A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells

Chemico-Biological Interactions

Volumn 181, Issue 3, 2009, Pages 440-446

  Chen, Yu Jen ^a   Chang, Wei Min ^b   Liu, Yi Wen ^b   Lee, Chia Yun ^b   Jang, Yi Hua ^b   Kuo, Cheng Deng ^c   Liao, Hui Fen ^b,c  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Colorectal cancer; Matrix metalloproteinase 9 (MMP 9); Norcantharidin; Sp1

Indexed keywords

CIS ACTING ELEMENT; GELATINASE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; NORCANTHARIDIN; STAT1 PROTEIN; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PLASMID; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; WILD TYPE;

BASE SEQUENCE; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOTTING, WESTERN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA PRIMERS; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; MATRIX METALLOPROTEINASE 9; NEOPLASM METASTASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

MELOIDAE; MYLABRIS PHALERATA;

EID: 70249142794     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.07.004     Document Type: Article

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