메뉴 건너뛰기




Volumn 1143, Issue , 2008, Pages 123-150

RANK/RANKL: Regulators of immune responses and bone physiology

Author keywords

Lymph node formation; Mammary gland biology; OPG; Osteoclastogenesis; Osteoimmunology; Osteoporosis; RANK; RANK RANKL signaling; RANKL; Rheumatoid arthritis

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; BETA INTERFERON; CALCINEURIN; CALCIUM; DENOSUMAB; GAMMA INTERFERON; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN BETA; MATRIX METALLOPROTEINASE 14; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR DERIVATIVE; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

EID: 56549098575     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1443.016     Document Type: Review
Times cited : (334)

References (202)
  • 1
    • 0030714605 scopus 로고    scopus 로고
    • A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    • Anderson, D.M. et al. 1997. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390 : 175 179.
    • (1997) Nature , vol.390 , pp. 175-179
    • Anderson, D.M.1
  • 2
    • 14444272043 scopus 로고    scopus 로고
    • TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
    • Wong, B.R. et al. 1997. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272 : 25190 25194.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25190-25194
    • Wong, B.R.1
  • 3
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey, D.L. et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 : 165 176.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1
  • 4
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda, H. et al. 1998. Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA 95 : 3597 3602.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3597-3602
    • Yasuda, H.1
  • 5
    • 0009660825 scopus 로고    scopus 로고
    • Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
    • Yasuda, H. et al. 1998. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 139 : 1329 1337.
    • (1998) Endocrinology , vol.139 , pp. 1329-1337
    • Yasuda, H.1
  • 6
    • 0030989969 scopus 로고    scopus 로고
    • Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
    • Tsuda, E. et al. 1997. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem. Biophys. Res. Commun. 234 : 137 142.
    • (1997) Biochem. Biophys. Res. Commun. , vol.234 , pp. 137-142
    • Tsuda, E.1
  • 7
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet, W.S. et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 : 309 319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1
  • 8
    • 0036218666 scopus 로고    scopus 로고
    • RANK-L and RANK: T cells, bone loss, and mammalian evolution
    • &
    • Theill, L.E., W.J. Boyle & J.M. Penninger. 2002. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20 : 795 823.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 9
    • 0033568341 scopus 로고    scopus 로고
    • RANK is essential for osteoclast and lymph node development
    • Dougall, W.C. et al. 1999. RANK is essential for osteoclast and lymph node development. Genes. Dev. 13 : 2412 2424.
    • (1999) Genes. Dev. , vol.13 , pp. 2412-2424
    • Dougall, W.C.1
  • 10
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong, Y.Y. et al. 1999. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397 : 315 323.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1
  • 11
    • 12944262423 scopus 로고    scopus 로고
    • RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    • Li, J. et al. 2000. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc. Natl. Acad. Sci. USA 97 : 1566 1571.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1566-1571
    • Li, J.1
  • 12
    • 0031578808 scopus 로고    scopus 로고
    • Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells
    • Tan, K.B. et al. 1997. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. Gene. 204 : 35 46.
    • (1997) Gene. , vol.204 , pp. 35-46
    • Tan, K.B.1
  • 13
    • 17344381882 scopus 로고    scopus 로고
    • TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption
    • Kwon, B.S. et al. 1998. TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J. 12 : 845 854.
    • (1998) FASEB J. , vol.12 , pp. 845-854
    • Kwon, B.S.1
  • 14
    • 0034784606 scopus 로고    scopus 로고
    • Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity
    • Lam, J. et al. 2001. Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity. J. Clin. Invest. 108 : 971 979.
    • (2001) J. Clin. Invest. , vol.108 , pp. 971-979
    • Lam, J.1
  • 15
    • 0037155157 scopus 로고    scopus 로고
    • Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution
    • Ito, S. et al. 2002. Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. J. Biol. Chem. 277 : 6631 6636.
    • (2002) J. Biol. Chem. , vol.277 , pp. 6631-6636
    • Ito, S.1
  • 16
    • 0031439265 scopus 로고    scopus 로고
    • TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
    • Wong, B.R. et al. 1997. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J. Exp. Med. 186 : 2075 2080.
    • (1997) J. Exp. Med. , vol.186 , pp. 2075-2080
    • Wong, B.R.1
  • 17
    • 0032836854 scopus 로고    scopus 로고
    • Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues
    • Kartsogiannis, V. et al. 1999. Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. Bone 25 : 525 534.
    • (1999) Bone , vol.25 , pp. 525-534
    • Kartsogiannis, V.1
  • 18
    • 0034730327 scopus 로고    scopus 로고
    • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    • Fata, J.E. et al. 2000. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 103 : 41 50.
    • (2000) Cell , vol.103 , pp. 41-50
    • Fata, J.E.1
  • 19
    • 33845543666 scopus 로고    scopus 로고
    • Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
    • Loser, K. et al. 2006. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat. Med. 12 : 1372 1379.
    • (2006) Nat. Med. , vol.12 , pp. 1372-1379
    • Loser, K.1
  • 20
    • 0035054126 scopus 로고    scopus 로고
    • Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus
    • Ikeda, T. et al. 2001. Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus. Endocrinology 142 : 1419 1426.
    • (2001) Endocrinology , vol.142 , pp. 1419-1426
    • Ikeda, T.1
  • 21
    • 0344875487 scopus 로고    scopus 로고
    • Multimerization of the receptor activator of nuclear factor-kappaB ligand (RANKL) isoforms and regulation of osteoclastogenesis
    • Ikeda, T. et al. 2003. Multimerization of the receptor activator of nuclear factor-kappaB ligand (RANKL) isoforms and regulation of osteoclastogenesis. J. Biol. Chem. 278 : 47217 47222.
    • (2003) J. Biol. Chem. , vol.278 , pp. 47217-47222
    • Ikeda, T.1
  • 22
    • 0942268164 scopus 로고    scopus 로고
    • Regulation of osteoclastogenesis by three human RANKL isoforms expressed in NIH3T3 cells
    • Suzuki, J. et al. 2004. Regulation of osteoclastogenesis by three human RANKL isoforms expressed in NIH3T3 cells. Biochem. Biophys. Res. Commun. 314 : 1021 1027.
    • (2004) Biochem. Biophys. Res. Commun. , vol.314 , pp. 1021-1027
    • Suzuki, J.1
  • 23
    • 0035805620 scopus 로고    scopus 로고
    • Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase
    • &
    • Schlondorff, J., L. Lum & C.P. Blobel. 2001. Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J. Biol. Chem. 276 : 14665 14674.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14665-14674
    • Schlondorff, J.1    Lum, L.2    Blobel, C.P.3
  • 24
    • 0038605290 scopus 로고    scopus 로고
    • Catalytic properties of ADAM19
    • Chesneau, V. et al. 2003. Catalytic properties of ADAM19. J. Biol. Chem. 278 : 22331 22340.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22331-22340
    • Chesneau, V.1
  • 25
    • 21144438505 scopus 로고    scopus 로고
    • MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL
    • Lynch, C.C. et al. 2005. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Can. Cell 7 : 485 496.
    • (2005) Can. Cell , vol.7 , pp. 485-496
    • Lynch, C.C.1
  • 26
    • 33845994375 scopus 로고    scopus 로고
    • Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand
    • Hikita, A. et al. 2006. Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. J. Biol. Chem. 281 : 36846 36855.
    • (2006) J. Biol. Chem. , vol.281 , pp. 36846-36855
    • Hikita, A.1
  • 27
    • 0032545355 scopus 로고    scopus 로고
    • RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
    • Nakagawa, N. et al. 1998. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem. Biophys. Res. Commun. 253 : 395 400.
