-
1
-
-
0018093829
-
A complete immunoglobulin gene is created by somatic recombination
-
Brack C, Hirama M, Lenhard-Schuller R, Tonegawa S. A complete immunoglobulin gene is created by somatic recombination. Cell 1978; 15:1-14.
-
(1978)
Cell
, vol.15
, pp. 1-14
-
-
Brack, C.1
Hirama, M.2
Lenhard-Schuller, R.3
Tonegawa, S.4
-
3
-
-
0020534965
-
Somatic generation of antibody diversity
-
Tonegawa S. Somatic generation of antibody diversity. Nature 1983; 302:575-81.
-
(1983)
Nature
, vol.302
, pp. 575-581
-
-
Tonegawa, S.1
-
4
-
-
0024846088
-
The V(D)J recombination activating gene, RAG-1
-
Schatz DG, Oettinger MA, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell 1989; 59:1035-48.
-
(1989)
Cell
, vol.59
, pp. 1035-1048
-
-
Schatz, D.G.1
Oettinger, M.A.2
Baltimore, D.3
-
5
-
-
0025301095
-
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
-
Oettinger M, Schatz D, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990; 248:1517-23.
-
(1990)
Science
, vol.248
, pp. 1517-1523
-
-
Oettinger, M.1
Schatz, D.2
Gorka, C.3
Baltimore, D.4
-
6
-
-
0024691453
-
V(D)J recombination - a functional definition of the joining signals
-
Hesse J, Lieber M, Mizuuchi K, Gellert M. V(D)J recombination - a functional definition of the joining signals. Genes Dev 1989; 3:1053-61.
-
(1989)
Genes Dev
, vol.3
, pp. 1053-1061
-
-
Hesse, J.1
Lieber, M.2
Mizuuchi, K.3
Gellert, M.4
-
7
-
-
0026664137
-
VDJ recombination
-
Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J. VDJ recombination. Immunol Today 1992; 13:306-14.
-
(1992)
Immunol Today
, vol.13
, pp. 306-314
-
-
Alt, F.W.1
Oltz, E.M.2
Young, F.3
Gorman, J.4
Taccioli, G.5
Chen, J.6
-
8
-
-
0001265782
-
RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination
-
Difilippantonio MJ, McMahan CJ, Eastman QM, Spanopoulou E, Schatz DG. RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell 1996; 87:253-62.
-
(1996)
Cell
, vol.87
, pp. 253-262
-
-
Difilippantonio, M.J.1
McMahan, C.J.2
Eastman, Q.M.3
Spanopoulou, E.4
Schatz, D.G.5
-
9
-
-
0029814965
-
DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
-
Cuomo CA, Mundy CL, Oettinger MA. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol Cell Biol 1996; 16:5683-90.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5683-5690
-
-
Cuomo, C.A.1
Mundy, C.L.2
Oettinger, M.A.3
-
10
-
-
0032400975
-
Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease
-
Nadel B, Tang A, Lugo G, Love V, Escuro G, Feeney AJ. Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease. J Immunol 1998; 161:6068-73.
-
(1998)
J Immunol
, vol.161
, pp. 6068-6073
-
-
Nadel, B.1
Tang, A.2
Lugo, G.3
Love, V.4
Escuro, G.5
Feeney, A.J.6
-
11
-
-
0028291092
-
Conservation of sequence in recombination signal sequence spacers
-
Ramsden DA, Baetz K, Wu GE. Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res 1994; 22:1785-96.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 1785-1796
-
-
Ramsden, D.A.1
Baetz, K.2
Wu, G.E.3
-
12
-
-
3242875994
-
A functional analysis of the spacer of V(D)J recombination signal sequences
-
Lee AI, Fugmann SD, Cowell LG, Ptaszek LM, Kelsoe G, Schatz DG. A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol 2003; 1:E1.
-
(2003)
PLoS Biol
, vol.1
-
-
Lee, A.I.1
Fugmann, S.D.2
Cowell, L.G.3
Ptaszek, L.M.4
Kelsoe, G.5
Schatz, D.G.6
-
13
-
-
0242578825
-
V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence
-
Montalbano A, Ogwaro KM, Tang A, Matthews AG, Larijani M, Oettinger MA, Feeney AJ. V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence. J Immunol 2003; 171:5296-304.
-
(2003)
J Immunol
, vol.171
, pp. 5296-5304
-
-
Montalbano, A.1
Ogwaro, K.M.2
Tang, A.3
Matthews, A.G.4
Larijani, M.5
Oettinger, M.A.6
Feeney, A.J.7
-
14
-
-
0030009253
-
The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
-
van Gent DC, Ramsden DA, Gellert M. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 1996; 85:107-13.
-
(1996)
Cell
, vol.85
, pp. 107-113
-
-
van Gent, D.C.1
Ramsden, D.A.2
Gellert, M.3
-
15
-
-
0029891597
-
Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage
-
Ramsden DA, McBlane JF, van Gent DC, Gellert M. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO J 1996; 15:3197-206.
