The protective effect of sonic hedgehog is mediated by the propidium iodide 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress

Neuroscience

Volumn 209, Issue , 2012, Pages 1-11

  Xia, Y P ^a   Dai, R L ^a   Li, Y N ^a   Mao, L ^a   Xue, Y M ^a   He, Q W ^a   Huang, M ^a   Huang, Y ^a   Mei, Y W ^a   Hu, B ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Astrocytes; Oxidative stress; Sonic hedgehog signaling

Indexed keywords

HYDROGEN PEROXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROPIDIUM IODIDE 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL STRESS; CELL SURVIVAL; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; SURVIVAL RATE; UPREGULATION;

ANIMALS; APOPTOSIS; ASTROCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HEDGEHOG PROTEINS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; NEURONS; OXIDANTS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84862809685     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.02.019     Document Type: Article

References (45)

1. Adams J.M., Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998, 281(5381):1322-1326.
2. Amankulor N.M., Hambardzumyan D., Pyonteck S.M., et al. Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. J Neurosci 2009, 29(33):10299-10308.
3. Atkinson P.J., Dellovade T., Albers D., et al. Sonic hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2. J Neurochem 2009, 108(6):1539-1549.
4. Banerjee S.B., Rajendran R., Dias B.G., et al. Recruitment of the sonic hedgehog signalling cascade in electroconvulsive seizure-mediated regulation of adult rat hippocampal neurogenesis. Eur J Neurosci 2005, 22(7):1570-1580.
5. Bar E.E., Chaudhry A., Farah M.H., et al. Hedgehog signaling promotes medulloblastoma survival via Bc/II. Am J Pathol 2007, 170(1):347-355.
6. Blanc E.M., Bruce Keller A.J., Mattson M.P. Astrocytic gap junctional communication decreases neuronal vulnerability to oxidative stress-induced disruption of Ca2+ homeostasis and cell death. J Neurochem 1998, 70(3):958-970.
7. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296(5573):1655-1657.
8. Chuang P.T., McMahon A.P. Vertebrate hedgehog signalling modulated by induction of a hedgehog-binding protein. Nature 1999, 397(6720):617-620.
9. Cohen M.M. The hedgehog signaling network. Am J Med Genet A 123A 2003, 1:5-28.
10. Curtin J.F., Donovan M., Cotter T.G. Regulation and measurement of oxidative stress in apoptosis. J Immunol Methods 2002, 265(1-2):49-72.
11. Dahia P.L.M., Aguiar R.C.T., Alberta J., et al. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies. Hum Mol Genet 1999, 8(2):185-193.
12. Dai R.L., Zhu S.Y., Xia Y.P., et al. Sonic hedgehog protects cortical neurons against oxidative stress. Neurochem Res 2011, 36:67-75.
13. Datta S.R., Dudek H., Tao X., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91(2):231-241.
14. del Zoppo G.J., Hallenbeck J.M. Advances in the vascular pathophysiology of ischemic stroke. Thromb Res 2000, 98(3):73-81.
15. Desagher S., Glowinski J., Premont J. Astrocytes protect neurons from hydrogen peroxide toxicity. J Neurosci 1996, 16(8):2553-2562.
16. Echelard Y., Epstein D.J., St-Jacques B., et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993, 75(7):1417-1430.
17. Ekestern E. Neurotrophic factors and amyotrophic lateral sclerosis. Neurodegener Dis 2004, 1(2-3):88-100.
18. Elia D., Madhala D., Ardon E., et al. Sonic hedgehog promotes proliferation and differentiation of adult muscle cells: involvement of MAPK/ERK and PI3K/Akt pathways. Biochim Biophys Acta 2007, 1773(9):1438-1446.
19. Hammond R., Blaess S., Ardon E., et al. Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons. PLoS One 2009, 4(9):e7007.