    • (1998) Biochem. Biophys. Res. Commun. , vol.253 , pp. 395-400
    • Nakagawa, N.1
  • 28
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu, H. et al. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. USA 96 : 3540 3545.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3540-3545
    • Hsu, H.1
  • 29
    • 0034733682 scopus 로고    scopus 로고
    • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
    • Chan, F.K. et al. 2000. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288 : 2351 2354.
    • (2000) Science , vol.288 , pp. 2351-2354
    • Chan, F.K.1
  • 30
    • 0034733584 scopus 로고    scopus 로고
    • Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
    • Siegel, R.M. et al. 2000. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288 : 2354 2357.
    • (2000) Science , vol.288 , pp. 2354-2357
    • Siegel, R.M.1
  • 31
    • 0033725002 scopus 로고    scopus 로고
    • Signaling by the TNF receptor superfamily and T cell homeostasis
    • &
    • Chan, K.F., M.R. Siegel & J.M. Lenardo. 2000. Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity 13 : 419 422.
    • (2000) Immunity , vol.13 , pp. 419-422
    • Chan, K.F.1    Siegel, M.R.2    Lenardo, J.M.3
  • 32
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: Integrating mammalian biology
    • &
    • Locksley, R.M., N. Killeen & M.J. Lenardo. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104 : 487 501.
    • (2001) Cell , vol.104 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 33
    • 0036784632 scopus 로고    scopus 로고
    • Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: Impact on tolerance induction
    • &
    • Williamson, E., J.M. Bilsborough & J.L. Viney. 2002. Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: impact on tolerance induction. J. Immunol. 169 : 3606 3612.
    • (2002) J. Immunol. , vol.169 , pp. 3606-3612
    • Williamson, E.1    Bilsborough, J.M.2    Viney, J.L.3
  • 34
    • 0033104614 scopus 로고    scopus 로고
    • TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells
    • Josien, R. et al. 1999. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells. J. Immunol. 162 : 2562 2568.
    • (1999) J. Immunol. , vol.162 , pp. 2562-2568
    • Josien, R.1
  • 35
    • 33846911452 scopus 로고    scopus 로고
    • RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    • Gonzalez-Suarez, E. et al. 2007. RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini. Mol. Cell Biol. 27 : 1442 1454.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 1442-1454
    • Gonzalez-Suarez, E.1
  • 36
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay, N. et al. 1998. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes. Dev. 12 : 1260 1268.
    • (1998) Genes. Dev. , vol.12 , pp. 1260-1268
    • Bucay, N.1
  • 37
    • 0032577903 scopus 로고    scopus 로고
    • Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
    • Mizuno, A. et al. 1998. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem. Biophys. Res. Commun. 247 : 610 615.
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 610-615
    • Mizuno, A.1
  • 38
    • 0033987358 scopus 로고    scopus 로고
    • Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
    • Hughes, A.E. et al. 2000. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat. Genet. 24 : 45 48.
    • (2000) Nat. Genet. , vol.24 , pp. 45-48
    • Hughes, A.E.1
  • 39
    • 0033681488 scopus 로고    scopus 로고
    • Expansile skeletal hyperphosphatasia: A new familial metabolic bone disease
    • Whyte, M.P. et al. 2000. Expansile skeletal hyperphosphatasia: a new familial metabolic bone disease. J. Bone. Miner. Res. 15 : 2330 2344.
    • (2000) J. Bone. Miner. Res. , vol.15 , pp. 2330-2344
    • Whyte, M.P.1
  • 40
    • 0036133351 scopus 로고    scopus 로고
    • Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis
    • &
    • Whyte, M.P. & A.E. Hughes. 2002. Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis. J. Bone. Miner. Res. 17 : 26 29.
    • (2002) J. Bone. Miner. Res. , vol.17 , pp. 26-29
    • Whyte, M.P.1    Hughes, A.E.2
  • 41
    • 18544371504 scopus 로고    scopus 로고
    • A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype
    • Cundy, T. et al. 2002. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum. Mol. Genet. 11 : 2119 2127.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2119-2127
    • Cundy, T.1
  • 42
    • 10744230044 scopus 로고    scopus 로고
    • Idiopathic hyperphosphatasia and TNFRSF11B mutations: Relationships between phenotype and genotype
    • Chong, B. et al. 2003. Idiopathic hyperphosphatasia and TNFRSF11B mutations: relationships between phenotype and genotype. J. Bone. Miner. Res. 18 : 2095 2104.
    • (2003) J. Bone. Miner. Res. , vol.18 , pp. 2095-2104
    • Chong, B.1
  • 43
    • 0034627798 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor-associated factor (TRAF) family: Adapter proteins that mediate cytokine signaling
    • Inoue, J. et al. 2000. Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. Exp. Cell Res. 254 : 14 24.
    • (2000) Exp. Cell Res. , vol.254 , pp. 14-24
    • Inoue, J.1
  • 44
    • 0032493737 scopus 로고    scopus 로고
    • Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase
    • Darnay, B.G. et al. 1998. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J. Biol. Chem. 273 : 20551 20555.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20551-20555
    • Darnay, B.G.1
  • 45
    • 0032561198 scopus 로고    scopus 로고
    • The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor
    • Wong, B.R. et al. 1998. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J. Biol. Chem. 273 : 28355 28359.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28355-28359
    • Wong, B.R.1
  • 46
    • 0000371126 scopus 로고    scopus 로고
    • TRANCE is a TNF family member that regulates dendritic cell and osteoclast function
    • &
    • Wong, B.R., R. Josien & Y. Choi. 1999. TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. J. Leukoc. Biol. 65 : 715 724.
    • (1999) J. Leukoc. Biol. , vol.65 , pp. 715-724
    • Wong, B.R.1    Josien, R.2    Choi, Y.3
  • 47
    • 0032545465 scopus 로고    scopus 로고
    • The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily
    • Galibert, L. et al. 1998. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J. Biol. Chem. 273 : 34120 34127.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34120-34127
    • Galibert, L.1
  • 48
    • 0033663777 scopus 로고    scopus 로고
    • Activation of c-Jun N-terminal kinase and activator protein 1 by receptor activator of nuclear factor kappa B
    • Lee, Z.H. et al. 2000. Activation of c-Jun N-terminal kinase and activator protein 1 by receptor activator of nuclear factor kappa B. Mol. Pharmacol. 58 : 1536 1545.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 1536-1545
    • Lee, Z.H.1
  • 49
    • 0033561039 scopus 로고    scopus 로고
    • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    • Lomaga, M.A. et al. 1999. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes. Dev. 13 : 1015 1024.
    • (1999) Genes. Dev. , vol.13 , pp. 1015-1024
    • Lomaga, M.A.1
  • 50
    • 6544270833 scopus 로고    scopus 로고
    • Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
    • Naito, A. et al. 1999. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes. Cells. 4 : 353 362.
    • (1999) Genes. Cells. , vol.4 , pp. 353-362
    • Naito, A.1
  • 51
    • 0035868884 scopus 로고    scopus 로고
    • Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis
    • Kobayashi, N. et al. 2001. Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J. 20 : 1271 1280.
    • (2001) EMBO J. , vol.20 , pp. 1271-1280
    • Kobayashi, N.1
  • 52
    • 0141678952 scopus 로고    scopus 로고
    • TRAF6 is a critical factor for dendritic cell maturation and development
    • Kobayashi, T. et al. 2003. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19 : 353 363.
