8
  • 13
    • 18944375734 scopus 로고    scopus 로고
    • Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    • 2-s2.0-18944375734
    • Dontu G., Jackson K. W., McNicholas E., Kawamura M. J., Abdallah W. M., Wicha M. S., Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Research 2004 6 6 R605 R615 2-s2.0-18944375734
    • (2004) Breast Cancer Research , vol.6 , Issue.6
    • Dontu, G.1    Jackson, K.W.2    McNicholas, E.3    Kawamura, M.J.4    Abdallah, W.M.5    Wicha, M.S.6
  • 14
    • 0033392360 scopus 로고    scopus 로고
    • Wnt signalling in mammalian development and cancer
    • DOI 10.1023/A:1006369223282
    • Smalley M. J., Dale T. C., Wnt signalling in mammalian development and cancer. Cancer and Metastasis Reviews 1999 18 2 215 230 2-s2.0-0033392360 10.1023/A:1006369223282 (Pubitemid 30043859)
    • (1999) Cancer and Metastasis Reviews , vol.18 , Issue.2 , pp. 215-230
    • Smalley, M.J.1    Dale, T.C.2
  • 15
    • 0016577166 scopus 로고
    • Elizaveta Nilolaevna Levkovich-75th birthday
    • 2-s2.0-0016577166
    • Pogodina V. V., Elizaveta Nilolaevna Levkovich-75th birthday. Acta Virologica 1975 19 6 509 2-s2.0-0016577166
    • (1975) Acta Virologica , vol.19 , Issue.6 , pp. 509
    • Pogodina, V.V.1
  • 16
    • 33846683203 scopus 로고    scopus 로고
    • Contrasting features of MDR phenotype in leukemias by using two fluorochromes: Implications for clinical practice
    • DOI 10.1016/j.leukres.2006.07.016, PII S0145212606002773
    • Vasconcelos F. C., Cavalcanti G. B. Jr., Silva K. L., de Meis E., Kwee J. K., Rumjanek V. M., Maia R. C., Contrasting features of MDR phenotype in leukemias by using two fluorochromes: implications for clinical practice. Leukemia Research 2007 31 4 445 454 2-s2.0-33846683203 10.1016/j.leukres.2006. 07.016 (Pubitemid 46198938)
    • (2007) Leukemia Research , vol.31 , Issue.4 , pp. 445-454
    • Vasconcelos, F.C.1    Cavalcanti Jr., G.B.2    Silva, K.L.3    De Meis, E.4    Kwee, J.K.5    Rumjanek, V.M.6    Maia, R.C.7
  • 17
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman M. M., Fojo T., Bates S. E., Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Reviews Cancer 2002 2 1 48 58 2-s2.0-0036364467 (Pubitemid 37328807)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 18
    • 0024428817 scopus 로고
    • Medical uses of mylabris in ancient China and recent studies
    • Wang G.-S., Medical uses of mylabris in ancient China and recent studies. Journal of Ethnopharmacology 1989 26 2 147 162 2-s2.0-0024428817 (Pubitemid 19257209)
    • (1989) Journal of Ethnopharmacology , vol.26 , Issue.2 , pp. 147-162
    • Wang, G.-S.1
  • 19
    • 0036208532 scopus 로고    scopus 로고
    • Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues
    • DOI 10.1023/A:1014460818734
    • Sakoff J. A., Ackland S. P., Baldwin M. L., Keane M. A., McCluskey A., Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues. Investigational New Drugs 2002 20 1 1 11 2-s2.0-0036208532 10.1023/A:1014460818734 (Pubitemid 34251646)
    • (2002) Investigational New Drugs , vol.20 , Issue.1 , pp. 1-11
    • Sakoff, J.A.1    Ackland, S.P.2    Baldwin, M.L.3    Keane, M.A.4    McCluskey, A.5
  • 21
    • 0034618205 scopus 로고    scopus 로고
    • Anhydride modified cantharidin analogues: Synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity
    • DOI 10.1016/S0960-894X(00)00323-1, PII S0960894X00003231
    • McCluskey A., Bowyer M. C., Collins E., Sim A. T. R., Sakoff J. A., Baldwin M. L., Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity. Bioorganic and Medicinal Chemistry Letters 2000 10 15 1687 1690 2-s2.0-0034618205 10.1016/S0960-894X(00)00323-1 (Pubitemid 30495241)
    • (2000) Bioorganic and Medicinal Chemistry Letters , vol.10 , Issue.15 , pp. 1687-1690
    • McCluskey, A.1    Bowyer, M.C.2    Collins, E.3    Sim, A.T.R.4    Sakoff, J.A.5    Baldwin, M.L.6
  • 24
    • 18744408486 scopus 로고    scopus 로고
    • Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells
    • Fan Y.-Z., Fu J.-Y., Zhao Z.-M., Chen C.-Q., Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells. World Journal of Gastroenterology 2005 11 16 2431 2437 2-s2.0-18744408486 (Pubitemid 40667977)
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.16 , pp. 2431-2437
    • Fan, Y.-Z.1    Fu, J.-Y.2    Zhao, Z.-M.3    Chen, C.-Q.4
  • 26
    • 79952043014 scopus 로고    scopus 로고
    • Norcantharidin induces apoptosis of breast cancer cells: Involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription
    • 2-s2.0-79952043014 10.1016/j.tiv.2011.01.011
    • Yang P.-Y., Chen M.-F., Kao Y.-H., Hu D.-N., Chang F.-R., Wu Y.-C., Norcantharidin induces apoptosis of breast cancer cells: involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription. Toxicology in Vitro 2011 25 3 699 707 2-s2.0-79952043014 10.1016/j.tiv.2011.01.011
    • (2011) Toxicology in Vitro , vol.25 , Issue.3 , pp. 699-707
    • Yang, P.-Y.1    Chen, M.-F.2    Kao, Y.-H.3    Hu, D.-N.4    Chang, F.-R.5    Wu, Y.-C.6
  • 27
    • 36549025029 scopus 로고    scopus 로고
    • Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells
    • DOI 10.1097/CAD.0b013e3282f18826, PII 0000181320080100000007
    • Chen Y.-J., Kuo C.-D., Tsai Y.-M., Yu C.-C., Wang G.-S., Liao H.-F., Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anti-Cancer Drugs 2008 19 1 55 64 2-s2.0-36549025029 10.1097/CAD.0b013e3282f18826 (Pubitemid 350190968)
    • (2008) Anti-Cancer Drugs , vol.19 , Issue.1 , pp. 55-64
    • Chen, Y.-J.1    Kuo, C.-D.2    Tsai, Y.-M.3    Yu, C.-C.4    Wang, G.-S.5    Liao, H.-F.6
  • 29
    • 0026095943 scopus 로고
    • Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro
    • 2-s2.0-0026095943 10.1016/0145-2126(91)90163-N
    • Yi S., Wass J., Vincent P., Iland H., Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro. Leukemia Research 1991 15 10 883 886 2-s2.0-0026095943 10.1016/0145-2126(91)90163-N
    • (1991) Leukemia Research , vol.15 , Issue.10 , pp. 883-886
