-
1
-
-
51949107835
-
Progress in metabolic engineering of sdccbdromyces cereviside
-
Nevoigt E (2008) Progress in metabolic engineering of Sdccbdromyces cereviside. Microbiol Mol Biol Rev 72: 379-412.
-
(2008)
Microbiol Mol Biol Rev
, vol.72
, pp. 379-412
-
-
Nevoigt, E.1
-
3
-
-
84864148741
-
Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in sdlvid scldred (l.) and their relevance for perfume manufacture
-
Caniard A, Zerbe P, Legrand S, Cohade A, Valot N, et al. (2012) Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Sdlvid scldred (L.) and their relevance for perfume manufacture. BMC Plant Biol 12: 119.
-
(2012)
BMC Plant Biol
, vol.12
, pp. 119
-
-
Caniard, A.1
Zerbe, P.2
Legrand, S.3
Cohade, A.4
Valot, N.5
-
4
-
-
84902199683
-
Method for producing sclareol
-
Firmenich SA
-
Schalk M (2011) Method for producing sclareol. US20110041218 Al. Firmenich SA.
-
(2011)
US20110041218 Al.
-
-
Schalk, M.1
-
6
-
-
53449087942
-
Ovarian cancer: Front-line standard treatment in 2008
-
Vasey PA (2008) Ovarian cancer: front-line standard treatment in 2008. Ann Oncol 19 Suppl 7: 61-66.
-
(2008)
Ann Oncol
, vol.19
, Issue.SUPPL. 7
, pp. 61-66
-
-
Vasey, P.A.1
-
7
-
-
31444454856
-
-
World Health Organization Geneva: World Health Organization.
-
World Health Organization (2010) Guidelines for the treatment of malaria. Geneva: World Health Organization.
-
(2010)
Guidelines for the Treatment of Malaria
-
-
-
8
-
-
65549102748
-
The future of artemisinins: Natural, synthetic or recombinant?
-
Hommel M (2008) The future of artemisinins: natural, synthetic or recombinant? J Biol 7: 38.
-
(2008)
J Biol
, vol.7
, pp. 38
-
-
Hommel, M.1
-
9
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, et al. (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440: 940-943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
-
10
-
-
84856389651
-
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
-
Westfall PJ, Pitera DJ, Lenihan JR Eng D, Woolard FX, et al. (2012) Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc Nad Acad Sci U S A 109: El11-118.
-
(2012)
Proc Nad Acad Sci U S A
, vol.109
-
-
Westfall, P.J.1
Pitera, D.J.2
Lenihan, J.R.3
Eng, D.4
Woolard, F.X.5
-
11
-
-
80053412686
-
Identification and microbial production of a terpene-based advanced biofuel
-
Peralta-Yahya PP, Ouellet M, Chan R, Mukhopadhyay A, Keasling JD, et al. (2011) Identification and microbial production of a terpene-based advanced biofuel. Nat Commun 2: 483.
-
(2011)
Nat Commun
, vol.2
, pp. 483
-
-
Peralta-Yahya, P.P.1
Ouellet, M.2
Chan, R.3
Mukhopadhyay, A.4
Keasling, J.D.5
-
13
-
-
84902154106
-
Fuel compositions including farnesane and farnesene derivatives and methods of making and using same
-
Renninger N, McPhee D (2008) Fuel compositions including farnesane and farnesene derivatives and methods of making and using same. WO2008045555.
-
(2008)
WO2008045555
-
-
Renninger, N.1
McPhee, D.2
-
15
-
-
1542329068
-
Production of lipid compounds in the yeast Saccharomyces cerevisiae
-
DOI 10.1007/s00253-003-1456-7
-
Veen M, Lang C (2004) Production of lipid compounds in the yeast Saccharomyces cerevisiae, Appl Microbiol Biotechnol 63: 635-646. (Pubitemid 38316689)
-
(2004)
Applied Microbiology and Biotechnology
, vol.63
, Issue.6
, pp. 635-646
-
-
Veen, M.1
Lang, C.2
-
16
-
-
78449281377
-
Efficacy and safety of more intensive lowering of ldl cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
-
Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, et al. (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376: 1670-1681.
