Dissecting the role of the S1P/S1PR axis in health and disease

Journal of Dental Research

Volumn 90, Issue 7, 2011, Pages 841-854

  Aarthi, J J ^a   Darendeliler, M A ^a   Pushparaj, P N ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Autocrine; Cancer; Paracrine; Rheumatoid arthritis; S1P receptors; Sepsis; Sphingosine 1 phosphate; Sphingosine kinase; Ulcerative colitis

Indexed keywords

DRUG DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

ANIMAL; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; CELL PROLIFERATION; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; HUMAN; LYMPH NODE METASTASIS; MANDIBLE CONDYLE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NEUROGENIC INFLAMMATION; PERIODONTITIS; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ATHEROSCLEROSIS; AUTOIMMUNE DISEASES; CELL PROLIFERATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN REGULATORS; HUMANS; LYMPHATIC METASTASIS; LYSOPHOSPHOLIPIDS; MANDIBULAR CONDYLE; NEOVASCULARIZATION, PATHOLOGIC; NEUROGENIC INFLAMMATION; PERIODONTITIS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84884211437     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510389178     Document Type: Review

References (163)

1. Albrektsson TO, Johansson CB, Sennerby L (1994). Biological aspects of implant dentistry: osseointegration. Periodontol 2000 4:58-73.
2. Alfonso C, McHeyzer-Williams MG, Rosen H (2006). CD69 downmodulation and inhibition of thymic egress by short-and long-term selective chemical agonism of sphingosine 1-phosphate receptors. Eur J Immunol 36:149-159. (Pubitemid 43116401)
3. Allende ML, Proia RL (2002). Sphingosine-1-phosphate receptors and the development of the vascular system. Biochim Biophys Acta 1582:222-227. (Pubitemid 34634133)
4. Allende ML, Dreier JL, Mandala S, Proia RL (2004). Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem 279:15396-15401. (Pubitemid 38618938)
5. Allende ML, Zhou D, Kalkofen DN, Benhamed S, Tuymetova G, Borowski C, et al. (2008). S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J 22:307-315.
6. Alvarez SE, Milstien S, Spiegel S (2007). Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol Metab 18:300-307. (Pubitemid 47531961)
7. Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, et al. (2010). Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465:1084-1088.
8. An S, Goetzl EJ, Lee H (1998). Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J Cell Biochem Suppl 30-31:147-157. (Pubitemid 29028736)
9. Balthasar S, Samulin J, Ahlgren H, Bergelin N, Lundqvist M, Toescu EC, et al. (2006). Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells. Biochem J 398:547-556. (Pubitemid 44453400)
10. Balthasar S, Bergelin N, Lof C, Vainio M, Andersson S, Tornquist K (2008). Interactions between sphingosine-1-phosphate and vascular endothelial growth factor signalling in ML-1 follicular thyroid carcinoma cells. Endocr Relat Cancer 15:521-534. (Pubitemid 351880840)
11. Bankovich AJ, Shiow LR, Cyster JG (2010). CD69 suppresses sphingosine-1-phosphate receptor-1 (S1P1) function through interaction with membrane helix 4. J Biol Chem 285:22328-22337.
12. Bassi R, Anelli V, Giussani P, Tettamanti G, Viani P, Riboni L (2006). Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. Glia 53:621-630.
13. Bird L (2010). Inflammation: hope for sepsis treatment. Nat Rev Immunol 10:464.
14. Bode C, Sensken SC, Peest U, Beutel G, Thol F, Levkau B, et al. (2010). Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. J Cell Biochem 109:1232-1243.
15. Brinkmann V (2007). Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 115:84-105. (Pubitemid 46990553)
16. Cattoretti G, Mandelbaum J, Lee N, Chaves AH, Mahler AM, Chadburn A, et al. (2009). Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res 69:8686-8692.
17. Charlier JP, Petrovic A, Herrmann-Stutzmann J (1969). Effects of mandibular hyperpropulsion on the pre chondroblastic zone of young rat condyle. Am J Orthod 55:71-74.