    • (2003) Immunity , vol.19 , pp. 353-363
    • Kobayashi, T.1
  • 53
    • 15444357762 scopus 로고    scopus 로고
    • Requirement for NF-kappaB in osteoclast and B-cell development
    • Franzoso, G. et al. 1997. Requirement for NF-kappaB in osteoclast and B-cell development. Genes. Dev. 11 : 3482 3496.
    • (1997) Genes. Dev. , vol.11 , pp. 3482-3496
    • Franzoso, G.1
  • 54
    • 0030715563 scopus 로고    scopus 로고
    • Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2
    • Iotsova, V. et al. 1997. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat. Med. 3 : 1285 1289.
    • (1997) Nat. Med. , vol.3 , pp. 1285-1289
    • Iotsova, V.1
  • 55
    • 0037370779 scopus 로고    scopus 로고
    • TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesis
    • Kanazawa, K. et al. 2003. TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesis. J. Bone. Miner. Res. 18 : 443 450.
    • (2003) J. Bone. Miner. Res. , vol.18 , pp. 443-450
    • Kanazawa, K.1
  • 56
    • 17644395610 scopus 로고    scopus 로고
    • TRAF2 is essential for TNF-alpha-induced osteoclastogenesis
    • &
    • Kanazawa, K. & A. Kudo. 2005. TRAF2 is essential for TNF-alpha-induced osteoclastogenesis. J. Bone. Miner. Res. 20 : 840 847.
    • (2005) J. Bone. Miner. Res. , vol.20 , pp. 840-847
    • Kanazawa, K.1    Kudo, A.2
  • 57
    • 17644393474 scopus 로고    scopus 로고
    • The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis
    • Wada, T. et al. 2005. The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat. Med. 11 : 394 399.
    • (2005) Nat. Med. , vol.11 , pp. 394-399
    • Wada, T.1
  • 58
    • 0036009115 scopus 로고    scopus 로고
    • NF-kappaB at the crossroads of life and death
    • &
    • Karin, M. & A. Lin. 2002. NF-kappaB at the crossroads of life and death. Nat. Immunol. 3 : 221 227.
    • (2002) Nat. Immunol. , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 59
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • &
    • Hayden, M.S. & S. Ghosh. 2008. Shared principles in NF-kappaB signaling. Cell 132 : 344 362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 60
    • 19344374949 scopus 로고    scopus 로고
    • I{kappa)B kinase (IKK){beta), but not IKK{alpha), is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    • Ruocco, M.G. et al. 2005. I{kappa)B kinase (IKK){beta), but not IKK{alpha), is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J. Exp. Med. 201 : 1677 1687.
    • (2005) J. Exp. Med. , vol.201 , pp. 1677-1687
    • Ruocco, M.G.1
  • 61
    • 0042386014 scopus 로고    scopus 로고
    • The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis
    • Novack, D.V. et al. 2003. The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis. J. Exp. Med. 198 : 771 781.
    • (2003) J. Exp. Med. , vol.198 , pp. 771-781
    • Novack, D.V.1
  • 62
    • 0034613188 scopus 로고    scopus 로고
    • Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)
    • Matsumoto, M. et al. 2000. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J. Biol. Chem. 275 : 31155 31161.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31155-31161
    • Matsumoto, M.1
  • 63
    • 0037113034 scopus 로고    scopus 로고
    • JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation- dependent and -independent mechanisms
    • David, J.P. et al. 2002. JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms. J. Cell Sci. 115 : 4317 4325.
    • (2002) J. Cell Sci. , vol.115 , pp. 4317-4325
    • David, J.P.1
  • 64
    • 0036838919 scopus 로고    scopus 로고
    • Functions of AP1 (Fos/Jun) in bone development
    • Wagner, E.F. 2002. Functions of AP1 (Fos/Jun) in bone development. Ann. Rheum. Dis. 61 (Suppl 2 ii40 ii42.
    • (2002) Ann. Rheum. Dis. , vol.61 , Issue.2
    • Wagner, E.F.1
  • 65
    • 0036006406 scopus 로고    scopus 로고
    • Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand
    • Yamamoto, A. et al. 2002. Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand. J. Bone. Miner. Res. 17 : 612 621.
    • (2002) J. Bone. Miner. Res. , vol.17 , pp. 612-621
    • Yamamoto, A.1
  • 66
    • 10744228707 scopus 로고    scopus 로고
    • Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects
    • Kenner, L. et al. 2004. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J. Cell Biol. 164 : 613 623.
    • (2004) J. Cell Biol. , vol.164 , pp. 613-623
    • Kenner, L.1
  • 67
    • 0346525140 scopus 로고    scopus 로고
    • U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells
    • Hotokezaka, H. et al. 2002. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J. Biol. Chem. 277 : 47366 47372.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47366-47372
    • Hotokezaka, H.1
  • 68
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    • Takayanagi, H. et al. 2002. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell. 3 : 889 901.
    • (2002) Dev. Cell. , vol.3 , pp. 889-901
    • Takayanagi, H.1
  • 69
    • 27744432009 scopus 로고    scopus 로고
    • Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
    • Asagiri, M. et al. 2005. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J. Exp. Med. 202 : 1261 1269.
    • (2005) J. Exp. Med. , vol.202 , pp. 1261-1269
    • Asagiri, M.1
  • 70
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi, H. 2007. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol. 7 : 292 304.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 292-304
    • Takayanagi, H.1
  • 71
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano, P. et al. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64 : 693 702.
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1
  • 72
    • 0028962845 scopus 로고
    • Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption
    • Nakamura, I. et al. 1995. Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption. FEBS Lett. 361 : 79 84.
    • (1995) FEBS Lett. , vol.361 , pp. 79-84
    • Nakamura, I.1
  • 73
    • 0033393957 scopus 로고    scopus 로고
    • TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
    • Wong, B.R. et al. 1999. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol. Cell. 4 : 1041 1049.
    • (1999) Mol. Cell. , vol.4 , pp. 1041-1049
    • Wong, B.R.1
  • 74
    • 0037799253 scopus 로고    scopus 로고
    • PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility
    • &
    • Sugatani, T., U. Alvarez & K.A. Hruska. 2003. PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J. Biol. Chem. 278 : 5001 5008.
    • (2003) J. Biol. Chem. , vol.278 , pp. 5001-5008
    • Sugatani, T.1    Alvarez, U.2    Hruska, K.A.3
  • 75
    • 0036732410 scopus 로고    scopus 로고
    • SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
    • Takeshita, S. et al. 2002. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat. Med. 8 : 943 949.
    • (2002) Nat. Med. , vol.8 , pp. 943-949
    • Takeshita, S.1
  • 76
    • 33750597150 scopus 로고    scopus 로고
    • PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
    • Mao, D. et al. 2006. PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J. Clin. Invest. 116 : 2869 2879.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2869-2879
    • Mao, D.1
  • 77
    • 11144355389 scopus 로고    scopus 로고
    • The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase
    • Mocsai, A. et al. 2004. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc. Natl. Acad. Sci. USA 101 : 6158 6163.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6158-6163
    • Mocsai, A.1
  • 78
    • 16844377831 scopus 로고    scopus 로고
    • Mechanistic insight into osteoclast differentiation in osteoimmunology
    • Takayanagi, H. 2005. Mechanistic insight into osteoclast differentiation in osteoimmunology. J. Mol. Med. 83 : 170 179.
    • (2005) J. Mol. Med. , vol.83 , pp. 170-179
    • Takayanagi, H.1
  • 79
    • 39749180445 scopus 로고    scopus 로고
    • Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals
    • Shinohara, M. et al. 2008. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132 : 794 806.
