Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma

Head and Neck

Volumn 34, Issue 11, 2012, Pages 1556-1561

  Wang, Yi Fen ^a,b   Chang, Chun Ju ^c   Lin, Chin Ping ^d   Chang, Shyue Yih ^a   Chu, Pen Yuan ^a,b   Tai, Shyh Kuan ^a,b   Li, Wing Yin ^b   Chao, K S Clifford ^e   Chen, Yu Jen ^d  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

hedgehog; metastasis; oral squamous cell carcinoma; prognosis; survival

Indexed keywords

PROTEIN PATCHED; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CLINICAL ARTICLE; CORRELATIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MOUTH SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR RECURRENCE; TUMOR VOLUME;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOUTH NEOPLASMS; PROGNOSIS; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84867869033     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21958     Document Type: Article

References (32)

1. Pindborg JJ,. Epidemiological studies of oral cancer. Int Dent J 1977; 27: 172-178.
2. Sankaranarayanan R,. Oral cancer in India: an epidemiologic and clinical review. Oral Surg Oral Med Oral Pathol 1990; 69: 325-330.
3. Hsieh LL, Wang PF, Chen IH, et al. Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese. Carcinogenesis 2001; 22: 1497-1503.
4. Zakrzewska JM,. Fortnightly review: oral cancer. BMJ 1999; 318: 1051-1054.
5. Chen YK, Huang HC, Lin LM, Lin CC,. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral Oncol 1999; 35: 173-179.
6. Wang YF, Chow KC, Chang SY, et al. Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma. Br J Cancer 2004; 90: 2186-2193.
7. Wang YF, Chen JY, Chang SY, et al. Nm23-H1 expression of metastatic tumors in the lymph nodes is a prognostic indicator of oral squamous cell carcinoma. Int J Cancer 2008; 122: 377-386.
8. Nusslein-Volhard C, Wieschaus E,. Mutations affecting segment number and polarity in Drosophila. Nature 1980; 287: 795-801.
9. Ingham PW, McMahon AP,. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15: 3059-3087.
10. Machold R, Hayashi S, Rutlin M, et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003; 39: 937-950.
11. Sasaki H, Nishizaki Y, Hui C, Nakafuku M, Kondoh H,. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999; 126: 3915-3924.
12. Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996; 85: 841-851.
13. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996; 272: 1668-1671.
14. Reifenberger J, Wolter M, Weber RG, et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1998; 58: 1798-1803.
15. Watkins DN, Peacock CD,. Hedgehog signalling in foregut malignancy. Biochem Pharmacol 2004; 68: 1055-1060.
16. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB,. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003; 422: 313-317.
17. Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003; 425: 851-856.
18. Sims-Mourtada J, Izzo JG, Apisarnthanarax S, et al. Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response. Clin Cancer Res 2006; 12: 6565-6572.
19. Chen YJ, Sims-Mourtada J, Izzo J, Chao KS,. Targeting the hedgehog pathway to mitigate treatment resistance. Cell Cycle 2007; 6: 1826-1830.
20. Yoshikawa R, Nakano Y, Tao L, et al. Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy. Br J Cancer 2008; 98: 1670-1674.
21. Varnat F, Duquet A, Malerba M, et al. Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 2009; 1: 338-351.
22. Chung CH, Dignam JJ, Hammond ME, et al. Glioma-associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003). J Clin Oncol 2011; 29: 1326-1334.
23. Fleming ID, Cooper JS, Henson DE, et al. AJCC Cancer Staging Manual. Philadelphia: Lippincott-Raven; 1997. pp 24-30.
24. Anneroth G, Batsakis J, Luna M,. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res 1987; 95: 229-249.
25. Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 2003; 100: 15178-15183.
26. Al-Hajj M, Clarke MF,. Self-renewal and solid tumor stem cells. Oncogene 2004; 23: 7274-7282.
27. Mori Y, Okumura T, Tsunoda S, Sakai Y, Shimada Y,. Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology 2006; 70: 378-389.
28. Nolan-Stevaux O, Lau J, Truitt ML, et al. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 2009; 23: 24-36.
29. Rizvi S, Demars CJ, Comba A, et al. Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis. Cancer Res 2010; 70: 6787-6796
30. Bailey JM, Mohr AM, Hollingsworth MA,. Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 2009; 28: 3513-3525.
31. Shaw A, Gipp J, Bushman W,. The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts. Oncogene 2009; 28: 4480-4490.
32. Dormoy V, Danilin S, Lindner V, et al. The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth. Mol Cancer 2009; 8: 123.