Refining siRNA in vivo transfection: Silencing SPHK1reveals its key role in C5a-induced inflammation in vivo

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 9, 2008, Pages 1817-1825

  Pushparaj, Peter N ^a   H'ng, Shiau Chen ^a   Melendez, Alirio J ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Anaphylatoxin; C5a; Delivery; Inflammation; siRNA

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C5A; GENE PRODUCT; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; DISEASE MODEL; GENE; GENE SILENCING; HYDRODYNAMICS; INFLAMMATION; MACROPHAGE; MOUSE; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; PERITONITIS; PRESSURE; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPHK1 GENE; SURVIVAL RATE; VALIDATION PROCESS;

ANAPHYLATOXINS; ANIMALS; CAPILLARY PERMEABILITY; CATTLE; COMPLEMENT C5A; CYTOKINES; GENE DELETION; GENE SILENCING; HUMANS; INFLAMMATION; INJECTIONS; MALE; MICE; MONOCYTES; NEUTROPHIL INFILTRATION; PERITONITIS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PRESSURE; RNA, SMALL INTERFERING; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TRANSFECTION;

MUS;

EID: 49949152287     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.01.015     Document Type: Article

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