Targeting of the B-lineage leukemia stem cells and their progeny with norcantharidin encapsulated liposomes modified with a novel CD19 monoclonal antibody 2E8 in vitro

Journal of Drug Targeting

Volumn 18, Issue 9, 2010, Pages 675-687

  Zhang, Jingying ^a   Tang, Yongmin ^a   Li, Sisi ^a   Liao, Chan ^a   Guo, Xiaoping ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

2E8(CD19); Immunoliposome; Leukemia stem cells; Norcantharidin; Targeting

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CD19 MONOCLONAL ANTIBODY 2E8; IMMUNOLIPOSOME; INTERLEUKIN 3; MONOCLONAL ANTIBODY; NORCANTHARIDIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRUCTURE; CLINICAL EVALUATION; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; CYTOTOXICITY; DNA FRAGMENTATION; DOWN REGULATION; DRUG ACTIVITY; DRUG MECHANISM; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL; MOLECULARLY TARGETED THERAPY; OUTCOME ASSESSMENT; PRE B LYMPHOCYTE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD19; ANTINEOPLASTIC AGENTS; APOPTOSIS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; CELL LINEAGE; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; HUMANS; LEUKEMIA, B-CELL; LIPOSOMES; NEOPLASTIC STEM CELLS;

EID: 77957783919     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/10611861003649720     Document Type: Article

References (29)

1. Allen TM. (2002). Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer, 2, 750-763.
2. Allen TM, Mumbengegwi DR, Charrois GJ. (2005). Anti-CD19-targeted liposomal doxorubicin improves the therapeutic efcacy in murine B-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates. Clin Cancer Res, 11, 3567-3573.
3. Bermejo-Rodríguez C, Pérez-Caro M, Pérez-Mancera PA, Sánchez-Beato M, Piris MA, Sánchez-García I. (2006). Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fbroblasts. Genomics, 87, 113-118.
4. Blair A, Sutherland HJ. (2000). Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117). Exp Hematol, 28, 660-671.
5. Cheng WW, Allen TM. (2008). Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: a comparison of whole monoclonal antibody, Fab' fragments and single chain Fv. J Control Release, 126, 50-58.
6. Chung KY, Morrone G, Schuringa JJ, Wong B, Dorn DC, Moore MA. (2005). Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis. Blood, 105, 77-84.
7. Crosasso P, Ceruti M, Brusa P, Arpicco S, Dosio F, Cattel L. (2000). Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes. J Control Release, 63, 19-30.
8. Lopes de Menezes DE, Pilarski LM, Belch AR, Allen TM. (2000). Selective targeting of immunoliposomal doxorubicin against human multiple myeloma in vitro and ex vivo. Biochim Biophys Acta, 1466, 205-220.
9. Dorn DC, Kou CA, Png KJ, Moore MA. (2009). Te efect of cantharidins on leukemic stem cells. Int J Cancer, 124, 2186-2199.
10. Harata M, Soda Y, Tani K, et al. (2004). CD19-targeting liposomes containing imatinib efciently kill Philadelphia chromosomepositive acute lymphoblastic leukemia cells. Blood, 104, 1442-1449.
11. Iden DL, Allen TM. (2001). In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach. Biochim Biophys Acta, 1513, 207-216.
12. Immordino ML, Brusa P, Arpicco S, Stella B, Dosio F, Cattel L. (2003). Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel. J Control Release, 91, 417-429.
13. Inukai T, Inoue A, Kurosawa H, et al. (1999). SLUG, a ces-1-related zinc fnger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell, 4, 343-352.
14. Jordan CT, Upchurch D, Szilvassy SJ, et al. (2000). Te interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia, 14, 1777-1784.
15. Köhler G, Milstein C. (1975). Continuous cultures of fused cells secreting antibody of predefned specifcity. Nature, 256, 495-497.
16. Kong Y, Yoshida S, Saito Y, et al. (2008). CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia, 22, 1207-1213.
17. Laginha K, Mumbengegwi D, Allen T. (2005). Liposomes targeted via two diferent antibodies: assay, B-cell binding and cytotoxicity. Biochim Biophys Acta, 1711, 25-32.
18. Li LX, Tang YM, Zhang HZ, Shen HQ, Qian BQ, Luo CF. (2008). [Preparation of the immunotoxin 2E8-norcantharidin and its targeting killing efect in vitro]. Zhonghua Er Ke Za Zhi, 46, 493-497.
19. Park JW, Hong K, Kirpotin DB, et al. (2002). Anti-HER2 immunoliposomes: enhanced efcacy attributable to targeted delivery. Clin Cancer Res, 8, 1172-1181.
20. Pastorino F, Brignole C, Marimpietri D, et al. (2003). Doxorubicinloaded Fab' fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice. Cancer Res, 63, 86-92.
21. Sapra P, Allen TM. (2002). Internalizing antibodies are necessary for improved therapeutic efcacy of antibody-targeted liposomal drugs. Cancer Res, 62, 7190-7194.
22. Sapra P, Allen TM. (2004). Improved outcome when B-cell lymphoma is treated with combinations of immunoliposomal anticancer drugs targeted to both the CD19 and CD20 epitopes. Clin Cancer Res, 10, 2530-2537.
23. Sapra P, Moase EH, Ma J, Allen TM. (2004). Improved therapeutic responses in a xenograft model of human B lymphoma (Namalwa) for liposomal vincristine versus liposomal doxorubicin targeted via anti-CD19 IgG2a or Fab' fragments. Clin Cancer Res, 10, 1100-1111.
24. Shojaei F, Trowbridge J, Gallacher L, et al. (2005). Hierarchical and ontogenic positions serve to defne the molecular basis of human hematopoietic stem cell behavior. Dev Cell, 8, 651-663.
25. Sugano M, Egilmez NK, Yokota SJ, et al. (2000). Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodefcient mice. Cancer Res, 60, 6942-6949.
26. Uckun FM, Jaszcz W, Ambrus JL, et al. (1988). Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins. Blood, 71, 13-29.
27. Wei YQ, Zhao X, Kariya Y, Fukata H, Teshigawara K, Uchida A. (1994). Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res, 54, 4952-4957.
28. Yang T, Choi MK, Cui FD, Kim JS, Chung SJ, Shim CK, Kim DD. (2007). Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome. J Control Release, 120, 169-177.
29. Zhang J, Tang Y, Shen H, Qian B. (2009). Targeting and internaliza-tion of sterically stabilized liposome modifed with ZCH-4-2E8. J Huazhong Univ Sci Technol Med Sci, 29, 273-280.