Application of functional genomics to pathway optimization for increased isoprenoid production

Applied and Environmental Microbiology

Volumn 74, Issue 10, 2008, Pages 3229-3241

  Kizer, Lance ^a   Pitera, Douglas J ^a   Pfleger, Brian F ^a   Keasling, Jay D ^a,b,c,d  

^a University of California   (United States)

^b University of California at Berkeley   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d Berkeley   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COENZYMES; GENE EXPRESSION; METABOLISM; OPTIMIZATION; SYNTHESIS (CHEMICAL);

CELL METABOLISM; DELETERIOUS INTERACTIONS; FUNCTIONAL GENOMICS;

BIOLOGICAL SYSTEMS;

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CARBON; ISOPRENOID; OLEIC ACID; PALMITIC ACID; TRANSCRIPTOME; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A; ACYL COENZYME A; ANTIINFECTIVE AGENT; FATTY ACID; TERPENE;

BIOCHEMISTRY; BIOLOGICAL PRODUCTION; COLIFORM BACTERIUM; GENETICALLY MODIFIED ORGANISM; GENOMICS; ISOPRENOID; METABOLISM; OPTIMIZATION; TOXICITY;

ARTICLE; BIOENGINEERING; BIOSYNTHESIS; CELL MEMBRANE; CELL STRESS; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA MICROARRAY; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; FUNCTIONAL GENOMICS; HOST; INHIBITION KINETICS; INTRACELLULAR SPACE; METABOLITE; METABOLOMICS; NONHUMAN; SIGNAL TRANSDUCTION; CHEMISTRY; DRUG ANTAGONISM; GENE EXPRESSION PROFILING; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ACYL COENZYME A; ANTI-BACTERIAL AGENTS; CELL MEMBRANE; ESCHERICHIA COLI; FATTY ACIDS; GENE EXPRESSION PROFILING; METABOLIC NETWORKS AND PATHWAYS; OLEIC ACID; PALMITIC ACID; TERPENES;

EID: 44249111668     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.02750-07     Document Type: Article

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