Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

Science

Volumn 279, Issue 5356, 1998, Pages 1552-1555

  Lee, Menq Jer ^a   Van Brocklyn, James R ^b   Thangada, Shobha ^a   Liu, Catherine H ^a   Hand, Arthur R ^c   Menzeleev, Ramil ^b   Spiegel, Sarah ^b   Hla, Timothy ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CYTOCHALASIN; EGTAZIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN EDG 1; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENDOTHELIUM CELL; GENE ISOLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; RECEPTOR BINDING; SECOND MESSENGER;

CADHERINS; CELL AGGREGATION; CELL DIFFERENTIATION; CELL LINE; CLONING, MOLECULAR; GENE EXPRESSION; GENES, IMMEDIATE-EARLY; GTP-BINDING PROTEINS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR JUNCTIONS; LIGANDS; LYSOPHOSPHOLIPIDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MORPHOGENESIS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHOLIPID; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSFECTION;

EID: 0032489574     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5356.1552     Document Type: Article

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52. We thank R. D. Berlin and T. Maciag for support and discussions and T. I. Bonner for sharing unpublished results. Supported by research grants from the NIH to T.H. (DK45659 and HL49094) and S.S. (GM43880 and CA61774) and by a grant from the American Cancer Society (BE-275) to S.S.