Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone

Journal of Molecular Medicine

Volumn 87, Issue 6, 2009, Pages 645-657

  Nieuwenhuis, Barbara ^a   Lüth, Anja ^a   Chun, Jerold ^b   Huwiler, Andrea ^c   Pfeilschifter, Josef ^d   Schäfer Korting, Monika ^a   Kleuser, Burkhard ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

ABC transporter; Dexamethasone; Glucocorticoids; S1P receptor subtypes; Sphingosine 1 phosphate; Sphingosine kinase

Indexed keywords

ABC TRANSPORTER; ABCC1 TRANSPORTER; DEXAMETHASONE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MALE; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST;

APOPTOSIS; CELLS, CULTURED; CYTOPROTECTION; DEXAMETHASONE; FIBROBLASTS; GLUCOCORTICOIDS; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RECEPTORS, LYSOSPHINGOLIPID;

EID: 67349170614     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0468-x     Document Type: Article

References (35)

1. T Rhen JA Cidlowski 2005 Antiinflammatory action of glucocorticoids new mechanisms for old drugs N Engl J Med 353 1711 1723
2. S Schoepe H Schacke E May 2006 Glucocorticoid therapy-induced skin atrophy Exp Dermatol 15 406 420
3. S Hammer B Sauer I Spika 2004 Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation J Cell Biochem 91 840 851
4. S Sharma A Lichtenstein 2008 Dexamethasone-induced apoptotic mechanisms in myeloma cells investigated by analysis of mutant glucocorticoid receptors Blood 112 1338 1345
5. I Herr N Gassler H Friess 2007 Regulation of differential pro- and anti-apoptotic signaling by glucocorticoids Apoptosis 12 271 291 (Pubitemid 46169909)
6. HY Oh S Namkoong SJ Lee 2006 Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP Cell Death Differ 13 512 523
7. S Spiegel S Milstien 2002 Sphingosine 1-phosphate, a key cell signaling molecule J Biol Chem 277 25851 25854 (Pubitemid 34967061)
8. K Takabe SW Paugh S Milstien 2008 "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets Pharmacol Rev 60 181 195
9. KR Watterson DA Lanning RF Diegelmann 2007 Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing Wound Repair Regen 15 607 616 (Pubitemid 47495881)
10. LP Hofmann S Ren S Schwalm 2008 Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner Biol Chem 389 1399 1407
11. OA Sukocheva L Wang N Albanese 2003 Sphingosine kinase transmits estrogen signaling in human breast cancer cells Mol Endocrinol 17 2002 2012 (Pubitemid 37281793)
12. EJ Goetzl W Wang C McGiffert 2007 Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity Acta Paediatr Suppl 96 49 52 (Pubitemid 46481119)
13. CD Keller P Rivera Gil M Tolle 2007 Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling Am J Pathol 170 281 292 (Pubitemid 47339207)
14. P Mitra CA Oskeritzian SG Payne 2006 Role of ABCC1 in export of sphingosine-1-phosphate from mast cells Proc Natl Acad Sci USA 103 16394 16399 (Pubitemid 44715207)
15. K Sato E Malchinkhuu Y Horiuchi 2007 Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes J Neurochem 103 2610 2619
16. I Ishii B Friedman X Ye 2001 Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3 J Biol Chem 276 33697 33704
17. M Manggau DS Kim L Ruwisch 2001 1Alpha, 25-Dihydroxyvitamnin D3 protects human keratinocytes from apoptosis by the formation of sphingosine 1-phosphate J Invest Dermatol 117 1241 1249 (Pubitemid 34205924)
18. L Ruwisch M Schafer-Korting B Kleuser 2001 An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. Naunyn Schmiedeberg's Arch Pharmacol 363 358 363 (Pubitemid 32186536)
19. M Ayaori S Sawada A Yonemura 2006 Glucocorticoid receptor regulates ATP-binding cassette transporter-A1 expression and apolipoprotein-mediated cholesterol efflux from macrophages Arterioscler Thromb Vasc Biol 26 163 168 (Pubitemid 43732244)
20. A Amsterdam K Tajima R Sasson 2002 Cell-specific regulation of apoptosis by glucocorticoids: implication to their anti-inflammatory action Biochem Pharmacol 64 843 850 (Pubitemid 35232258)
21. M Schmidt HG Pauels N Lugering 1999 Glucocorticoids induce apoptosis in human monocytes: potential role of IL-1 beta J Immunol 163 3484 3490 (Pubitemid 29431853)
22. MC Davis KS McColl F Zhong 2008 Dexamethasone-induced inositol 1, 4, 5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis J Biol Chem 283 10357 10365
23. WJ Tissing JP Meijerink ML den Boer 2003 Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia Leukemia 17 17 25 (Pubitemid 36175883)
24. T Chittenden 2002 BH3 domains: intracellular death-ligands critical for initiating apoptosis Cancer Cell 2 165 166 (Pubitemid 41043968)
25. H Liu RE Toman SK Goparaju 2003 Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis J Biol Chem 278 40330 40336 (Pubitemid 37248601)
26. A Letai MC Bassik LD Walensky 2002 Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics Cancer Cell 2 183 192 (Pubitemid 41043974)
27. AS Saffar S Dragon P Ezzati 2008 Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils J Allergy Clin Immunol 121 492 498
28. RB Evans-Storms JA Cidlowski 2000 Delineation of an antiapoptotic action of glucocorticoids in hepatoma cells: the role of nuclear factor-kappaB Endocrinol 141 1854 1862 (Pubitemid 32274415)
29. B Sauer H Gonska M Manggau 2005 Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat Pharmazie 60 298 304 (Pubitemid 40571196)
30. D Shida K Takabe D Kapitonov 2008 Targeting SphK1 as a new strategy against cancer Curr Drug Targets 9 662 673
31. TA Taha KM Argraves LM Obeid 2004 Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy Biochim Biophys Acta 1682 48 55 (Pubitemid 38670534)
32. HM Sankala NC Hait SW Paugh 2007 Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin Cancer Res 67 10466 10474 (Pubitemid 350070822)
33. NC Hait CA Oskeritzian SW Paugh 2006 Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases Biochim Biophys Acta 1758 2016 2026 (Pubitemid 44879368)
34. N Kobayashi T Nishi T Hirata 2006 Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner J Lipid Res 47 614 621 (Pubitemid 43345602)
35. P Martin R Riley DJ Back 2008 Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells Br J Pharmacol 153 805 819