메뉴 건너뛰기




Volumn 9, Issue 4, 2010, Pages 414-422

Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo

Author keywords

Apoptosis; Cell cycle; Gallbladder neoplasm; Norcantharidin; Tumor growth

Indexed keywords

BIOTIN; CYCLIN D1; NORCANTHARIDIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P27; STREPTAVIDIN; SURVIVIN;

EID: 77955608840     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (35)

References (52)
  • 2
    • 62549119553 scopus 로고    scopus 로고
    • Surgical management of gallbladder cancer
    • ix
    • Reddy SK, Clary BM. Surgical management of gallbladder cancer. Surg Oncol Clin N Am 2009;18:307-324, ix.
    • (2009) Surg Oncol Clin N Am , vol.18 , pp. 307-324
    • Reddy, S.K.1    Clary, B.M.2
  • 3
    • 67650960677 scopus 로고    scopus 로고
    • Gallbladder cancer: We need to do better!
    • Shukla PJ, Barreto SG. Gallbladder cancer: we need to do better! Ann Surg Oncol 2009;16:2084-2085.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2084-2085
    • Shukla, P.J.1    Barreto, S.G.2
  • 5
    • 0031437038 scopus 로고    scopus 로고
    • Research on characteristics of mortality spectrum and type composition of malignant tumors in China
    • Li LD, Zhang SW, Lu FZ, Mu R, Sun XD, Huangpu XM. Research on characteristics of mortality spectrum and type composition of malignant tumors in China. Zhonghua Zhong Liu Za Zhi 1997;19:323-328.
    • (1997) Zhonghua Zhong Liu Za Zhi , vol.19 , pp. 323-328
    • Li, L.D.1    Zhang, S.W.2    Lu, F.Z.3    Mu, R.4    Sun, X.D.5    Huangpu, X.M.6
  • 7
    • 62949113284 scopus 로고    scopus 로고
    • Factors influencing long-term survival in patients with T3 gallbladder adenocarcinoma
    • Chakravarty KD, Yeh CN, Jan YY, Chen MF. Factors influencing long-term survival in patients with T3 gallbladder adenocarcinoma. Digestion 2009;79:151-157.
    • (2009) Digestion , vol.79 , pp. 151-157
    • Chakravarty, K.D.1    Yeh, C.N.2    Jan, Y.Y.3    Chen, M.F.4
  • 8
    • 66249115606 scopus 로고    scopus 로고
    • Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: A single-institution experience
    • Konstantinidis IT, Deshpande V, Genevay M, Berger D, Fernandez-del Castillo C, Tanabe KK, et al. Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience. Arch Surg 2009;144:441-447.
    • (2009) Arch Surg , vol.144 , pp. 441-447
    • Konstantinidis, I.T.1    Deshpande, V.2    Genevay, M.3    Berger, D.4    Fernandez-Del, C.C.5    Tanabe, K.K.6
  • 9
    • 68049128326 scopus 로고    scopus 로고
    • A review of the surgical strategies for the management of gallbladder carcinoma based on T stage and growth type of the tumour
    • Pilgrim C, Usatoff V, Evans PM. A review of the surgical strategies for the management of gallbladder carcinoma based on T stage and growth type of the tumour. Eur J Surg Oncol 2009;35:903-907.
    • (2009) Eur J Surg Oncol , vol.35 , pp. 903-907
    • Pilgrim, C.1    Usatoff, V.2    Evans, P.M.3
  • 11
    • 70249150089 scopus 로고    scopus 로고
    • Gallbladder cancer: The role of laparoscopy and radical resection
    • Singh S, Agarwal AK. Gallbladder cancer: the role of laparoscopy and radical resection. Ann Surg 2009;250:494-495.
    • (2009) Ann Surg , vol.250 , pp. 494-495
    • Singh, S.1    Agarwal, A.K.2
  • 13
    • 67651004847 scopus 로고    scopus 로고
    • Evolving treatment strategies for gallbladder cancer
    • Hueman MT, Vollmer CM Jr, Pawlik TM. Evolving treatment strategies for gallbladder cancer. Ann Surg Oncol 2009;16:2101-2015.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2015-2101
    • Hueman, M.T.1    Vollmer Jr., C.M.2    Pawlik, T.M.3
  • 15
    • 67649213198 scopus 로고    scopus 로고
    • Usefulness of gemcitabine combined with 5-fluorouracil and cisplatin (GFP) in patients for unresectable biliary carcinoma
    • Morine Y, Shimada M, Ikegami T, Imura S, Kanemura H, Arakawa Y, et al. Usefulness of gemcitabine combined with 5-fluorouracil and cisplatin (GFP) in patients for unresectable biliary carcinoma. Hepatogastroenterology 2009;56:307-312.