    • (2008) Cell , vol.132 , pp. 794-806
    • Shinohara, M.1
  • 80
    • 0442325388 scopus 로고    scopus 로고
    • The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
    • Duran, A. et al. 2004. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell. 6 : 303 309.
    • (2004) Dev. Cell. , vol.6 , pp. 303-309
    • Duran, A.1
  • 81
    • 0034735773 scopus 로고    scopus 로고
    • T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma
    • Takayanagi, H. et al. 2000. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408 : 600 605.
    • (2000) Nature , vol.408 , pp. 600-605
    • Takayanagi, H.1
  • 82
    • 0037129205 scopus 로고    scopus 로고
    • RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    • Takayanagi, H. et al. 2002. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 416 : 744 749.
    • (2002) Nature , vol.416 , pp. 744-749
    • Takayanagi, H.1
  • 83
    • 13444256417 scopus 로고    scopus 로고
    • Mechanisms of sex steroid effects on bone
    • &
    • Syed, F. & S. Khosla. 2005. Mechanisms of sex steroid effects on bone. Biochem. Biophys. Res. Commun. 328 : 688 696.
    • (2005) Biochem. Biophys. Res. Commun. , vol.328 , pp. 688-696
    • Syed, F.1    Khosla, S.2
  • 84
    • 34548274444 scopus 로고    scopus 로고
    • Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
    • Nakamura, T. et al. 2007. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 130 : 811 823.
    • (2007) Cell , vol.130 , pp. 811-823
    • Nakamura, T.1
  • 85
    • 0034992555 scopus 로고    scopus 로고
    • IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB
    • Abu-Amer, Y. 2001. IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB. J. Clin. Invest. 107 : 1375 1385.
    • (2001) J. Clin. Invest. , vol.107 , pp. 1375-1385
    • Abu-Amer, Y.1
  • 86
    • 0036135923 scopus 로고    scopus 로고
    • Role of TGF-beta family in osteoclastogenesis induced by RANKL
    • Koseki, T. et al. 2002. Role of TGF-beta family in osteoclastogenesis induced by RANKL. Cell Signal. 14 : 31 36.
    • (2002) Cell Signal. , vol.14 , pp. 31-36
    • Koseki, T.1
  • 87
    • 0033398996 scopus 로고    scopus 로고
    • Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors
    • Arai, F. et al. 1999. Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J. Exp. Med. 190 : 1741 1754.
    • (1999) J. Exp. Med. , vol.190 , pp. 1741-1754
    • Arai, F.1
  • 88
    • 0035808458 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways
    • Zhang, Y.H. et al. 2001. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J. Biol. Chem. 276 : 563 568.
    • (2001) J. Biol. Chem. , vol.276 , pp. 563-568
    • Zhang, Y.H.1
  • 89
    • 0028277665 scopus 로고
    • Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin
    • De Togni, P. et al. 1994. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264 : 703 707.
    • (1994) Science , vol.264 , pp. 703-707
    • De Togni, P.1
  • 90
    • 0030864294 scopus 로고    scopus 로고
    • Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization
    • &
    • Rennert, P.D., J.L. Browning & P.S. Hochman. 1997. Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization. Int. Immunol. 9 : 1627 1639.
    • (1997) Int. Immunol. , vol.9 , pp. 1627-1639
    • Rennert, P.D.1    Browning, J.L.2    Hochman, P.S.3
  • 91
    • 0030917003 scopus 로고    scopus 로고
    • Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice
    • Koni, P.A. et al. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 6 : 491 500.
    • (1997) Immunity , vol.6 , pp. 491-500
    • Koni, P.A.1
  • 92
    • 0030741389 scopus 로고    scopus 로고
    • Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice
    • Alimzhanov, M.B. et al. 1997. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc. Natl. Acad. Sci. USA 94 : 9302 9307.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9302-9307
    • Alimzhanov, M.B.1
  • 93
    • 0029991923 scopus 로고    scopus 로고
    • Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
    • Matsumoto, M. et al. 1996. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271 : 1289 1291.
    • (1996) Science , vol.271 , pp. 1289-1291
    • Matsumoto, M.1
  • 94
    • 0032127301 scopus 로고    scopus 로고
    • The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
    • Futterer, A. et al. 1998. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9 : 59 70.
    • (1998) Immunity , vol.9 , pp. 59-70
    • Futterer, A.1
  • 95
    • 0032127288 scopus 로고    scopus 로고
    • Lymph node genesis is induced by signaling through the lymphotoxin beta receptor
    • Rennert, P.D. et al. 1998. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Immunity 9 : 71 79.
    • (1998) Immunity , vol.9 , pp. 71-79
    • Rennert, P.D.1
  • 96
    • 34547521058 scopus 로고    scopus 로고
    • Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
    • Sobacchi, C. et al. 2007. Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL. Nat. Genet. 39 : 960 962.
    • (2007) Nat. Genet. , vol.39 , pp. 960-962
    • Sobacchi, C.1
  • 97
    • 0033006011 scopus 로고    scopus 로고
    • Development and maturation of secondary lymphoid tissues
    • &
    • Fu, Y.X. & D.D. Chaplin. 1999. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17 : 399 433.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 399-433
    • Fu, Y.X.1    Chaplin, D.D.2
  • 98
    • 0037978900 scopus 로고    scopus 로고
    • Organogenesis of lymphoid tissues
    • Mebius, R.E. 2003. Organogenesis of lymphoid tissues. Nat. Rev. Immunol. 3 : 292 303.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 292-303
    • Mebius, R.E.1
  • 99
    • 0030710079 scopus 로고    scopus 로고
    • Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    • &
    • Mebius, R.E., P. Rennert & I.L. Weissman. 1997. Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7 : 493 504.
    • (1997) Immunity , vol.7 , pp. 493-504
    • Mebius, R.E.1    Rennert, P.2    Weissman, I.L.3
  • 100
    • 0034694090 scopus 로고    scopus 로고
    • Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE
    • Kim, D. et al. 2000. Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE. J. Exp. Med. 192 : 1467 1478.
    • (2000) J. Exp. Med. , vol.192 , pp. 1467-1478
    • Kim, D.1
  • 101
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • &
    • Banchereau, J. & R.M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392 : 245 252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 102
    • 0030918820 scopus 로고    scopus 로고
    • In vivo detection of dendritic cell antigen presentation to CD4(+) T cells
    • Ingulli, E. et al. 1997. In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J. Exp. Med. 185 : 2133 2141.
    • (1997) J. Exp. Med. , vol.185 , pp. 2133-2141
    • Ingulli, E.1
  • 103
    • 0033538475 scopus 로고    scopus 로고
    • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
    • Wang, J. et al. 1999. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 98 : 47 58.
    • (1999) Cell , vol.98 , pp. 47-58
    • Wang, J.1
  • 104
    • 0034614892 scopus 로고    scopus 로고
    • TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo
    • Josien, R. et al. 2000. TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo. J. Exp. Med. 191 : 495 502.
    • (2000) J. Exp. Med. , vol.191 , pp. 495-502
    • Josien, R.1
  • 105
    • 0033526021 scopus 로고    scopus 로고
    • TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
    • Bachmann, M.F. et al. 1999. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J. Exp. Med. 189 : 1025 1031.
    • (1999) J. Exp. Med. , vol.189 , pp. 1025-1031
    • Bachmann, M.F.1
  • 106
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • Kong, Y.Y. et al. 1999. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402 : 304 309.