-
(2010)
Lancet
, vol.376
, pp. 1670-1681
-
-
Baigent, C.1
Blackwell, L.2
Emberson, J.3
Holland, L.E.4
Reith, C.5
-
17
-
-
70350731753
-
Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants
-
Degenhardt J, Kollner TG, Gershenzon J (2009) Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants. Phytochemistry 70: 1621-1637.
-
(2009)
Phytochemistry
, vol.70
, pp. 1621-1637
-
-
Degenhardt, J.1
Kollner, T.G.2
Gershenzon, J.3
-
18
-
-
43049107992
-
Unearthing the roots of the terpenome
-
Christianson DW (2008) Unearthing the roots of the terpenome. Curr Opin Chem Biol 12: 141-150.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 141-150
-
-
Christianson, D.W.1
-
19
-
-
44749083814
-
Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards taxol (paclitaxel) production
-
Engels B, Dahm P, Jennewein S (2008) Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab Eng 10: 201-206.
-
(2008)
Metab Eng
, vol.10
, pp. 201-206
-
-
Engels, B.1
Dahm, P.2
Jennewein, S.3
-
20
-
-
38449112770
-
Production of plant sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 repression on sesquiterpene biosynthesis
-
DOI 10.1002/bit.21581
-
Asadollahi MA, Maury J, Moller K, Nielsen KF, Schalk M, et al. (2008) Production of plant sesquiterpenes in Saccharomyces cerevisiae: effect of ERG9 repression on sesquiterpene biosynthesis. Biotechnol Bioeng 99: 666-677. (Pubitemid 351158264)
-
(2008)
Biotechnology and Bioengineering
, vol.99
, Issue.3
, pp. 666-677
-
-
Asadollahi, M.A.1
Maury, J.2
Moller, K.3
Nielsen, K.F.4
Schalk, M.5
Clark, A.6
Nielsen, J.7
-
21
-
-
79251574154
-
Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids
-
Ignea C, Cvetkovic I, Loupassaki S, Kefalas P, Johnson CB, et al. (2011) Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microb Cell Fact 10: 1-18.
-
(2011)
Microb Cell Fact
, vol.10
, pp. 1-18
-
-
Ignea, C.1
Cvetkovic, I.2
Loupassaki, S.3
Kefalas, P.4
Johnson, C.B.5
-
22
-
-
80051678912
-
Reconstitution of the costunolide biosynthetic pathway in yeast and nicotiana benthamiana
-
Liu Q, Majdi M, Cankar K, Goedbloed M, Charnikhova T, et al. (2011) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. PLoS One 6: e23255.
-
(2011)
PLoS One
, vol.6
-
-
Liu, Q.1
Majdi, M.2
Cankar, K.3
Goedbloed, M.4
Charnikhova, T.5
-
23
-
-
84860696106
-
Functional characterization of four sesquiterpene synthases from ricinus communis (castor bean)
-
Xie X, Kirby J, Keasling JD (2012) Functional characterization of four sesquiterpene synthases from Ricinus communis (castor bean). Phytochemistry 78: 20-28.
-
(2012)
Phytochemistry
, vol.78
, pp. 20-28
-
-
Xie, X.1
Kirby, J.2
Keasling, J.D.3
-
24
-
-
84862827747
-
Dynamic control of gene expression in saccharomyces cerevisiae engineered for the production of plant sesquitepene alpha-santalene in a fed-batch mode
-
Scalcinati G, Knuf C, Partow S, Chen Y, Maury J, et al. (2012) Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene alpha-santalene in a fed-batch mode. Metab Eng 14: 91-103.
-
(2012)
Metab Eng
, vol.14
, pp. 91-103
-
-
Scalcinati, G.1
Knuf, C.2
Partow, S.3
Chen, Y.4
Maury, J.5
-
25
-
-
84863116515
-
Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
-
Zhou YJ, Gao W, Rong Q, Jin G, Chu H, et al. (2012) Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. J Am Chem Soc 134: 3234-3241.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 3234-3241
-
-
Zhou, Y.J.1
Gao, W.2
Rong, Q.3
Jin, G.4
Chu, H.5
-
26
-
-
84865241938
-
Enzymatic synthesis of valerena-4,7(h)-diene by a unique sesquiterpene synthase from the valerian plant (valeriana ojficinalis)
-
Pyle BW, Tran HT, Pickel B, Haslam TM, Gao Z, et al. (2012) Enzymatic synthesis of valerena-4,7(H)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana ojficinalis). FebsJ 279: 3136-3146.