    • (2009) Hepatogastroenterology , vol.56 , pp. 307-312
    • Morine, Y.1    Shimada, M.2    Ikegami, T.3    Imura, S.4    Kanemura, H.5    Arakawa, Y.6
  • 16
    • 67650021895 scopus 로고    scopus 로고
    • Treatment of patients with unresectable advanced carcinoma of biliary tract-chemotherapy and surgical resection
    • Morise Z, Sugioka A, Tanahashi Y, Okabe Y, Ikeda M, Kagawa T, et al. Treatment of patients with unresectable advanced carcinoma of biliary tract-chemotherapy and surgical resection. Anticancer Res 2009;29:1783-1786.
    • (2009) Anticancer Res , vol.29 , pp. 1783-1786
    • Morise, Z.1    Sugioka, A.2    Tanahashi, Y.3    Okabe, Y.4    Ikeda, M.5    Kagawa, T.6
  • 19
  • 20
    • 34347350058 scopus 로고    scopus 로고
    • Adjuvant radiation therapy is associated with improved survival for gallbladder carcinoma with regional metastatic disease
    • DOI 10.1002/jso.20831
    • Mojica P, Smith D, Ellenhorn J. Adjuvant radiation therapy is associated with improved survival for gallbladder carcinoma with regional metastatic disease. J Surg Oncol 2007;96:8-13. (Pubitemid 47015442)
    • (2007) Journal of Surgical Oncology , vol.96 , Issue.1 , pp. 8-13
    • Mojica, P.1    Smith, D.2    Ellenhorn, J.3
  • 21
    • 0024428817 scopus 로고
    • Medical uses of mylabris in ancient China and recent studies
    • Wang GS. Medical uses of mylabris in ancient China and recent studies. J Ethnopharmacol 1989;26:147-162.
    • (1989) J Ethnopharmacol , vol.26 , pp. 147-162
    • Wang, G.S.1
  • 22
    • 1542785316 scopus 로고    scopus 로고
    • Advances in the study of Cantharidin and its derivatives
    • Liu J, Gao J, Liu X. Advances in the study of Cantharidin and its derivatives. Zhong Yao Cai 2003;26:453-455.
    • (2003) Zhong Yao Cai , vol.26 , pp. 453-455
    • Liu, J.1    Gao, J.2    Liu, X.3
  • 23
    • 0035927443 scopus 로고    scopus 로고
    • Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety
    • Ho YP, To KK, Au-Yeung SC, Wang X, Lin G, Han X. Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety. J Med Chem 2001;44:2065-2068.
    • (2001) J Med Chem , vol.44 , pp. 2065-2068
    • Ho, Y.P.1    To, K.K.2    Au-Yeung, S.C.3    Wang, X.4    Lin, G.5    Han, X.6
  • 24
    • 0030751395 scopus 로고    scopus 로고
    • Norcantharidin inhibits growth of human HepG2 celltransplanted tumor in nude mice and prolongs host survival
    • Yang EB, Tang WY, Zhang K, Cheng LY, Mack PO. Norcantharidin inhibits growth of human HepG2 celltransplanted tumor in nude mice and prolongs host survival. Cancer Lett 1997;117:93-98.
    • (1997) Cancer Lett , vol.117 , pp. 93-98
    • Yang, E.B.1    Tang, W.Y.2    Zhang, K.3    Cheng, L.Y.4    Mack, P.O.5
  • 25
    • 0026095943 scopus 로고
    • Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro
    • Yi SN, Wass J, Vincent P, Iland H. Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro. Leuk Res 1991;15:883-886.
    • (1991) Leuk Res , pp. 883-886
    • Yi, S.N.1    Wass, J.2    Vincent, P.3    Iland, H.4
  • 26
    • 0037211088 scopus 로고    scopus 로고
    • Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes
    • Kok SH, Hong CY, Kuo MY, Lee CH, Lee JJ, Lou IU, et al. Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes. Oral Oncol 2003;39:19-26.