    • Yi, S.1    Wass, J.2    Vincent, P.3    Iland, H.4
  • 30
    • 63449135103 scopus 로고    scopus 로고
    • The effect of cantharidins on leukemic stem cells
    • 2-s2.0-63449135103 10.1002/ijc.24157
    • Dorn D. C., Kou C. A., Png K. J., Moore M. A. S., The effect of cantharidins on leukemic stem cells. International Journal of Cancer 2009 124 9 2186 2199 2-s2.0-63449135103 10.1002/ijc.24157
    • (2009) International Journal of Cancer , vol.124 , Issue.9 , pp. 2186-2199
    • Dorn, D.C.1    Kou, C.A.2    Png, K.J.3    Moore, M.A.S.4
  • 31
    • 77957783919 scopus 로고    scopus 로고
    • Targeting of the B-lineage leukemia stem cells and their progeny with norcantharidin encapsulated liposomes modified with a novel CD19 monoclonal antibody 2E8 in vitro
    • 2-s2.0-77957783919 10.3109/10611861003649720
    • Zhang J., Tang Y., Li S., Liao C., Guo X., Targeting of the B-lineage leukemia stem cells and their progeny with norcantharidin encapsulated liposomes modified with a novel CD19 monoclonal antibody 2E8 in vitro. Journal of Drug Targeting 2010 18 9 675 687 2-s2.0-77957783919 10.3109/10611861003649720
    • (2010) Journal of Drug Targeting , vol.18 , Issue.9 , pp. 675-687
    • Zhang, J.1    Tang, Y.2    Li, S.3    Liao, C.4    Guo, X.5
  • 32
    • 83055173058 scopus 로고    scopus 로고
    • Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/ β -catenin signaling
    • 2-s2.0-83055173058 10.1007/s11060-011-0645-y
    • Cimmino F., Scoppettuolo M. N., Carotenuto M., De Antonellis P., Dato V. D., De Vita G., Zollo M., Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/ β -catenin signaling. Journal of Neuro-Oncology 2012 106 1 59 70 2-s2.0-83055173058 10.1007/s11060-011-0645-y
    • (2012) Journal of Neuro-Oncology , vol.106 , Issue.1 , pp. 59-70
    • Cimmino, F.1    Scoppettuolo, M.N.2    Carotenuto, M.3    De Antonellis, P.4    Dato, V.D.5    De Vita, G.6    Zollo, M.7
  • 33
    • 78149272917 scopus 로고    scopus 로고
    • Evaluation of anti-Wnt/ β -catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system
    • 2-s2.0-78149272917 10.1590/S0100-879X2010007500091
    • Chuang K. A., Lieu C. H., Tsai W. J., Wu M. H., Chen Y. C., Liao J. F., Wang C. C., Kuo Y. C., Evaluation of anti-Wnt/ β -catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system. Brazilian Journal of Medical and Biological Research 2010 43 10 931 941 2-s2.0-78149272917 10.1590/S0100-879X2010007500091
    • (2010) Brazilian Journal of Medical and Biological Research , vol.43 , Issue.10 , pp. 931-941
    • Chuang, K.A.1    Lieu, C.H.2    Tsai, W.J.3    Wu, M.H.4    Chen, Y.C.5    Liao, J.F.6    Wang, C.C.7    Kuo, Y.C.8
  • 34
    • 14144249977 scopus 로고    scopus 로고
    • Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT28 colorectal adenocarcinoma cells
    • DOI 10.1097/00001813-200503000-00008
    • Chen Y.-J., Shieh C.-J., Tsai T.-H., Kuo C.-D., Ho L.-T., Liu T.-Y., Liao H.-F., Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT28 colorectal adenocarcinoma cells. Anti-Cancer Drugs 2005 16 3 293 299 2-s2.0-14144249977 10.1097/00001813-200503000-00008 (Pubitemid 40283944)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.3 , pp. 293-299
    • Chen, Y.-J.1    Shieh, C.-J.2    Tsai, T.-H.3    Kuo, C.-D.4    Ho, L.-T.5    Liu, T.-Y.6    Liao, H.-F.7
  • 35
    • 77955608840 scopus 로고    scopus 로고
    • Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo
    • 2-s2.0-77955608840
    • Fan Y.-Z., Zhao Z.-M., Fu J.-Y., Chen C.-Q., Sun W., Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo. Hepatobiliary and Pancreatic Diseases International 2010 9 4 414 422 2-s2.0-77955608840
    • (2010) Hepatobiliary and Pancreatic Diseases International , vol.9 , Issue.4 , pp. 414-422
    • Fan, Y.-Z.1    Zhao, Z.-M.2    Fu, J.-Y.3    Chen, C.-Q.4    Sun, W.5
  • 36
    • 33846967813 scopus 로고    scopus 로고
    • Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro
    • Fan Y.-Z., Fu J.-Y., Zhao Z.-M., Chen C.-Q., Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro. Hepatobiliary and Pancreatic Diseases International 2007 6 1 72 80 2-s2.0-33846967813 (Pubitemid 46243165)
    • (2007) Hepatobiliary and Pancreatic Diseases International , vol.6 , Issue.1 , pp. 72-80
    • Fan, Y.-Z.1    Fu, J.-Y.2    Zhao, Z.-M.3    Chen, C.-Q.4
  • 37
    • 58249124759 scopus 로고    scopus 로고
    • Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells
    • 2-s2.0-58249124759 10.1016/j.lfs.2008.11.020
    • Chen Y.-C., Chang S.-C., Wu M.-H., Chuang K.-A., Wu J.-Y., Tsai W.-J., Kuo Y.-C., Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells. Life Sciences 2009 84 7-8 218 226 2-s2.0-58249124759 10.1016/j.lfs.2008.11.020
    • (2009) Life Sciences , vol.84 , Issue.7-8 , pp. 218-226
    • Chen, Y.-C.1    Chang, S.-C.2    Wu, M.-H.3    Chuang, K.-A.4    Wu, J.-Y.5    Tsai, W.-J.6    Kuo, Y.-C.7
  • 38
    • 70349748544 scopus 로고    scopus 로고
    • Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect
    • 2-s2.0-70349748544 10.1016/j.lfs.2009.09.003
    • Chen Y.-J., Tsai Y.-M., Kuo C.-D., Ku K.-L., Shie H.-S., Liao H.-F., Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect. Life Sciences 2009 85 17-18 642 651 2-s2.0-70349748544 10.1016/j.lfs.2009.09.003
    • (2009) Life Sciences , vol.85 , Issue.17-18 , pp. 642-651
    • Chen, Y.-J.1    Tsai, Y.-M.2    Kuo, C.-D.3    Ku, K.-L.4    Shie, H.-S.5    Liao, H.-F.6
  • 39
    • 84870840267 scopus 로고    scopus 로고
    • Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells
    • e37006
    • Chen Y. J., Kuo C. D., Chen S. H., Chen W.-J., Huang W.-C., Chao K. S. C., Liao H.-F., Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells. PLoS One 2012 7 5 e37006
    • (2012) PLoS One , vol.7 , Issue.5
    • Chen, Y.J.1    Kuo, C.D.2    Chen, S.H.3    Chen, W.-J.4    Huang, W.-C.5    Chao, K.S.C.6    Liao, H.-F.7
  • 40
    • 70249142794 scopus 로고    scopus 로고