18. Chellaiah M, Fitzgerald C, Alvarez U, Hruska K (1998). c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase. J Biol Chem 273:11908-11916. (Pubitemid 28272099)
19. Chi H, Flavell RA (2005). Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. J Immunol 174:2485-2488. (Pubitemid 40279659)
20. Coussin F, Scott RH, Wise A, Nixon GF (2002). Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. Circ Res 91:151-157. (Pubitemid 34827226)
21. Cummings RJ, Parinandi NL, Zaiman A, Wang L, Usatyuk PV, Garcia JG, et al. (2002). Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. J Biol Chem 277:30227-30235.
22. Davis MD, Clemens JJ, Macdonald TL, Lynch KR (2005). Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem 280:9833-9841. (Pubitemid 40395829)
23. Davis MD, Kehrl JH (2009). The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an "immature" vascular maturation factor to a "mature" mediator of lymphocyte behavior and function. Immunol Res 43:187-197.
24. Donati C, Meacci E, Nuti F, Becciolini L, Farnararo M, Bruni P (2005). Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. FASEB J 19:449-451. (Pubitemid 40316546)
25. Donati C, Cencetti F, Nincheri P, Bernacchioni C, Brunelli S, Clementi E, et al. (2007). Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. Stem Cells 25:1713-1719. (Pubitemid 47121849)
26. Dunlap KA, Kwak HI, Burghardt RC, Bazer FW, Magness RR, Johnson GA, et al. (2010). The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep. Biol Reprod 82:876-887.
27. Eskan MA, Benakanakere MR, Rose BG, Zhang P, Zhao J, Stathopoulou P, et al. (2008a). Interleukin-1beta modulates proinflammatory cytokine production in human epithelial cells. Infect Immun 76:2080-2089. (Pubitemid 351656141)
28. Eskan MA, Rose BG, Benakanakere MR, Lee MJ, Kinane DF (2008b). Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells. J Immunol 180:1818-1825.
29. Eskan MA, Rose BG, Benakanakere MR, Zeng Q, Fujioka D, Martin MH, et al. (2008c). TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells. Eur J Immunol 38:1138-1147.
30. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811. (Pubitemid 28099681)
31. Fujishiro J, Kudou S, Iwai S, Takahashi M, Hakamata Y, Kinoshita M, et al. (2006a). Use of sphingosine-1-phosphate 1 receptor agonist, KRP-203, in combination with a subtherapeutic dose of cyclosporine A for rat renal transplantation. Transplantation 82:804-812. (Pubitemid 44472474)
32. Fujishiro J, Suzuki C, Kudou S, Yasue T, Hakamata Y, Takahashi M, et al. (2006b). Change from cyclosporine to combination therapy of mycophenolic acid with the new sphingosine-1-phosphate receptor agonist, KRP-203, prevents host nephrotoxicity and transplant vasculopathy in rats. J Heart Lung Transplant 25:825-833. (Pubitemid 43963378)
33. Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (1998). The involvement of multiple tumor necrosis factor receptor (TNFR) - associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem 273:34120-34127.
34. Grabski AD, Shimizu T, Deou J, Mahoney WM Jr, Reidy MA, Daum G (2009). Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. Arterioscler Thromb Vasc Biol 29:1644-1650.
35. Graeler M, Goetzl EJ (2002). Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J 16:1874-1878. (Pubitemid 35462606)
36. Gravallese EM, Manning C, Tsay A, Naito A, Pan C, Amento E, et al. (2000). Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 43:250-258. (Pubitemid 30395732)
37. Han XL, Bai D, Meng Y, Yang L, Guo J (2007). [Bending mechanical properties of NiTi round wire]. Zhonghua Kou Qiang Yi Xue Za Zhi 42:525-528 [article in Chinese].
38. Hanel P, Andreani P, Graler MH (2007). Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J 21:1202-1209. (Pubitemid 46495709)
39. Hannun YA, Luberto C, Argraves KM (2001). Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40:4893-4903. (Pubitemid 32332534)
40. Harada J, Foley M, Moskowitz MA, Waeber C (2004). Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. J Neurochem 88:1026-1039. (Pubitemid 38199325)
41. Herr DR, Grillet N, Schwander M, Rivera R, Muller U, Chun J (2007). Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2. J Neurosci 27:1474-1478.
