Stopping sepsis by targeting sphingosine kinase 1

Science Translational Medicine

Volumn 2, Issue 36, 2010, Pages

  O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; COMPLEMENT COMPONENT C5; ERITORAN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE C DELTA; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; ENZYME INHIBITOR; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE;

CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; GRAM NEGATIVE SEPSIS; HUMAN; IN VIVO STUDY; INFECTION CONTROL; LETHALITY; MACROPHAGE MIGRATION INHIBITION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; SEPSIS; SEPTIC SHOCK; SIGNAL TRANSDUCTION; UPREGULATION; VALIDATION PROCESS; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM;

ENZYME INHIBITORS; HUMANS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SEPSIS; SIGNAL TRANSDUCTION;

EID: 77955631166     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3001299     Document Type: Review

References (4)

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3. M. Tidswell, W. Tillis, S. P. Larosa, M. Lynn, A. E. Wittek, R. Kao, J. Wheeler, J. Gogate, S. M. Opal, Eritoran Sepsis Study Group, Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis. Crit. Care Med. 38, 72-83 (2010).
4. P. Puneet, C. T. Yap, L. Wong, L. Yulin, D. R. Koh, S. Moochhala, J. Pfeilschifter, A. Huwiler, A. J. Melendez, SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science 328, 1290-1294 (2010).