20. Heine V.M., Rowitch D.H. Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism. J Clin Invest 2009, 119(2):267-277.
21. Hurtado-Lorenzo A., Millan E., Gonzalez-Nicolini V., et al. Differentiation and transcription factor gene therapy in experimental Parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration. Mol Ther 2004, 10(3):507-524.
22. Johnson R.L., Tabin C. The long and short of hedgehog signaling. Cell 1995, 81(3):313-316.
23. Lee T.H., Kato H., Chen S.T., et al. Expression disparity of brain-derived neurotrophic factor immunoreactivity and mRNA in ischemic hippocampal neurons. Neuroreport 2002, 13(17):2271-2275.
24. Mattson M.P., Barger S.W., Furukawa K., et al. Cellular signaling roles of TGF [beta], TNF [alpha] and [beta] APP in brain injury responses and Alzheimer's disease. Brain Res Rev 1997, 23(1-2):47-61.
25. Matus A., Bernhardt R., Hugh-Jones T. High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain. Proc Natl Acad Sci USA 1981, 78(5):3010-3014.
26. McCall T.D., Pedone C.A., Fults D.W. Apoptosis suppression by somatic cell transfer of Bcl-2 promotes sonic hedgehog-dependent medulloblastoma formation in mice. Cancer Res 2007, 67(11):5179-5185.
27. McCarthy K.D., de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980, 85(3):890-902.
28. Park L.C.H., Zhang H., Gibson G.E. Co-culture with astrocytes or microglia protects metabolically impaired neurons. Mech Ageing Dev 2001, 123(1):21-27.
29. Porter J.A., von Kessler D.P., Ekker S.C., et al. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 1995, 374(6520):363-366.
30. Riobo N.A., Lu K., Ai X., et al. Phosphoinositide 3-kinase and Akt are essential for sonic hedgehog signaling. Proc Natl Acad Sci U S A 2006, 103(12):4505-4510.
31. Riobo N.A., Manning D.R. Pathways of signal transduction employed by vertebrate hedgehogs. Biochem J 2007, 403(3):369-379.
32. Rouach N., Calvo C.F., Duquennoy H., et al. Hydrogen peroxide increases gap junctional communication and induces astrocyte toxicity: regulation by brain macrophages. Glia 2004, 45(1):28-38.
33. Sims J.R., Lee S.W., Topalkara K., et al. Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke 2009, 40(11):3618-3626.
34. Takano T., Tian G.F., Peng W., et al. ) Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 2006, 9(2):260-267.
35. Takuma K., Mori K., Lee E., et al. Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes. Brain Res 2002, 946(2):232-238.
36. Tam S.J., Watts R.J. Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier. Annu Rev Neurosci 2010, 33:379-408.
37. Tokumine J., Kakinohana O., Cizkova D., et al. Changes in spinal GDNF, BDNF, and NT-3 expression after transient spinal cord ischemia in the rat. J Neurosci Res 2003, 74(4):552-561.
38. Traiffort E., Angot E., Ruat M. Sonic hedgehog signaling in the mammalian brain. J Neurochem 2010, 113(3):576-590.
39. Ueda K., Takano H., Niitsuma Y., et al. Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice. J Clin Invest 2010, 120(6):2016-2029.
40. Van Den Bosch L., Storkebaum E., Vleminckx V., et al. Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiol Dis 2004, 17(1):21-28.
41. van den Heuvel M., Ingham P.W. Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 1996, 382(6591):547-551.
42. Wallace V.A., Raff M.C. A role for sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. Development 1999, 126(13):2901-2909.
43. Yang Y., Li Q., Deng Z., et al. Protection from lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by activation of hedgehog signaling pathway. Mol Biol Rep 2011, 1-8.
44. Yin K.J., Deng Z., Huang H., et al. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiol Dis 2010, 38(1):17-26.
45. Zhu D., Tan K.S., Zhang X., et al. Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes. J Cell Sci 2005, 118(Pt 16):3695-3703.