42. Hla T (2004). Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol 15:513-520. (Pubitemid 38953947)
43. Hla T, Lee MJ, Ancellin N, Thangada S, Liu CH, Kluk M, et al. (2000). Sphingosine-1-phosphate signaling via the EDG-1 family of G-proteincoupled receptors. Ann NY Acad Sci 905:16-24. (Pubitemid 30255402)
44. Huang H, Chang EJ, Ryu J, Lee ZH, Lee Y, Kim HH (2006). Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway. Biochem Biophys Res Commun 351:99-105. (Pubitemid 44635412)
45. Idzko M, Panther E, Corinti S, Morelli A, Ferrari D, Herouy Y, et al. (2002). Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J 16:625-627.
46. Idzko M, Hammad H, van Nimwegen M, Kool M, Muller T, Soullie T, et al. (2006). Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J Clin Invest 116:2935-2944. (Pubitemid 44684478)
47. Imasawa T, Kitamura H, Ohkawa R, Satoh Y, Miyashita A, Yatomi Y (2010). Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy. Exp Toxicol Pathol 62:53-60. (Pubitemid 47284808)
48. Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, et al. (2002). Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P (2)/LP (B2)/EDG-5 and S1P (3)/LP (B3)/EDG-3. J Biol Chem 277:25152-25159. (Pubitemid 34951821)
49. Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, et al. (2009). Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature 458:524-528.
50. Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, et al. (2007). Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. Biochem Biophys Res Commun 357:212-217. (Pubitemid 46574517)
51. Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, et al. (2009). T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med 206:2469-2481.
52. Jimi E, Akiyama S, Tsurukai T, Okahashi N, Kobayashi K, Udagawa N, et al. (1999). Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol 163:434-442. (Pubitemid 29295871)
53. Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD (2008). Sphingosine-1- phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int 73:1220-1230. (Pubitemid 351693151)
54. Jolly PS, Bektas M, Olivera A, Gonzalez-Espinosa C, Proia RL, Rivera J, et al. (2004). Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med 199:959-970. (Pubitemid 38481087)
55. Kaneko T, Murakami T, Kawana H, Takahashi M, Yasue T, Kobayashi E (2006). Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice. Biochem Biophys Res Commun 345:85-92.
56. Kartsogiannis V, Zhou H, Horwood NJ, Thomas RJ, Hards DK, Quinn JM, et al. (1999). Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. Bone 25:525-534. (Pubitemid 29469458)
57. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A (2005). Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms. Surgery 138:1102-1109.
58. Keul P, Tolle M, Lucke S, von Wnuck Lipinski K, Heusch G, Schuchardt M, et al. (2007). The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 27:607-613.
59. Kihara A, Ikeda M, Kariya Y, Lee EY, Lee YM, Igarashi Y (2003). Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. J Biol Chem 278:14578-14585. (Pubitemid 36800012)
60. Kim K, Kim YL, Sacket SJ, Kim HL, Han M, Park DS, et al. (2007). Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors. J Pharm Pharmacol 59:1035-1041. (Pubitemid 47051086)
61. Kim RH, Takabe K, Milstien S, Spiegel S (2009). Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta 1791:692-696.
62. Kim YD, Kim SS, Hwang DS, Kim SG, Kwon YH, Shin SH, et al. (2007). Effect of low-level laser treatment after installation of dental titanium implant-immunohistochemical study of RANKL, RANK, OPG: an experimental study in rats. Lasers Surg Med 39:441-450.
63. Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, et al. (2006). Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum 54:742-753.