    • A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells
    • 2-s2.0-70249142794 10.1016/j.cbi.2009.07.004
    • Chen Y.-J., Chang W.-M., Liu Y.-W., Lee C.-Y., Jang Y.-H., Kuo C.-D., Liao H.-F., A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. Chemico-Biological Interactions 2009 181 3 440 446 2-s2.0-70249142794 10.1016/j.cbi.2009.07.004
    • (2009) Chemico-Biological Interactions , vol.181 , Issue.3 , pp. 440-446
    • Chen, Y.-J.1    Chang, W.-M.2    Liu, Y.-W.3    Lee, C.-Y.4    Jang, Y.-H.5    Kuo, C.-D.6    Liao, H.-F.7
  • 41
    • 70449530514 scopus 로고    scopus 로고
    • Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action
    • 2-s2.0-70449530514 10.1007/s10616-009-9210-3
    • Huang Y., Liu Q., Liu K., Yagasaki K., Zhang G., Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action. Cytotechnology 2009 59 3 201 208 2-s2.0-70449530514 10.1007/s10616-009-9210-3
    • (2009) Cytotechnology , vol.59 , Issue.3 , pp. 201-208
    • Huang, Y.1    Liu, Q.2    Liu, K.3    Yagasaki, K.4    Zhang, G.5
  • 42
    • 70449524216 scopus 로고    scopus 로고
    • Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells
    • 2-s2.0-70449524216 10.1007/s10616-009-9223-y
    • Liu Q., Duan H., Luan J., Yagasaki K., Zhang G., Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells. Cytotechnology 2009 59 3 211 217 2-s2.0-70449524216 10.1007/s10616-009-9223-y
    • (2009) Cytotechnology , vol.59 , Issue.3 , pp. 211-217
    • Liu, Q.1    Duan, H.2    Luan, J.3    Yagasaki, K.4    Zhang, G.5
  • 43
    • 0034885358 scopus 로고    scopus 로고
    • New insights into the role of nuclear factor-B in cell growth regulation
    • Chen F., Castranova V., Shi X., New insights into the role of nuclear factor- B in cell growth regulation. American Journal of Pathology 2001 159 2 387 397 2-s2.0-0034885358 (Pubitemid 32751067)
    • (2001) American Journal of Pathology , vol.159 , Issue.2 , pp. 387-397
    • Chen, F.1    Castranova, V.2    Shi, X.3
  • 44
    • 84856750556 scopus 로고    scopus 로고
    • Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-Kb activity
    • 2-s2.0-84856750556 10.1371/journal.pone.0031055 e31055
    • Yeh C.-B., Hsieh M.-J., Hsieh Y.-H., Chien M.-H., Chiou H.-L., Yang S.-F., Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-Kb activity. PLoS One 2012 7 2 2-s2.0-84856750556 10.1371/journal.pone.0031055 e31055
    • (2012) PLoS One , vol.7 , Issue.2
    • Yeh, C.-B.1    Hsieh, M.-J.2    Hsieh, Y.-H.3    Chien, M.-H.4    Chiou, H.-L.5    Yang, S.-F.6
  • 45
    • 84870342662 scopus 로고    scopus 로고
    • Uptake and transport of a novel anticancer drug-delivery system: Lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers
    • Guan M., Zhu Q. L., Liu Y., Bei Y. Y., Gu Z. L., Zhang X. N., Zhang Q., Uptake and transport of a novel anticancer drug-delivery system: lactosyl-norcantharidin-associated N-trimethyl chitosan nanoparticles across intestinal Caco-2 cell monolayers. International Journal of Nanomedicine 2012 7 1921 1930
    • (2012) International Journal of Nanomedicine , vol.7 , pp. 1921-1930
    • Guan, M.1    Zhu, Q.L.2    Liu, Y.3    Bei, Y.Y.4    Gu, Z.L.5    Zhang, X.N.6    Zhang, Q.7
  • 46
    • 10444235120 scopus 로고    scopus 로고
    • Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio
    • DOI 10.1016/j.canlet.2004.07.045, PII S0304383504006305
    • Kok S.-H., Cheng S.-J., Hong C.-Y., Lee J.-J., Lin S.-K., Kuo Y.-S., Chiang C.-P., Kuo M. Y.-P., Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. Cancer Letters 2005 217 1 43 52 2-s2.0-10444235120 10.1016/j.canlet.2004. 07.045 (Pubitemid 39642865)
    • (2005) Cancer Letters , vol.217 , Issue.1 , pp. 43-52
    • Kok, S.-H.1    Cheng, S.-J.2    Hong, C.-Y.3    Lee, J.-J.4    Lin, S.-K.5    Kuo, Y.-S.6    Chiang, C.-P.7    Kuo, M.Y.-P.8
  • 47
    • 80054764025 scopus 로고    scopus 로고
    • Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival
    • 2-s2.0-80054764025 10.1097/TP.0b013e31822d8708
    • Hsieh C.-H., Liao H.-F., Kuo C.-D., Huang Y.-C., Shueng P.-W., Hsu Y.-P., Wang L.-Y., Tsai T.-H., Chen Y.-J., Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival. Transplantation 2011 92 8 848 857 2-s2.0-80054764025 10.1097/TP.0b013e31822d8708
    • (2011) Transplantation , vol.92 , Issue.8 , pp. 848-857
    • Hsieh, C.-H.1    Liao, H.-F.2    Kuo, C.-D.3    Huang, Y.-C.4    Shueng, P.-W.5    Hsu, Y.-P.6    Wang, L.-Y.7    Tsai, T.-H.8    Chen, Y.-J.9
  • 49
    • 79951972078 scopus 로고    scopus 로고
    • Norcantharidin attenuates tubulointerstitial fibrosis in rat models with diabetic nephropathy
    • 2-s2.0-79951972078 10.3109/0886022X.2011.553305 553305
    • Li Y., Chen Q., Liu F.-Y., Peng Y.-M., Hou T., Duan S.-B., Li J., Luo J.-H., Sun L., Ling G.-H., Norcantharidin attenuates tubulointerstitial fibrosis in rat models with diabetic nephropathy. Renal Failure 2011 33 2 233 241 2-s2.0-79951972078 10.3109/0886022X.2011.553305 553305
    • (2011) Renal Failure , vol.33 , Issue.2 , pp. 233-241
    • Li, Y.1    Chen, Q.2    Liu, F.-Y.3    Peng, Y.-M.4    Hou, T.5    Duan, S.-B.6    Li, J.7    Luo, J.-H.8    Sun, L.9    Ling, G.-H.10
  • 50
    • 0027401133 scopus 로고
    • The preliminary observation on immunosuppressive effect of norcantharidin in mice
    • Yan M. S., Xiue S., Wei L. X., Piao X. H., The preliminary observation on immunosuppressive effect of norcantharidin in mice. Immunopharmacology and Immunotoxicology 1993 15 1 79 85 2-s2.0-0027401133 (Pubitemid 23069481)
    • (1993) Immunopharmacology and Immunotoxicology , vol.15 , Issue.1 , pp. 79-85
    • Yan, M.S.1    Xiue, S.2    Wei, L.X.3    Piao, X.H.4
  • 51
    • 33847389710 scopus 로고    scopus 로고
    • Wnt signaling pathway in mammary gland development and carcinogenesis
    • 2-s2.0-33847389710 10.1159/000098207
    • Turashvili G., Bouchal J., Burkadze G., Kolar Z., Wnt signaling pathway in mammary gland development and carcinogenesis. Pathobiology 2007 73 5 213 223 2-s2.0-33847389710 10.1159/000098207