    • (1999) Nature , vol.402 , pp. 304-309
    • Kong, Y.Y.1
  • 107
    • 0027293241 scopus 로고
    • The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells
    • Roy, M. et al. 1993. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J. Immunol. 151 : 2497 2510.
    • (1993) J. Immunol. , vol.151 , pp. 2497-2510
    • Roy, M.1
  • 108
    • 2542476167 scopus 로고    scopus 로고
    • CD40/CD154 interactions at the interface of tolerance and immunity
    • Quezada, S.A. et al. 2004. CD40/CD154 interactions at the interface of tolerance and immunity. Annu. Rev. Immunol. 22 : 307 328.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 307-328
    • Quezada, S.A.1
  • 109
    • 0030014527 scopus 로고    scopus 로고
    • CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions
    • Oxenius, A. et al. 1996. CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions. J. Exp. Med. 183 : 2209 2218.
    • (1996) J. Exp. Med. , vol.183 , pp. 2209-2218
    • Oxenius, A.1
  • 110
    • 7344233085 scopus 로고    scopus 로고
    • Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
    • Emery, J.G. et al. 1998. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J. Biol. Chem. 273 : 14363 14367.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14363-14367
    • Emery, J.G.1
  • 111
    • 0032400933 scopus 로고    scopus 로고
    • OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40
    • Yun, T.J. et al. 1998. OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. J. Immunol. 161 : 6113 6121.
    • (1998) J. Immunol. , vol.161 , pp. 6113-6121
    • Yun, T.J.1
  • 112
    • 0033304632 scopus 로고    scopus 로고
    • Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
    • Hofbauer, L.C. et al. 1999. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 140 : 4367 4370.
    • (1999) Endocrinology , vol.140 , pp. 4367-4370
    • Hofbauer, L.C.1
  • 114
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • &
    • Kyewski, B. & L. Klein. 2006. A central role for central tolerance. Annu. Rev. Immunol. 24 : 571 606.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 115
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson, M.S. et al. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298 : 1395 1401.
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 116
    • 33745516115 scopus 로고    scopus 로고
    • Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium
    • Rossi, S.W. et al. 2006. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441 : 988 991.
    • (2006) Nature , vol.441 , pp. 988-991
    • Rossi, S.W.1
  • 117
    • 34250336454 scopus 로고    scopus 로고
    • RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
    • Rossi, S.W. et al. 2007. RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J. Exp. Med. 204 : 1267 1272.
    • (2007) J. Exp. Med. , vol.204 , pp. 1267-1272
    • Rossi, S.W.1
  • 118
    • 0242624626 scopus 로고    scopus 로고
    • Lymphotoxin pathway directs thymic Aire expression
    • Chin, R.K. et al. 2003. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4 : 1121 1127.
    • (2003) Nat. Immunol. , vol.4 , pp. 1121-1127
    • Chin, R.K.1
  • 119
    • 0041884736 scopus 로고    scopus 로고
    • Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR
    • Boehm, T. et al. 2003. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J. Exp. Med. 198 : 757 769.
    • (2003) J. Exp. Med. , vol.198 , pp. 757-769
    • Boehm, T.1
  • 120
    • 16444377660 scopus 로고    scopus 로고
    • Dependence of self-tolerance on TRAF6-directed development of thymic stroma
    • Akiyama, T. et al. 2005. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 : 248 251.
    • (2005) Science , vol.308 , pp. 248-251
    • Akiyama, T.1
  • 121
    • 36448949476 scopus 로고    scopus 로고
    • Generating intrathymic microenvironments to establish T-cell tolerance
    • &
    • Anderson, G., P.J. Lane & E.J. Jenkinson. 2007. Generating intrathymic microenvironments to establish T-cell tolerance. Nat. Rev. Immunol. 7 : 954 963.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 954-963
    • Anderson, G.1    Lane, P.J.2    Jenkinson, E.J.3
  • 122
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi, S. 2005. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6 : 345 352.
    • (2005) Nat. Immunol. , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 124
    • 0035801477 scopus 로고    scopus 로고
    • Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity
    • Mehling, A. et al. 2001. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J. Exp. Med. 194 : 615 628.
    • (2001) J. Exp. Med. , vol.194 , pp. 615-628
    • Mehling, A.1
  • 125
    • 0033625501 scopus 로고    scopus 로고
    • The temporal importance of TNFalpha expression in the development of diabetes
    • &
    • Green, E.A. & R.A. Flavell. 2000. The temporal importance of TNFalpha expression in the development of diabetes. Immunity 12 : 459 469.
    • (2000) Immunity , vol.12 , pp. 459-469
    • Green, E.A.1    Flavell, R.A.2
  • 126
    • 0036196305 scopus 로고    scopus 로고
    • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: Highly potent regulators of diabetes that require TRANCE-RANK signals
    • &
    • Green, E.A., Y. Choi & R.A. Flavell. 2002. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16 : 183 191.
    • (2002) Immunity , vol.16 , pp. 183-191
    • Green, E.A.1    Choi, Y.2    Flavell, R.A.3
  • 127
    • 0035253693 scopus 로고    scopus 로고
    • Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function
    • Yun, T.J. et al. 2001. Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. J. Immunol. 166 : 1482 1491.
    • (2001) J. Immunol. , vol.166 , pp. 1482-1491
    • Yun, T.J.1
  • 128
    • 0033623876 scopus 로고    scopus 로고
    • Prostaglandin E2 induces expression of receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ligand on pre-B cells: Implications for accelerated osteoclastogenesis in estrogen deficiency
    • Kanematsu, M. et al. 2000. Prostaglandin E2 induces expression of receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ligand on pre-B cells: implications for accelerated osteoclastogenesis in estrogen deficiency. J. Bone. Miner. Res. 15 : 1321 1329.
    • (2000) J. Bone. Miner. Res. , vol.15 , pp. 1321-1329
    • Kanematsu, M.1
  • 129
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse, P. et al. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270 : 985 988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1
  • 131
    • 0031576524 scopus 로고    scopus 로고
    • A new mechanism of bone destruction in rheumatoid arthritis: Synovial fibroblasts induce osteoclastogenesis
    • Takayanagi, H. et al. 1997. A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis. Biochem. Biophys. Res. Commun. 240 : 279 286.
    • (1997) Biochem. Biophys. Res. Commun. , vol.240 , pp. 279-286
    • Takayanagi, H.1
  • 132
    • 0026752620 scopus 로고
    • The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis
    • &
    • Panayi, G.S., J.S. Lanchbury & G.H. Kingsley. 1992. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis. Rheum. 35 : 729 735.
    • (1992) Arthritis. Rheum. , vol.35 , pp. 729-735
    • Panayi, G.S.1    Lanchbury, J.S.2    Kingsley, G.H.3
  • 133
    • 0033019404 scopus 로고    scopus 로고
    • Animal models of arthritis: Relevance to human disease
    • Bendele, A. et al. 1999. Animal models of arthritis: relevance to human disease. Toxicol. Pathol. 27 : 134 142.
    • (1999) Toxicol. Pathol. , vol.27 , pp. 134-142
    • Bendele, A.1
  • 135
    • 0036068297 scopus 로고    scopus 로고
    • Kinetics of bone protection by recombinant osteoprotegerin therapy in Lewis rats with adjuvant arthritis
    • &
    • Campagnuolo, G., B. Bolon & U. Feige. 2002. Kinetics of bone protection by recombinant osteoprotegerin therapy in Lewis rats with adjuvant arthritis. Arthritis. Rheum. 46 : 1926 1936.
