Wnt/β-catenin signaling

Cytokine and Growth Factor Reviews

Volumn 11, Issue 4, 2000, Pages 273-282

  Akiyama, Tetsu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Catenin; APC; Axin; TCF LEF; Wnt signaling

Indexed keywords

AXIN; AXIN PROTEIN; BETA CATENIN; CYTOSKELETON PROTEIN; DNA BINDING PROTEIN; DNA BINDING PROTEINS; LEF-1 PROTEIN; LYMPHOID ENHANCER FACTOR 1; ONCOPROTEIN; PROTEIN; PROTO ONCOGENE PROTEIN INT 1; PROTO ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEIN INT-1; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ANIMAL; CANCER; CARCINOGENESIS; EMBRYO DEVELOPMENT; FETUS DEVELOPMENT; GENE MUTATION; GENE TARGETING; HUMAN; MOLECULAR GENETICS; MUTATION; NEOPLASM; NONHUMAN; SHORT SURVEY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMAL; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; EMBRYO AND FETAL DEVELOPMENT; GENES, APC; HUMAN; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PROTEINS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0033830945     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(00)00011-3     Document Type: Short Survey

References (109)

1. Wnt signaling: A common theme in animal development
2. Signal transduction through beta-catenin and specification of cell fate during embryogenesis
3. Signaling by wingless in Drosophila
4. Signal transduction of beta-catenin
5. Wnt genes
6. The adenomatous polyposis coli (APC) tumor suppressor
7. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
8. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability
9. The role of Wnt genes in vertebrate development
10. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system
11. Lessons from hereditary colorectal cancer
12. APC: The plot thickens
13. Functional interaction of beta-catenin with the transcription factor LEF-1
14. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
15. Pangolin encodes a Lef-I homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
16. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
17. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
18. Cadherin cell adhesion receptors as a morphogenetic regulator
19. Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin
20. Cadherins in the developing central nervous system: An adhesive code for segmental and functional subdivisions
21. Beta-catenin associates with the actin-bundling protein fascin in a noncadherin complex
22. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
23. Prescnilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin
24. Lack of beta-catenin affects mouse development at gastrulation
25. Requirement for beta-catenin in anteriorposterior axis formation in mice
26. Three-dimensional structure of the armadillo repeat region of beta-catenin
27. Association of the APC gene product with beta-catenin
28. The APC protein and E-cadherin form similar bul independent complexes with alpha-catenin, beta-catenin and plakoglobin
29. An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling
30. Drosophila alpha-catenin and E-cadherin bind to distinct regions of Drosophila Armadillo
31. The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase
32. Apoptosis and APC in colorectal tumorigenesis
33. The APC gene product in normal and tumor cells
34. Subcellular localization of the APC protein: Immunoelectron microscopic study of the association of the APC protein with catenin
35. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in actixe cell migration
36. The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells
37. Association of the APC tumor suppressor protein with catenins
38. APC binds to the novel protein EB1
39. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
40. Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene
41. Constitutive transcriptional activation bY a beta-catenin-Tcf complex in APC-/colon carcinoma
42. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
43. Stabilization of beta-catenin by genetic defects in melanoma cell lines
44. The oncogenic activation of beta-catenin
45. Beta-catenin signaling and cancer
46. Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin
47. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
48. 2-terminal truncated Beta-catenin on mouse intestinal epithelial homeostasis
49. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
50. A common human skin tumour is caused by activating mutations in beta-catenin
51. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
52. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor
53. Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis
54. A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo
55. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
56. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
57. Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
58. Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
59. A new Drosophila APC homologue associated with adhesive zones of epithelial cells
60. Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization
61. Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus
62. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
63. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
64. Extraction and analysis of diagnostically useful proteins from formalin-fixed, paraffin-embedded tissue sections
65. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin
66. Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
67. Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
68. Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription
69. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK 3beta
70. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
71. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
72. Functional domains of axin. Importance of the C terminus as an oligomerization domain
73. Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
74. Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex
75. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
76. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
77. Axin and Fratl interact with dvl and GSK, bridging Dvl to GSK in Writ-mediated regulation of LEF-1
78. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
79. Down-regulation of β-catenin by the colorectal tumor supressor APC requires association with Axin and β-catenin
80. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
81. Beta-catenin is a target for the ubiquitin-proteasome pathway
82. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
83. Direct and long-range action of a wingless morphogen gradient
84. Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein
85. Negative regulation of Armadillo, a Wingless effector in Drosophila
86. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
87. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
88. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
89. HOS, a human homolog of Slimb, forms an SCF complex with Skpl and Cullinl and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin
90. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
91. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function
92. A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer
93. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box
94. The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures
95. An HMG-box-containing T-cell factor required for thymocyte differentiation
96. Critical involvement of Tcf-1 in expansion of thymocytes
97. Synergy between tumor suppressor APC and the β-catenin-Tcf4 target Tcfl
98. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
99. Wnt3a-/-like phenotype and limb deficiency in Lef1(-/-)Tcfl(-/-) mice
100. Drosophila Tcf and Groucho interact to repress Wingless signalling activity
101. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
102. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
103. The TAK1-NLK-MAPK-related pathway antagonizes signalling between betacatenin and transcription factor TCF
104. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
105. A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
106. The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer
107. LEF-I/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter
108. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
109. Identification of c-MYC as a target of the APC pathway