-
1
-
-
2942738996
-
The Hedgehog response network: Sensors, switches, and routers
-
Lum L, Beachy PA (2004) The Hedgehog response network: Sensors, switches, and routers. Science 304:1755-1759
-
(2004)
Science
, vol.304
, pp. 1755-1759
-
-
Lum, L.1
Beachy, P.A.2
-
2
-
-
38949150396
-
Two gene networks underlying the formation of the anterior-posterior and dorso-ventral wing imaginal disc compartment boundaries in Drosophila melanogaster
-
In: Kolchanov NA and Hofestaedt R (eds) BGRS-2004. Institute of Cytology and Genetics Press
-
Gunbin KV, Omelyanchuk LV, Ananko EA (2004) Two gene networks underlying the formation of the anterior-posterior and dorso-ventral wing imaginal disc compartment boundaries in Drosophila melanogaster. In: Kolchanov NA and Hofestaedt R (eds) Proceedings of the Fourth International Conference on Bioinformatics of Genome Regulation and Structure, BGRS'2004. Institute of Cytology and Genetics Press, Vol. 2, pp 56-59
-
(2004)
Proceedings of the Fourth International Conference on Bioinformatics of Genome Regulation and Structure
, vol.2
, pp. 56-59
-
-
Gunbin, K.V.1
Omelyanchuk, L.V.2
Ananko, E.A.3
-
3
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer
-
Taipale J, Beachy PA (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature 411:349-354
-
(2001)
Nature
, vol.411
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
4
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale J, Cooper MK, Maiti T, Beachy PA (2002) Patched acts catalytically to suppress the activity of Smoothened. Nature 418:892-897
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
5
-
-
0037737726
-
Wnt proteins are lipid-modified and can act as stem cell growth factors
-
Willert K, Brown JD, Danenberg E et al (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423:448-452
-
(2003)
Nature
, vol.423
, pp. 448-452
-
-
Willert, K.1
Brown, J.D.2
Danenberg, E.3
-
6
-
-
15444359695
-
Identification of a palmitic acid-modified form of human Sonic hedgehog
-
Pepinsky RB, Zeng C, Wen D et al (1998) Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem 273:14037-14045
-
(1998)
J Biol Chem
, vol.273
, pp. 14037-14045
-
-
Pepinsky, R.B.1
Zeng, C.2
Wen, D.3
-
7
-
-
15844386540
-
Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
-
Porter JA, Ekker SC, Park WJ et al (1996) Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 86:21-34
-
(1996)
Cell
, vol.86
, pp. 21-34
-
-
Porter, J.A.1
Ekker, S.C.2
Park, W.J.3
-
8
-
-
0033598964
-
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signalling cells
-
Burke R, Nellen D, Bellotto M et al (1999) Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signalling cells. Cell 99:803-815
-
(1999)
Cell
, vol.99
, pp. 803-815
-
-
Burke, R.1
Nellen, D.2
Bellotto, M.3
-
9
-
-
0035860538
-
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
-
Chamoun Z, Mann RK, Nellen D et al (2001) Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293:2080-2084
-
(2001)
Science
, vol.293
, pp. 2080-2084
-
-
Chamoun, Z.1
Mann, R.K.2
Nellen, D.3
-
10
-
-
0035822098
-
A freely diffusible form of Sonic hedgehog mediates longrange signalling
-
Zeng X, Goetz JA, Suber LM et al (2001) A freely diffusible form of Sonic hedgehog mediates longrange signalling. Nature 411:716-720
-
(2001)
Nature
, vol.411
, pp. 716-720
-
-
Zeng, X.1
Goetz, J.A.2
Suber, L.M.3
-
11
-
-
0035811492
-
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
-
Dann CE, Hsieh JC, Rattner A et al (2001) Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412:86-90
-
(2001)
Nature
, vol.412
, pp. 86-90
-
-
Dann, C.E.1
Hsieh, J.C.2
Rattner, A.3
-
12
-
-
0034738979
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
-
Taipale J, Chen JK, Cooper MK et al (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406:1005-1009
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
Chen, J.K.2
Cooper, M.K.3
-
13
-
-
0037067722
-
Megalin functions as an endocytic sonic hedgehog receptor
-
McCarthy RA, Barth JL, Chintalapudi MR et al (2002) Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem 277:25660-25667
-
(2002)
J Biol Chem
, vol.277
, pp. 25660-25667
-
-
McCarthy, R.A.1
Barth, J.L.2
Chintalapudi, M.R.3