    • (2002) Arthritis. Rheum. , vol.46 , pp. 1926-1936
    • Campagnuolo, G.1    Bolon, B.2    Feige, U.3
  • 136
    • 0036710615 scopus 로고    scopus 로고
    • Duration of bone protection by a single osteoprotegerin injection in rats with adjuvant-induced arthritis
    • &
    • Bolon, B., G. Campagnuolo & U. Feige. 2002. Duration of bone protection by a single osteoprotegerin injection in rats with adjuvant-induced arthritis. Cell Mol. Life Sci. 59 : 1569 1576.
    • (2002) Cell Mol. Life Sci. , vol.59 , pp. 1569-1576
    • Bolon, B.1    Campagnuolo, G.2    Feige, U.3
  • 137
    • 0031805430 scopus 로고    scopus 로고
    • Molecular biology of cartilage and bone destruction
    • &
    • Muller-Ladner, U., R.E. Gay & S. Gay. 1998. Molecular biology of cartilage and bone destruction. Curr. Opin. Rheumatol. 10 : 212 219.
    • (1998) Curr. Opin. Rheumatol. , vol.10 , pp. 212-219
    • Muller-Ladner, U.1    Gay, R.E.2    Gay, S.3
  • 138
    • 0030606310 scopus 로고    scopus 로고
    • Organ-specific disease provoked by systemic autoimmunity
    • Kouskoff, V. et al. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87 : 811 822.
    • (1996) Cell , vol.87 , pp. 811-822
    • Kouskoff, V.1
  • 139
    • 0033118675 scopus 로고    scopus 로고
    • From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
    • Korganow, A.S. et al. 1999. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 10 : 451 461.
    • (1999) Immunity , vol.10 , pp. 451-461
    • Korganow, A.S.1
  • 140
    • 0035153246 scopus 로고    scopus 로고
    • TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis
    • Pettit, A.R. et al. 2001. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol. 159 : 1689 1699.
    • (2001) Am J Pathol. , vol.159 , pp. 1689-1699
    • Pettit, A.R.1
  • 141
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer, J. et al. 1991. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 10 : 4025 4031.
    • (1991) EMBO J. , vol.10 , pp. 4025-4031
    • Keffer, J.1
  • 142
    • 0036207011 scopus 로고    scopus 로고
    • RANK ligand, RANK, and OPG expression in type II collagen-induced arthritis mouse
    • Mori, H. et al. 2002. RANK ligand, RANK, and OPG expression in type II collagen-induced arthritis mouse. Histochem. Cell Biol. 117 : 283 292.
    • (2002) Histochem. Cell Biol. , vol.117 , pp. 283-292
    • Mori, H.1
  • 143
    • 0036185343 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin
    • Redlich, K. et al. 2002. Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis. Rheum. 46 : 785 792.
    • (2002) Arthritis. Rheum. , vol.46 , pp. 785-792
    • Redlich, K.1
  • 144
    • 0036792512 scopus 로고    scopus 로고
    • Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis
    • Romas, E. et al. 2002. Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. Am. J. Pathol. 161 : 1419 1427.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1419-1427
    • Romas, E.1
  • 145
    • 0038746729 scopus 로고    scopus 로고
    • RANKL and RANK as novel therapeutic targets for arthritis
    • &
    • Nakashima, T., T. Wada & J.M. Penninger. 2003. RANKL and RANK as novel therapeutic targets for arthritis. Curr. Opin. Rheumatol. 15 : 280 287.
    • (2003) Curr. Opin. Rheumatol. , vol.15 , pp. 280-287
    • Nakashima, T.1    Wada, T.2    Penninger, J.M.3
  • 146
    • 17444452820 scopus 로고    scopus 로고
    • Activated human T cells directly induce osteoclastogenesis from human monocytes: Possible role of T cells in bone destruction in rheumatoid arthritis patients
    • Kotake, S. et al. 2001. Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis. Rheum. 44 : 1003 1012.
    • (2001) Arthritis. Rheum. , vol.44 , pp. 1003-1012
    • Kotake, S.1
  • 147
    • 0034121039 scopus 로고    scopus 로고
    • Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
    • Takayanagi, H. et al. 2000. Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis. Rheum. 43 : 259 269.
    • (2000) Arthritis. Rheum. , vol.43 , pp. 259-269
    • Takayanagi, H.1
  • 148
    • 43949139580 scopus 로고    scopus 로고
    • Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial
    • Cohen, S.B. et al. 2008. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis. Rheum. 58 : 1299 1309.
    • (2008) Arthritis. Rheum. , vol.58 , pp. 1299-1309
    • Cohen, S.B.1
  • 149
    • 0026002488 scopus 로고
    • Vertebral compression fractures at the onset of acute lymphoblastic leukemia in a child
    • Oliveri, M.B. et al. 1991. Vertebral compression fractures at the onset of acute lymphoblastic leukemia in a child. Henry Ford. Hosp. Med. J. 39 : 45 48.
    • (1991) Henry Ford. Hosp. Med. J. , vol.39 , pp. 45-48
    • Oliveri, M.B.1
  • 150
    • 0022403884 scopus 로고
    • Bone loss in autoimmune chronic active hepatitis on maintenance corticosteroid therapy
    • Stellon, A.J. et al. 1985. Bone loss in autoimmune chronic active hepatitis on maintenance corticosteroid therapy. Gastroenterology 89 : 1078 1083.
    • (1985) Gastroenterology , vol.89 , pp. 1078-1083
    • Stellon, A.J.1
  • 151
    • 0031464518 scopus 로고    scopus 로고
    • Bone mineral density and bone metabolism in diabetes mellitus
    • Piepkorn, B. et al. 1997. Bone mineral density and bone metabolism in diabetes mellitus. Horm. Metab. Res. 29 : 584 591.
    • (1997) Horm. Metab. Res. , vol.29 , pp. 584-591
    • Piepkorn, B.1
  • 152
    • 0021885108 scopus 로고
    • Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus
    • &
    • Seitz, M. & W. Hunstein. 1985. Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus. Ann. Rheum. Dis. 44 : 438 445.
    • (1985) Ann. Rheum. Dis. , vol.44 , pp. 438-445
    • Seitz, M.1    Hunstein, W.2
  • 153
    • 0031825521 scopus 로고    scopus 로고
    • Bone mineral density and bone turnover in asthmatics treated with long-term inhaled or oral glucocorticoids
    • Ebeling, P.R. et al. 1998. Bone mineral density and bone turnover in asthmatics treated with long-term inhaled or oral glucocorticoids. J. Bone. Miner. Res. 13 : 1283 1289.
    • (1998) J. Bone. Miner. Res. , vol.13 , pp. 1283-1289
    • Ebeling, P.R.1
  • 154
    • 33750720949 scopus 로고    scopus 로고
    • Future treatment of bone metastases
    • Lipton, A. 2006. Future treatment of bone metastases. Clin. Cancer Res. 12 : 6305s 6308s.
    • (2006) Clin. Cancer Res. , vol.12
    • Lipton, A.1
  • 155
    • 0033805254 scopus 로고    scopus 로고
    • Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection
    • Teng, Y.T. et al. 2000. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J. Clin. Invest. 106 : R59 R67.
    • (2000) J. Clin. Invest. , vol.106
    • Teng, Y.T.1
  • 156
    • 17844376542 scopus 로고    scopus 로고
    • G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice
    • Mahamed, D.A. et al. 2005. G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes 54 : 1477 1486.