    • (2007) Pathobiology , vol.73 , Issue.5 , pp. 213-223
    • Turashvili, G.1    Bouchal, J.2    Burkadze, G.3    Kolar, Z.4
  • 52
    • 0033830945 scopus 로고    scopus 로고
    • Wnt/ β -catenin signaling
    • 2-s2.0-0033830945 10.1016/S1359-6101(00)00011-3
    • Akiyama T., Wnt/ β -catenin signaling. Cytokine and Growth Factor Reviews 2000 11 4 273 282 2-s2.0-0033830945 10.1016/S1359-6101(00)00011-3
    • (2000) Cytokine and Growth Factor Reviews , vol.11 , Issue.4 , pp. 273-282
    • Akiyama, T.1
  • 53
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P., Wnt signaling and cancer. Genes and Development 2000 14 15 1837 1851 2-s2.0-0033895709 (Pubitemid 30639518)
    • (2000) Genes and Development , vol.14 , Issue.15 , pp. 1837-1851
    • Polakis, P.1
  • 54
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, Catenin, and Cadherin pathways
    • DOI 10.1126/science.1094291
    • Nelson W. J., Nusse R., Convergence of Wnt, β -catenin, and cadherin pathways. Science 2004 303 5663 1483 1487 2-s2.0-1542347695 10.1126/science.1094291 (Pubitemid 38314410)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 56
    • 0033119801 scopus 로고    scopus 로고
    • Catenin regulates expression of cyclin D1 in colon carcinoma cells
    • DOI 10.1038/18884
    • Tetsu O., McCormick F., β -catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999 398 6726 422 426 2-s2.0-0033119801 10.1038/18884 (Pubitemid 29180374)
    • (1999) Nature , vol.398 , Issue.6726 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 58
    • 33746808398 scopus 로고    scopus 로고
    • Wnt-catenin signaling in development and disease
    • DOI 10.1016/j.cell.2006.10.018, PII S0092867406013444
    • Clevers H., Wnt/ β -catenin signaling in development and disease. Cell 2006 127 3 469 480 2-s2.0-33746808398 10.1016/j.cell.2006.10.018 (Pubitemid 44647433)
    • (2006) Cell , vol.127 , Issue.3 , pp. 469-480
    • Clevers, H.1
  • 60
    • 0032891720 scopus 로고    scopus 로고
    • E-cadherin binding prevents catenin nuclear localization and catenin/LEF-1-mediated transactivation
    • Orsulic S., Huber O., Aberle H., Arnold S., Kemler R., E-cadherin binding prevents β -catenin nuclear localization and β -catenin/LEF-1- mediated transactivation. Journal of Cell Science 1999 112 part 8 1237 1245 2-s2.0-0032891720 (Pubitemid 29218912)
    • (1999) Journal of Cell Science , vol.112 , Issue.8 , pp. 1237-1245
    • Orsulic, S.1    Huber, O.2    Aberle, H.3    Arnold, S.4    Kemler, R.5
  • 61
    • 0036914924 scopus 로고    scopus 로고
    • Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization
    • DOI 10.1242/dev.00100
    • Gritli-Linde A., Bei M., Maas R., Zhang X. M., Linde A., McMahon A. P., Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 2002 129 23 5323 5337 2-s2.0-0036914924 10.1242/dev.00100 (Pubitemid 36040329)
    • (2002) Development , vol.129 , Issue.23 , pp. 5323-5337
    • Gritli-Linde, A.1    Bei, M.2    Maas, R.3    Zhang, X.M.4    Linde, A.5    McMahon, A.P.6
  • 62
    • 75749139262 scopus 로고    scopus 로고
    • Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
    • 2-s2.0-75749139262 10.1038/onc.2009.392
    • Yang L., Xie G., Fan Q., Xie J., Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 2010 29 4 469 481 2-s2.0-75749139262 10.1038/onc.2009.392
    • (2010) Oncogene , vol.29 , Issue.4 , pp. 469-481
    • Yang, L.1    Xie, G.2    Fan, Q.3    Xie, J.4
  • 63
    • 18944407603 scopus 로고    scopus 로고
    • Mammary stem cells, self-renewal pathways, and carcinogenesis
    • DOI 10.1186/bcr1021, 86
    • Liu S., Dontu G., Wicha M. S., Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Research 2005 7 3 86 95 2-s2.0-18944407603 10.1186/bcr1021 (Pubitemid 40704127)
    • (2005) Breast Cancer Research , vol.7 , Issue.3 , pp. 86-95
    • Liu, S.1    Dontu, G.2    Wicha, M.S.3
  • 64
    • 0142153787 scopus 로고    scopus 로고
    • The hedgehog signaling network
    • Cohen M. M. Jr., The hedgehog signaling network. American Journal of Medical Genetics 2003 123 1 5 28 2-s2.0-0142153787 (Pubitemid 37309353)
    • (2003) American Journal of Medical Genetics , vol.123 , Issue.1 , pp. 5-28
    • Cohen Jr., M.M.1
  • 65
    • 4444327331 scopus 로고    scopus 로고
    • Next top, the twilight zone: Hedgehog network regulation of mammary gland development
    • DOI 10.1023/B:JOMG.0000037160.24731.35, Embryonic Genes in Mammary Gland Development and Tumorigenesis
    • Lewis M. T., Veltmaat J. M., Next top, the twilight zone: hedgehog network regulation of mammary gland development. Journal of Mammary Gland Biology and Neoplasia 2004 9 2 165 181 2-s2.0-4444327331 10.1023/B:JOMG. 0000037160.24731.35 (Pubitemid 39177501)
    • (2004) Journal of Mammary Gland Biology and Neoplasia , vol.9 , Issue.2 , pp. 165-181
    • Lewis, M.T.1    Veltmaat, J.M.2
  • 66
    • 33947357165 scopus 로고    scopus 로고
    • Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells
    • DOI 10.1158/1078-0432.CCR-06-1407
    • Feng Y.-Z., Shiozawa T., Miyamoto T., Kashima H., Kurai M., Suzuki A., Ying-Song J., Konishi I., Overexpression of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells. Clinical Cancer Research 2007 13 5 1389 1398 2-s2.0-33947357165 10.1158/1078-0432.CCR-06- 1407 (Pubitemid 46450427)
    • (2007) Clinical Cancer Research , vol.13 , Issue.5 , pp. 1389-1398
    • Feng, Y.-Z.1    Shiozawa, T.2    Miyamoto, T.3    Kashima, H.4    Kurai, M.5    Suzuki, A.6    Ying-Song, J.7    Konishi, I.8
  • 67
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer formation and maintenance
    • Di Magliano M. P., Hebrok M., Hedgehog signalling in cancer formation and maintenance. Nature Reviews Cancer 2003 3 12 903 911 2-s2.0-0345059765 (Pubitemid 37500175)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.12 , pp. 903-911
    • Di Magliano, M.P.1    Hebrok, M.2
  • 68
    • 67650249220 scopus 로고    scopus 로고