64. Kohno T, Matsuyuki H, Inagaki Y, Igarashi Y (2003). Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells. Genes Cells 8:685-697. (Pubitemid 36974697)
65. Kono M, Mi Y, Liu Y, Sasaki T, Allende ML, Wu YP, et al. (2004). The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem 279:29367-29373. (Pubitemid 38915815)
66. Kono M, Belyantseva IA, Skoura A, Frolenkov GI, Starost MF, Dreier JL, et al. (2007). Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem 282:10690-10696. (Pubitemid 47093459)
67. Kostenis E (2004). Novel clusters of receptors for sphingosine-1- phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands. J Cell Biochem 92:923-936. (Pubitemid 44264242)
68. Krishnan V, Davidovitch Z (2006). Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop 129:469.e1-469.e32.
69. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, et al. (1998). Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176. (Pubitemid 28180851)
70. Le Stunff H, Peterson C, Liu H, Milstien S, Spiegel S (2002a). Sphingosine-1-phosphate and lipid phosphohydrolases. Biochim Biophys Acta 1582:8-17. (Pubitemid 34634106)
71. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S (2002b). Characterization of murine sphingosine-1-phosphate phosphohydrolase. J Biol Chem 277:8920-8927. (Pubitemid 34952962)
72. Le Stunff H, Milstien S, Spiegel S (2004). Generation and metabolism of bioactive sphingosine-1-phosphate. J Cell Biochem 92:882-899. (Pubitemid 44264239)
73. Lee JF, Ozaki H, Zhan X, Wang E, Hla T, Lee MJ (2006a). Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. Histochem Cell Biol 126:297-304.
74. Lee JF, Zeng Q, Ozaki H, Wang L, Hand AR, Hla T, et al. (2006b). Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. J Biol Chem 281:29190-29200. (Pubitemid 44507063)
75. Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, et al. (1998). Sphingosine-1-phosphate as a ligand for the G proteincoupled receptor EDG-1. Science 279:1552-1555. (Pubitemid 28217081)
76. Lee MJ, Thangada S, Claffey KP, Ancellin N, Liu CH, Kluk M, et al. (1999). Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99:301-312. (Pubitemid 29519909)
77. Leibbrandt A, Penninger JM (2008). RANK/RANKL: regulators of immune responses and bone physiology. Ann NY Acad Sci 1143:123-150.
78. Li C, Jiang X, Yang L, Liu X, Yue S, Li L (2009a). Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. Am J Pathol 175:1464-1472.
79. Li C, Kong Y, Wang H, Wang S, Yu H, Liu X, et al. (2009b). Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. J Hepatol 50:1174-1183.
80. Li QF, Wu CT, Guo Q, Wang H, Wang LS (2008). Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. Biochem Biophys Res Commun 371:159-162.
81. Li Z, Chen W, Hale JJ, Lynch CL, Mills SG, Hajdu R, et al. (2005). Discovery of potent 3, 5-diphenyl-1, 2, 4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem 48:6169-6173. (Pubitemid 41428971)
82. Lin CI, Chen CN, Lin PW, Lee H (2007). Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3. Biochem Biophys Res Commun 355:895-901. (Pubitemid 46366912)
83. Liu F, Verin AD, Wang P, Day R, Wersto RP, Chrest FJ, et al. (2001). Differential regulation of sphingosine-1-phosphate-and VEGF-induced endothelial cell chemotaxis. Involvement of G (ialpha2)-linked Rho kinase activity. Am J Respir Cell Mol Biol 24:711-719. (Pubitemid 32550593)
84. Liu Y, Wada R, Yamashita T, Mi Y, Deng CX, Hobson JP, et al. (2000). Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 106:951-961.
85. Lorenz JN, Arend LJ, Robitz R, Paul RJ, MacLennan AJ (2007). Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice. Am J Physiol Regul Integr Comp Physiol 292:R440-R446. (Pubitemid 46089859)
86. Luthi-Carter R, Strand A, Peters NL, Solano SM, Hollingsworth ZR, Menon AS, et al. (2000). Decreased expression of striatal signaling genes in a mouse model of Huntington's disease. Hum Mol Genet 9:1259-1271. (Pubitemid 30312475)
87. Malchinkhuu E, Sato K, Horiuchi Y, Mogi C, Ohwada S, Ishiuchi S, et al. (2005). Role of p38 mitogen-activated kinase and c-Jun. terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. Oncogene 24:6676-6688. (Pubitemid 41486798)
88. Manikandan J, Pushparaj PN, Melendez AJ (2007). Protein i: interference at protein level by intrabodies. Front Biosci 12:1344-1352. (Pubitemid 46846838)
89. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, et al. (2004). Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427:355-360. (Pubitemid 38133663)
90. McVerry BJ, Garcia JG (2004). Endothelial cell barrier regulation by sphingosine 1-phosphate. J Cell Biochem 92:1075-1085. (Pubitemid 44264219)
91. McVerry BJ, Garcia JG (2005). In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal 17:131-139. (Pubitemid 39371042)