    • (2005) Diabetes , vol.54 , pp. 1477-1486
    • Mahamed, D.A.1
  • 157
    • 0034094123 scopus 로고    scopus 로고
    • Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal antibody infliximab
    • Brandt, J. et al. 2000. Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal antibody infliximab. Arthritis. Rheum. 43 : 1346 1352.
    • (2000) Arthritis. Rheum. , vol.43 , pp. 1346-1352
    • Brandt, J.1
  • 158
    • 0031156936 scopus 로고    scopus 로고
    • Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice
    • Vermeire, K. et al. 1997. Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J. Immunol. 158 : 5507 5513.
    • (1997) J. Immunol. , vol.158 , pp. 5507-5513
    • Vermeire, K.1
  • 159
    • 0031159108 scopus 로고    scopus 로고
    • High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors
    • Manoury-Schwartz, B. et al. 1997. High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J. Immunol. 158 : 5501 5506.
    • (1997) J. Immunol. , vol.158 , pp. 5501-5506
    • Manoury-Schwartz, B.1
  • 160
    • 0035871615 scopus 로고    scopus 로고
    • IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro
    • Horwood, N.J. et al. 2001. IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro. J. Immunol. 166 : 4915 4921.
    • (2001) J. Immunol. , vol.166 , pp. 4915-4921
    • Horwood, N.J.1
  • 161
    • 0035957017 scopus 로고    scopus 로고
    • IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1
    • Bendixen, A.C. et al. 2001. IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1. Proc. Natl. Acad. Sci. USA 98 : 2443 2448.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 2443-2448
    • Bendixen, A.C.1
  • 162
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato, K. et al. 2006. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203 : 2673 2682.
    • (2006) J. Exp. Med. , vol.203 , pp. 2673-2682
    • Sato, K.1
  • 163
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L.E. et al. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 : 1123 1132.
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 164
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park, H. et al. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6 : 1133 1141.
    • (2005) Nat. Immunol. , vol.6 , pp. 1133-1141
    • Park, H.1
  • 165
    • 33645318217 scopus 로고    scopus 로고
    • Diversification of T-helper-cell lineages: Finding the family root of IL-17-producing cells
    • Dong, C. 2006. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat. Rev. Immunol. 6 : 329 333.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 329-333
    • Dong, C.1
  • 166
    • 0033134608 scopus 로고    scopus 로고
    • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    • Kotake, S. et al. 1999. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103 : 1345 1352.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1345-1352
    • Kotake, S.1
  • 167
    • 45149124792 scopus 로고    scopus 로고
    • Effects of denosumab on bone mineral density and bone turnover in postmenopausal women
    • Bone, H.G. et al. 2008. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J. Clin. Endocrinol. Metab. 93 : 2149 2157.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 2149-2157
    • Bone, H.G.1
  • 168
    • 35348897212 scopus 로고    scopus 로고
    • Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases
    • Lipton, A. et al. 2007. Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases. J Clin Oncol. 25 : 4431 4437.
    • (2007) J Clin Oncol. , vol.25 , pp. 4431-4437
    • Lipton, A.1
  • 169
    • 33846081104 scopus 로고    scopus 로고
    • The RANK/RANKL/OPG triad in cancer-induced bone diseases
    • &
    • Dougall, W.C. & M. Chaisson. 2006. The RANK/RANKL/OPG triad in cancer-induced bone diseases. Can. Metastasis Rev. 25 : 541 549.
    • (2006) Can. Metastasis Rev. , vol.25 , pp. 541-549
    • Dougall, W.C.1    Chaisson, M.2
  • 170
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung, M.R. et al. 2006. Denosumab in postmenopausal women with low bone mineral density. N. Engl. J. Med. 354 : 821 831.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 821-831
    • McClung, M.R.1
  • 171
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body, J.J. et al. 2006. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin. Can. Res. 12 : 1221 1228.
    • (2006) Clin. Can. Res. , vol.12 , pp. 1221-1228
    • Body, J.J.1
  • 172
    • 33947605557 scopus 로고    scopus 로고
    • RANKL Inhibition with Denosumab Decreases Markers of Bone and Cartilage Turnover in Patients with Rheumatoid Arthritis
    • Lane, N.E. et al. 2006. RANKL Inhibition with Denosumab Decreases Markers of Bone and Cartilage Turnover in Patients with Rheumatoid Arthritis. Arthritis. Rheum. 54 : S225 S226.
    • (2006) Arthritis. Rheum. , vol.54
    • Lane, N.E.1
  • 173
    • 42049116799 scopus 로고    scopus 로고
    • Denosumab Increases Bone Mineral Density in Patients with Rheumatoid Arthritis
    • Dore, R. et al. 2006. Denosumab Increases Bone Mineral Density in Patients With Rheumatoid Arthritis. Arthritis. Rheum. 54 : S240.
    • (2006) Arthritis. Rheum. , vol.54
    • Dore, R.1
  • 174
    • 34249337867 scopus 로고    scopus 로고
    • RANKL Inhibition with denosumab reduces progression of bone erosions in patients with rheumatoid arthritis: Month 6 MRI results
    • Cohen, S.B. et al. 2006. RANKL Inhibition with denosumab reduces progression of bone erosions in patients with rheumatoid arthritis: month 6 MRI results. Arthritis. Rheum. 54 : S831 S832.
    • (2006) Arthritis. Rheum. , vol.54
    • Cohen, S.B.1
  • 175
    • 0032578611 scopus 로고    scopus 로고
    • Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines
    • Hofbauer, L.C. et al. 1998. Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines. Biochem. Biophys. Res. Commun. 250 : 776 781.
    • (1998) Biochem. Biophys. Res. Commun. , vol.250 , pp. 776-781
    • Hofbauer, L.C.1
  • 176
    • 0142093039 scopus 로고    scopus 로고
    • Expression of RANK is dependent upon differentiation into the macrophage/osteoclast lineage: Induction by 1alpha,25-dihydroxyvitamin D3 and TPA in a human myelomonocytic cell line, HL60
    • Kido, S. et al. 2003. Expression of RANK is dependent upon differentiation into the macrophage/osteoclast lineage: induction by 1alpha,25-dihydroxyvitamin D3 and TPA in a human myelomonocytic cell line, HL60. Bone 32 : 621 629.
    • (2003) Bone , vol.32 , pp. 621-629
    • Kido, S.1
  • 177
    • 0036773564 scopus 로고    scopus 로고
    • RANK ligand is a prerequisite for cancer-associated osteolytic lesions
    • &
    • Kitazawa, S. & R. Kitazawa. 2002. RANK ligand is a prerequisite for cancer-associated osteolytic lesions. J. Pathol. 198 : 228 236.
    • (2002) J. Pathol. , vol.198 , pp. 228-236
    • Kitazawa, S.1    Kitazawa, R.2
  • 178
    • 0037292208 scopus 로고    scopus 로고
    • The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts
    • Bord, S. et al. 2003. The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts. Bone 32 : 136 141.
    • (2003) Bone , vol.32 , pp. 136-141
    • Bord, S.1
  • 179
    • 8444253709 scopus 로고    scopus 로고
    • Testosterone increases osteoprotegerin mRNA expression in mouse osteoblast cells
    • Chen, Q. et al. 2004. Testosterone increases osteoprotegerin mRNA expression in mouse osteoblast cells. Horm. Metab. Res. 36 : 674 678.
    • (2004) Horm. Metab. Res. , vol.36 , pp. 674-678
    • Chen, Q.1
  • 180
    • 39149089665 scopus 로고    scopus 로고
    • Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio
    • Seriwatanachai, D. et al. 2008. Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio. Bone 42 : 535 546.
