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Volumn 4, Issue MAR, 2013, Pages

Secondary mechanisms of diversification in the human antibody repertoire

Author keywords

B Cell Biology; Human; Insertion deletion; VDJ rearrangement; VH replacement

Indexed keywords

ANTIGEN RECOGNITION; COMPLEMENTARITY DETERMINING REGION; DNA END JOINING REPAIR; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC RECOMBINATION; GENETIC VARIABILITY; HUMAN; IMMUNE RESPONSE; NONHUMAN; POLYMERASE CHAIN REACTION; REVIEW; SOMATIC HYPERMUTATION; VDJ RECOMBINATION;

EID: 84883755842     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00042     Document Type: Review
Times cited : (31)

References (116)
  • 2
    • 0023475193 scopus 로고
    • Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining
    • Akira, S., Okazaki, K., and Sakano, H. (1987). Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining. Science 238, 1134-1138.
    • (1987) Science , vol.238 , pp. 1134-1138
    • Akira, S.1    Okazaki, K.2    Sakano, H.3
  • 3
    • 0023513107 scopus 로고
    • Development of the primary antibody repertoire
    • Alt, F., Blackwell, T., and Yancopoulos, G. (1987). Development of the primary antibody repertoire. Science 238, 1079-1087.
    • (1987) Science , vol.238 , pp. 1079-1087
    • Alt, F.1    Blackwell, T.2    Yancopoulos, G.3
  • 4
    • 0041646843 scopus 로고
    • Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions
    • Alt, F. W., and Baltimore, D. (1982). Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc. Natl. Acad. Sci. U.S.A. 79, 4118-4122.
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 4118-4122
    • Alt, F.W.1    Baltimore, D.2
  • 6
    • 0043023488 scopus 로고    scopus 로고
    • By-products of immunoglobulin somatic hypermutation
    • Bemark, M., and Neuberger, M. S. (2003). By-products of immunoglobulin somatic hypermutation. Genes Chromosomes Cancer 38, 32-39.
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 32-39
    • Bemark, M.1    Neuberger, M.S.2
  • 7
    • 77953632929 scopus 로고    scopus 로고
    • Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements
    • Boyd, S. D., Gaëta, B. A., Jackson, K. J., Fire, A. Z., Marshall, E. L., Merker, J. D., et al. (2010). Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. J. Immunol. 184, 6986-6992.
    • (2010) J. Immunol. , vol.184 , pp. 6986-6992
    • Boyd, S.D.1    Gaëta, B.A.2    Jackson, K.J.3    Fire, A.Z.4    Marshall, E.L.5    Merker, J.D.6
  • 8
    • 77954601328 scopus 로고    scopus 로고
    • Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing
    • Boyd, S. D., Marshall, E. L., Merker, J. D., Maniar, J. M., Zhang, L. N., Sahaf, B., et al. (2009). Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Sci. Transl. Med. 1, 12ra23.
    • (2009) Sci. Transl. Med. , vol.1
    • Boyd, S.D.1    Marshall, E.L.2    Merker, J.D.3    Maniar, J.M.4    Zhang, L.N.5    Sahaf, B.6
  • 9
    • 0018093829 scopus 로고
    • A complete immunoglobulin gene is created by somatic recombination
    • Brack, C., Hirama, M., Lenhard-Schuller, R., and Tonegawa, S. (1978). A complete immunoglobulin gene is created by somatic recombination. Cell 15, 1-14.
    • (1978) Cell , vol.15 , pp. 1-14
    • Brack, C.1    Hirama, M.2    Lenhard-Schuller, R.3    Tonegawa, S.4
  • 10
    • 0014019617 scopus 로고
    • Origin of antibody variation
    • Brenner, S., and Milstein, C. (1966). Origin of antibody variation. Nature 211, 242-243.
    • (1966) Nature , vol.211 , pp. 242-243
    • Brenner, S.1    Milstein, C.2
  • 11
    • 84860706280 scopus 로고    scopus 로고
    • Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes
    • doi: 10.1371/journal.pone.0036750
    • Briney, B. S., Willis, J. R., and Crowe, J. E. (2012a). Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes. PLoS ONE 7:e36750. doi: 10.1371/journal.pone.0036750
    • (2012) PLoS ONE , vol.7
    • Briney, B.S.1    Willis, J.R.2    Crowe, J.E.3
  • 12
    • 84864762364 scopus 로고    scopus 로고
    • Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire
    • Briney, B. S., Willis, J. R., Hicar, M. D., Thomas, J. W., and Crowe, J. E. (2012b). Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire. Immunology 137, 56-64.
    • (2012) Immunology , vol.137 , pp. 56-64
    • Briney, B.S.1    Willis, J.R.2    Hicar, M.D.3    Thomas, J.W.4    Crowe, J.E.5
  • 13
    • 84867742557 scopus 로고    scopus 로고
    • Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity
    • Briney, B. S., Willis, J. R., and Crowe, J. E. Jr. (2012c). Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity. Genes Immun. 13, 523-529.