92. Means CK, Brown JH (2009). Sphingosine-1-phosphate receptor signalling in the heart. Cardiovasc Res 82:193-200.
93. Melendez AJ, Harnett MM, Pushparaj PN, Wong WS, Tay HK, McSharry CP, et al. (2007). Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nat Med 13:1375-1381. (Pubitemid 350073593)
94. Meng H, Lee VM (2009). Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system. Dev Dyn 238:487-500.
95. Miller WE, Lefkowitz RJ (2001). Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Curr Opin Cell Biol 13:139-145. (Pubitemid 32209213)
96. Miller WE, Houtz DA, Nelson CD, Kolattukudy PE, Lefkowitz RJ (2003). G-protein-coupled receptor (GPCR) kinase phosphorylation and betaarrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. J Biol Chem 278:21663-21671. (Pubitemid 36792567)
97. Mitra P, Oskeritzian CA, Payne SG, Beaven MA, Milstien S, Spiegel S (2006). Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci USA 103:16394-16399. (Pubitemid 44715207)
98. Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL (2005). Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 25:11113-11121. (Pubitemid 41747151)
99. Murakami M, Shiraishi A, Tabata K, Fujita N (2008). Identification of the orphan GPCR, P2Y (10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun 371:707-712.
100. Murata N, Sato K, Kon J, Tomura H, Okajima F (2000a). Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay. Anal Biochem 282:115-120. (Pubitemid 30409432)
101. Murata N, Sato K, Kon J, Tomura H, Yanagita M, Kuwabara A, et al. (2000b). Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. Biochem J 352(Pt 3):809-815. (Pubitemid 32015038)
102. Nayak D, Huo Y, Kwang WX, Pushparaj PN, Kumar SD, Ling EA, et al. (2010). Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience 166:132-144.
103. Nieuwenhuis B, Luth A, Chun J, Huwiler A, Pfeilschifter J, Schafer-Korting M, et al. (2009). Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P (3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med 87:645-657.
104. O'Brien CA (2010). Control of RANKL gene expression. Bone 46:911-919.
105. O'Neill LA (2010). Stopping sepsis by targeting sphingosine kinase 1. Sci Transl Med 2(36):36ps29.
106. Ogawa R, Takahashi M, Hirose S, Morimoto H, Ise H, Murakami T, et al. (2007). A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis. Biochem Biophys Res Commun 361:621-628. (Pubitemid 47238032)
107. Olivera A, Spiegel S (1993). Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365:557-560. (Pubitemid 23317779)
108. Olivera A, Eisner C, Kitamura Y, Dillahunt S, Allende L, Tuymetova G, et al. (2010). Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J Clin Invest 120:1429-1440.
109. Oskeritzian CA, Price MM, Hait NC, Kapitonov D, Falanga YT, Morales JK, et al. (2010). Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. J Exp Med 207:465-474.
110. Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Rey JM, Garcia-Garcia A (2010). RANK/RANKL/OPG role in distraction osteogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:679-686.
111. Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, et al. (2003). The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J 17:1411-1421. (Pubitemid 36939148)
112. Peyruchaud O (2009). Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer. Anticancer Agents Med Chem 9:381-391.
113. Proffit W (2007). Contemporary orthodontics. 4th ed. St. Louis: Mosby.
114. Puneet P, Yap CT, Wong L, Lam Y, Koh DR, Moochhala S, et al. (2010). SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science 328:1290-1294.
115. Pushparaj PN, Melendez AJ (2006). Short interfering RNA (siRNA) as a novel therapeutic. Clin Exp Pharmacol Physiol 33:504-510.
