The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity

Journal of Immunology

Volumn 175, Issue 12, 2005, Pages 7973-7980

  Sawicka, Elzbieta ^a   Dubois, Gerald ^a   Jarai, Gabor ^a   Edwards, Matthew ^a   Thomas, Matthew ^a   Nicholls, Andy ^a   Albert, Rainer ^b   Newson, Catherine ^a   Brinkmann, Volker ^b   Walker, Christoph ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AML 627; AML 629; CD4 ANTIGEN; FINGOLIMOD; INTERLEUKIN 2 RECEPTOR ALPHA; SPHINGOSINE 1 PHOSPHATE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFER; CONTROLLED STUDY; CORRELATION ANALYSIS; EFFECTOR CELL; HELPER CELL; IMMUNOMODULATION; INFLAMMATION; LYMPHOCYTE; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

EID: 29144514700     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.12.7973     Document Type: Article

References (38)

1. Kiuchi, M., K. Adachi, T. Kohara, K. Teshima, Y. Masubuchi, T, Mishina, and T. Fujita. 1998. Synthesis and biological evaluation of 2,2-disubstituted 2-aminoethanols: analogues of FTY720. Bioorg. Med. Chem. Lett. 8: 101-106.
2. Kiuchi, M., K. Adachi, T. Kohara, M. Minoguchi, T. Hanano, Y. Aoki, T. Mishina, M. Arita, N. Nakao, M. Ohtsuki, et al. 2000. Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. J. Med. Chem. 43: 2946-2961.
3. Brinkmann, V., M. D, Davis, C. E. Heise, R. Albert, S. Cottens, R. Hof, C. Bruns, E. Prieschl, T. Baumruker, P. Hiestand, et al. 2002. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277: 21453-21457.
4. Mandala, S., R. Hajdu, J. Bergstrom, E. Quackenbush, J. Xie, J. Milligan. R. Thornton, G.-J. Shei, D. Card, C. Keohane, et al. 2002. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296: 346-349.
5. Brinkmann, V., C. Wilt, C. Kristofic, Z. Nikolova, R. P. Hof, S. Chen, R. Albert, and S. Cottens. 2001. FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects. Transplant. Proc. 33: 3078-3080.
6. Pinschewer, D. D., A. F. Ochsenbein, B. Odermatt, V. Brinkmann, H. Hengartner. and R. M, Zinkernagel. 2000. FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory. J. Immunol. 164: 5761-5770.
7. Rosen, H., and E. J. Goetzl. 2005. Spingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol 5: 560-570.
8. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360.
9. Allende, M. L., J. L. Dreier, S. Mandala. and R. L. Proia. 2004. Expression of the spingosine 1-phosphate receptor, S1P1, on T cells controls thymic emigration. J. Biol. Chem. 279: 15396-15401.
10. Brinkmann, V., D. Pinschewer, K. Chiba, and L. Feng. 2000. FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. Trends Pharmacol. Sci. 21: 49-52.
11. Suzuki, S., S. Enosawa, T. Kakefuda, X. K. Li, M. Mitsusada, S. Takahara, and H. Amemiya. 1996. Immunosuppressive effect of a new drug. FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. Transplant. Immunol. 4: 252-255.
12. Yanagawa, Y., K. Sugahara, H. Kataoka, T. Kawaguchi, Y. Masubuchi, and K. Chiba. 1998. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J. Immunol. 160: 5493-5499.
13. Brinkmann, V., D. D. Pinschewer, L. Feng, and S. Chen. 2001. FTY720: altered lymphocyte traffic results in allograft protection. Transplantation 72: 764-769.
14. Brinkmann, V., and K. R. Lynch. 2002. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr. Opin. Immunol. 14: 569-575.
15. Matsuura, M., T. Imayoshi, and T. Okumoto. 2000. Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats. Int. J. Immunopharmacol. 22: 323-331.
16. Suzuki, K., X.-K. Van, H. Amemiya, S. Suzuki, and K, Hiromitsu. 1998. Prevention of experimentally induced autoimmune type I diabetes in rats by the new immunosuppressive reagent FTY720. Transplant. Proc. 30: 1044-1045.
17. Sawicka, E., C. Zuany-Amorim, C. Manlius, A. Trifilieff, V. Brinkmann, D. M. Kemeny, and C. Walker. 2003. Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720. J. Immunol. 171: 6206-6214.
18. + regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways. Am. J. Respir. Crit. Care Med. 164: 680-687.
19. Zuany-Amorim, C., E. Sawicka, C. Manlius, A. Le Moine, L. R. Brunet, D. M. Kemeny, G. Bowen, G. Rook, and C. Walker. 2002. Suppression of airway eosinophilia by killed Mycobacterium vaccae-indaced allergen-specific regulatory T-cells. Nat. Med. 8: 625-629.
20. Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2: 816-822.
21. + suppressor T cells: more questions than answers. Nat. Rev. 2: 389-400.
22. + regulatory T cells. FASEB J. 18: 1043-1045.
23. Chiba, K., Y. Yanagawa, Y. Masubuchi, H. Kataoka, T. Kawaguchi, M. Ohtsuki, and Y. Hoshino. 1998. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol, 160: 5037-5044.
24. Schuurman, H.-J., K, Menninger, M. Audet, A. Kunkler, C. Maurer, C. Vedrine, M. Bernhard, L. Gaschen, V. Brinkmann, and V. Quesniaux. 2002. Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD. Transplantation 74: 951-960.
25. + T-regulatory cell subset has optimal suppressive and proliferative potential. Am. J. Transplant. 4: 65-78.
26. Zuany-Amorim, C., C. Manlius, A. Trifilieff, L. R. Brunet, G. Rook, G. Bowen, G. Pay, and C. Walker. 2002. Long-term protective and antigen-specific effect of heat-killed Mycobacterium vaccae in a murine model of allergic pulmonary inflammation. J. Immunol 169: 1492-1499.
27. + regulatory T cells. Nat. Immunol. 4: 330-336.
28. + T regulatory cells. Nat. Immunol. 4: 337-342.
29. + regulatory cells which control intestinal inflammation. J. Exp. Med. 192: 295-302.
30. Akbari O., G. J. Freeman, E. H. Meyer, E. A. Green field, T. T. Chang, A. H. Sharpe, G. Berry, R. H. DeKruyff, and D. T. Umetsu. 2002. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8: 1024-1032.
31. Billich, A., F. Bomancin, P. Devay, D. Mechtcheriakova. N. Urtz, and T. Baumruker. 2003. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J. Biol Chem. 278: 47408-47415.
32. Sanna, M. G., S. Liao, E. Jo, C. Alfonso. M. Y. Ahn, M. S. Peterson, B. Webb, S. Lefebvre, J. Chun, N. Gray, and H. Rosen. 2004. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279: 13839-13848.
33. Masopust, D., V. Vezys, A. L. Marzo, and L. Lefrancois. 2001. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291: 2413-2417.
34. Sallusto, F., D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712.
35. Schluns, K. S., and L. Lefrancois. 2003. Cytokine control of memory T-cell development and survival. Nat. Rev. 3: 269-279.
36. Graeler, M., and E. J. Goetzl. 2002. Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J. 16: 1874-1878.
37. + endothelial cells in splenic marginal sinus organization. J. Exp. Med. 200: 1491-1501.
38. Cinamon, G., M. Matloubian, M. J. Lesneski, Y. Xu, C. Low, T. Lu, R. L. Proia, and J. G. Cyster. 2004. Sphingosine 1-phosphate receptor 1 promote B cell localisation in the splenic marginal zone. Nat. Immunol. 5: 713-720.