    • Hedgehog signalling as a target in cancer stem cells
    • 2-s2.0-67650249220 10.1007/s12094-009-0341-y
    • Medina V., Calvo M. B., Díaz-Prado S., Espada J., Hedgehog signalling as a target in cancer stem cells. Clinical and Translational Oncology 2009 11 4 199 207 2-s2.0-67650249220 10.1007/s12094-009-0341-y
    • (2009) Clinical and Translational Oncology , vol.11 , Issue.4 , pp. 199-207
    • Medina, V.1    Calvo, M.B.2    Díaz-Prado, S.3    Espada, J.4
  • 69
    • 84862269410 scopus 로고    scopus 로고
    • Hedgehog pathway and GLI1 isoforms in human cancer
    • Carpenter R. L., Lo H. W., Hedgehog pathway and GLI1 isoforms in human cancer. Discovery Medicine 2012 13 69 105 113
    • (2012) Discovery Medicine , vol.13 , Issue.69 , pp. 105-113
    • Carpenter, R.L.1    Lo, H.W.2
  • 70
    • 0035479835 scopus 로고    scopus 로고
    • New aspects of Wnt signaling pathways in higher vertebrates
    • DOI 10.1016/S0959-437X(00)00231-8, PII S0959437X00002318
    • Huelsken J., Birchmeier W., New aspects of Wnt signaling pathways in higher vertebrates. Current Opinion in Genetics and Development 2001 11 5 547 553 2-s2.0-0035479835 10.1016/S0959-437X(00)00231-8 (Pubitemid 32800729)
    • (2001) Current Opinion in Genetics and Development , vol.11 , Issue.5 , pp. 547-553
    • Huelsken, J.1    Birchmeier, W.2
  • 71
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • DOI 10.1101/gad.938601
    • Ingham P. W., McMahon A. P., Hedgehog signaling in animal development: paradigms and principles. Genes and Development 2001 15 23 3059 3087 2-s2.0-0035577854 10.1101/gad.938601 (Pubitemid 33115673)
    • (2001) Genes and Development , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 72
    • 0037155737 scopus 로고    scopus 로고
    • Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
    • DOI 10.1016/S0092-8674(02)00664-5
    • Price M. A., Kalderon D., Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 2002 108 6 823 835 2-s2.0-0037155737 10.1016/S0092- 8674(02)00664-5 (Pubitemid 34327533)
    • (2002) Cell , vol.108 , Issue.6 , pp. 823-835
    • Price, M.A.1    Kalderon, D.2
  • 73
    • 0036849497 scopus 로고    scopus 로고
    • Similarities between the Hedgehog and Wnt signaling pathways
    • DOI 10.1016/S0962-8924(02)02388-7, PII S0962892402023887
    • Kalderon D., Similarities between the Hedgehog and Wnt signaling pathways. Trends in Cell Biology 2002 12 11 523 531 2-s2.0-0036849497 10.1016/S0962-8924(02)02388-7 (Pubitemid 35346703)
    • (2002) Trends in Cell Biology , vol.12 , Issue.11 , pp. 523-531
    • Kalderon, D.1
  • 75
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3- kinase/Akt cell survival pathway
    • DOI 10.1074/jbc.273.32.19929
    • Pap M., Cooper G. M., Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. Journal of Biological Chemistry 1998 273 32 19929 19932 2-s2.0-0032493729 10.1074/jbc.273.32.19929 (Pubitemid 28377539)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.32 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 76
    • 0029683606 scopus 로고    scopus 로고
    • The axis-inducing activity, stability, and subcellular distribution of catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    • Yost C., Torres M., Miller J. R., Huang E., Kimelman D., Moon R. T., The axis-inducing activity, stability, and subcellular distribution of β -catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes and Development 1996 10 12 1443 1454 2-s2.0-0029683606 (Pubitemid 26260702)
    • (1996) Genes and Development , vol.10 , Issue.12 , pp. 1443-1454
    • Yost, C.1    Torres, M.2    Miller, J.R.3    Huang, E.4    Kimelman, D.5    Moon, R.T.6
  • 77
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin- 1 leads to phosphorylation and activation of the NF-B p65/RelA subunit
    • Sizemore N., Leung S., Stark G. R., Activation of phosphatidylinositol 3-kinase in response to interleukin- 1 leads to phosphorylation and activation of the NF- B p65/RelA subunit. Molecular and Cellular Biology 1999 19 7 4798 4805 2-s2.0-0033038491 (Pubitemid 29289518)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.7 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 78
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-B: The enemy within
    • DOI 10.1016/j.ccr.2004.09.003, PII S1535610804002442
    • Aggarwal B. B., Nuclear factor- B: the enemy within. Cancer Cell 2004 6 3 203 208 2-s2.0-4544342570 10.1016/j.ccr.2004.09.003 (Pubitemid 39222032)
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 203-208
    • Aggarwal, B.B.1
  • 80
    • 1642474000 scopus 로고    scopus 로고
    • Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
    • DOI 10.1242/dev.00891
    • Kenney A. M., Widlund H. R., Rowitch D. H., Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 2004 131 1 217 228 (Pubitemid 38111428)
    • (2004) Development , vol.131 , Issue.1 , pp. 217-228
    • Kenney, A.M.1    Widlund, H.R.2    Rowitch, D.H.3
  • 81
    • 33745379407 scopus 로고    scopus 로고
    • Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways
    • DOI 10.1111/j.1745-7254.2006.00335.x
    • Fu J.-R., Liu W.-L., Zhou J.-F., Sun H.-Y., Xu H.-Z., Luo L., Zhang H., Zhou Y.-F., Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways. Acta Pharmacologica Sinica 2006 27 6 685 693 2-s2.0-33745379407 10.1111/j.1745-7254.2006.00335.x (Pubitemid 43943916)
    • (2006) Acta Pharmacologica Sinica , vol.27 , Issue.6 , pp. 685-693
    • Fu, J.-R.1    Liu, W.-L.2    Zhou, J.-F.3    Sun, H.-Y.4    Xu, H.-Z.5    Luo, L.6    Zhang, H.7    Zhou, Y.-F.8
  • 82
    • 0037424249 scopus 로고    scopus 로고
    • Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase
    • DOI 10.1074/jbc.M210635200
    • Kanda S., Mochizuki Y., Suematsu T., Miyata Y., Nomata K., Kanetake H., Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. Journal of Biological Chemistry 2003 278 10 8244 8249 2-s2.0-0037424249 10.1074/jbc.M210635200 (Pubitemid 36800569)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8244-8249