-
(2012)
Febs J
, vol.279
, pp. 3136-3146
-
-
Pyle, B.W.1
Tran, H.T.2
Pickel, B.3
Haslam, T.M.4
Gao, Z.5
-
27
-
-
43549105634
-
Terpenoid biomaterials
-
DOI 10.1111/j.1365-313X.2008.03449.x
-
Bohlmann J, Keeling CI (2008) Terpenoid biomaterials. Plant J 54: 656-669. (Pubitemid 351678044)
-
(2008)
Plant Journal
, vol.54
, Issue.4
, pp. 656-669
-
-
Bohlmann, J.1
Keeling, C.I.2
-
28
-
-
20344404474
-
Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase
-
DOI 10.1073/pnas.0500825102
-
Ro DK, Arimura G, Lau SY, Piers E, Bohlmann J (2005) Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase. Proc Nad Acad Sci U S A 102: 8060-8065. (Pubitemid 40781062)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.22
, pp. 8060-8065
-
-
Ro, D.-K.1
Arimura, G.-I.2
Lau, S.Y.W.3
Piers, E.4
Bohlmann, J.5
-
29
-
-
67651030513
-
Biosynthesis of plant isoprenoids: Perspectives for microbial engineering
-
Kirby J, Keasling JD (2009) Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu Rev Plant Biol 60: 335-355.
-
(2009)
Annu Rev Plant Biol
, vol.60
, pp. 335-355
-
-
Kirby, J.1
Keasling, J.D.2
-
30
-
-
83255165496
-
The cyt p450 enzyme cyp716a47 catalyzes the formation of protopanaxadiol from dammarenediol-ii during ginsenoside biosynthesis in panax ginseng
-
Han JY, Kim HJ, Kwon YS, Choi YE (2011) The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol 52: 2062-2073.
-
(2011)
Plant Cell Physiol
, vol.52
, pp. 2062-2073
-
-
Han, J.Y.1
Kim, H.J.2
Kwon, Y.S.3
Choi, Y.E.4
-
31
-
-
0035843962
-
Structural mechanism for statin inhibition of HMG-CoA reductase
-
DOI 10.1126/science.1059344
-
Istvan ES, Deisenhofer J (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292: 1160-1164. (Pubitemid 32440937)
-
(2001)
Science
, vol.292
, Issue.5519
, pp. 1160-1164
-
-
Istvan, E.S.1
Deisenhofer, J.2
-
32
-
-
64749083589
-
Protein quality control as a strategy for cellular regulation: Lessons from ubiquitin-mediated regulation of the sterol pathway
-
Hampton RY, Garza RM (2009) Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chem Rev 109: 1561-1574.
-
(2009)
Chem Rev
, vol.109
, pp. 1561-1574
-
-
Hampton, R.Y.1
Garza, R.M.2
-
33
-
-
0025649280
-
The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum
-
Chun KT, Bar-Nun S, Simoni RD (1990) The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum. J Biol Chem 265: 22004-22010. (Pubitemid 120014256)
-
(1990)
Journal of Biological Chemistry
, vol.265
, Issue.35
, pp. 22004-22010
-
-
Chun, K.T.1
Bar-Nun, S.2
Simoni, R.D.3
-
34
-
-
0028213166
-
Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast
-
Hampton RY, Rine J (1994) Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast. J Cell Biol 125: 299-312. (Pubitemid 24135944)
-
(1994)
Journal of Cell Biology
, vol.125
, Issue.2
, pp. 299-312
-
-
Hampton, R.Y.1
Rine, J.2
-
35
-
-
0031962865
-
Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast
-
DOI 10.1007/s002530051138
-
Polakowski T, Stahl U, Lang C (1998) Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast. Appl Microbiol Biotechnol 49: 66-71. (Pubitemid 28055383)
-
(1998)
Applied Microbiology and Biotechnology
, vol.49
, Issue.1
, pp. 66-71
-
-
Polakowski, T.1
Stahl, U.2
Lang, C.3
-
36
-
-
77951531018
-
Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in saccharomyces cerevisiae
-
Asadollahi MA, Maury J, Schalk M, Clark A, Nielsen J (2010) Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. Biotechnol Bioeng 106: 86-96.