-
14
-
-
12144288863
-
Distinct roles of PTCH2 splice variants in Hedgehog signalling
-
Rahnama F, Toftgard R, Zaphiropoulos PG (2004) Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J 378:325-334
-
(2004)
Biochem J
, vol.378
, pp. 325-334
-
-
Rahnama, F.1
Toftgard, R.2
Zaphiropoulos, P.G.3
-
15
-
-
4544353067
-
Suppressor of fused regulates Gli activity through a dual binding mechanism
-
Merchant M, Vajdos FF, Ultsch M et al (2004) Suppressor of fused regulates Gli activity through a dual binding mechanism. Mol Cell Biol 24:8627-8641
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8627-8641
-
-
Merchant, M.1
Vajdos, F.F.2
Ultsch, M.3
-
16
-
-
1642370648
-
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins
-
Paces-Fessy M, Boucher D, Petit E et al (2004) The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Biochem J 378:353-362
-
(2004)
Biochem J
, vol.378
, pp. 353-362
-
-
Paces-Fessy, M.1
Boucher, D.2
Petit, E.3
-
17
-
-
14744268335
-
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
-
Tay SY, Ingham PW, Roy S (2005) A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development 132:625-634
-
(2005)
Development
, vol.132
, pp. 625-634
-
-
Tay, S.Y.1
Ingham, P.W.2
Roy, S.3
-
18
-
-
3042740428
-
Iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
-
Wolff C, Roy S, Lewis KE et al (2004) Iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev 18:1565-1576
-
(2004)
Genes Dev
, vol.18
, pp. 1565-1576
-
-
Wolff, C.1
Roy, S.2
Lewis, K.E.3
-
19
-
-
0035849901
-
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
-
Eggenschwiler JT, Espinoza E, Anderson KV (2001) Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412:194-198
-
(2001)
Nature
, vol.412
, pp. 194-198
-
-
Eggenschwiler, J.T.1
Espinoza, E.2
Anderson, K.V.3
-
20
-
-
0034672020
-
A gain-of-function mutant of patched dissects different responses to the hedgehog gradient
-
Mullor JL, Guerrero I (2000) A gain-of-function mutant of patched dissects different responses to the hedgehog gradient. Dev Biol 228:211-224
-
(2000)
Dev Biol
, vol.228
, pp. 211-224
-
-
Mullor, J.L.1
Guerrero, I.2
-
21
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
Huangfu D, Liu A, Rakeman AS et al (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426:83-87
-
(2003)
Nature
, vol.426
, pp. 83-87
-
-
Huangfu, D.1
Liu, A.2
Rakeman, A.S.3
-
22
-
-
0037218819
-
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
-
Lai K, Kaspar BK, Gage FH, Schaffer DV (2003) Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 6:21-27
-
(2003)
Nat Neurosci
, vol.6
, pp. 21-27
-
-
Lai, K.1
Kaspar, B.K.2
Gage, F.H.3
Schaffer, D.V.4
-
23
-
-
10744230965
-
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches
-
Machold R, Hayashi S, Rutlin M et al (2003) Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39:937-950
-
(2003)
Neuron
, vol.39
, pp. 937-950
-
-
Machold, R.1
Hayashi, S.2
Rutlin, M.3
-
24
-
-
13344282140
-
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
-
Palma V, Lim DA, Dahmane N et al (2005) Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 132:335-344
-
(2005)
Development
, vol.132
, pp. 335-344
-
-
Palma, V.1
Lim, D.A.2
Dahmane, N.3
-
25
-
-
0842279815
-
Hedgehog-GLI signalling regulates the behavior of cells with stem cell properties in the developing neocortex
-
Palma V, Ruiz i Altaba A (2004) Hedgehog-GLI signalling regulates the behavior of cells with stem cell properties in the developing neocortex. Development 131:337-345
-
(2004)
Development
, vol.131
, pp. 337-345
-
-
Palma, V.1
Ruiz i Altaba, A.2
-
26
-
-
10744233571
-
Indian Hedgehog is an antagonist of Wnt signalling in colonic epithelial cell differentiation
-
van den Brink GR, Bleuming SA, Hardwick JC et al (2004) Indian Hedgehog is an antagonist of Wnt signalling in colonic epithelial cell differentiation. Nat Genet 36:277-282
-
(2004)
Nat Genet
, vol.36
, pp. 277-282
-
-
van den Brink, G.R.1
Bleuming, S.A.2
Hardwick, J.C.3
-
28
-
-
0033179931
-
Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths
-
Parmantier E, Lynn B, Lawson D et al (1999) Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron 23:713-724
-
(1999)
Neuron
, vol.23