-
(1996)
EMBO J
, vol.15
, pp. 3197-3206
-
-
Ramsden, D.A.1
McBlane, J.F.2
van Gent, D.C.3
Gellert, M.4
-
16
-
-
0030155949
-
The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
-
Steen S, Gomelsky L, Roth D. The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1996; 1:543-53.
-
(1996)
Genes Cells
, vol.1
, pp. 543-553
-
-
Steen, S.1
Gomelsky, L.2
Roth, D.3
-
17
-
-
3242888974
-
V(D)J recombination
-
Schatz DG. V(D)J recombination. Immunol Rev 2004; 200:5-11.
-
(2004)
Immunol Rev
, vol.200
, pp. 5-11
-
-
Schatz, D.G.1
-
18
-
-
0026792892
-
V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
-
Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 1992; 70:983-91.
-
(1992)
Cell
, vol.70
, pp. 983-991
-
-
Roth, D.B.1
Menetski, J.P.2
Nakajima, P.B.3
Bosma, M.J.4
Gellert, M.5
-
19
-
-
0027769386
-
Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated
-
Schlissel M, Constantinescu A, Morrow T, Baxter M, Peng A. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev 1993; 7:2520-32.
-
(1993)
Genes Dev
, vol.7
, pp. 2520-2532
-
-
Schlissel, M.1
Constantinescu, A.2
Morrow, T.3
Baxter, M.4
Peng, A.5
-
20
-
-
0028805853
-
Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
-
McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 1995; 83:387-95.
-
(1995)
Cell
, vol.83
, pp. 387-395
-
-
McBlane, J.F.1
van Gent, D.C.2
Ramsden, D.A.3
Romeo, C.4
Cuomo, C.A.5
Gellert, M.6
Oettinger, M.A.7
-
21
-
-
0035312712
-
The RAG proteins in V(D)J recombination: more than just a nuclease
-
Sadofsky MJ. The RAG proteins in V(D)J recombination: more than just a nuclease. Nucleic Acids Res 2001; 29:1399-409.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 1399-1409
-
-
Sadofsky, M.J.1
-
22
-
-
0028048275
-
The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses
-
Lewis SM. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv Immunol 1994; 56:27-150.
-
(1994)
Adv Immunol
, vol.56
, pp. 27-150
-
-
Lewis, S.M.1
-
23
-
-
0033598831
-
Association of terminal deoxynucleotidyl transferase with Ku
-
Mahajan KN, Gangi-Peterson L, Sorscher DH, Wang J, Gathy KN, Mahajan NP, Reeves WH, Mitchell BS. Association of terminal deoxynucleotidyl transferase with Ku. Proc Natl Acad Sci USA 1999; 96:13926-31.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13926-13931
-
-
Mahajan, K.N.1
Gangi-Peterson, L.2
Sorscher, D.H.3
Wang, J.4
Gathy, K.N.5
Mahajan, N.P.6
Reeves, W.H.7
Mitchell, B.S.8
-
24
-
-
0032973315
-
DNA hairpin opening mediated by the RAG1 and RAG2 proteins
-
Shockett PE, Schatz DG. DNA hairpin opening mediated by the RAG1 and RAG2 proteins. Mol Cell Biol 1999; 19:4159-66.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4159-4166
-
-
Shockett, P.E.1
Schatz, D.G.2
-
25
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker JR, Corpina RA, Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001; 412:607-14.
-
(2001)
Nature
, vol.412
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
Goldberg, J.3
-
26
-
-
0037416170
-
VDJ recombination: artemis and its in vivo role in hairpin opening
-
Mansilla-Soto J, Cortes P. VDJ recombination: artemis and its in vivo role in hairpin opening. J Exp Med 2003; 197:543-7.
-
(2003)
J Exp Med
, vol.197
, pp. 543-547
-
-
Mansilla-Soto, J.1
Cortes, P.2
-
27
-
-
0141720776
-
Restraining the V(D)J recombinase
-
Roth DB. Restraining the V(D)J recombinase. Nat Rev Immunol 2003; 3:656-66.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 656-666
-
-
Roth, D.B.1
-
29
-
-
0020041687
-
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments
-
Kurosawa Y, Tonegawa S. Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. J Exp Med 1982; 155:201-18.
-
(1982)
J Exp Med
, vol.155
, pp. 201-218
-
-
Kurosawa, Y.1
Tonegawa, S.2
-
30
-
-
0023513107
-
Development of the primary antibody repertoire
-
Alt F, Blackwell T, Yancopoulos G. Development of the primary antibody repertoire. Science 1987; 238:1079-87.
-
(1987)
Science
, vol.238
, pp. 1079-1087
-
-
Alt, F.1
Blackwell, T.2
Yancopoulos, G.3
-
32
-
-
0019850678
-
Human immunoglobulin D segments encoded in tandem multigenic families
-
Siebenlist UU, Ravetch JVJ, Korsmeyer SS, Waldmann TT, Leder PP. Human immunoglobulin D segments encoded in tandem multigenic families. Nature 1981; 294:631-5.