    • (2003) Oral Oncol , vol.39 , pp. 19-26
    • Kok, S.H.1    Hong, C.Y.2    Kuo, M.Y.3    Lee, C.H.4    Lee, J.J.5    Lou, I.U.6
  • 28
    • 0037054929 scopus 로고    scopus 로고
    • Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells
    • Chen YN, Chen JC, Yin SC, Wang GS, Tsauer W, Hsu SF, et al. Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells. Int J Cancer 2002;100:158-165.
    • (2002) Int J Cancer , vol.100 , pp. 158-165
    • Chen, Y.N.1    Chen, J.C.2    Yin, S.C.3    Wang, G.S.4    Tsauer, W.5    Hsu, S.F.6
  • 29
    • 0142184964 scopus 로고    scopus 로고
    • Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells
    • Chen YN, Cheng CC, Chen JC, Tsauer W, Hsu SL. Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells. Br J Pharmacol 2003;140:461-470.
    • (2003) Br J Pharmacol , vol.140 , pp. 461-470
    • Chen, Y.N.1    Cheng, C.C.2    Chen, J.C.3    Tsauer, W.4    Hsu, S.L.5
  • 30
    • 0036204047 scopus 로고    scopus 로고
    • Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: Involvement of the CD95 receptor/ligand
    • Peng F, Wei YQ, Tian L, Yang L, Zhao X, Lu Y, et al. Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand. J Cancer Res Clin Oncol 2002;128:223-230.
    • (2002) J Cancer Res Clin Oncol , vol.128 , pp. 223-230
    • Peng, F.1    Wei, Y.Q.2    Tian, L.3    Yang, L.4    Zhao, X.5    Lu, Y.6
  • 31
    • 9444249625 scopus 로고    scopus 로고
    • The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism
    • Fan YZ, Fu JY, Zhao ZM, Chen CQ. The in vitro effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells and its mechanism. Zhonghua Zhong Liu Za Zhi 2004;26:271-274.
    • (2004) Zhonghua Zhong Liu Za Zhi , vol.26 , pp. 271-274
    • Fan, Y.Z.1    Fu, J.Y.2    Zhao, Z.M.3    Chen, C.Q.4
  • 32
    • 18744408486 scopus 로고    scopus 로고
    • Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells
    • Fan YZ, Fu JY, Zhao ZM, Chen CQ. Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells. World J Gastroenterol 2005;11:2431-2437.
    • (2005) World J Gastroenterol , vol.11 , pp. 2431-2437
    • Fan, Y.Z.1    Fu, J.Y.2    Zhao, Z.M.3    Chen, C.Q.4
  • 33
    • 33846967813 scopus 로고    scopus 로고
    • Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro
    • Fan YZ, Fu JY, Zhao ZM, Chen CQ. Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro. Hepatobiliary Pancreat Dis Int 2007;6:72-80.
    • (2007) Hepatobiliary Pancreat Dis Int , vol.6 , pp. 72-80
    • Fan, Y.Z.1    Fu, J.Y.2    Zhao, Z.M.3    Chen, C.Q.4
  • 34
    • 34547093861 scopus 로고    scopus 로고
    • Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells
    • Liao HF, Su SL, Chen YJ, Chou CH, Kuo CD. Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells. Food Chem Toxicol 2007;45:1678-1687.
    • (2007) Food Chem Toxicol , vol.45 , pp. 1678-1687
    • Liao, H.F.1    Su, S.L.2    Chen, Y.J.3    Chou, C.H.4    Kuo, C.D.5
  • 35
    • 70649101084 scopus 로고    scopus 로고
    • Norcantharidin induces HT-29 colon cancer cell apoptosis through the alphavbeta6-extracellular signal-related kinase signaling pathway
    • Peng C, Liu X, Liu E, Xu K, Niu W, Chen R, et al. Norcantharidin induces HT-29 colon cancer cell apoptosis through the alphavbeta6-extracellular signal-related kinase signaling pathway. Cancer Sci 2009;100:2302-2308.
    • (2009) Cancer Sci , vol.100 , pp. 2302-2308
    • Peng, C.1    Liu, X.2    Liu, E.3    Xu, K.4    Niu, W.5    Chen, R.6
  • 36
    • 36549025029 scopus 로고    scopus 로고
    • Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells
    • Chen YJ, Kuo CD, Tsai YM, Yu CC, Wang GS, Liao HF. Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anticancer Drugs 2008;19:55-64.