, pp. 713-724
-
-
Parmantier, E.1
Lynn, B.2
Lawson, D.3
-
29
-
-
0034960583
-
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
-
Pola R, Ling LE, Silver M et al (2001) The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 7:706-711
-
(2001)
Nat Med
, vol.7
, pp. 706-711
-
-
Pola, R.1
Ling, L.E.2
Silver, M.3
-
30
-
-
0037118056
-
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
-
Duman-Scheel M, Weng L, Xin S, Du W (2002) Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417:299-304
-
(2002)
Nature
, vol.417
, pp. 299-304
-
-
Duman-Scheel, M.1
Weng, L.2
Xin, S.3
Du, W.4
-
31
-
-
13944259054
-
Epithelial hedgehog signals pattern the intestinal crypt-villus axis
-
Madison BB, Braunstein K, Kuizon E et al (2005) Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 132:279-289
-
(2005)
Development
, vol.132
, pp. 279-289
-
-
Madison, B.B.1
Braunstein, K.2
Kuizon, E.3
-
32
-
-
33846809490
-
Hedgehog signalling in the prostate
-
Shaw A, Bushman W (2007) Hedgehog signalling in the prostate. J Urol 177:832-838
-
(2007)
J Urol
, vol.177
, pp. 832-838
-
-
Shaw, A.1
Bushman, W.2
-
33
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn H, Wicking C, Zaphiropoulous PG et al (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85:841-851
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
-
34
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson RL, Rothman AL, Xie J et al (1996) Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272:1668-1671
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
-
35
-
-
0030844141
-
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
-
Dahmane N, Lee J, Robins P et al (1997) Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 389:876-881
-
(1997)
Nature
, vol.389
, pp. 876-881
-
-
Dahmane, N.1
Lee, J.2
Robins, P.3
-
36
-
-
0032080853
-
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumours of the central nervous system
-
Reifenberger J, Wolter M, Weber RG et al (1998) Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumours of the central nervous system. Cancer Res 58:1798-1803
-
(1998)
Cancer Res
, vol.58
, pp. 1798-1803
-
-
Reifenberger, J.1
Wolter, M.2
Weber, R.G.3
-
37
-
-
0030990735
-
Human patched (PTCH) mRNA is overexpressed consistently in tumour cells of both familial and sporadic basal cell carcinoma
-
Unden AB, Zaphiropoulos PG, Bruce K et al (1997) Human patched (PTCH) mRNA is overexpressed consistently in tumour cells of both familial and sporadic basal cell carcinoma. Cancer Res 57:2336-2340
-
(1997)
Cancer Res
, vol.57
, pp. 2336-2340
-
-
Unden, A.B.1
Zaphiropoulos, P.G.2
Bruce, K.3
-
38
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
Xie J, Murone M, Luoh SM et al (1998) Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391:90-92
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.M.3
-
39
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor MD, Liu L, Raffel C et al (2002) Mutations in SUFU predispose to medulloblastoma. Nat Genet 31:306-310
-
(2002)
Nat Genet
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
-
40
-
-
0034091805
-
Basal cell carcinomas in mice overexpressing Gli2 in skin
-
Grachtchouk M, Mo R, Yu S et al (2000) Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet 24:216-217
-
(2000)
Nat Genet
, vol.24
, pp. 216-217
-
-
Grachtchouk, M.1
Mo, R.2
Yu, S.3
-
41
-
-
0034724219
-
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
-
Nilsson M, Unden AB, Krause D et al (2000) Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci U S A 97:3438-3443
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3438-3443
-
-
Nilsson, M.1
Unden, A.B.2
Krause, D.3
-
42
-
-
0030955557
-
Basal cell carcinomas in mice overexpressing sonic hedgehog
-
Oro AE, Higgins KM, Hu Z et al (1997) Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276:817-821
-
(1997)
Science
, vol.276
, pp. 817-821
-
-
Oro, A.E.1
Higgins, K.M.2
Hu, Z.3
-
43
-
-
0032694528
-
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
-
Aszterbaum M, Epstein J, Oro A et al (1999) Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 5:1285-1291
-
(1999)
Nat Med
, vol.5
, pp. 1285-1291
-
-
Aszterbaum, M.1
Epstein, J.2
Oro, A.3
|