    • (2012) Genes Immun. , vol.13 , pp. 523-529
    • Briney, B.S.1    Willis, J.R.2    Crowe, J.E.Jr.3
  • 14
    • 84865631443 scopus 로고    scopus 로고
    • High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals
    • Briney, B. S., Willis, J. R., McKinney, B. A., and Crowe, J. E. Jr. (2012d). High-throughput antibody sequencing reveals genetic evidence of global regulation of the naïve and memory repertoires that extends across individuals. Genes Immun. 13, 469-473.
    • (2012) Genes Immun. , vol.13 , pp. 469-473
    • Briney, B.S.1    Willis, J.R.2    McKinney, B.A.3    Crowe, J.E.Jr.4
  • 15
    • 0016412693 scopus 로고
    • Hypervariable regions, idiotypy, and the antibody-combining site
    • Capra, J. D., and Kehoe, J. M. (1975). Hypervariable regions, idiotypy, and the antibody-combining site. Adv. Immunol. 20, 1-40.
    • (1975) Adv. Immunol. , vol.20 , pp. 1-40
    • Capra, J.D.1    Kehoe, J.M.2
  • 16
    • 33745498089 scopus 로고    scopus 로고
    • DNA repair in antibody somatic hypermutation
    • Casali, P., Pal, Z., Xu, Z., and Zan, H. (2006). DNA repair in antibody somatic hypermutation. Trends Immunol. 27, 313-321.
    • (2006) Trends Immunol. , vol.27 , pp. 313-321
    • Casali, P.1    Pal, Z.2    Xu, Z.3    Zan, H.4
  • 17
    • 0030026711 scopus 로고    scopus 로고
    • Affinity maturation and hypermutation in a simulation of the humoral immune response
    • Celada, F., and Seiden, P. E. (1996). Affinity maturation and hypermutation in a simulation of the humoral immune response. Eur. J. Immunol. 26, 1350-1358.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1350-1358
    • Celada, F.1    Seiden, P.E.2
  • 18
    • 0029553058 scopus 로고
    • Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing
    • Chen, C., Nagy, Z., Prak, E., and Weigert, M. (1995). Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3, 747-755.
    • (1995) Immunity , vol.3 , pp. 747-755
    • Chen, C.1    Nagy, Z.2    Prak, E.3    Weigert, M.4
  • 20
    • 0029814965 scopus 로고    scopus 로고
    • DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
    • Cuomo, C. A., Mundy, C. L., and Oettinger, M. A. (1996). DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol. Cell. Biol. 16, 5683-5690.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5683-5690
    • Cuomo, C.A.1    Mundy, C.L.2    Oettinger, M.A.3
  • 21
    • 13444252473 scopus 로고    scopus 로고
    • V(H) replacement in rearranged immunoglobulin genes
    • Darlow, J. M., and Stott, D. I. (2005). V(H) replacement in rearranged immunoglobulin genes. Immunology 114, 155-165.
    • (2005) Immunology , vol.114 , pp. 155-165
    • Darlow, J.M.1    Stott, D.I.2
  • 23
    • 0001265782 scopus 로고    scopus 로고
    • RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination
    • Difilippantonio, M. J., McMahan, C. J., Eastman, Q. M., Spanopoulou, E., and Schatz, D. G. (1996). RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell 87, 253-262.
    • (1996) Cell , vol.87 , pp. 253-262
    • Difilippantonio, M.J.1    McMahan, C.J.2    Eastman, Q.M.3    Spanopoulou, E.4    Schatz, D.G.5
  • 24
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • Di Noia, J., and Neuberger, M. S. (2002). Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419, 43-48.
    • (2002) Nature , vol.419 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 25
    • 77951939875 scopus 로고    scopus 로고
    • Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
    • Diskin, R., Marcovecchio, P. M., and Bjorkman, P. J. (2010). Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity. Nat. Struct. Mol. Biol. 17, 608-613.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 608-613
    • Diskin, R.1    Marcovecchio, P.M.2    Bjorkman, P.J.3
  • 26
    • 0031688707 scopus 로고    scopus 로고
    • Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands
    • Dörner, T., Foster, S., Farner, N., and Lipsky, P. (1998). Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands. Eur. J. Immunol. 28, 3384-3396.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3384-3396
    • Dörner, T.1    Foster, S.2    Farner, N.3    Lipsky, P.4
  • 27
    • 0018843979 scopus 로고
    • An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH
    • Early, P., Huang, H., Davis, M., Calame, K., and Hood, L. (1980). An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell 19, 981-992.
    • (1980) Cell , vol.19 , pp. 981-992
    • Early, P.1    Huang, H.2    Davis, M.3    Calame, K.4    Hood, L.5
  • 29
    • 0029662223 scopus 로고    scopus 로고
    • An alpha beta T cell receptor structure at 2.5 angstrom and its orientation in the TCR-MHC complex
    • Garcia, K., Degano, M., Stanfield, R., Brunmark, A., Jackson, M., Peterson, P., et al. (1996). An alpha beta T cell receptor structure at 2.5 angstrom and its orientation in the TCR-MHC complex. Science 274, 209-219.