116. Pushparaj PN, Aarthi JJ, Manikandan J, Kumar SD (2008a). siRNA, miRNA, and shRNA: in vivo applications. J Dent Res 87:992-1003.
117. Pushparaj PN, H'Ng SC, Melendez AJ (2008b). Refining siRNA in vivo transfection: silencing SPHK1 reveals its key role in C5a-induced inflammation in vivo. Int J Biochem Cell Biol 40:1817-1825.
118. Pushparaj PN, Manikandan J, Tay HK, H'Ng SC, Kumar SD, Pfeilschifter J, et al. (2009). Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo. J Immunol 183:221-227.
119. Rivera J, Proia RL, Olivera A (2008). The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol 8:753-763.
120. Roviezzo F, Del Galdo F, Abbate G, Bucci M, D'Agostino B, Antunes E, et al. (2004). Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate. Proc Natl Acad Sci USA 101:11170-11175. (Pubitemid 38989602)
121. Ruf S, Pancherz H (1998). Temporomandibular joint growth adaptation in Herbst treatment: a prospective magnetic resonance imaging and cephalometric roentgenographic study. Eur J Orthod 20:375-388. (Pubitemid 128491543)
122. Ruf S, Pancherz H (1999). Dentoskeletal effects and facial profile changes in young adults treated with the Herbst appliance. Angle Orthod 69:239-246.
123. Ruf S, Hansen K, Pancherz H (1998). Does orthodontic proclination of lower incisors in children and adolescents cause gingival recession? Am J Orthod Dentofacial Orthop 114:100-106.
124. Ryu J, Kim HJ, Chang EJ, Huang H, Banno Y, Kim HH (2006). Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclastosteoblast coupling. EMBO J 25:5840-5851. (Pubitemid 44967767)
125. Salavati R, Altman S (1998). Improving the efficiency of antisense and EGS methods. Antisense Nucleic Acid Drug Dev 8:63-65. (Pubitemid 28121933)
126. Sandhoff K, Kolter T (2003). Biosynthesis and degradation of mammalian glycosphingolipids. Philos Trans R Soc Lond B Biol Sci 358:847-861. (Pubitemid 36639708)
127. Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, et al. (2004). Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 279:13839-13848. (Pubitemid 38468916)
128. Sawicka E, Dubois G, Jarai G, Edwards M, Thomas M, Nicholls A, et al. (2005). The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity. J Immunol 175:7973-7980. (Pubitemid 41798358)
129. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG (2005). Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309:1735-1739. (Pubitemid 41285945)
130. Seo J, Koo NY, Choi WY, Kang JA, Min JH, Jo SH, et al. (2010). Sphingosine-1-phosphate signaling in human submandibular cells. J Dent Res 89:1148-1153.
131. Sethu S, Pushparaj PN, Melendez AJ (2010). Phospholipase D1 mediates TNFalpha-induced inflammation in a murine model of TNFalphainduced peritonitis. PLoS One 5:e10506.
132. Shatrov VA, Lehmann V, Chouaib S (1997). Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. Biochem Biophys Res Commun 234:121-124. (Pubitemid 27267544)
133. Shen G, Darendeliler MA (2005). The adaptive remodeling of condylar cartilage-a transition from chondrogenesis to osteogenesis. J Dent Res 84:691-699.
134. Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, et al. (2009). Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci USA 106:8163-8168.
