Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH 2-terminal kinase signaling pathways in human hepatoma HepG2 cells

British Journal of Pharmacology

Volumn 140, Issue 3, 2003, Pages 461-470

  Chen, Yan Nian ^a,b   Cheng, Chi Chih ^c   Chen, Jung Chou ^d   Tsauer, Wei ^d   Hsu, Shih Lan ^a,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b St Martin De Porres Hospital   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d Taichung Veterans General Hospital ^*

Author keywords

AP 1; Apoptosis; Caspase 9; ERK; JNK; NF B; Norcantharidin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; NORCANTHARIDIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA BINDING; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOSIS INHIBITION; NICK END LABELING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

APOPTOSIS; BICYCLO COMPOUNDS, HETEROCYCLIC; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 0142184964     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705461     Document Type: Article

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