    • (1996) Science , vol.274 , pp. 209-219
    • Garcia, K.1    Degano, M.2    Stanfield, R.3    Brunmark, A.4    Jackson, M.5    Peterson, P.6
  • 30
    • 0035663555 scopus 로고    scopus 로고
    • Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation
    • Goossens, T., Bräuninger, A., Klein, U., Küppers, R., and Rajewsky, K. (2001). Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation. Eur. J. Immunol. 31, 3638-3648.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3638-3648
    • Goossens, T.1    Bräuninger, A.2    Klein, U.3    Küppers, R.4    Rajewsky, K.5
  • 31
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease
    • Goossens, T., Klein, U., and Küppers, R. (1998). Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. U.S.A. 95, 2463-2468.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Küppers, R.3
  • 32
    • 0030764978 scopus 로고    scopus 로고
    • V(D)J recombinase activity in a subset of germinal center B lymphocytes
    • Han, S., Dillon, S. R., Zheng, B., Shimoda, M., Schlissel, M. S., and Kelsoe, G. (1997). V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 278, 301-305.
    • (1997) Science , vol.278 , pp. 301-305
    • Han, S.1    Dillon, S.R.2    Zheng, B.3    Shimoda, M.4    Schlissel, M.S.5    Kelsoe, G.6
  • 33
    • 0032537732 scopus 로고    scopus 로고
    • V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling
    • Hertz, M., Kouskoff, V., Nakamura, T., and Nemazee, D. (1998). V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling. Nature 394, 292-295.
    • (1998) Nature , vol.394 , pp. 292-295
    • Hertz, M.1    Kouskoff, V.2    Nakamura, T.3    Nemazee, D.4
  • 34
    • 0024691453 scopus 로고
    • V(D)J recombination - a functional definition of the joining signals
    • Hesse, J., Lieber, M., Mizuuchi, K., and Gellert, M. (1989). V(D)J recombination - a functional definition of the joining signals. Genes Dev. 3, 1053-1061.
    • (1989) Genes Dev. , vol.3 , pp. 1053-1061
    • Hesse, J.1    Lieber, M.2    Mizuuchi, K.3    Gellert, M.4
  • 35
    • 0030475466 scopus 로고    scopus 로고
    • Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
    • Hikida, M., Mori, M., Takai, T., Tomochika, K., Hamatani, K., and Ohmori, H. (1996). Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 274, 2092-2094.
    • (1996) Science , vol.274 , pp. 2092-2094
    • Hikida, M.1    Mori, M.2    Takai, T.3    Tomochika, K.4    Hamatani, K.5    Ohmori, H.6
  • 36
    • 0034675956 scopus 로고    scopus 로고
    • Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes
    • Itoh, K., Meffre, E., Albesiano, E., Farber, A., Dines, D., Stein, P., et al. (2000). Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes. J. Exp. Med. 192, 1151-1164.
    • (2000) J. Exp. Med. , vol.192 , pp. 1151-1164
    • Itoh, K.1    Meffre, E.2    Albesiano, E.3    Farber, A.4    Dines, D.5    Stein, P.6
  • 37
    • 0036682598 scopus 로고    scopus 로고
    • Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
    • Jones, J. M., and Gellert, M. (2002). Ordered assembly of the V(D)J synaptic complex ensures accurate recombination. EMBO J. 21, 4162-4171.
    • (2002) EMBO J. , vol.21 , pp. 4162-4171
    • Jones, J.M.1    Gellert, M.2
  • 39
    • 0028356909 scopus 로고
    • B cell diversification and differentiation in the periphery
    • Kelsoe, G. (1994). B cell diversification and differentiation in the periphery. J. Exp. Med. 180, 5-6.
    • (1994) J. Exp. Med. , vol.180 , pp. 5-6
    • Kelsoe, G.1
  • 40
    • 0030978963 scopus 로고    scopus 로고
    • Codon bias and plasticity in immunoglobulins
    • Kepler, T. B. (1997). Codon bias and plasticity in immunoglobulins. Mol. Biol. Evol. 14, 637-643.
    • (1997) Mol. Biol. Evol. , vol.14 , pp. 637-643
    • Kepler, T.B.1
  • 41
    • 0026552320 scopus 로고
    • Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells
    • Kiyoi, H., Naoe, T., Horibe, K., and Ohno, R. (1992). Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. J. Clin. Invest. 89, 739-746.
    • (1992) J. Clin. Invest. , vol.89 , pp. 739-746
    • Kiyoi, H.1    Naoe, T.2    Horibe, K.3    Ohno, R.4
  • 42
    • 0022502863 scopus 로고
    • Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma
    • Kleinfield, R., Hardy, R. R., Tarlinton, D., Dangl, J., Herzenberg, L. A., and Weigert, M. (1986). Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature 322, 843-846.
    • (1986) Nature , vol.322 , pp. 843-846
    • Kleinfield, R.1    Hardy, R.R.2    Tarlinton, D.3    Dangl, J.4    Herzenberg, L.A.5    Weigert, M.6
  • 43
    • 0024475241 scopus 로고
    • Analysis of VH gene replacement events in a B cell lymphoma
    • Kleinfield, R. W., and Weigert, M. G. (1989). Analysis of VH gene replacement events in a B cell lymphoma. J. Immunol. 142, 4475-4482.