-
(2010)
Biotechnol Bioeng
, vol.106
, pp. 86-96
-
-
Asadollahi, M.A.1
Maury, J.2
Schalk, M.3
Clark, A.4
Nielsen, J.5
-
37
-
-
44449098258
-
Redirection of flux through the FPP branch-point in saccharomyces cerevisiae by down-regulating squalene synthase
-
DOI 10.1002/bit.21766
-
Paradise EM, Kirby J, Chan R, Keasling JD (2008) Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase.Biotechnol Bioeng 100: 371-378. (Pubitemid 351758178)
-
(2008)
Biotechnology and Bioengineering
, vol.100
, Issue.2
, pp. 371-378
-
-
Paradise, E.M.1
Kirby, J.2
Chan, R.3
Keasling, J.D.4
-
38
-
-
0033615648
-
A highly conserved signal controls degradation of 3-hydroxy-3- methylglutaryl-coenzyme a (hmg-coa) reductase in eukaryotes
-
Gardner RG, Hampton RY (1999) A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. J Biol Chem 274: 31671-31678.
-
(1999)
J Biol Chem
, vol.274
, pp. 31671-31678
-
-
Gardner, R.G.1
Hampton, R.Y.2
-
39
-
-
79952348850
-
A synthetic library of rna control modules for predictable tuning of gene expression in yeast
-
Babiskin AH, Smolke CD (2011) A synthetic library of RNA control modules for predictable tuning of gene expression in yeast. Mol Syst Biol 7: 471.
-
(2011)
Mol Syst Biol
, vol.7
, pp. 471
-
-
Babiskin, A.H.1
Smolke, C.D.2
-
41
-
-
0027418531
-
Characterization of a lysine-to-glutamic acid mutation in a conservative sequence of farnesyl diphosphate synthase from saccharomyces cerevisiae
-
Blanchard L, Karst F (1993) Characterization of a lysine-to-glutamic acid mutation in a conservative sequence of farnesyl diphosphate synthase from Saccharomyces cerevisiae. Gene 125: 185-189.
-
(1993)
Gene
, vol.125
, pp. 185-189
-
-
Blanchard, L.1
Karst, F.2
-
42
-
-
80052663778
-
Identification of a lysine residue important for the catalytic activity of yeast farnesyl diphosphate synthase
-
Fischer MJ, Meyer S, Claudel P, Bergdoll M, Karst F (2011) Identification of a lysine residue important for the catalytic activity of yeast farnesyl diphosphate synthase. Protein J 30: 334-339.
-
(2011)
Protein J
, vol.30
, pp. 334-339
-
-
Fischer, M.J.1
Meyer, S.2
Claudel, P.3
Bergdoll, M.4
Karst, F.5
-
43
-
-
33847378479
-
Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids
-
DOI 10.1016/j.ymben.2006.10.005, PII S1096717606001042
-
Shiba Y, Paradise EM, Kirby J, Ro DK, Keasling JD (2007) Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids. Metab Eng 9: 160-168. (Pubitemid 46331877)
-
(2007)
Metabolic Engineering
, vol.9
, Issue.2
, pp. 160-168
-
-
Shiba, Y.1
Paradise, E.M.2
Kirby, J.3
Ro, D.-K.4
Keasling, J.D.5
-
44
-
-
0031856845
-
A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae
-
Crowley JH, Leak FW, Jr., Shianna KV, Tove S, Parks LW (1998) A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae. J Bacteriol 180: 4177-4183. (Pubitemid 28373523)
-
(1998)
Journal of Bacteriology
, vol.180
, Issue.16
, pp. 4177-4183
-
-
Crowley, J.H.1
Leak Jr., F.W.2
Shianna, K.V.3
Tove, S.4
Parks, L.W.5
-
46
-
-
70449396286
-
Metabolic engineering of saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance
-
Ukibe K, Hashida K, Yoshida N, Takagi H (2009) Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance. Appl Environ Microbiol 75: 7205-7211.