-
(1981)
Nature
, vol.294
, pp. 631-635
-
-
Siebenlist, U.U.1
Ravetch, J.V.J.2
Korsmeyer, S.S.3
Waldmann, T.T.4
Leder, P.P.5
-
33
-
-
0031586221
-
Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination
-
Corbett SJ, Tomlinson IM, Sonnhammer EL, Buck D, Winter G. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J Mol Biol 1997; 270:587-97.
-
(1997)
J Mol Biol
, vol.270
, pp. 587-597
-
-
Corbett, S.J.1
Tomlinson, I.M.2
Sonnhammer, E.L.3
Buck, D.4
Winter, G.5
-
34
-
-
0024293529
-
Organization of human immunoglobulin heavy chain diversity gene loci
-
Ichihara YY, Matsuoka HH, Kurosawa YY. Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J 1988; 7:4141-50.
-
(1988)
EMBO J
, vol.7
, pp. 4141-4150
-
-
Ichihara, Y.Y.1
Matsuoka, H.H.2
Kurosawa, Y.Y.3
-
35
-
-
0025781883
-
Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions
-
Sanz I. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J Immunol 1991; 147:1720-9.
-
(1991)
J Immunol
, vol.147
, pp. 1720-1729
-
-
Sanz, I.1
-
36
-
-
0026552320
-
Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells
-
Kiyoi H, Naoe T, Horibe K, Ohno R. Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. J Clin Invest 1992; 89:739-46.
-
(1992)
J Clin Invest
, vol.89
, pp. 739-746
-
-
Kiyoi, H.1
Naoe, T.2
Horibe, K.3
Ohno, R.4
-
37
-
-
0030864457
-
Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences
-
Raaphorst FM, Raman CS, Tami J, Fischbach M, Sanz I. Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences. Int Immunol 1997; 9:1503-15.
-
(1997)
Int Immunol
, vol.9
, pp. 1503-1515
-
-
Raaphorst, F.M.1
Raman, C.S.2
Tami, J.3
Fischbach, M.4
Sanz, I.5
-
41
-
-
0023475193
-
Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining
-
Akira S, Okazaki K, Sakano H. Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining. Science 1987; 238:1134-8.
-
(1987)
Science
, vol.238
, pp. 1134-1138
-
-
Akira, S.1
Okazaki, K.2
Sakano, H.3
-
42
-
-
0028172537
-
Essential residues in V(D)J recombination signals
-
Akamatsu Y, Tsurushita N, Nagawa F, Matsuoka M, Okazaki K, Imai M, Sakano H. Essential residues in V(D)J recombination signals. J Immunol 1994; 153:4520-9.
-
(1994)
J Immunol
, vol.153
, pp. 4520-4529
-
-
Akamatsu, Y.1
Tsurushita, N.2
Nagawa, F.3
Matsuoka, M.4
Okazaki, K.5
Imai, M.6
Sakano, H.7
-
43
-
-
0025017688
-
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
-
Shlomchik M, Mascelli M, Shan H, Radic MZ, Pisetsky D, Marshak-Rothstein A, Weigert M. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med 1990; 171:265-92.
-
(1990)
J Exp Med
, vol.171
, pp. 265-292
-
-
Shlomchik, M.1
Mascelli, M.2
Shan, H.3
Radic, M.Z.4
Pisetsky, D.5
Marshak-Rothstein, A.6
Weigert, M.7
-
44
-
-
0028101448
-
Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments
-
Ichiyoshi Y, Casali P. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. J Exp Med 1994; 180:885-95.
-
(1994)
J Exp Med
, vol.180
, pp. 885-895
-
-
Ichiyoshi, Y.1
Casali, P.2
-
45
-
-
0029902365
-
Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection
-
Ditzel HJ, Itoh K, Burton DR. Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection. J Immunol 1996; 157:739-49.
-
(1996)
J Immunol
, vol.157
, pp. 739-749
-
-
Ditzel, H.J.1
Itoh, K.2
Burton, D.R.3
-
46
-
-
0041689676
-
Predominant autoantibody production by early human B cell precursors
-
Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science 2003; 301:1374-7.
-
(2003)
Science
, vol.301
, pp. 1374-1377
-
-
Wardemann, H.1
Yurasov, S.2
Schaefer, A.3
Young, J.W.4
Meffre, E.5
Nussenzweig, M.C.6
-
47
-
-
9144265458
-
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936
-
van Dongen JJ, Langerak AW, Brüggemann M et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17:2257-317.
-
(2003)
Leukemia
, vol.17
, pp. 2257-2317
-
-
van Dongen, J.J.1
Langerak, A.W.2
Brüggemann, M.3
-
48
-
-
33846200858
-
Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells
-
Tian C, Luskin GK, Dischert KM, Higginbotham JN, Shepherd BE, Crowe JE Jr. Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naïve and memory B cells. Mol Immunol 2007; 44:2173-83.
-
(2007)
Mol Immunol
, vol.44
, pp. 2173-2183
-
-
Tian, C.1
Luskin, G.K.2
Dischert, K.M.3
Higginbotham, J.N.4
Shepherd, B.E.5
Crowe Jr., J.E.6
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