    • (1989) J. Immunol. , vol.142 , pp. 4475-4482
    • Kleinfield, R.W.1    Weigert, M.G.2
  • 44
    • 0034667899 scopus 로고    scopus 로고
    • Heavy chain revision in MRL mice: a potential mechanism for the development of autoreactive B cell precursors
    • Klonowski, K. D., and Monestier, M. (2000). Heavy chain revision in MRL mice: a potential mechanism for the development of autoreactive B cell precursors. J. Immunol. 165, 4487-4493.
    • (2000) J. Immunol. , vol.165 , pp. 4487-4493
    • Klonowski, K.D.1    Monestier, M.2
  • 46
    • 33746004544 scopus 로고    scopus 로고
    • Antibody repertoires generated by VH replacement and direct VH to JH joining
    • Koralov, S. B., Novobrantseva, T. I., Königsmann, J., Ehlich, A., and Rajewsky, K. (2006). Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity 25, 43-53.
    • (2006) Immunity , vol.25 , pp. 43-53
    • Koralov, S.B.1    Novobrantseva, T.I.2    Königsmann, J.3    Ehlich, A.4    Rajewsky, K.5
  • 47
    • 79955113580 scopus 로고    scopus 로고
    • An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody
    • Krause, J. C., Ekiert, D. C., Tumpey, T. M., Smith, P. B., Wilson, I. A., and Crowe, J. E. (2011). An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody. MBio 2, e00345-10.
    • (2011) MBio , vol.2
    • Krause, J.C.1    Ekiert, D.C.2    Tumpey, T.M.3    Smith, P.B.4    Wilson, I.A.5    Crowe, J.E.6
  • 48
    • 0020041687 scopus 로고
    • Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments
    • Kurosawa, Y., and Tonegawa, S. (1982). Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. J. Exp. Med. 155, 201-218.
    • (1982) J. Exp. Med. , vol.155 , pp. 201-218
    • Kurosawa, Y.1    Tonegawa, S.2
  • 49
    • 3242875994 scopus 로고    scopus 로고
    • A functional analysis of the spacer of V(D)J recombination signal sequences
    • doi: 10.1371/journal.pbio.0000001
    • Lee, A. I., Fugmann, S. D., Cowell, L. G., Ptaszek, L. M., Kelsoe, G., and Schatz, D. G. (2003). A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol. 1:e1. doi: 10.1371/journal.pbio.0000001
    • (2003) PLoS Biol. , vol.1
    • Lee, A.I.1    Fugmann, S.D.2    Cowell, L.G.3    Ptaszek, L.M.4    Kelsoe, G.5    Schatz, D.G.6
  • 50
    • 0141884397 scopus 로고    scopus 로고
    • Receptor revision of immunoglobulin heavy chain genes in human MALT lymphomas
    • Lenze, D., Greiner, A., Knörr, C., Anagnostopoulos, I., Stein, H., and Hummel, M. (2003). Receptor revision of immunoglobulin heavy chain genes in human MALT lymphomas. Mol. Pathol. 56, 249-255.
    • (2003) Mol. Pathol. , vol.56 , pp. 249-255
    • Lenze, D.1    Greiner, A.2    Knörr, C.3    Anagnostopoulos, I.4    Stein, H.5    Hummel, M.6
  • 51
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses
    • Lewis, S. M. (1994). The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150.
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 52
    • 0031816533 scopus 로고    scopus 로고
    • Structure-function studies of T-cell receptor superantigen interactions
    • Li, H., Llera, A., and Mariuzza, R. (1998). Structure-function studies of T-cell receptor superantigen interactions. Immunol. Rev. 163, 177-186.
    • (1998) Immunol. Rev. , vol.163 , pp. 177-186
    • Li, H.1    Llera, A.2    Mariuzza, R.3
  • 53
    • 0347758541 scopus 로고    scopus 로고
    • The generation of antibody diversity through somatic hypermutation and class switch recombination
    • Li, Z., Woo, C. J., Iglesias-Ussel, M. D., Ronai, D., and Scharff, M. D. (2004). The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes Dev. 18, 1-11.
    • (2004) Genes Dev. , vol.18 , pp. 1-11
    • Li, Z.1    Woo, C.J.2    Iglesias-Ussel, M.D.3    Ronai, D.4    Scharff, M.D.5
  • 54
    • 33750836920 scopus 로고    scopus 로고
    • VH replacement rescues progenitor B cells with two nonproductive VDJ alleles
    • Lutz, J., Müller, W., and Jäck, H.-M. (2006). VH replacement rescues progenitor B cells with two nonproductive VDJ alleles. J. Immunol. 177, 7007-7014.
    • (2006) J. Immunol. , vol.177 , pp. 7007-7014
    • Lutz, J.1    Müller, W.2    Jäck, H.-M.3
  • 56
    • 0026845876 scopus 로고
    • Maturation and dispersal of B-cell clones during T cell-dependent antibody responses
    • MacLennan, I. C., Liu, Y. J., and Johnson, G. D. (1992). Maturation and dispersal of B-cell clones during T cell-dependent antibody responses. Immunol. Rev. 126, 143-161.
    • (1992) Immunol. Rev. , vol.126 , pp. 143-161
    • MacLennan, I.C.1    Liu, Y.J.2    Johnson, G.D.3
  • 58
    • 0037416170 scopus 로고    scopus 로고
    • VDJ Recombination: Artemis and its in vivo role in hairpin opening
    • Mansilla-Soto, J., and Cortes, P. (2003). VDJ Recombination: Artemis and its in vivo role in hairpin opening. J. Exp. Med. 197, 543-547.