135. Silvestrini G, Ballanti P, Patacchioli F, Leopizzi M, Gualtieri N, Monnazzi P, et al. (2005). Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat. J Mol Histol 36:59-67. (Pubitemid 40614383)
136. Skoura A, Sanchez T, Claffey K, Mandala SM, Proia RL, Hla T (2007). Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest 117:2506-2516. (Pubitemid 47494352)
137. Song J, Matsuda C, Kai Y, Nishida T, Nakajima K, Mizushima T, et al. (2008). A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice. J Pharmacol Exp Ther 324:276-283. (Pubitemid 350294170)
138. Spiegel S (2000). Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. Ann NY Acad Sci 905:54-60. (Pubitemid 30255405)
139. Spiegel S, Milstien S (2000). Functions of a new family of sphingosine-1-phosphate receptors. Biochim Biophys Acta 1484:107-116. (Pubitemid 30175961)
140. Spiegel S, Milstien S (2003). Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 4:397-407. (Pubitemid 36565571)
141. Spiegel S, Cuvillier O, Edsall L, Kohama T, Menzeleev R, Olivera A, et al. (1998a). Roles of sphingosine-1-phosphate in cell growth, differentiation, and death. Biochemistry (Mosc) 63:69-73. (Pubitemid 128588478)
142. Spiegel S, Cuvillier O, Edsall LC, Kohama T, Menzeleev R, Olah Z, et al. (1998b). Sphingosine-1-phosphate in cell growth and cell death. Ann NY Acad Sci 845:11-18. (Pubitemid 28365296)
143. Stradner MH, Hermann J, Angerer H, Setznagl D, Sunk IG, Windhager R, et al. (2008). Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes. Osteoarthritis Cartilage 16:305-311. (Pubitemid 351309177)
144. Takabe K, Paugh SW, Milstien S, Spiegel S (2008). "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 60:181-195. (Pubitemid 351962008)
145. Theill LE, Boyle WJ, Penninger JM (2002). RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 20:795-823. (Pubitemid 34293440)
146. Vachal P, Toth LM, Hale JJ, Yan L, Mills SG, Chrebet GL, et al. (2006). Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Bioorg Med Chem Lett 16:3684-3687. (Pubitemid 44164271)
147. van Koppen C, Meyerzu Heringdorf M, Laser KT, Zhang C, Jakobs KH, Bunemann M, et al. (1996). Activation of a high affinity Gi proteincoupled plasma membrane receptor by sphingosine-1-phosphate. J Biol Chem 271:2082-2087.
148. Verzijl D, Peters SL, Alewijnse AE (2010). Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications. Mol Cells 29:99-104.
149. Visentin B, Vekich JA, Sibbald BJ, Cavalli AL, Moreno KM, Matteo RG, et al. (2006). Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 9:225-238. (Pubitemid 43357948)
150. Vogel P, Donoviel MS, Read R, Hansen GM, Hazlewood J, Anderson SJ, et al. (2009). Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS One 4:e4112.
151. Vora KA, Nichols E, Porter G, Cui Y, Keohane CA, Hajdu R, et al. (2005). Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement. J Leukoc Biol 78:471-480. (Pubitemid 41061319)
152. Waeber C, Blondeau N, Salomone S (2004). Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. Drug News Perspect 17:365-382. (Pubitemid 39295641)
153. Walzer T, Chiossone L, Chaix J, Calver A, Carozzo C, Garrigue-Antar L, et al. (2007). Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nat Immunol 8:1337-1344. (Pubitemid 350131171)
154. Wang W, Graeler MH, Goetzl EJ (2005). Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration. FASEB J 19:1731-1733. (Pubitemid 41429545)
155. Waymire KG, Mahuren JD, Jaje JM, Guilarte TR, Coburn SP, MacGregor GR (1995). Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nat Genet 11:45-51.
156. Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, et al. (2005). Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol 6:1228-1235. (Pubitemid 43045634)
157. Wenderfer SE, Stepkowski SM, Braun MC (2008). Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1- phosphate receptor agonist. Kidney Int 74:1319-1326.
158. Wolf AM, Eller K, Zeiser R, Durr C, Gerlach UV, Sixt M, et al. (2009). The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol 183:3751-3760.
159. Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, et al. (2009). BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 10:R130.
160. Xin C, Ren S, Pfeilschifter J, Huwiler A (2004). Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. Br J Pharmacol 143:581-589. (Pubitemid 39524275)
161. Yamaguchi M (2009). RANK/RANKL/OPG during orthodontic tooth movement. Orthod Craniofac Res 12:113-119.
162. Yoon CM, Hong BS, Moon HG, Lim S, Suh PG, Kim YK, et al. (2008). Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Blood 112:1129-1138.
163. Zhang H, Desai NN, Olivera A, Seki T, Brooker G, Spiegel S (1991). Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J Cell Biol 114:155-167. (Pubitemid 21909788)