    • (2008) Bone , vol.42 , pp. 535-546
    • Seriwatanachai, D.1
  • 181
    • 0032581327 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells
    • Brandstrom, H. et al. 1998. Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. Biochem. Biophys. Res. Commun. 248 : 454 457.
    • (1998) Biochem. Biophys. Res. Commun. , vol.248 , pp. 454-457
    • Brandstrom, H.1
  • 182
    • 0032588998 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells
    • Hofbauer, L.C. et al. 1999. Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone 25 : 255 259.
    • (1999) Bone , vol.25 , pp. 255-259
    • Hofbauer, L.C.1
  • 183
    • 0032581424 scopus 로고    scopus 로고
    • Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells
    • Vidal, O.N. et al. 1998. Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells. Biochem. Biophys. Res. Commun. 248 : 696 700.
    • (1998) Biochem. Biophys. Res. Commun. , vol.248 , pp. 696-700
    • Vidal, O.N.1
  • 184
    • 0037105542 scopus 로고    scopus 로고
    • IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae
    • Palmqvist, P. et al. 2002. IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae. J. Immunol. 169 : 3353 3362.
    • (2002) J. Immunol. , vol.169 , pp. 3353-3362
    • Palmqvist, P.1
  • 185
    • 0031735152 scopus 로고    scopus 로고
    • Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells
    • Horwood, N.J. et al. 1998. Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology 139 : 4743 4746.
    • (1998) Endocrinology , vol.139 , pp. 4743-4746
    • Horwood, N.J.1
  • 186
    • 0032538566 scopus 로고    scopus 로고
    • Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells
    • Takai, H. et al. 1998. Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells. J. Biol. Chem. 273 : 27091 27096.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27091-27096
    • Takai, H.1
  • 187
    • 0242581709 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression
    • Karsdal, M.A. et al. 2003. Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression. J. Biol. Chem. 278 : 44975 44987.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44975-44987
    • Karsdal, M.A.1
  • 188
    • 39749130982 scopus 로고    scopus 로고
    • Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2
    • Usui, M. et al. 2008. Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2. J. Bone. Miner. Res. 23 : 314 325.
    • (2008) J. Bone. Miner. Res. , vol.23 , pp. 314-325
    • Usui, M.1
  • 189
    • 18544384875 scopus 로고    scopus 로고
    • IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo
    • Rubin, J. et al. 2002. IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo. J. Clin. Endocrinol. Metab. 87 : 4273 4279.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4273-4279
    • Rubin, J.1
  • 190
    • 0141891249 scopus 로고    scopus 로고
    • Vascular endothelial growth factor up-regulates expression of receptor activator of NF-kappa B (RANK) in endothelial cells. Concomitant increase of angiogenic responses to RANK ligand
    • Min, J.K. et al. 2003. Vascular endothelial growth factor up-regulates expression of receptor activator of NF-kappa B (RANK) in endothelial cells. Concomitant increase of angiogenic responses to RANK ligand. J. Biol. Chem. 278 : 39548 39557.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39548-39557
    • Min, J.K.1
  • 191
    • 0031721590 scopus 로고    scopus 로고
    • Osteoprotegerin mRNA is expressed in primary human osteoblast-like cells: Down-regulation by glucocorticoids
    • Vidal, N.O. et al. 1998. Osteoprotegerin mRNA is expressed in primary human osteoblast-like cells: down-regulation by glucocorticoids. J. Endocrinol. 159 : 191 195.
    • (1998) J. Endocrinol. , vol.159 , pp. 191-195
    • Vidal, N.O.1
  • 192
    • 0033304809 scopus 로고    scopus 로고
    • Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis
    • Hofbauer, L.C. et al. 1999. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 140 : 4382 4389.
    • (1999) Endocrinology , vol.140 , pp. 4382-4389
    • Hofbauer, L.C.1
  • 193
    • 33745138231 scopus 로고    scopus 로고
    • Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones
    • Swanson, C. et al. 2006. Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones. Endocrinology 147 : 3613 3622.
    • (2006) Endocrinology , vol.147 , pp. 3613-3622
    • Swanson, C.1
  • 194
    • 0034817070 scopus 로고    scopus 로고
    • Effects of immunosuppressants on receptor activator of NF-kappaB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells
    • Hofbauer, L.C. et al. 2001. Effects of immunosuppressants on receptor activator of NF-kappaB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells. Biochem. Biophys. Res. Commun. 280 : 334 339.
    • (2001) Biochem. Biophys. Res. Commun. , vol.280 , pp. 334-339
    • Hofbauer, L.C.1
  • 195
    • 0032543354 scopus 로고    scopus 로고
    • Regulation of osteoprotegerin mRNA levels by prostaglandin E2 in human bone marrow stroma cells
    • Brandstrom, H. et al. 1998. Regulation of osteoprotegerin mRNA levels by prostaglandin E2 in human bone marrow stroma cells. Biochem. Biophys. Res. Commun. 247 : 338 341.
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 338-341
    • Brandstrom, H.1
  • 196
    • 0032573559 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells
    • Murakami, T. et al. 1998. Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells. Biochem. Biophys. Res. Commun. 252 : 747 752.
    • (1998) Biochem. Biophys. Res. Commun. , vol.252 , pp. 747-752
    • Murakami, T.1
  • 197
    • 0034618580 scopus 로고    scopus 로고
    • Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: Modulation of the expression by osteotropic factors and cytokines
    • Nakashima, T. et al. 2000. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem. Biophys. Res. Commun. 275 : 768 775.
    • (2000) Biochem. Biophys. Res. Commun. , vol.275 , pp. 768-775
    • Nakashima, T.1
  • 198
    • 0034522704 scopus 로고    scopus 로고
    • Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts
    • Takami, M. et al. 2000. Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts. Endocrinology 141 : 4711 4719.
    • (2000) Endocrinology , vol.141 , pp. 4711-4719
    • Takami, M.1
  • 199
    • 0038622051 scopus 로고    scopus 로고
    • Effect of high phosphate concentration on osteoclast differentiation as well as bone-resorbing activity
    • Kanatani, M. et al. 2003. Effect of high phosphate concentration on osteoclast differentiation as well as bone-resorbing activity. J. Cell Physiol. 196 : 180 189.
    • (2003) J. Cell Physiol. , vol.196 , pp. 180-189
    • Kanatani, M.1
  • 200
    • 0842343433 scopus 로고    scopus 로고
    • Suppression of osteoprotegerin expression by prostaglandin E2 is crucially involved in lipopolysaccharide-induced osteoclast formation
    • Suda, K. et al. 2004. Suppression of osteoprotegerin expression by prostaglandin E2 is crucially involved in lipopolysaccharide-induced osteoclast formation. J. Immunol. 172 : 2504 2510.
    • (2004) J. Immunol. , vol.172 , pp. 2504-2510
    • Suda, K.1
  • 201
    • 0034465867 scopus 로고    scopus 로고
    • Role of ascorbic acid in the osteoclast formation: Induction of osteoclast differentiation factor with formation of the extracellular collagen matrix
    • Otsuka, E. et al. 2000. Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix. Endocrinology 141 : 3006 3011.
    • (2000) Endocrinology , vol.141 , pp. 3006-3011
    • Otsuka, E.1
  • 202
    • 18644368708 scopus 로고    scopus 로고
    • LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin
    • Nagasawa, T. et al. 2002. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin. Clin. Exp. Immunol. 130 : 338 344.
    • (2002) Clin. Exp. Immunol. , vol.130 , pp. 338-344
    • Nagasawa, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.