    • (2003) J. Exp. Med. , vol.197 , pp. 543-547
    • Mansilla-Soto, J.1    Cortes, P.2
  • 59
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J. F., van Gent, D. C., Ramsden, D. A., Romeo, C., Cuomo, C. A., Gellert, M., et al. (1995). Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6
  • 60
    • 0242578825 scopus 로고    scopus 로고
    • V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence
    • Montalbano, A., Ogwaro, K. M., Tang, A., Matthews, A. G. W., Larijani, M., Oettinger, M. A., et al. (2003). V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence. J. Immunol. 171, 5296-5304.
    • (2003) J. Immunol. , vol.171 , pp. 5296-5304
    • Montalbano, A.1    Ogwaro, K.M.2    Tang, A.3    Matthews, A.G.W.4    Larijani, M.5    Oettinger, M.A.6
  • 61
    • 0025774040 scopus 로고
    • Somatic mutation in constant regions of mouse lambda 1 light chains
    • Motoyama, N., Okada, H., and Azuma, T. (1991). Somatic mutation in constant regions of mouse lambda 1 light chains. Proc. Natl. Acad. Sci. U.S.A. 88, 7933-7937.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 7933-7937
    • Motoyama, N.1    Okada, H.2    Azuma, T.3
  • 62
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., and Honjo, T. (2000). Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 63
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O., et al. (1999). Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 274, 18470-18476.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18470-18476
    • Muramatsu, M.1    Sankaranand, V.S.2    Anant, S.3    Sugai, M.4    Kinoshita, K.5    Davidson, N.O.6
  • 64
    • 0032400975 scopus 로고    scopus 로고
    • Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease
    • Nadel, B., Tang, A., Lugo, G., Love, V., Escuro, G., and Feeney, A. J. (1998). Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease. J. Immunol. 161, 6068-6073.
    • (1998) J. Immunol. , vol.161 , pp. 6068-6073
    • Nadel, B.1    Tang, A.2    Lugo, G.3    Love, V.4    Escuro, G.5    Feeney, A.J.6
  • 65
    • 33748992038 scopus 로고    scopus 로고
    • Receptor editing in lymphocyte development and central tolerance
    • Nemazee, D. (2006). Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 6, 728-740.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 728-740
    • Nemazee, D.1
  • 66
    • 0034608364 scopus 로고    scopus 로고
    • Revising B cell receptors
    • Nemazee, D., and Weigert, M. (2000). Revising B cell receptors. J. Exp. Med. 191, 1813-1817.
    • (2000) J. Exp. Med. , vol.191 , pp. 1813-1817
    • Nemazee, D.1    Weigert, M.2
  • 67
    • 0032442391 scopus 로고    scopus 로고
    • Immune receptor editing: revise and select
    • Nussenzweig, M. C. (1998). Immune receptor editing: revise and select. Cell 95, 875-878.
    • (1998) Cell , vol.95 , pp. 875-878
    • Nussenzweig, M.C.1
  • 68
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M., Schatz, D., Gorka, C., and Baltimore, D. (1990). RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.1    Schatz, D.2    Gorka, C.3    Baltimore, D.4
  • 69
    • 0030803748 scopus 로고    scopus 로고
    • V(D)J recombination in mature B cells: a mechanism for altering antibody responses
    • Papavasiliou, F., Casellas, R., Suh, H., Qin, X. F., Besmer, E., Pelanda, R., et al. (1997). V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science 278, 298-301.
    • (1997) Science , vol.278 , pp. 298-301
    • Papavasiliou, F.1    Casellas, R.2    Suh, H.3    Qin, X.F.4    Besmer, E.5    Pelanda, R.6
  • 70
    • 82255179322 scopus 로고    scopus 로고
    • A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield
    • Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P.-S., Wang, S.-K., et al. (2011). A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science 334, 1097-1103.
    • (2011) Science , vol.334 , pp. 1097-1103
    • Pejchal, R.1    Doores, K.J.2    Walker, L.M.3    Khayat, R.4    Huang, P.-S.5    Wang, S.-K.6
  • 71
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham, P., Bransteitter, R., Petruska, J., and Goodman, M. F. (2003). Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424, 103-107.
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 72
    • 0032101611 scopus 로고    scopus 로고
    • Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
    • Phung, Q. H., Winter, D. B., Cranston, A., Tarone, R. E., Bohr, V. A., Fishel, R., et al. (1998). Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187, 1745-1751.
    • (1998) J. Exp. Med. , vol.187 , pp. 1745-1751
    • Phung, Q.H.1    Winter, D.B.2    Cranston, A.3    Tarone, R.E.4    Bohr, V.A.5    Fishel, R.6
  • 73
    • 0030267309 scopus 로고    scopus 로고
    • Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs
    • Potter, K. N., Li, Y., and Capra, J. D. (1996). Staphylococcal protein A simultaneously interacts with framework region 1, complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs. J. Immunol. 157, 2982-2988.