    • (2008) Anticancer Drugs , vol.19 , pp. 55-64
    • Chen, Y.J.1    Kuo, C.D.2    Tsai, Y.M.3    Yu, C.C.4    Wang, G.S.5    Liao, H.F.6
  • 37
    • 0029034492 scopus 로고
    • Effects of norcantharidin, a protein phosphatase type-2A inhibitor, on the growth of normal and malignant haemopoietic cells
    • Liu XH, Blazsek I, Comisso M, Legras S, Marion S, Quittet P, et al. Effects of norcantharidin, a protein phosphatase type-2A inhibitor, on the growth of normal and malignant haemopoietic cells. Eur J Cancer 1995;31A:953-963.
    • (1995) Eur J Cancer , vol.31 A , pp. 953-963
    • Liu, X.H.1    Blazsek, I.2    Comisso, M.3    Legras, S.4    Marion, S.5    Quittet, P.6
  • 38
    • 0035759228 scopus 로고    scopus 로고
    • The inhibition of protein phosphatases 1 and 2A: A new target for rational anti-cancer drug design?
    • McCluskey A, Ackland SP, Gardiner E, Walkom CC, Sakoff JA. The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design? Anticancer Drug Des 2001;16:291-303.
    • (2001) Anticancer Drug des , vol.16 , pp. 291-303
    • McCluskey, A.1    Ackland, S.P.2    Gardiner, E.3    Walkom, C.C.4    Sakoff, J.A.5
  • 39
    • 1642603545 scopus 로고    scopus 로고
    • Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity
    • Hart ME, Chamberlin AR, Walkom C, Sakoff JA, McCluskey A. Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity. Bioorg Med Chem Lett 2004;14:1969-1973.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 1969-1973
    • Hart, M.E.1    Chamberlin, A.R.2    Walkom, C.3    Sakoff, J.A.4    McCluskey, A.5
  • 40
    • 33646088119 scopus 로고    scopus 로고
    • Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells
    • Li JL, Cai YC, Liu XH, Xian LJ. Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells. Anticancer Drugs 2006;17:307-314.
    • (2006) Anticancer Drugs , vol.17 , pp. 307-314
    • Li, J.L.1    Cai, Y.C.2    Liu, X.H.3    Xian, L.J.4
  • 41
    • 0028049248 scopus 로고
    • How cells cycle toward cancer
    • Marx J. How cells cycle toward cancer. Science 1994;263: 319-321.
    • (1994) Science , vol.263 , pp. 319-321
    • Marx, J.1
  • 42
    • 58249124759 scopus 로고    scopus 로고
    • Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells
    • Chen YC, Chang SC, Wu MH, Chuang KA, Wu JY, Tsai WJ, et al. Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells. Life Sci 2009;84:218-226.
    • (2009) Life Sci , vol.84 , pp. 218-226
    • Chen, Y.C.1    Chang, S.C.2    Wu, M.H.3    Chuang, K.A.4    Wu, J.Y.5    Tsai, W.J.6
  • 43
    • 0033731195 scopus 로고    scopus 로고
    • Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma
    • Hui AM, Li X, Shi YZ, Takayama T, Torzilli G, Makuuchi M. Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma. Clin Cancer Res 2000;6:4272-4277.
    • (2000) Clin Cancer Res , vol.6 , pp. 4272-4277
    • Hui, A.M.1    Li, X.2    Shi, Y.Z.3    Takayama, T.4    Torzilli, G.5    Makuuchi, M.6
  • 44
    • 17544366706 scopus 로고    scopus 로고
    • P27(Kip1) expression in normal epithelia, precancerous lesions, and carcinomas of the gallbladder: Association with cancer progression and prognosis
    • Hui AM, Li X, Shi YZ, Torzilli G, Takayama T, Makuuchi M. p27(Kip1) expression in normal epithelia, precancerous lesions, and carcinomas of the gallbladder: association with cancer progression and prognosis. Hepatology 2000;31:1068-1072.