-
(2009)
Appl Environ Microbiol
, vol.75
, pp. 7205-7211
-
-
Ukibe, K.1
Hashida, K.2
Yoshida, N.3
Takagi, H.4
-
47
-
-
34447543117
-
High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous
-
DOI 10.1128/AEM.02759-06
-
Verwaal R, Wang J, Meijnen JP, Visser H, Sandmann G, et al. (2007) High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous. Appl Environ Microbiol 73: 4342-4350. (Pubitemid 47068176)
-
(2007)
Applied and Environmental Microbiology
, vol.73
, Issue.13
, pp. 4342-4350
-
-
Verwaal, R.1
Wang, J.2
Meijnen, J.-P.3
Visser, H.4
Sandmann, G.5
Van Den Berg, J.A.6
Van Ooyen, A.J.J.7
-
48
-
-
77955554464
-
Production of geranylgeraniol on overexpression of a prenyl diphosphate synthase fusion gene in saccharomyces cerevisiae
-
Ohto C, Muramatsu M, Obata S, Sakuradani E, Shimizu S (2010) Production of geranylgeraniol on overexpression of a prenyl diphosphate synthase fusion gene in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 87: 1327-1334.
-
(2010)
Appl Microbiol Biotechnol
, vol.87
, pp. 1327-1334
-
-
Ohto, C.1
Muramatsu, M.2
Obata, S.3
Sakuradani, E.4
Shimizu, S.5
-
49
-
-
69449089724
-
Overproduction of geranylgeraniol by metabolically engineered saccharomyces cerevisiae
-
Tokuhiro K, Muramatsu M, Ohto C, Kawaguchi T, Obata S, et al. (2009) Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae.Appl Environ Microbiol 75: 5536-5543.
-
(2009)
Appl Environ Microbiol
, vol.75
, pp. 5536-5543
-
-
Tokuhiro, K.1
Muramatsu, M.2
Ohto, C.3
Kawaguchi, T.4
Obata, S.5
-
50
-
-
42749086594
-
Isolation and functional analysis of two cistus creticus cdnas encoding geranylgeranyl diphosphate synthase
-
Pateraki I, Kanellis AK (2008) Isolation and functional analysis of two Cistus creticus cDNAs encoding geranylgeranyl diphosphate synthase. Phytochemistry 69: 1641-1652.
-
(2008)
Phytochemistry
, vol.69
, pp. 1641-1652
-
-
Pateraki, I.1
Kanellis, A.K.2
-
51
-
-
74549181298
-
The isoprenoid pathway and transcriptional response to its inhibitors in the yeast saccbaromyces cerevisiae
-
Kuranda K, Francois J, Palamarczyk G (2010) The isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccbaromyces cerevisiae. FEMS Yeast Res 10: 14-27.
-
(2010)
FEMS Yeast Res
, vol.10
, pp. 14-27
-
-
Kuranda, K.1
Francois, J.2
Palamarczyk, G.3
-
52
-
-
0033591216
-
The lpp1 and dpp1 gene products account for most of the isoprenoid phosphate phosphatase activities in saccharomyces cerevisiae
-
Faulkner A, Chen X, Rush J, Horazdovsky B, Waechter CJ, et al. (1999) The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae. J Biol Chem 274: 14831-14837.
-
(1999)
J Biol Chem
, vol.274
, pp. 14831-14837
-
-
Faulkner, A.1
Chen, X.2
Rush, J.3
Horazdovsky, B.4
Waechter, C.J.5
-
53
-
-
79551478567
-
Diversion of flux toward sesquiterpene production in saccharomyces cerevisiae by fusion of host and heterologous enzymes
-
Albertsen L, Chen Y, Bach LS, Rattleff S, Maury J, et al. (2011) Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes. Appl Environ Microbiol 77: 1033-1040.