    • (1996) J. Immunol. , vol.157 , pp. 2982-2988
    • Potter, K.N.1    Li, Y.2    Capra, J.D.3
  • 74
    • 84862269218 scopus 로고    scopus 로고
    • Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations
    • Prabakaran, P., Chen, W., Singarayan, M. G., Stewart, C. C., Streaker, E., Feng, Y., et al. (2011). Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations. Immunogenetics 64, 337-350.
    • (2011) Immunogenetics , vol.64 , pp. 337-350
    • Prabakaran, P.1    Chen, W.2    Singarayan, M.G.3    Stewart, C.C.4    Streaker, E.5    Feng, Y.6
  • 75
    • 0029164869 scopus 로고
    • Light chain replacement: a new model for antibody gene rearrangement
    • Prak, E. L., and Weigert, M. (1995). Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 182, 541-548.
    • (1995) J. Exp. Med. , vol.182 , pp. 541-548
    • Prak, E.L.1    Weigert, M.2
  • 76
    • 0030864457 scopus 로고    scopus 로고
    • Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences
    • Raaphorst, F. M., Raman, C. S., Tami, J., Fischbach, M., and Sanz, I. (1997). Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences. Int. Immunol. 9, 1503-1515.
    • (1997) Int. Immunol. , vol.9 , pp. 1503-1515
    • Raaphorst, F.M.1    Raman, C.S.2    Tami, J.3    Fischbach, M.4    Sanz, I.5
  • 77
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • Rada, C., Ehrenstein, M. R., Neuberger, M. S., and Milstein, C. (1998). Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9, 135-141.
    • (1998) Immunity , vol.9 , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 78
    • 0035881820 scopus 로고    scopus 로고
    • The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
    • Rada, C., and Milstein, C. (2001). The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J. 20, 4570-4576.
    • (2001) EMBO J. , vol.20 , pp. 4570-4576
    • Rada, C.1    Milstein, C.2
  • 79
    • 0030483540 scopus 로고    scopus 로고
    • Receptor editing, immune diversification, and self-tolerance
    • Radic, M., and Zouali, M. (1996). Receptor editing, immune diversification, and self-tolerance. Immunity 5, 505-511.
    • (1996) Immunity , vol.5 , pp. 505-511
    • Radic, M.1    Zouali, M.2
  • 80
    • 0023510298 scopus 로고
    • Evolutionary and somatic selection of the antibody repertoire in the mouse
    • Rajewsky, K., Förster, I., and Cumano, A. (1987). Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238, 1088-1094.
    • (1987) Science , vol.238 , pp. 1088-1094
    • Rajewsky, K.1    Förster, I.2    Cumano, A.3
  • 81
    • 0028291092 scopus 로고
    • Conservation of sequence in recombination signal sequence spacers
    • Ramsden, D. A., Baetz, K., and Wu, G. E. (1994). Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res. 22, 1785-1796.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 1785-1796
    • Ramsden, D.A.1    Baetz, K.2    Wu, G.E.3
  • 82
    • 0029891597 scopus 로고    scopus 로고
    • Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage
    • Ramsden, D. A., McBlane, J. F., van Gent, D. C., and Gellert, M. (1996). Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO J. 15, 3197-3206.
    • (1996) EMBO J. , vol.15 , pp. 3197-3206
    • Ramsden, D.A.1    McBlane, J.F.2    van Gent, D.C.3    Gellert, M.4
  • 83
    • 34248168050 scopus 로고    scopus 로고
    • Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires
    • Reason, D. C., and Zhou, J. (2006). Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires. Biol. Direct 1, 24.
    • (2006) Biol. Direct , vol.1 , pp. 24
    • Reason, D.C.1    Zhou, J.2
  • 84
    • 0022557584 scopus 로고
    • A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production
    • Reth, M., Gehrmann, P., Petrac, E., and Wiese, P. (1986). A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature 322, 840-842.
    • (1986) Nature , vol.322 , pp. 840-842
    • Reth, M.1    Gehrmann, P.2    Petrac, E.3    Wiese, P.4
  • 85
    • 0032487518 scopus 로고    scopus 로고
    • Receptor editing occurs frequently during normal B cell development
    • Retter, M. W., and Nemazee, D. (1998). Receptor editing occurs frequently during normal B cell development. J. Exp. Med. 188, 1231-1238.
    • (1998) J. Exp. Med. , vol.188 , pp. 1231-1238
    • Retter, M.W.1    Nemazee, D.2
  • 86
    • 0141720776 scopus 로고    scopus 로고
    • Restraining the V(D)J recombinase
    • Roth, D. B. (2003). Restraining the V(D)J recombinase. Nat. Rev. Immunol. 3, 656-666.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 656-666
    • Roth, D.B.1
  • 87
    • 0026792892 scopus 로고
    • V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth, D. B., Menetski, J. P., Nakajima, P. B., Bosma, M. J., and Gellert, M. (1992). V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70, 983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 88
    • 0035312712 scopus 로고    scopus 로고
    • The RAG proteins in V(D)J recombination: more than just a nuclease
    • Sadofsky, M. J. (2001). The RAG proteins in V(D)J recombination: more than just a nuclease. Nucleic Acids Res. 29, 1399-1409.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 1399-1409
    • Sadofsky, M.J.1
  • 89
    • 0025781883 scopus 로고
    • Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions
    • Sanz, I. (1991). Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J. Immunol. 147, 1720-1729.
