Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

Journal of Cellular Biochemistry

Volumn , Issue SUPPL. 30/31, 1998, Pages 147-157

  An, Songzhu ^a   Goetzl, Edward J ^a   Lee, Hsinyu ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Edg receptors; G protein; Intracellular signaling pathways; LPA; S1P

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; SPHINGOSINE 1 PHOSPHATE; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHOLIPID RECEPTOR;

ARTICLE; CALCIUM MOBILIZATION; CELL COMMUNICATION; CELL DIFFERENTIATION; ENDOTHELIUM CELL; GROWTH REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; GTP-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHATIDIC ACID; RECEPTORS, LYSOPHOSPHOLIPID; SIGNAL TRANSDUCTION;

EID: 0032429270     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4644(1998)72:30/31+<147::aid-jcb19>3.3.co;2-6     Document Type: Article

References (20)

1. An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ (1997a): Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett 417:279-282.
2. An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (1997b): Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem Biophys Res Commun 231: 619-622.
3. An S, Bleu T, Hallmark OG, Goetzl EJ (1998a): Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 273:7906-7910.
4. An S, Bleu T, Zheng Y, Goetzl E (1998b): Recombinant human Edg2 and Edg4 lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol Pharmacol (in press).
5. Choi OH, Kim JH, Kinet JP (1996): Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. Nature 380:634-636.
6. Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S (1996): Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381:800-803.
7. Daub H, Weiss FU, Wallasch C, Ullrich A (1996): Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379:557-560.
8. Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J (1996): A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547-550.
9. Durieux ME, Carlisle SJ, Salafranca MN, Lynch KR (1993): Responses to sphingosine-1-phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling. Am J Physiol 264:C1360-C1364.
10. Erickson JR, Wu JJ, Goddard JG, Tigyi G, Kawanishi K, Tomei LD, Kiefer MC (1998): Edg-2/Vzg-l couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J Biol Chem 273:1506-1510.
11. Fukushima N, Kimura Y, Chun J (1998): A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc Natl Acad Sci USA 95:6151-6156.
12. Gaits F, Fourcade O, Le Balle F, Gueguen G, Gaige B, Gassama-Diagne A, Fauvel J, Salles JP, Mauco G, Simon MF, Chap H (1997): Lysophosphatidic acid as a phospholipid mediator, pathways of synthesis. FEBS Lett 410:54-58.
13. Goetzl EJ, An S (1998): Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J (in press)
14. Goodemote KA, Mattie ME, Berger A, Spiegel S (1995): Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate. J Biol Chem 270:10272-10277.
15. Guo Z, Liliom K, Fischer DJ, Bathurst IC, Tomei LD, Kiefer MC, Tigyi G (1996): Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes. Proc Natl Acad Sci USA 93:14367-14372.
16. Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (1998): Direct stimulation of the guanine nucleotide exchange activity of p115 Rho-GEF by Galpha13 [see comments]. Science 280:2112-2114.
17. Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ (1996): Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. J Biol Chem 271:12133-12136.
18. Hecht JH, Weiner JA, Post SR, Chun J (1996): Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 135:1071-1083.
19. Hill CS, Oh SY, Schmidt SA, Clark KJ, Murray AW (1994): Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: possible involvement of the mitogen-activated protein kinase cascade. Biochem J 303:475-479.
20. Hill CS, Wynne J, Treisman R (1995): The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81:1159-1170.