An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody

mBio

Volumn 2, Issue 1, 2011, Pages

  Krause, Jens C ^a   Ekiert, Damian C ^b   Tumpey, Terrence M ^c   Smith, Patricia B ^a   Wilson, Ian A ^b   Crowe, James E ^a,d  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2D1; UNCLASSIFIED DRUG; IMMUNOGLOBULIN HEAVY CHAIN; VIRUS ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FEMALE; HEAVY CHAIN; HEMAGGLUTINATION INHIBITION; INDEL MUTATION; INFLUENZA A (H1N1); MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION; STRUCTURE ACTIVITY RELATION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; INFLUENZA; INFLUENZA VIRUS A H1N1; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; VIROLOGY;

ORTHOMYXOVIRIDAE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; BASE SEQUENCE; BINDING SITES, ANTIBODY; CELL LINE; FEMALE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 79955113580     PISSN: None     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00345-10     Document Type: Article

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