    • (1991) J. Immunol. , vol.147 , pp. 1720-1729
    • Sanz, I.1
  • 90
    • 3242888974 scopus 로고    scopus 로고
    • V(D)J recombination
    • Schatz, D. G. (2004). V(D)J recombination. Immunol. Rev. 200, 5-11.
    • (2004) Immunol. Rev. , vol.200 , pp. 5-11
    • Schatz, D.G.1
  • 91
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz, D. G., Oettinger, M. A., and Baltimore, D. (1989). The V(D)J recombination activating gene, RAG-1. Cell 59, 1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 92
  • 93
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated
    • Schlissel, M., Constantinescu, A., Morrow, T., Baxter, M., and Peng, A. (1993). Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7, 2520-2532.
    • (1993) Genes Dev. , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 94
    • 0036449454 scopus 로고    scopus 로고
    • DNA target motifs of somatic mutagenesis in antibody genes
    • Shapiro, G., and Wysocki, L. (2002). DNA target motifs of somatic mutagenesis in antibody genes. Crit. Rev. Immunol. 22, 183-200.
    • (2002) Crit. Rev. Immunol. , vol.22 , pp. 183-200
    • Shapiro, G.1    Wysocki, L.2
  • 95
    • 0032973315 scopus 로고    scopus 로고
    • DNA hairpin opening mediated by the RAG1 and RAG2 proteins
    • Shockett, P. E., and Schatz, D. G. (1999). DNA hairpin opening mediated by the RAG1 and RAG2 proteins. Mol. Cell. Biol. 19, 4159-4166.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4159-4166
    • Shockett, P.E.1    Schatz, D.G.2
  • 96
    • 0030155949 scopus 로고    scopus 로고
    • The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
    • Steen, S., Gomelsky, L., and Roth, D. (1996). The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1, 543-553.
    • (1996) Genes Cells , vol.1 , pp. 543-553
    • Steen, S.1    Gomelsky, L.2    Roth, D.3
  • 97
    • 0027691148 scopus 로고
    • Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus
    • Taki, S., Meiering, M., and Rajewsky, K. (1993). Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science 262, 1268-1271.
    • (1993) Science , vol.262 , pp. 1268-1271
    • Taki, S.1    Meiering, M.2    Rajewsky, K.3
  • 98
    • 58049198443 scopus 로고    scopus 로고
    • Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells
    • doi: 10.1371/journal.pone.0003942
    • Throsby, M., van den Brink, E., Jongeneelen, M., Poon, L. L. M., Alard, P., Cornelissen, L., et al. (2008). Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS ONE 3:e3942. doi: 10.1371/journal.pone.0003942
    • (2008) PLoS ONE , vol.3
    • Throsby, M.1    van den Brink, E.2    Jongeneelen, M.3    Poon, L.L.M.4    Alard, P.5    Cornelissen, L.6
  • 99
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. (1983). Somatic generation of antibody diversity. Nature 302, 575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 100
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent, D. C., Ramsden, D. A., and Gellert, M. (1996). The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85, 107-113.
    • (1996) Cell , vol.85 , pp. 107-113
    • van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 102
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker, J. R., Corpina, R. A., and Goldberg, J. (2001). Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412, 607-614.
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 103
    • 80053132436 scopus 로고    scopus 로고
    • Broad neutralization coverage of HIV by multiple highly potent antibodies
    • Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J.-P., et al. (2011). Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 477, 466-470.
    • (2011) Nature , vol.477 , pp. 466-470
    • Walker, L.M.1    Huber, M.2    Doores, K.J.3    Falkowska, E.4    Pejchal, R.5    Julien, J.-P.6
  • 104
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • Walker, L. M., Phogat, S. K., Chan-Hui, P.-Y., Wagner, D., Phung, P., Goss, J. L., et al. (2009). Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 326, 285-289.
    • (2009) Science , vol.326 , pp. 285-289
    • Walker, L.M.1    Phogat, S.K.2    Chan-Hui, P.-Y.3    Wagner, D.4    Phung, P.5    Goss, J.L.6
  • 105
    • 33745872580 scopus 로고    scopus 로고
    • Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice
    • Watson, L. C., Moffatt-Blue, C. S., McDonald, R. Z., Kompfner, E., Ait-Azzouzene, D., Nemazee, D., et al. (2006). Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice. J. Immunol. 177, 1120-1128.
    • (2006) J. Immunol. , vol.177 , pp. 1120-1128
    • Watson, L.C.1    Moffatt-Blue, C.S.2    McDonald, R.Z.3    Kompfner, E.4    Ait-Azzouzene, D.5    Nemazee, D.6
  • 106
    • 0034614916 scopus 로고    scopus 로고
    • Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
    • Wiesendanger, M., Kneitz, B., Edelmann, W., and Scharff, M. D. (2000). Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J. Exp. Med. 191, 579-584.