    • Kanda, S.1    Mochizuki, Y.2    Suematsu, T.3    Miyata, Y.4    Nomata, K.5    Kanetake, H.6
  • 84
    • 4444273153 scopus 로고    scopus 로고
    • Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
    • DOI 10.1038/sj.onc.1207818
    • Rao G., Pedone C. A., Valle L. D., Reiss K., Holland E. C., Fults D. W., Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 2004 23 36 6156 6162 2-s2.0-4444273153 10.1038/sj.onc.1207818 (Pubitemid 39178868)
    • (2004) Oncogene , vol.23 , Issue.36 , pp. 6156-6162
    • Rao, G.1    Pedone, C.A.2    Valle, L.D.3    Reiss, K.4    Holland, E.C.5    Fults, D.W.6
  • 85
    • 81155126047 scopus 로고    scopus 로고
    • Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer
    • 2-s2.0-81155126047 10.1158/0008-5472.CAN-11-1338
    • Yoo Y. A., Kang M. H., Lee H. J., Kim B.-H., Park J. K., Kim H. K., Kim J. S., Oh S. C., Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. Cancer Research 2011 71 22 7061 7070 2-s2.0-81155126047 10.1158/0008-5472.CAN-11-1338
    • (2011) Cancer Research , vol.71 , Issue.22 , pp. 7061-7070
    • Yoo, Y.A.1    Kang, M.H.2    Lee, H.J.3    Kim, B.-H.4    Park, J.K.5    Kim, H.K.6    Kim, J.S.7    Oh, S.C.8
  • 86
    • 84862809685 scopus 로고    scopus 로고
    • The protective effect of sonic hedgehog is mediated by the propidium iodide 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress
    • 2-s2.0-84859264334 10.1016/j.neuroscience.2012.02.019
    • Xia Y.-P., Dai R.-L., Li Y.-N., Mao L., Xue Y.-M., He Q.-W., Huang M., Huang Y., Mei Y.-W., Hu B., The protective effect of sonic hedgehog is mediated by the propidium iodide 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress. Neuroscience 2012 209 1 11 2-s2.0-84859264334 10.1016/j.neuroscience.2012.02.019
    • (2012) Neuroscience , vol.209 , pp. 1-11
    • Xia, Y.-P.1    Dai, R.-L.2    Li, Y.-N.3    Mao, L.4    Xue, Y.-M.5    He, Q.-W.6    Huang, M.7    Huang, Y.8    Mei, Y.-W.9    Hu, B.10
  • 87
    • 33746888182 scopus 로고    scopus 로고
    • Nuclear factor-B contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer
    • DOI 10.1158/0008-5472.CAN-05-4588
    • Nakashima H., Nakamura M., Yamaguchi H., Yamanaka N., Akiyoshi T., Koga K., Yamaguchi K., Tsuneyoshi M., Tanaka M., Katano M., Nuclear factor- B contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Research 2006 66 14 7041 7049 2-s2.0-33746888182 10.1158/0008-5472.CAN-05-4588 (Pubitemid 44197680)
    • (2006) Cancer Research , vol.66 , Issue.14 , pp. 7041-7049
    • Nakashima, H.1    Nakamura, M.2    Yamaguchi, H.3    Yamanaka, N.4    Akiyoshi, T.5    Koga, K.6    Yamaguchi, K.7    Tsuneyoshi, M.8    Tanaka, M.9    Katano, M.10
  • 88
    • 58249124375 scopus 로고    scopus 로고
    • Characterization of sonic hedgehog as a novel NF- B target gene that promotes NF- B-mediated apoptosis resistance and tumor growth in vivo
    • 2-s2.0-58249124375 10.1096/fj.08-111096
    • Kasperczyk H., Baumann B., Debatin K.-M., Fulda S., Characterization of sonic hedgehog as a novel NF- B target gene that promotes NF- B-mediated apoptosis resistance and tumor growth in vivo. The FASEB Journal 2009 23 1 21 33 2-s2.0-58249124375 10.1096/fj.08-111096
    • (2009) The FASEB Journal , vol.23 , Issue.1 , pp. 21-33
    • Kasperczyk, H.1    Baumann, B.2    Debatin, K.-M.3    Fulda, S.4
  • 89
    • 67349193226 scopus 로고    scopus 로고
    • Emerging role of Notch in stem cells and cancer
    • 2-s2.0-67349193226 10.1016/j.canlet.2008.09.030
    • Wang Z., Li Y., Banerjee S., Sarkar F. H., Emerging role of Notch in stem cells and cancer. Cancer Letters 2009 279 1 8 12 2-s2.0-67349193226 10.1016/j.canlet.2008.09.030
    • (2009) Cancer Letters , vol.279 , Issue.1 , pp. 8-12
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Sarkar, F.H.4
  • 90
    • 33646551228 scopus 로고    scopus 로고
    • Multiple functions of Notch signaling in self-renewing organs and cancer
    • DOI 10.1016/j.febslet.2006.03.024, PII S0014579306003267
    • Wilson A., Radtke F., Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Letters 2006 580 12 2860 2868 2-s2.0-33646551228 10.1016/j.febslet.2006.03.024 (Pubitemid 43729170)
    • (2006) FEBS Letters , vol.580 , Issue.12 , pp. 2860-2868
    • Wilson, A.1    Radtke, F.2
  • 91
    • 45549097925 scopus 로고    scopus 로고
    • Cancer stem cells and the ontogeny of lung cancer
    • 2-s2.0-45549097925 10.1200/JCO.2007.15.2702
    • Peacock C. D., Watkins D. N., Cancer stem cells and the ontogeny of lung cancer. Journal of Clinical Oncology 2008 26 17 2883 2889 2-s2.0-45549097925 10.1200/JCO.2007.15.2702
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.17 , pp. 2883-2889
    • Peacock, C.D.1    Watkins, D.N.2
  • 92
    • 45549091581 scopus 로고    scopus 로고
    • Medulloblastoma stem cells
    • 2-s2.0-45549091581 10.1200/JCO.2007.15.2264
    • Fan X., Eberhart C. G., Medulloblastoma stem cells. Journal of Clinical Oncology 2008 26 17 2821 2827 2-s2.0-45549091581 10.1200/JCO.2007.15.2264
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.17 , pp. 2821-2827
    • Fan, X.1    Eberhart, C.G.2
  • 93
    • 45549103691 scopus 로고    scopus 로고
    • Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy
    • 2-s2.0-45549103691 10.1200/JCO.2008.16.3931
    • Kakarala M., Wicha M. S., Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. Journal of Clinical Oncology 2008 26 17 2813 2820 2-s2.0-45549103691 10.1200/JCO.2008.16.3931
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.17 , pp. 2813-2820
    • Kakarala, M.1    Wicha, M.S.2
  • 94
    • 39749092525 scopus 로고    scopus 로고
    • Current View: Intestinal Stem Cells and Signaling
    • DOI 10.1053/j.gastro.2008.01.079, PII S0016508508001856
    • Scoville D. H., Sato T., He X. C., Li L., Current view: intestinal stem cells and signaling. Gastroenterology 2008 134 3 849 864 2-s2.0-39749092525 10.1053/j.gastro.2008.01.079 (Pubitemid 351312767)
