Norcantharidin induces apoptosis of breast cancer cells: Involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription

Toxicology in Vitro

Volumn 25, Issue 3, 2011, Pages 699-707

  Yang, Pei Yu ^a,b   Chen, Ming Feng ^b   Kao, Ying Hsien ^c   Hu, Dan Ning ^b,d   Chang, Fang Rong ^a   Wu, Yang Chang ^a,e,f  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

^c I SHOU UNIVERSITY   (Taiwan)

^d NEW YORK MEDICAL COLLEGE   (United States)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Breast cancer; Chemosensitivity; Estrogen receptor; Mitogen activated protein kinase; Norcantharidin; Signal transducer and activator of transcription

Indexed keywords

CASPASE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN B; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; DEATH RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NORCANTHARIDIN; PROTEIN BCL 2; PROTEIN CDC25C; PROTEIN TYROSINE PHOSPHATASE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BICYCLO COMPOUNDS, HETEROCYCLIC; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; STAT TRANSCRIPTION FACTORS;

EID: 79952043014     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.01.011     Document Type: Article

References (45)

1. An W.W., Gong X.F., Wang M.W., Tashiro S., Onodera S., Ikejima T. Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK, and mitochondrial pathways. Acta Pharmacol. Sin. 2004, 25:1502-1508.
2. An W.W., Wang M.W., Tashiro S., Onodera S., Ikejima T. Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways. J. Korean Med. Sci. 2004, 19:560-566.
3. An W.W., Wang M.W., Tashiro S., Onodera S., Ikejima T. Mitogen-activated protein kinase-dependent apoptosis in norcantharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C. Chin. Med. J. (Engl) 2005, 118:198-203.
4. Andre F., Slimane K., Bachelot T., Dunant A., Namer M., Barrelier A., Kabbaj O., Spano J.P., Marsiglia H., Rouzier R., Delaloge S., Spielmann M. Breast cancer with synchronous metastases: trends in survival during a 14-year period. J. Clin. Oncol. 2004, 22:3302-3308.
5. Battle T.E., Frank D.A. The role of STATs in apoptosis. Curr. Mol. Med. 2002, 2:381-392.
6. Bromberg J.F. Activation of STAT proteins and growth control. BioEssays 2001, 23:161-169.
7. Chen Y.C., Chang S.C., Wu M.H., Chuang K.A., Wu J.Y., Tsai W.J., Kuo Y.C. Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclear cells. Life Sci. 2009, 84:218-226.
8. Chen Y.J., Chang W.M., Liu Y.W., Lee C.Y., Jang Y.H., Kuo C.D., Liao H.F. A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. Chem. Biol. Interact. 2009, 181:440-446.
9. Chen Y.J., Kuo C.D., Tsai Y.M., Yu C.C., Wang G.S., Liao H.F. Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anticancer Drugs 2008, 19:55-64.
10. Chen Y.J., Shieh C.J., Tsai T.H., Kuo C.D., Ho L.T., Liu T.Y., Liao H.F. Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anticancer Drugs 2005, 16:293-299.
11. Chen Y.N., Chen J.C., Yin S.C., Wang G.S., Tsauer W., Hsu S.F., Hsu S.L. Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells. Int. J. Cancer 2002, 100:158-165.
12. Chen Y.N., Cheng C.C., Chen J.C., Tsauer W., Hsu S.L. Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells. Br. J. Pharmacol. 2003, 140:461-470.
13. Dickson R.B., Russo J. Biochemical control of breast development. Diseases of the Breast 2000, 15. Lippincott Williams & Wilkins, Philadelphia. J.R. Harris, M.E. Lippman, M. Morrow (Eds.).
14. Emi M., Kim R., Tanabe K., Uchida Y., Toge T. Targeted therapy against Bcl-2-related proteins in breast cancer cells. Breast Cancer Res. 2005, 7:R940-R952.
15. Fan Y.Z., Fu J.Y., Zhao Z.M., Chen C.Q. Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro. Hepatobiliary Pancreat. Dis. Int. 2007, 6:72-80.
16. Guarneri V., Broglio K., Kau S.W., Cristofanilli M., Buzdar A.U., Valero V., Buchholz T., Meric F., Middleton L., Hortobagyi G.N., Gonzalez-Angulo A.M. Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors. J. Clin. Oncol. 2006, 24:1037-1044.
17. Hengartner M.O. The biochemistry of apoptosis. Nature 2000, 407:770-776.
18. Hong C.Y., Huang S.C., Lin S.K., Lee J.J., Chueh L.L., Lee C.H., Lin J.H., Hsiao M. Norcantharidin-induced post-G(2)/M apoptosis is dependent on wild-type p53 gene. Biochem. Biophys. Res. Commun. 2000, 276:278-285.