-
(2011)
Appl Environ Microbiol
, vol.77
, pp. 1033-1040
-
-
Albertsen, L.1
Chen, Y.2
Bach, L.S.3
Rattleff, S.4
Maury, J.5
-
54
-
-
34247479948
-
Metabolic engineering of sesquiterpene metabolism in yeast
-
DOI 10.1002/bit.21216
-
Takahashi S, Yeo Y, Greenhagen BT, McMullin T, Song L, et al. (2007) Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnol Bioeng 97: 170-181. (Pubitemid 46649764)
-
(2007)
Biotechnology and Bioengineering
, vol.97
, Issue.1
, pp. 170-181
-
-
Takahashi, S.1
Yeo, Y.2
Greenhagen, B.T.3
McMullin, T.4
Song, L.5
Maurina-Brunker, J.6
Rosson, R.7
Noel, J.P.8
Chappell, J.9
-
55
-
-
0035814339
-
The in vivo synthesis of plant sesquiterpenes by Escherichia coli
-
DOI 10.1002/bit.10037
-
Martin VJ, Yoshikuni Y, Keasling JD (2001) The in vivo synthesis of plant sesquiterpenes by Escherichia coli. Biotechnol Bioeng 75: 497-503. (Pubitemid 33134982)
-
(2001)
Biotechnology and Bioengineering
, vol.75
, Issue.5
, pp. 497-503
-
-
Martin, V.J.J.1
Yoshikuni, Y.2
Keasling, J.D.3
-
56
-
-
44949201614
-
Redesigning Enzymes Based on Adaptive Evolution for Optimal Function in Synthetic Metabolic Pathways
-
DOI 10.1016/j.chembiol.2008.05.006, PII S1074552108001981
-
Yoshikuni Y, Dietrich JA, Nowroozi FF, Babbitt PC, Keasling JD (2008) Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways. Chem Biol 15: 607-618. (Pubitemid 351815056)
-
(2008)
Chemistry and Biology
, vol.15
, Issue.6
, pp. 607-618
-
-
Yoshikuni, Y.1
Dietrich, J.A.2
Nowroozi, F.F.3
Babbitt, P.C.4
Keasling, J.D.5
-
57
-
-
77956371200
-
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
-
Leonard E, Ajikumar PK, Thayer K, Xiao WH, Mo JD, et al. (2010) Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control. Proc Nad Acad Sci U S A 107: 13654-13659.
-
(2010)
Proc Nad Acad Sci U S A
, vol.107
, pp. 13654-13659
-
-
Leonard, E.1
Ajikumar, P.K.2
Thayer, K.3
Xiao, W.H.4
Mo, J.D.5
-
58
-
-
33646178621
-
Designed divergent evolution of enzyme function
-
Yoshikuni Y, Ferrin TE, Keasling JD (2006) Designed divergent evolution of enzyme function. Nature 440: 1078-1082.
-
(2006)
Nature
, vol.440
, pp. 1078-1082
-
-
Yoshikuni, Y.1
Ferrin, T.E.2
Keasling, J.D.3
-
59
-
-
33745631233
-
Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases
-
DOI 10.1073/pnas.0601605103
-
Greenhagen BT, O'Maille PE, Noel JP, Chappell J (2006) Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases. Proc Nad Acad Sci U S A 103:9826-9831. (Pubitemid 43993582)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.26
, pp. 9826-9831
-
-
Greenhagen, B.T.1
O'Maille, P.E.2
Noel, J.P.3
Chappell, J.4
-
60
-
-
34547696794
-
Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: Structural insights into the evolution of terpene synthase function
-
DOI 10.1105/tpc.106.047779
-
Kampranis SC, Ioannidis D, Purvis A, Mahrez W, Ninga E, et al. (2007) Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: structural insights into the evolution of terpene synthase function. Plant Cell 19: 1994-2005. (Pubitemid 47218854)
-
(2007)
Plant Cell
, vol.19
, Issue.6
, pp. 1994-2005
-
-
Kampranis, S.C.1
Ioannidis, D.2
Purvis, A.3
Mahrez, W.4
Ninga, E.5
Katerelos, N.A.6
Anssour, S.7
Dunwell, J.M.8
Degenhardt, J.9
Makris, A.M.10
Goodenough, P.W.11
Johnsona, C.B.12
-
61
-
-
34250688380
-
Following evolution's lead to a single residue switch for diterpene synthase product outcome
-
Xu M, Wilderman PR, Peters RJ (2007) Following evolution's lead to a single residue switch for diterpene synthase product outcome. Proc Nad Acad Sci U S A 104: 7397-7401.