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 849-864
    • Scoville, D.H.1    Sato, T.2    He, X.C.3    Li, L.4
  • 95
    • 0031594575 scopus 로고    scopus 로고
    • NF-B2 is a putative target gene of activated Notch-1 via RBP-J
    • Oswald F., Liptay S., Adler G., Schmid R. M., NF- B2 is a putative target gene of activated Notch-1 via RBP-J Molecular and Cellular Biology 1998 18 4 2077 2088 2-s2.0-0031594575 (Pubitemid 28152657)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.4 , pp. 2077-2088
    • Oswald, F.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 96
    • 2342471446 scopus 로고    scopus 로고
    • Notch-1 Regulates Cell Death Independently of Differentiation in Murine Erythroleukemia Cells Through Multiple Apoptosis and Cell Cycle Pathways
    • DOI 10.1002/jcp.10467
    • Jang M.-S., Miao H., Carlesso N., Shelly L., Zlobin A., Darack N., Qin J.-Z., Nickoloff B. J., Miele L., Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways. Journal of Cellular Physiology 2004 199 3 418 433 2-s2.0-2342471446 10.1002/jcp.10467 (Pubitemid 38580438)
    • (2004) Journal of Cellular Physiology , vol.199 , Issue.3 , pp. 418-433
    • Jang, M.-S.1    Miao, H.2    Carlesso, N.3    Shelly, L.4    Zlobin, A.5    Darack, N.6    Qin, J.-Z.7    Nickoloff, B.J.8    Miele, L.9
  • 97
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 inhibits invasion by inactivation of nuclear factor- B, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    • 2-s2.0-33645049305 10.1158/0008-5472.CAN-05-4281
    • Wang Z., Banerjee S., Li Y., Rahman K. M. W., Zhang Y., Sarkar F. H., Down-regulation of Notch-1 inhibits invasion by inactivation of nuclear factor- B, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Research 2006 66 5 2778 2784 2-s2.0-33645049305 10.1158/0008-5472.CAN-05-4281
    • (2006) Cancer Research , vol.66 , Issue.5 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.W.4    Zhang, Y.5    Sarkar, F.H.6
  • 99
    • 59749090797 scopus 로고    scopus 로고
    • CCL5 increases lung cancer migration via PI3K, Akt and NF- B pathways
    • 2-s2.0-59749090797 10.1016/j.bcp.2008.11.014
    • Huang C.-Y., Fong Y.-C., Lee C.-Y., Chen M.-Y., Tsai H.-C., Hsu H.-C., Tang C.-H., CCL5 increases lung cancer migration via PI3K, Akt and NF- B pathways. Biochemical Pharmacology 2009 77 5 794 803 2-s2.0-59749090797 10.1016/j.bcp.2008.11.014
    • (2009) Biochemical Pharmacology , vol.77 , Issue.5 , pp. 794-803
    • Huang, C.-Y.1    Fong, Y.-C.2    Lee, C.-Y.3    Chen, M.-Y.4    Tsai, H.-C.5    Hsu, H.-C.6    Tang, C.-H.7
  • 100
    • 45949095352 scopus 로고    scopus 로고
    • Osteoblasts-derived TGF-1 enhance motility and integrin upregulation through Akt, ERK, and NF-B-dependent pathway in human breast cancer cells
    • DOI 10.1002/mc.20411
    • Wei Y.-Y., Chen Y.-J., Hsiao Y.-C., Huang Y.-C., Lai T.-H., Tang C.-H., Osteoblasts-derived TGF- β 1 enhance motility and integrin upregulation through Akt, ERK, and NF- B-dependent pathway in human breast cancer cells. Molecular Carcinogenesis 2008 47 7 526 537 2-s2.0-45949095352 10.1002/mc.20411 (Pubitemid 351898583)
    • (2008) Molecular Carcinogenesis , vol.47 , Issue.7 , pp. 526-537
    • Wei, Y.-Y.1    Chen, Y.-J.2    Hsiao, Y.-C.3    Huang, Y.-C.4    Lai, T.-H.5    Tang, C.-H.6
  • 101
    • 0028308901 scopus 로고
    • Multidrug resistance in cancer chemotherapy
    • DOI 10.1007/BF00873229
    • Patel N. H., Rothenberg M. L., Multidrug resistance in cancer chemotherapy. Investigational New Drugs 1994 12 1 1 13 2-s2.0-0028308901 10.1007/BF00873229 (Pubitemid 24209059)
    • (1994) Investigational New Drugs , vol.12 , Issue.1 , pp. 1-13
    • Patel, N.H.1    Rothenberg, M.L.2
  • 102
    • 0344825356 scopus 로고    scopus 로고
    • P-glycoprotein: From genomics to mechanism
    • DOI 10.1038/sj.onc.1206948, Drug Resistance
    • Ambudkar S. V., Kimchi-Sarfaty C., Sauna Z. E., Gottesman M. M., P-glycoprotein: from genomics to mechanism. Oncogene 2003 22 47 7468 7485 2-s2.0-0344825356 10.1038/sj.onc.1206948 (Pubitemid 37487170)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISSUE. 6 , pp. 7468-7485
    • Ambudkar, S.V.1    Kimchi-Sarfaty, C.2    Sauna, Z.E.3    Gottesman, M.M.4
  • 103
    • 0029894447 scopus 로고    scopus 로고
    • MDR1/P-glycoprotein in haematological neoplasms
    • 2-s2.0-0029894447 10.1016/0959-8049(96)00055-X
    • Marie J.-P., Zhou D.-C., Gurbuxani S., Legrand O., Zittoun R., MDR1/P-glycoprotein in haematological neoplasms. European Journal of Cancer 1996 32 6 1034 1038 2-s2.0-0029894447 10.1016/0959-8049(96)00055-X
    • (1996) European Journal of Cancer , vol.32 , Issue.6 , pp. 1034-1038
    • Marie, J.-P.1    Zhou, D.-C.2    Gurbuxani, S.3    Legrand, O.4    Zittoun, R.5
  • 105
    • 0345724724 scopus 로고    scopus 로고
    • The MRP family of drug efflux pumps
    • DOI 10.1038/sj.onc.1206953, Drug Resistance
    • Kruh G. D., Belinsky M. G., The MRP family of drug efflux pumps. Oncogene 2003 22 47 7537 7552 2-s2.0-0345724724 10.1038/sj.onc.1206953 (Pubitemid 37487175)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISSUE. 6 , pp. 7537-7552
    • Kruh, G.D.1    Belinsky, M.G.2
  • 108
    • 0033179207 scopus 로고    scopus 로고
    • Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia
    • Legrand O., Simonin G., Beauchamp-Nicoud A., Zittoun R., Marie J.-P., Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia. Blood 1999 94 3 1046 1056 2-s2.0-0033179207 (Pubitemid 29361837)
    • (1999) Blood , vol.94 , Issue.3 , pp. 1046-1056
    • Legrand, O.1    Simonin, G.2    Beauchamp-Nicoud, A.3    Zittoun, R.4    Marie, J.-P.5
  • 110
    • 0032895533 scopus 로고    scopus 로고
    • Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
    • Miyake K., Mickley L., Litman T., Zhan Z., Robey R., Cristensen B., Brangi M., Greenberger L., Dean M., Fojo T., Bates S. E., Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Research 1999 59 1 8 13 2-s2.0-0032895533 (Pubitemid 29062946)