19. Huang Y., Liu Q., Liu K., Yagasaki K., Zhang G. Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action. Cytotechnology 2009, 59:209.
20. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M.J. Cancer statistics, 2009. CA Cancer J. Clin. 2009, 59:225-249.
21. Jänicke R.U., Sprengart M.L., Wati M.R., Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 1998, 273:9357-9360.
22. Kim H.S., Lee M.S. STAT1 as a key modulator of cell death. Cell. Signal. 2007, 19:454-465.
23. Kok S.H., Cheng S.J., Hong C.Y., Lee J.J., Lin S.K., Kuo Y.S., Chiang C.P., Kuo M.Y. Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio. Cancer Lett. 2005, 217:43-52.
24. Kok S.H., Hong C.Y., Kuo M.Y., Lee C.H., Lee J.J., Lou I.U., Lee M.S., Hsiao M., Lin S.K. Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes. Oral Oncol. 2003, 39:19-26.
25. Kunigal S., Lakka S.S., Sodadasu P.K., Estes N., Rao J.S. Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. Int. J. Oncol. 2009, 34:1209-1220.
26. LaPennsee E.W., Ben-Jonathan N. Novel roles of prolactin and estrogens in breast cancer: resistance to chemotherapy. Endocr. Relat. Cancer 2010, 17:R91-R107.
27. Liao H.F., Su S.L., Chen Y.J., Chou C.H., Kuo C.D. Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells. Food Chem. Toxicol. 2007, 45:1678-1687.
28. Marsh S., McLeod H.L. Pharmacogenetics and oncology treatment for breast cancer. Expert. Opin. Pharmacother. 2007, 8:119-127.
29. Orlando L., Colleoni M., Fedele P., Cusmai A., Rizzo P., D'Amico M., Chetri M.C., Cinieri S. Management of advanced breast cancer. Ann. Oncol. 2007, 18(Suppl. 6):vi74-76.
30. Peng F., Wei Y.Q., Tian L., Yang L., Zhao X., Lu Y., Mao Y.Q., Kan B., Lei S., Wang G.S., Jiang Y., Wang Q.R., Luo F., Zou L.Q., Liu J.Y. Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand. J. Cancer Res. Clin. Oncol. 2002, 128:223-230.
31. Phillips R.M., Bibby M.C., Double J.A. A critical appraisal of the predictive value of in vitro chemosensitivity assays. J. Natl. Cancer Inst. 1990, 82:1457-1468.
32. Ring A.E., Smith I.E., Ashley S., Fulford L.G., Lakhani S.R. Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer. Br. J. Cancer 2004, 91:2012-2017.
33. Rodrik V., Zheng Y., Harrow F., Chen Y., Foster D.A. Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc. Mol. Cell. Biol. 2005, 25:7917-7925.
34. Shitashige M., Toi M., Yano T., Shibata M., Matsuo Y., Shibasaki F. Dissociation of Bax from a Bcl-2/Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2. J. Biochem. 2001, 130:741-748.
35. Silva C.M. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 2004, 23:8017-8023.
36. Tabuchi Y., Matsuoka J., Gunduz M., Imada T., Ono R., Ito M., Motoki T., Yamatsuji T., Shirakawa Y., Takaoka M., Haisa M., Tanaka N., Kurebayashi J., Jordan V.C., Naomoto Y. Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancer. Int. J. Oncol. 2009, 34:313-319.
37. Taylor W.R., Stark G.R. Regulation of the G2/M transition by p53. Oncogene 2001, 20:1803-1815.
38. Tewari M., Krishnamurthy A., Shukla H.S. Predictive markers of response to neoadjuvant chemotherapy in breast cancer. Surg. Oncol. 2008, 17:301-311.
39. Walker S.R., Nelson E.A., Zou L., Chaudhury M., Signoretti S., Richardson A., Frank D.A. Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol. Cancer Res. 2009, 7:966-976.
40. Wang G.S. Medical uses of mylabris in ancient China and recent studies. J. Ethnopharmacol. 1989, 26:147-162.
41. Wang Y., Wu T.R., Cai S., Welte T., Chin Y.E. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol. Cell. Biol. 2000, 20:4505-4512.
42. Wen Z., Zhong Z., Darnell J.E. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995, 82:241-250.
43. Yang E.B., Tang W.Y., Zhang K., Cheng L.Y., Mack P.O. Norcantharidin inhibits growth of human HepG2 cell-transplanted tumor in nude mice and prolongs host survival. Cancer Lett. 1997, 117:93-98.
44. Yang P.Y., Chen M.F., Tsai C.H., Hu D.N., Chang F.R., Wu Y.C. Involvement of caspase and MAPK activities in norcantharidin-induced colorectal cancer cell apoptosis. Toxicol. In Vitro 2010, 24:766-775.
45. Yin Z.H., Ren C.P., Li F., Yang X.Y., Li H., Zhao M., Yao K.T. Suppression of bcl-2 gene by RNA interference increases chemosensitivity to cisplatin in nasopharyngeal carcinoma cell line CNE1. Acta. Biochim. Biophys. Sin. (Shanghai) 2004, 36:749-753.