-
(2007)
Proc Nad Acad Sci U S A
, vol.104
, pp. 7397-7401
-
-
Xu, M.1
Wilderman, P.R.2
Peters, R.J.3
-
62
-
-
38949096144
-
Functional plasticity of paralogous diterpene synthases involved in conifer defense
-
Keeling CI, Weisshaar S, Lin RP, Bohlmann J (2008) Functional plasticity of paralogous diterpene synthases involved in conifer defense. Proc Nad Acad Sci U S A 105: 1085-1090.
-
(2008)
Proc Nad Acad Sci U S A
, vol.105
, pp. 1085-1090
-
-
Keeling, C.I.1
Weisshaar, S.2
Lin, R.P.3
Bohlmann, J.4
-
63
-
-
80052030821
-
Harnessing yeast subcellular compartments for the production of plant terpenoids
-
Farhi M, Marhevka E, Masci T, Marcos E, Eyal Y, et al. (2011) Harnessing yeast subcellular compartments for the production of plant terpenoids. Metab Eng 13: 474-481.
-
(2011)
Metab Eng
, vol.13
, pp. 474-481
-
-
Farhi, M.1
Marhevka, E.2
Masci, T.3
Marcos, E.4
Eyal, Y.5
-
64
-
-
68449088806
-
Synthetic protein scaffolds provide modular control over metabolic flux
-
Dueber JE, Wu GC, Malmirchegini GR, Moon TS, Petzold CJ, et al. (2009) Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol 27: 753-759.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 753-759
-
-
Dueber, J.E.1
Wu, G.C.2
Malmirchegini, G.R.3
Moon, T.S.4
Petzold, C.J.5
-
65
-
-
57049089897
-
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid
-
Ro DK, Ouellet M, Paradise EM, Burd H, Eng D, et al. (2008) Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. BMC Biotechnol 8: 83.
-
(2008)
BMC Biotechnol
, vol.8
, pp. 83
-
-
Ro, D.K.1
Ouellet, M.2
Paradise, E.M.3
Burd, H.4
Eng, D.5
-
66
-
-
78650276516
-
Whole genome sequencing of saccharomyces cerevisiae: From genotype to phenotype for improved metabolic engineering applications
-
Otero JM, Vongsangnak W, Asadollahi MA, Olivares-Hernandes R, Maury J, et al. (2010) Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications. BMC Genomics 11: 723.
-
(2010)
BMC Genomics
, vol.11
, pp. 723
-
-
Otero, J.M.1
Vongsangnak, W.2
Asadollahi, M.A.3
Olivares-Hernandes, R.4
Maury, J.5
-
67
-
-
79952806663
-
Linking genotype and phenotype of saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers
-
Madsen KM, Udatha GD, Semba S, Otero JM, Koetter P, et al. (2011) Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers. PLoS One 6: el4763.
-
(2011)
PLoS One
, vol.6
-
-
Madsen, K.M.1
Udatha, G.D.2
Semba, S.3
Otero, J.M.4
Koetter, P.5
-
68
-
-
70449592325
-
Enhancing sesquiterpene production in saccharomyces cerevisiae through in silico driven metabolic engineering
-
Asadollahi MA, Maury J, Patil KR, Schalk M, Clark A, et al. (2009) Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering. Metab Eng 11: 328-334.
-
(2009)
Metab Eng
, vol.11
, pp. 328-334
-
-
Asadollahi, M.A.1
Maury, J.2
Patil, K.R.3
Schalk, M.4
Clark, A.5
|