    • (2000) J. Exp. Med. , vol.191 , pp. 579-584
    • Wiesendanger, M.1    Kneitz, B.2    Edelmann, W.3    Scharff, M.D.4
  • 107
    • 0031983725 scopus 로고    scopus 로고
    • Somatic hypermutation introduces insertions and deletions into immunoglobulin genes
    • Wilson, P. C., de Bouteiller, O., Liu, Y., Potter, K., Banchereau, J., Capra, J. D., et al. (1998a). Somatic hypermutation introduces insertions and deletions into immunoglobulin genes. J. Exp. Med. 187, 59-70.
    • (1998) J. Exp. Med. , vol.187 , pp. 59-70
    • Wilson, P.C.1    de Bouteiller, O.2    Liu, Y.3    Potter, K.4    Banchereau, J.5    Capra, J.D.6
  • 108
    • 0031916926 scopus 로고    scopus 로고
    • Amino acid insertions and deletions contribute to diversify the human Ig repertoire
    • Wilson, P. C., Liu, Y. J., Banchereau, J., Capra, J. D., and Pascual, V. (1998b). Amino acid insertions and deletions contribute to diversify the human Ig repertoire. Immunol. Rev. 162, 143-151.
    • (1998) Immunol. Rev. , vol.162 , pp. 143-151
    • Wilson, P.C.1    Liu, Y.J.2    Banchereau, J.3    Capra, J.D.4    Pascual, V.5
  • 109
    • 0034608480 scopus 로고    scopus 로고
    • Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes
    • Wilson, P. C., Wilson, K., Liu, Y. J., Banchereau, J., Pascual, V., and Capra, J. D. (2000). Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J. Exp. Med. 191, 1881-1894.
    • (2000) J. Exp. Med. , vol.191 , pp. 1881-1894
    • Wilson, P.C.1    Wilson, K.2    Liu, Y.J.3    Banchereau, J.4    Pascual, V.5    Capra, J.D.6
  • 110
    • 77954920017 scopus 로고    scopus 로고
    • Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    • Wu, X., Yang, Z.-Y., Li, Y., Hogerkorp, C.-M., Schief, W. R., Seaman, M. S., et al. (2010a). Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329, 856-861.
    • (2010) Science , vol.329 , pp. 856-861
    • Wu, X.1    Yang, Z.-Y.2    Li, Y.3    Hogerkorp, C.-M.4    Schief, W.R.5    Seaman, M.S.6
  • 111
    • 77956551877 scopus 로고    scopus 로고
    • High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations
    • Wu, Y.-C., Kipling, D., Leong, H. S., Martin, V., Ademokun, A. A., and Dunn-Walters, D. K. (2010b). High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations. Blood 116, 1070-1078.
    • (2010) Blood , vol.116 , pp. 1070-1078
    • Wu, Y.-C.1    Kipling, D.2    Leong, H.S.3    Martin, V.4    Ademokun, A.A.5    Dunn-Walters, D.K.6
  • 112
    • 0942290431 scopus 로고    scopus 로고
    • The molecular basis and biological significance of VH replacement
    • Zhang, Z., Burrows, P. D., and Cooper, M. D. (2004). The molecular basis and biological significance of VH replacement. Immunol. Rev. 197, 231-242.
    • (2004) Immunol. Rev. , vol.197 , pp. 231-242
    • Zhang, Z.1    Burrows, P.D.2    Cooper, M.D.3
  • 113
    • 0038783610 scopus 로고    scopus 로고
    • Contribution of Vh gene replacement to the primary B cell repertoire
    • Zhang, Z., Zemlin, M., Wang, Y.-H., Munfus, D., Huye, L. E., Findley, H. W., et al. (2003). Contribution of Vh gene replacement to the primary B cell repertoire. Immunity 19, 21-31.
    • (2003) Immunity , vol.19 , pp. 21-31
    • Zhang, Z.1    Zemlin, M.2    Wang, Y.-H.3    Munfus, D.4    Huye, L.E.5    Findley, H.W.6
  • 114
    • 18644366944 scopus 로고    scopus 로고
    • Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation
    • Zheng, N.-Y., Wilson, K., Jared, M., and Wilson, P. C. (2005). Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J. Exp. Med. 201, 1467-1478.
    • (2005) J. Exp. Med. , vol.201 , pp. 1467-1478
    • Zheng, N.-Y.1    Wilson, K.2    Jared, M.3    Wilson, P.C.4
  • 115
    • 2542556728 scopus 로고    scopus 로고
    • Somatic hypermutation and diverse immunoglobulin gene usage in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae Type 6B
    • Zhou, J., Lottenbach, K. R., Barenkamp, S. J., and Reason, D. C. (2004). Somatic hypermutation and diverse immunoglobulin gene usage in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae Type 6B. Infect. Immun. 72, 3505-3514.
    • (2004) Infect. Immun. , vol.72 , pp. 3505-3514
    • Zhou, J.1    Lottenbach, K.R.2    Barenkamp, S.J.3    Reason, D.C.4
  • 116
    • 77954943648 scopus 로고    scopus 로고
    • Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
    • Zhou, T., Georgiev, I., Wu, X., Yang, Z.-Y., Dai, K., Finzi, A., et al. (2010). Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science 329, 811-817.
    • (2010) Science , vol.329 , pp. 811-817
    • Zhou, T.1    Georgiev, I.2    Wu, X.3    Yang, Z.-Y.4    Dai, K.5    Finzi, A.6


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