    • (1999) Cancer Research , vol.59 , Issue.1 , pp. 8-13
    • Miyake, K.1    Mickley, L.2    Litman, T.3    Zhan, Z.4    Robey, R.5    Cristensen, B.6    Brangi, M.7    Greenberger, L.8    Dean, M.9    Fojo, T.10    Bates, S.E.11
  • 111
    • 0345688604 scopus 로고    scopus 로고
    • Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
    • DOI 10.1038/sj.onc.1206938, Drug Resistance
    • Doyle L. A., Ross D. D., Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 2003 22 47 7340 7358 2-s2.0-0345688604 10.1038/sj.onc.1206938 (Pubitemid 37487163)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISSUE. 6 , pp. 7340-7358
    • Doyle, L.A.1    Ross, D.D.2
  • 113
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • DOI 10.1038/nature05384, PII NATURE05384
    • Ricci-Vitiani L., Lombardi D. G., Pilozzi E., Biffoni M., Todaro M., Peschle C., De Maria R., Identification and expansion of human colon-cancer-initiating cells. Nature 2007 445 7123 111 115 2-s2.0-33846095137 10.1038/nature05384 (Pubitemid 46067311)
    • (2007) Nature , vol.445 , Issue.7123 , pp. 111-115
    • Ricci-Vitiani, L.1    Lombardi, D.G.2    Pilozzi, E.3    Biffoni, M.4    Todaro, M.5    Peschle, C.6    De Maria, R.7
  • 114
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • DOI 10.1038/35102167
    • Reya T., Morrison S. J., Clarke M. F., Weissman I. L., Stem cells, cancer, and cancer stem cells. Nature 2001 414 6859 105 111 2-s2.0-0035499267 10.1038/35102167 (Pubitemid 33041634)
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 116
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • DOI 10.1038/nature03100
    • Beachy P. A., Karhadkar S. S., Berman D. M., Tissue repair and stem cell renewal in carcinogenesis. Nature 2004 432 7015 324 331 2-s2.0-9244221172 10.1038/nature03100 (Pubitemid 39551660)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 117
    • 1942473030 scopus 로고    scopus 로고
    • Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity
    • Taş S., Avci O., Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity. European Journal of Dermatology 2004 14 2 96 102 2-s2.0-1942473030 (Pubitemid 38510025)
    • (2004) European Journal of Dermatology , vol.14 , Issue.2 , pp. 96-102
    • Tas, S.1    Avci, O.2
  • 118
    • 62549160588 scopus 로고    scopus 로고
    • First-in-class, first-in-human phase i results of targeted agents: Highlights of the 2008 American society of clinical oncology meeting
    • 2-s2.0-62549160588
    • Molckovsky A., Siu L. L., First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting. Journal of Hematology & Oncology 2008 1 20 2-s2.0-62549160588
    • (2008) Journal of Hematology & Oncology , vol.1 , pp. 20
    • Molckovsky, A.1    Siu, L.L.2
  • 119
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • DOI 10.1146/annurev.cellbio.14.1.59
    • Wodarz A., Nusse R., Mechanisms of Wnt signaling in development. Annual Review of Cell and Developmental Biology 1998 14 59 88 2-s2.0-0032406715 10.1146/annurev.cellbio.14.1.59 (Pubitemid 29001449)
    • (1998) Annual Review of Cell and Developmental Biology , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 120
    • 0033486152 scopus 로고    scopus 로고
    • Beta-catenin signaling and cancer
    • Morin P. J., beta-catenin signaling and cancer. Bioessays 1999 21 12 1021 1030
    • (1999) Bioessays , vol.21 , Issue.12 , pp. 1021-1030
    • Morin, P.J.1
  • 121
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through catenin
    • DOI 10.1126/science.1071549
    • Moon R. T., Bowerman B., Boutros M., Perrimon N., The promise and perils of Wnt signaling through β -catenin. Science 2002 296 5573 1644 1646 2-s2.0-0037205007 10.1126/science.1071549 (Pubitemid 34579151)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 125
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • DOI 10.1038/nbt1137, PII N1137
    • Adams G. P., Weiner L. M., Monoclonal antibody therapy of cancer. Nature Biotechnology 2005 23 9 1147 1157 2-s2.0-27144449009 10.1038/nbt1137 (Pubitemid 41486396)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 126
    • 70349638289 scopus 로고    scopus 로고
    • Tumour-initiating cells: Challenges and opportunities for anticancer drug discovery
    • 2-s2.0-70349638289 10.1038/nrd2137
    • Zhou B.-B. S., Zhang H., Damelin M., Geles K. G., Grindley J. C., Dirks P. B., Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nature Reviews Drug Discovery 2009 8 10 806 823 2-s2.0-70349638289 10.1038/nrd2137
    • (2009) Nature Reviews Drug Discovery , vol.8 , Issue.10 , pp. 806-823
    • Zhou, B.-B.S.1    Zhang, H.2    Damelin, M.3    Geles, K.G.4    Grindley, J.C.5    Dirks, P.B.6
  • 128
    • 84867869033 scopus 로고    scopus 로고
    • Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma
    • Wang Y. F., Chang C. J., Lin C. P., Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma. Head Neck 2012 34 11 1556 1561
    • (2012) Head Neck , vol.34 , Issue.11 , pp. 1556-1561
    • Wang, Y.F.1    Chang, C.J.2    Lin, C.P.3
  • 129
    • 0002723564 scopus 로고
    • X-Ray and ultraviolet sensitivity of synchronized Chinese hamster cells at various stages of the cell cycle
    • Sinclair W. K., Morton R. A., X-Ray and ultraviolet sensitivity of synchronized Chinese hamster cells at various stages of the cell cycle. Biophysical Journal 1965 5 1 25
    • (1965) Biophysical Journal , vol.5 , pp. 1-25
    • Sinclair, W.K.1    Morton, R.A.2
  • 130
    • 0013973616 scopus 로고
    • X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells
    • 2-s2.0-0013973616
    • Sinclair W. K., Morton R. A., X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiation Research 1966 29 3 450 474 2-s2.0-0013973616
    • (1966) Radiation Research , vol.29 , Issue.3 , pp. 450-474
    • Sinclair, W.K.1    Morton, R.A.2


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