    • (2000) Hepatology , vol.31 , pp. 1068-1072
    • Hui, A.M.1    Li, X.2    Shi, Y.Z.3    Torzilli, G.4    Takayama, T.5    Makuuchi, M.6
  • 45
    • 1542682345 scopus 로고    scopus 로고
    • Prognostic significance of p27/kip1 and apoptosis in patients with colorectal carcinoma
    • Noguchi T, Kikuchi R, Ono K, Takeno S, Moriyama H, Uchida Y. Prognostic significance of p27/kip1 and apoptosis in patients with colorectal carcinoma. Oncol Rep 2003;10: 827-831.
    • (2003) Oncol Rep , vol.10 , pp. 827-831
    • Noguchi, T.1    Kikuchi, R.2    Ono, K.3    Takeno, S.4    Moriyama, H.5    Uchida, Y.6
  • 46
    • 13844253349 scopus 로고    scopus 로고
    • Bovine herpesvirus VP22 induces apoptosis in neuroblastoma cells by upregulating the expression ratio of Bax to Bcl-2
    • Qiu Z, Zhu J, Harms JS, Friedrichsen J, Splitter GA. Bovine herpesvirus VP22 induces apoptosis in neuroblastoma cells by upregulating the expression ratio of Bax to Bcl-2. Hum Gene Ther 2005;16:101-108.
    • (2005) Hum Gene Ther , vol.16 , pp. 101-108
    • Qiu, Z.1    Zhu, J.2    Harms, J.S.3    Friedrichsen, J.4    Splitter, G.A.5
  • 47
    • 4043090563 scopus 로고    scopus 로고
    • Astilbic acid induced COLO 205 cell apoptosis by regulating Bcl-2 and Bax expression and activating caspase-3
    • Zheng XL, Sun HX, Liu XL, Chen YX, Qian BC. Astilbic acid induced COLO 205 cell apoptosis by regulating Bcl-2 and Bax expression and activating caspase-3. Acta Pharmacol Sin 2004;25:1090-1095.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 1090-1095
    • Zheng, X.L.1    Sun, H.X.2    Liu, X.L.3    Chen, Y.X.4    Qian, B.C.5
  • 48
    • 14644409675 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans
    • Bowen JM, Gibson RJ, Keefe DM, Cummins AG. Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans. Pathology 2005;37:56-62.
    • (2005) Pathology , vol.37 , pp. 56-62
    • Bowen, J.M.1    Gibson, R.J.2    Keefe, D.M.3    Cummins, A.G.4
  • 49
    • 10444235120 scopus 로고    scopus 로고
    • Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio
    • Kok SH, Cheng SJ, Hong CY, Lee JJ, Lin SK, Kuo YS, et al. Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. Cancer Lett 2005;217:43-52.
    • (2005) Cancer Lett , vol.217 , pp. 43-52
    • Kok, S.H.1    Cheng, S.J.2    Hong, C.Y.3    Lee, J.J.4    Lin, S.K.5    Kuo, Y.S.6
  • 50
    • 19944433469 scopus 로고    scopus 로고
    • Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma
    • Santini D, Tonini G, Vecchio FM, Borzomati D, Vincenzi B, Valeri S, et al. Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma. J Clin Pathol 2005;58:159-165.
    • (2005) J Clin Pathol , vol.58 , pp. 159-165
    • Santini, D.1    Tonini, G.2    Vecchio, F.M.3    Borzomati, D.4    Vincenzi, B.5    Valeri, S.6
  • 51
    • 16644370192 scopus 로고    scopus 로고
    • Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma
    • Morinaga S, Nakamura Y, Ishiwa N, Yoshikawa T, Noguchi Y, Yamamoto Y, et al. Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma. Oncol Rep 2004;12: 1189-1194.
    • (2004) Oncol Rep , vol.12 , pp. 1189-1194
    • Morinaga, S.1    Nakamura, Y.2    Ishiwa, N.3    Yoshikawa, T.4    Noguchi, Y.5    Yamamoto, Y.6
  • 52
    • 12344250640 scopus 로고    scopus 로고
    • Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells
    • Dai DJ, Lu CD, Lai RY, Guo JM, Meng H, Chen WS, et al. Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells. World J Gastroenterol 2005;11:193-199.
    • (2005) World J Gastroenterol , vol.11 , pp. 193-199
    • Dai, D.J.1    Lu, C.D.2    Lai, R.Y.3    Guo, J.M.4    Meng, H.5    Chen, W.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.